Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region/Periplasmic copper-binding protein (NosD) - putative

Species:

Leishmania infantum

UniProt:

A4HRE6_LEIIN

TriTrypDb:

LINF_010007400

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.555
CLV_C14_Caspase3-7	309	313	PF00656	0.719
CLV_C14_Caspase3-7	487	491	PF00656	0.657
CLV_C14_Caspase3-7	763	767	PF00656	0.447
CLV_NRD_NRD_1	116	118	PF00675	0.419
CLV_NRD_NRD_1	27	29	PF00675	0.567
CLV_NRD_NRD_1	378	380	PF00675	0.715
CLV_NRD_NRD_1	398	400	PF00675	0.651
CLV_NRD_NRD_1	407	409	PF00675	0.700
CLV_NRD_NRD_1	498	500	PF00675	0.697
CLV_NRD_NRD_1	565	567	PF00675	0.755
CLV_NRD_NRD_1	642	644	PF00675	0.563
CLV_PCSK_KEX2_1	116	118	PF00082	0.419
CLV_PCSK_KEX2_1	27	29	PF00082	0.548
CLV_PCSK_KEX2_1	378	380	PF00082	0.715
CLV_PCSK_KEX2_1	407	409	PF00082	0.735
CLV_PCSK_KEX2_1	498	500	PF00082	0.694
CLV_PCSK_KEX2_1	565	567	PF00082	0.742
CLV_PCSK_KEX2_1	641	643	PF00082	0.581
CLV_PCSK_SKI1_1	116	120	PF00082	0.388
CLV_PCSK_SKI1_1	344	348	PF00082	0.526
CLV_Separin_Metazoa	326	330	PF03568	0.540
DEG_APCC_DBOX_1	102	110	PF00400	0.395
DEG_APCC_DBOX_1	718	726	PF00400	0.383
DEG_SCF_FBW7_1	224	230	PF00400	0.593
DEG_SPOP_SBC_1	359	363	PF00917	0.478
DOC_CDC14_PxL_1	753	761	PF14671	0.539
DOC_CKS1_1	224	229	PF01111	0.594
DOC_CKS1_1	56	61	PF01111	0.487
DOC_CKS1_1	571	576	PF01111	0.710
DOC_CKS1_1	595	600	PF01111	0.556
DOC_CYCLIN_RxL_1	341	352	PF00134	0.521
DOC_MAPK_gen_1	250	260	PF00069	0.502
DOC_MAPK_gen_1	296	306	PF00069	0.660
DOC_MAPK_gen_1	378	384	PF00069	0.715
DOC_MAPK_gen_1	82	89	PF00069	0.397
DOC_MAPK_gen_1	823	833	PF00069	0.349
DOC_MAPK_gen_1	903	911	PF00069	0.375
DOC_MAPK_gen_1	93	102	PF00069	0.421
DOC_MAPK_MEF2A_6	329	337	PF00069	0.557
DOC_MAPK_MEF2A_6	82	89	PF00069	0.397
DOC_MAPK_NFAT4_5	82	90	PF00069	0.399
DOC_PP2B_LxvP_1	279	282	PF13499	0.479
DOC_USP7_MATH_1	155	159	PF00917	0.613
DOC_USP7_MATH_1	197	201	PF00917	0.639
DOC_USP7_MATH_1	227	231	PF00917	0.537
DOC_USP7_MATH_1	366	370	PF00917	0.634
DOC_USP7_MATH_1	414	418	PF00917	0.743
DOC_USP7_MATH_1	446	450	PF00917	0.755
DOC_USP7_MATH_1	46	50	PF00917	0.478
DOC_USP7_MATH_1	471	475	PF00917	0.673
DOC_USP7_MATH_1	480	484	PF00917	0.607
DOC_USP7_MATH_1	491	495	PF00917	0.492
DOC_USP7_MATH_1	5	9	PF00917	0.456
DOC_USP7_MATH_1	516	520	PF00917	0.653
DOC_USP7_MATH_1	586	590	PF00917	0.653
DOC_USP7_MATH_1	662	666	PF00917	0.504
DOC_USP7_MATH_1	743	747	PF00917	0.614
DOC_USP7_MATH_1	749	753	PF00917	0.560
DOC_WW_Pin1_4	189	194	PF00397	0.625
DOC_WW_Pin1_4	195	200	PF00397	0.581
DOC_WW_Pin1_4	223	228	PF00397	0.665
DOC_WW_Pin1_4	229	234	PF00397	0.622
DOC_WW_Pin1_4	282	287	PF00397	0.648
DOC_WW_Pin1_4	467	472	PF00397	0.627
DOC_WW_Pin1_4	520	525	PF00397	0.693
DOC_WW_Pin1_4	545	550	PF00397	0.713
DOC_WW_Pin1_4	55	60	PF00397	0.486
DOC_WW_Pin1_4	554	559	PF00397	0.618
DOC_WW_Pin1_4	567	572	PF00397	0.569
DOC_WW_Pin1_4	594	599	PF00397	0.655
DOC_WW_Pin1_4	603	608	PF00397	0.685
DOC_WW_Pin1_4	612	617	PF00397	0.642
DOC_WW_Pin1_4	619	624	PF00397	0.621
DOC_WW_Pin1_4	631	636	PF00397	0.554
DOC_WW_Pin1_4	645	650	PF00397	0.388
LIG_14-3-3_CanoR_1	145	154	PF00244	0.620
LIG_14-3-3_CanoR_1	168	175	PF00244	0.771
LIG_14-3-3_CanoR_1	329	337	PF00244	0.532
LIG_14-3-3_CanoR_1	35	43	PF00244	0.480
LIG_14-3-3_CanoR_1	498	506	PF00244	0.691
LIG_14-3-3_CanoR_1	518	526	PF00244	0.692
LIG_14-3-3_CanoR_1	552	557	PF00244	0.718
LIG_14-3-3_CanoR_1	587	595	PF00244	0.633
LIG_14-3-3_CanoR_1	6	12	PF00244	0.458
LIG_14-3-3_CanoR_1	602	607	PF00244	0.578
LIG_14-3-3_CanoR_1	642	648	PF00244	0.543
LIG_14-3-3_CanoR_1	65	72	PF00244	0.476
LIG_14-3-3_CanoR_1	655	663	PF00244	0.401
LIG_14-3-3_CanoR_1	702	711	PF00244	0.418
LIG_14-3-3_CanoR_1	750	760	PF00244	0.520
LIG_14-3-3_CanoR_1	82	88	PF00244	0.381
LIG_14-3-3_CanoR_1	832	840	PF00244	0.349
LIG_14-3-3_CanoR_1	887	895	PF00244	0.359
LIG_14-3-3_CanoR_1	905	910	PF00244	0.259
LIG_14-3-3_CanoR_1	912	916	PF00244	0.324
LIG_Actin_WH2_2	502	520	PF00022	0.547
LIG_Actin_WH2_2	69	86	PF00022	0.403
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BIR_III_2	214	218	PF00653	0.593
LIG_CSL_BTD_1	646	649	PF09270	0.529
LIG_FHA_1	28	34	PF00498	0.503
LIG_FHA_1	288	294	PF00498	0.699
LIG_FHA_1	512	518	PF00498	0.547
LIG_FHA_1	551	557	PF00498	0.761
LIG_FHA_1	75	81	PF00498	0.379
LIG_FHA_1	793	799	PF00498	0.399
LIG_FHA_1	848	854	PF00498	0.375
LIG_FHA_1	890	896	PF00498	0.399
LIG_FHA_1	906	912	PF00498	0.239
LIG_FHA_2	359	365	PF00498	0.624
LIG_FHA_2	449	455	PF00498	0.652
LIG_FHA_2	842	848	PF00498	0.399
LIG_LIR_Gen_1	161	167	PF02991	0.570
LIG_LIR_Gen_1	331	342	PF02991	0.488
LIG_LIR_Gen_1	343	349	PF02991	0.399
LIG_LIR_Gen_1	74	83	PF02991	0.506
LIG_LIR_Nem_3	161	165	PF02991	0.563
LIG_LIR_Nem_3	331	337	PF02991	0.500
LIG_LIR_Nem_3	343	348	PF02991	0.400
LIG_LIR_Nem_3	74	78	PF02991	0.410
LIG_LYPXL_SIV_4	693	701	PF13949	0.491
LIG_NRBOX	323	329	PF00104	0.546
LIG_Pex14_2	334	338	PF04695	0.513
LIG_SH2_NCK_1	717	721	PF00017	0.374
LIG_SH2_SRC	810	813	PF00017	0.349
LIG_SH2_STAP1	677	681	PF00017	0.453
LIG_SH2_STAT5	656	659	PF00017	0.368
LIG_SH2_STAT5	75	78	PF00017	0.520
LIG_SH2_STAT5	810	813	PF00017	0.399
LIG_SH2_STAT5	839	842	PF00017	0.399
LIG_SH2_STAT5	915	918	PF00017	0.399
LIG_SH3_2	291	296	PF14604	0.564
LIG_SH3_3	288	294	PF00018	0.561
LIG_SH3_3	379	385	PF00018	0.702
LIG_SH3_3	457	463	PF00018	0.715
LIG_SH3_3	568	574	PF00018	0.709
LIG_SH3_3	613	619	PF00018	0.655
LIG_SH3_3	632	638	PF00018	0.468
LIG_SH3_3	667	673	PF00018	0.442
LIG_SH3_3	697	703	PF00018	0.552
LIG_SH3_3	754	760	PF00018	0.540
LIG_SUMO_SIM_par_1	76	81	PF11976	0.373
LIG_SUMO_SIM_par_1	760	766	PF11976	0.446
LIG_TRAF2_1	349	352	PF00917	0.534
LIG_TRAF2_1	844	847	PF00917	0.399
LIG_TRAF2_1	882	885	PF00917	0.399
LIG_TYR_ITIM	675	680	PF00017	0.449
LIG_UBA3_1	135	142	PF00899	0.432
LIG_WW_2	757	760	PF00397	0.432
LIG_WW_3	524	528	PF00397	0.617
LIG_WW_3	615	619	PF00397	0.694
MOD_CDC14_SPxK_1	198	201	PF00782	0.559
MOD_CDK_SPK_2	287	292	PF00069	0.654
MOD_CDK_SPK_2	558	563	PF00069	0.691
MOD_CDK_SPxK_1	195	201	PF00069	0.557
MOD_CDK_SPxK_1	612	618	PF00069	0.704
MOD_CDK_SPxxK_3	282	289	PF00069	0.660
MOD_CDK_SPxxK_3	520	527	PF00069	0.644
MOD_CDK_SPxxK_3	545	552	PF00069	0.716
MOD_CDK_SPxxK_3	55	62	PF00069	0.492
MOD_CDK_SPxxK_3	558	565	PF00069	0.562
MOD_CDK_SPxxK_3	603	610	PF00069	0.545
MOD_CDK_SPxxK_3	634	641	PF00069	0.629
MOD_CK1_1	149	155	PF00069	0.646
MOD_CK1_1	158	164	PF00069	0.624
MOD_CK1_1	232	238	PF00069	0.535
MOD_CK1_1	285	291	PF00069	0.649
MOD_CK1_1	318	324	PF00069	0.498
MOD_CK1_1	445	451	PF00069	0.656
MOD_CK1_1	469	475	PF00069	0.633
MOD_CK1_1	520	526	PF00069	0.734
MOD_CK1_1	557	563	PF00069	0.694
MOD_CK1_1	567	573	PF00069	0.618
MOD_CK1_1	603	609	PF00069	0.636
MOD_CK1_1	634	640	PF00069	0.663
MOD_CK1_1	650	656	PF00069	0.378
MOD_CK1_1	751	757	PF00069	0.596
MOD_CK2_1	158	164	PF00069	0.678
MOD_CK2_1	299	305	PF00069	0.711
MOD_CK2_1	358	364	PF00069	0.569
MOD_CK2_1	448	454	PF00069	0.784
MOD_CK2_1	715	721	PF00069	0.456
MOD_CK2_1	840	846	PF00069	0.399
MOD_CK2_1	888	894	PF00069	0.377
MOD_Cter_Amidation	397	400	PF01082	0.603
MOD_Cter_Amidation	563	566	PF01082	0.603
MOD_GlcNHglycan	13	16	PF01048	0.454
MOD_GlcNHglycan	157	160	PF01048	0.665
MOD_GlcNHglycan	209	212	PF01048	0.676
MOD_GlcNHglycan	229	232	PF01048	0.616
MOD_GlcNHglycan	279	282	PF01048	0.624
MOD_GlcNHglycan	300	304	PF01048	0.630
MOD_GlcNHglycan	416	419	PF01048	0.726
MOD_GlcNHglycan	443	447	PF01048	0.655
MOD_GlcNHglycan	473	476	PF01048	0.672
MOD_GlcNHglycan	520	523	PF01048	0.719
MOD_GlcNHglycan	566	569	PF01048	0.806
MOD_GlcNHglycan	588	591	PF01048	0.697
MOD_GlcNHglycan	664	667	PF01048	0.483
MOD_GlcNHglycan	691	694	PF01048	0.562
MOD_GlcNHglycan	7	10	PF01048	0.455
MOD_GSK3_1	1	8	PF00069	0.467
MOD_GSK3_1	146	153	PF00069	0.623
MOD_GSK3_1	167	174	PF00069	0.567
MOD_GSK3_1	185	192	PF00069	0.639
MOD_GSK3_1	195	202	PF00069	0.596
MOD_GSK3_1	223	230	PF00069	0.642
MOD_GSK3_1	232	239	PF00069	0.621
MOD_GSK3_1	295	302	PF00069	0.609
MOD_GSK3_1	336	343	PF00069	0.452
MOD_GSK3_1	35	42	PF00069	0.481
MOD_GSK3_1	442	449	PF00069	0.698
MOD_GSK3_1	467	474	PF00069	0.586
MOD_GSK3_1	516	523	PF00069	0.737
MOD_GSK3_1	543	550	PF00069	0.735
MOD_GSK3_1	554	561	PF00069	0.596
MOD_GSK3_1	586	593	PF00069	0.692
MOD_GSK3_1	608	615	PF00069	0.746
MOD_GSK3_1	643	650	PF00069	0.588
MOD_GSK3_1	748	755	PF00069	0.612
MOD_LATS_1	496	502	PF00433	0.642
MOD_N-GLC_1	315	320	PF02516	0.504
MOD_N-GLC_1	847	852	PF02516	0.375
MOD_NEK2_1	1	6	PF00069	0.470
MOD_NEK2_1	109	114	PF00069	0.508
MOD_NEK2_1	11	16	PF00069	0.454
MOD_NEK2_1	328	333	PF00069	0.603
MOD_NEK2_1	34	39	PF00069	0.483
MOD_NEK2_1	511	516	PF00069	0.616
MOD_NEK2_1	517	522	PF00069	0.555
MOD_NEK2_1	770	775	PF00069	0.435
MOD_NEK2_1	83	88	PF00069	0.414
MOD_NEK2_1	834	839	PF00069	0.399
MOD_NEK2_1	863	868	PF00069	0.399
MOD_NEK2_1	904	909	PF00069	0.349
MOD_NEK2_2	591	596	PF00069	0.674
MOD_PIKK_1	336	342	PF00454	0.623
MOD_PIKK_1	372	378	PF00454	0.592
MOD_PIKK_1	572	578	PF00454	0.636
MOD_PIKK_1	648	654	PF00454	0.539
MOD_PK_1	39	45	PF00069	0.474
MOD_PKA_1	27	33	PF00069	0.465
MOD_PKA_1	498	504	PF00069	0.691
MOD_PKA_2	167	173	PF00069	0.774
MOD_PKA_2	27	33	PF00069	0.465
MOD_PKA_2	295	301	PF00069	0.700
MOD_PKA_2	328	334	PF00069	0.492
MOD_PKA_2	34	40	PF00069	0.475
MOD_PKA_2	497	503	PF00069	0.694
MOD_PKA_2	5	11	PF00069	0.456
MOD_PKA_2	517	523	PF00069	0.694
MOD_PKA_2	534	540	PF00069	0.546
MOD_PKA_2	551	557	PF00069	0.720
MOD_PKA_2	564	570	PF00069	0.571
MOD_PKA_2	577	583	PF00069	0.573
MOD_PKA_2	586	592	PF00069	0.563
MOD_PKA_2	601	607	PF00069	0.558
MOD_PKA_2	64	70	PF00069	0.490
MOD_PKA_2	654	660	PF00069	0.403
MOD_PKA_2	701	707	PF00069	0.518
MOD_PKA_2	749	755	PF00069	0.572
MOD_PKA_2	819	825	PF00069	0.399
MOD_PKA_2	83	89	PF00069	0.376
MOD_PKA_2	904	910	PF00069	0.399
MOD_PKA_2	911	917	PF00069	0.329
MOD_PKB_1	641	649	PF00069	0.526
MOD_PKB_1	903	911	PF00069	0.375
MOD_Plk_1	150	156	PF00069	0.646
MOD_Plk_1	299	305	PF00069	0.684
MOD_Plk_1	315	321	PF00069	0.476
MOD_Plk_1	489	495	PF00069	0.644
MOD_Plk_1	841	847	PF00069	0.382
MOD_Plk_2-3	74	80	PF00069	0.386
MOD_Plk_4	29	35	PF00069	0.475
MOD_Plk_4	455	461	PF00069	0.641
MOD_Plk_4	834	840	PF00069	0.399
MOD_Plk_4	864	870	PF00069	0.399
MOD_Plk_4	911	917	PF00069	0.399
MOD_ProDKin_1	189	195	PF00069	0.623
MOD_ProDKin_1	223	229	PF00069	0.666
MOD_ProDKin_1	282	288	PF00069	0.652
MOD_ProDKin_1	467	473	PF00069	0.625
MOD_ProDKin_1	520	526	PF00069	0.694
MOD_ProDKin_1	545	551	PF00069	0.715
MOD_ProDKin_1	55	61	PF00069	0.488
MOD_ProDKin_1	554	560	PF00069	0.618
MOD_ProDKin_1	567	573	PF00069	0.570
MOD_ProDKin_1	594	600	PF00069	0.652
MOD_ProDKin_1	603	609	PF00069	0.687
MOD_ProDKin_1	612	618	PF00069	0.643
MOD_ProDKin_1	619	625	PF00069	0.624
MOD_ProDKin_1	631	637	PF00069	0.547
MOD_ProDKin_1	645	651	PF00069	0.395
MOD_SUMO_rev_2	718	725	PF00179	0.433
MOD_SUMO_rev_2	842	850	PF00179	0.372
TRG_DiLeu_BaEn_1	256	261	PF01217	0.547
TRG_DiLeu_BaEn_1	323	328	PF01217	0.542
TRG_DiLeu_BaEn_4	104	110	PF01217	0.391
TRG_DiLeu_BaEn_4	350	356	PF01217	0.518
TRG_DiLeu_BaLyEn_6	757	762	PF01217	0.482
TRG_ENDOCYTIC_2	677	680	PF00928	0.449
TRG_ENDOCYTIC_2	717	720	PF00928	0.379
TRG_ENDOCYTIC_2	75	78	PF00928	0.414
TRG_ER_diArg_1	115	117	PF00400	0.427
TRG_ER_diArg_1	406	408	PF00400	0.668
TRG_ER_diArg_1	641	643	PF00400	0.581
TRG_ER_diArg_1	711	714	PF00400	0.455
TRG_ER_diArg_1	82	85	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJ81	Leishmania donovani	100%	100%
A4H350	Leishmania braziliensis	67%	98%
E9AC14	Leishmania major	89%	99%
E9AJB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%