BPH_2 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HRF5_LEIIN

TriTrypDb:

LINF_010008300

Length:

210

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005787	signal peptidase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1

Expansion

Sequence features

A4HRF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRF5

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.389
CLV_PCSK_SKI1_1	129	133	PF00082	0.365
CLV_PCSK_SKI1_1	30	34	PF00082	0.396
CLV_PCSK_SKI1_1	54	58	PF00082	0.287
CLV_PCSK_SKI1_1	59	63	PF00082	0.330
DOC_MAPK_FxFP_2	187	190	PF00069	0.523
DOC_MAPK_gen_1	129	138	PF00069	0.518
DOC_MAPK_gen_1	74	82	PF00069	0.376
DOC_MAPK_MEF2A_6	132	140	PF00069	0.503
DOC_PP4_FxxP_1	163	166	PF00568	0.612
DOC_PP4_FxxP_1	187	190	PF00568	0.506
DOC_USP7_MATH_1	120	124	PF00917	0.647
DOC_USP7_MATH_1	203	207	PF00917	0.547
DOC_WW_Pin1_4	161	166	PF00397	0.580
LIG_14-3-3_CanoR_1	139	145	PF00244	0.547
LIG_14-3-3_CanoR_1	18	28	PF00244	0.521
LIG_14-3-3_CanoR_1	30	39	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.673
LIG_BRCT_BRCA1_1	159	163	PF00533	0.580
LIG_BRCT_BRCA1_1	183	187	PF00533	0.606
LIG_BRCT_BRCA1_1	83	87	PF00533	0.356
LIG_Clathr_ClatBox_1	149	153	PF01394	0.484
LIG_EH1_1	74	82	PF00400	0.241
LIG_FHA_1	111	117	PF00498	0.530
LIG_FHA_1	20	26	PF00498	0.555
LIG_FHA_1	31	37	PF00498	0.523
LIG_FHA_1	96	102	PF00498	0.491
LIG_FHA_2	2	8	PF00498	0.610
LIG_GBD_Chelix_1	93	101	PF00786	0.221
LIG_LIR_Apic_2	160	166	PF02991	0.614
LIG_LIR_Apic_2	184	190	PF02991	0.517
LIG_LIR_Gen_1	153	162	PF02991	0.495
LIG_LIR_Nem_3	153	157	PF02991	0.550
LIG_LIR_Nem_3	175	181	PF02991	0.526
LIG_LIR_Nem_3	38	42	PF02991	0.583
LIG_LIR_Nem_3	84	89	PF02991	0.334
LIG_MLH1_MIPbox_1	83	87	PF16413	0.275
LIG_PCNA_yPIPBox_3	194	208	PF02747	0.591
LIG_SH2_NCK_1	169	173	PF00017	0.540
LIG_SH2_STAT5	39	42	PF00017	0.512
LIG_SH2_STAT5	70	73	PF00017	0.382
LIG_TYR_ITIM	40	45	PF00017	0.552
LIG_WW_1	166	169	PF00397	0.393
MOD_CK2_1	1	7	PF00069	0.589
MOD_CK2_1	167	173	PF00069	0.450
MOD_GlcNHglycan	77	80	PF01048	0.449
MOD_GSK3_1	110	117	PF00069	0.398
MOD_GSK3_1	157	164	PF00069	0.508
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	110	115	PF00069	0.273
MOD_NEK2_1	181	186	PF00069	0.498
MOD_NEK2_1	75	80	PF00069	0.424
MOD_NEK2_1	81	86	PF00069	0.274
MOD_NEK2_1	95	100	PF00069	0.241
MOD_PIKK_1	120	126	PF00454	0.611
MOD_PIKK_1	138	144	PF00454	0.468
MOD_PIKK_1	167	173	PF00454	0.554
MOD_PKA_2	114	120	PF00069	0.429
MOD_PKA_2	138	144	PF00069	0.407
MOD_PKA_2	75	81	PF00069	0.275
MOD_Plk_1	172	178	PF00069	0.473
MOD_Plk_4	1	7	PF00069	0.545
MOD_Plk_4	82	88	PF00069	0.340
MOD_Plk_4	97	103	PF00069	0.412
MOD_ProDKin_1	161	167	PF00069	0.463
MOD_SUMO_for_1	150	153	PF00179	0.373
TRG_ENDOCYTIC_2	169	172	PF00928	0.384
TRG_ENDOCYTIC_2	178	181	PF00928	0.350
TRG_ENDOCYTIC_2	42	45	PF00928	0.439
TRG_ER_diLys_1	207	210	PF00400	0.530
TRG_NLS_MonoExtN_4	126	133	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JMH0	Bodo saltans	30%	77%
A0A1X0P325	Trypanosomatidae	32%	94%
A0A3S5H4U6	Leishmania donovani	100%	100%
A0A3S5ISA1	Trypanosoma rangeli	27%	92%
A4H358	Leishmania braziliensis	75%	100%
C9ZXH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
E9AC23	Leishmania major	94%	100%
E9AJC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%