Mitochondrial pyruvate carrier

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0041) - putative

Species:

Leishmania infantum

UniProt:

A4HRF6_LEIIN

TriTrypDb:

LINF_010008400

Length:

Annotations

LeishMANIAdb annotations

Homologous to mammalian MCP1 proteins. Localization: Mitochondrial (by homology)

Annotations by Jardim et al.

Pyruvate metabolism, Mitochondrial pyruvate carrier 1

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	9
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	9
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HRF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRF6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006811	monoatomic ion transport	4	10
GO:0006820	monoatomic anion transport	5	10
GO:0006848	pyruvate transport	6	10
GO:0006850	mitochondrial pyruvate transmembrane transport	4	10
GO:0009987	cellular process	1	10
GO:0015711	organic anion transport	5	10
GO:0015718	monocarboxylic acid transport	7	10
GO:0015849	organic acid transport	5	10
GO:0034220	monoatomic ion transmembrane transport	3	10
GO:0046942	carboxylic acid transport	6	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0071702	organic substance transport	4	10
GO:0098656	monoatomic anion transmembrane transport	4	10
GO:1901475	pyruvate transmembrane transport	5	10
GO:1903825	organic acid transmembrane transport	3	10
GO:1905039	carboxylic acid transmembrane transport	4	10
GO:1990542	mitochondrial transmembrane transport	3	10

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0008028	monocarboxylic acid transmembrane transporter activity	5	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0008514	organic anion transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1
GO:0050833	pyruvate transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_MDM2_SWIB_1	51	59	PF02201	0.310
DOC_USP7_MATH_1	71	75	PF00917	0.453
LIG_14-3-3_CanoR_1	32	41	PF00244	0.316
LIG_14-3-3_CanoR_1	54	58	PF00244	0.497
LIG_BRCT_BRCA1_1	2	6	PF00533	0.542
LIG_BRCT_BRCA1_1	48	52	PF00533	0.278
LIG_LIR_Nem_3	3	9	PF02991	0.546
LIG_MLH1_MIPbox_1	48	52	PF16413	0.310
LIG_PDZ_Class_2	92	97	PF00595	0.492
LIG_Pex14_2	51	55	PF04695	0.310
LIG_REV1ctd_RIR_1	49	58	PF16727	0.310
LIG_SH2_STAP1	48	52	PF00017	0.245
LIG_SH2_STAT5	9	12	PF00017	0.311
LIG_SH3_3	27	33	PF00018	0.288
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.479
MOD_GSK3_1	28	35	PF00069	0.214
MOD_N-GLC_1	72	77	PF02516	0.228
MOD_NEK2_1	53	58	PF00069	0.321
MOD_NEK2_2	46	51	PF00069	0.310
MOD_PIKK_1	87	93	PF00454	0.476
MOD_PKA_2	53	59	PF00069	0.309
MOD_Plk_1	72	78	PF00069	0.462
MOD_Plk_4	40	46	PF00069	0.305
MOD_Plk_4	55	61	PF00069	0.485
TRG_ENDOCYTIC_2	48	51	PF00928	0.257
TRG_ENDOCYTIC_2	64	67	PF00928	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P1	Leptomonas seymouri	81%	95%
A0A0S4JMG3	Bodo saltans	59%	98%
A0A451EJ90	Leishmania donovani	100%	100%
A4H359	Leishmania braziliensis	89%	100%
C9ZXI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AC24	Leishmania major	98%	100%
E9AJC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74847	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	69%
P0DKB6	Homo sapiens	34%	71%
P53157	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	75%
P63030	Mus musculus	39%	89%
P63031	Rattus norvegicus	39%	89%
Q21828	Caenorhabditis elegans	41%	71%
Q3ZCG2	Bos taurus	40%	89%
Q55GU4	Dictyostelium discoideum	48%	100%
Q7KSC4	Drosophila melanogaster	36%	91%
Q949R9	Arabidopsis thaliana	46%	88%
Q9Y5U8	Homo sapiens	40%	89%
V5BEK3	Trypanosoma cruzi	70%	100%