LeishMANIAdb
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Putative cyclophilin 12

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cyclophilin 12
Gene product:
cyclophilin 12 - putative
Species:
Leishmania infantum
UniProt:
A4HRE3_LEIIN
TriTrypDb:
LINF_010007100
Length:
334

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, cyclophilin 12 CYP12

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 32
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 6
GO:0005737 cytoplasm 2 4
GO:0005930 axoneme 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4HRE3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRE3

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 26
GO:0006807 nitrogen compound metabolic process 2 26
GO:0008152 metabolic process 1 26
GO:0018193 peptidyl-amino acid modification 5 26
GO:0018208 peptidyl-proline modification 6 26
GO:0019538 protein metabolic process 3 26
GO:0036211 protein modification process 4 26
GO:0043170 macromolecule metabolic process 3 26
GO:0043412 macromolecule modification 4 26
GO:0044238 primary metabolic process 2 26
GO:0071704 organic substance metabolic process 2 26
GO:1901564 organonitrogen compound metabolic process 3 26
GO:0006457 protein folding 2 13
GO:0009987 cellular process 1 13
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 26
GO:0003824 catalytic activity 1 26
GO:0016853 isomerase activity 2 26
GO:0016859 cis-trans isomerase activity 3 26
GO:0140096 catalytic activity, acting on a protein 2 26
GO:0005488 binding 1 3
GO:0016018 cyclosporin A binding 4 3
GO:0033218 amide binding 2 3
GO:0042277 peptide binding 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 220 224 PF00656 0.226
CLV_NRD_NRD_1 51 53 PF00675 0.342
CLV_PCSK_KEX2_1 51 53 PF00082 0.342
CLV_PCSK_SKI1_1 105 109 PF00082 0.426
CLV_PCSK_SKI1_1 140 144 PF00082 0.370
CLV_PCSK_SKI1_1 2 6 PF00082 0.313
CLV_PCSK_SKI1_1 219 223 PF00082 0.357
CLV_Separin_Metazoa 43 47 PF03568 0.287
DEG_Nend_UBRbox_1 1 4 PF02207 0.365
DOC_MAPK_gen_1 146 155 PF00069 0.290
DOC_MAPK_MEF2A_6 148 157 PF00069 0.293
DOC_PP1_RVXF_1 162 168 PF00149 0.279
DOC_PP1_RVXF_1 288 295 PF00149 0.322
DOC_PP2B_LxvP_1 42 45 PF13499 0.290
DOC_PP4_FxxP_1 202 205 PF00568 0.199
DOC_USP7_MATH_1 197 201 PF00917 0.374
DOC_USP7_MATH_1 318 322 PF00917 0.208
DOC_USP7_MATH_1 54 58 PF00917 0.364
LIG_14-3-3_CanoR_1 105 113 PF00244 0.496
LIG_14-3-3_CanoR_1 186 191 PF00244 0.400
LIG_14-3-3_CanoR_1 282 287 PF00244 0.278
LIG_BIR_III_4 258 262 PF00653 0.224
LIG_BRCT_BRCA1_1 198 202 PF00533 0.199
LIG_BRCT_BRCA1_1 273 277 PF00533 0.449
LIG_FHA_1 250 256 PF00498 0.353
LIG_FHA_2 116 122 PF00498 0.467
LIG_FHA_2 12 18 PF00498 0.477
LIG_FHA_2 218 224 PF00498 0.233
LIG_FHA_2 323 329 PF00498 0.312
LIG_LIR_Apic_2 199 205 PF02991 0.208
LIG_LIR_Apic_2 250 256 PF02991 0.287
LIG_LIR_Gen_1 168 176 PF02991 0.292
LIG_LIR_Gen_1 275 284 PF02991 0.267
LIG_LIR_Gen_1 34 44 PF02991 0.306
LIG_LIR_Nem_3 137 142 PF02991 0.268
LIG_LIR_Nem_3 168 173 PF02991 0.360
LIG_LIR_Nem_3 215 221 PF02991 0.249
LIG_LIR_Nem_3 275 281 PF02991 0.411
LIG_LIR_Nem_3 34 39 PF02991 0.312
LIG_LIR_Nem_3 5 10 PF02991 0.389
LIG_PDZ_Class_1 329 334 PF00595 0.343
LIG_Pex14_1 166 170 PF04695 0.332
LIG_REV1ctd_RIR_1 215 223 PF16727 0.213
LIG_SH2_CRK 10 14 PF00017 0.393
LIG_SH2_CRK 170 174 PF00017 0.243
LIG_SH2_CRK 253 257 PF00017 0.243
LIG_SH2_CRK 36 40 PF00017 0.287
LIG_SH2_NCK_1 170 174 PF00017 0.226
LIG_SH2_PTP2 278 281 PF00017 0.308
LIG_SH2_STAP1 170 174 PF00017 0.224
LIG_SH2_STAP1 36 40 PF00017 0.370
LIG_SH2_STAT3 131 134 PF00017 0.290
LIG_SH2_STAT5 131 134 PF00017 0.410
LIG_SH2_STAT5 150 153 PF00017 0.269
LIG_SH2_STAT5 278 281 PF00017 0.231
LIG_SH2_STAT5 291 294 PF00017 0.224
LIG_SH3_3 198 204 PF00018 0.346
LIG_TYR_ITSM 6 13 PF00017 0.370
LIG_WRC_WIRS_1 4 9 PF05994 0.280
MOD_CK2_1 322 328 PF00069 0.189
MOD_CK2_1 68 74 PF00069 0.512
MOD_CK2_1 96 102 PF00069 0.569
MOD_GlcNHglycan 136 139 PF01048 0.298
MOD_GlcNHglycan 235 238 PF01048 0.300
MOD_GlcNHglycan 274 277 PF01048 0.395
MOD_GlcNHglycan 56 59 PF01048 0.371
MOD_GlcNHglycan 74 77 PF01048 0.515
MOD_GlcNHglycan 82 85 PF01048 0.482
MOD_GSK3_1 185 192 PF00069 0.343
MOD_GSK3_1 213 220 PF00069 0.265
MOD_GSK3_1 229 236 PF00069 0.407
MOD_GSK3_1 318 325 PF00069 0.415
MOD_GSK3_1 68 75 PF00069 0.796
MOD_N-GLC_1 272 277 PF02516 0.322
MOD_N-GLC_2 180 182 PF02516 0.281
MOD_NEK2_1 142 147 PF00069 0.314
MOD_NEK2_1 169 174 PF00069 0.271
MOD_NEK2_1 217 222 PF00069 0.285
MOD_NEK2_1 277 282 PF00069 0.295
MOD_NEK2_1 72 77 PF00069 0.527
MOD_NEK2_2 197 202 PF00069 0.208
MOD_NEK2_2 239 244 PF00069 0.313
MOD_PIKK_1 204 210 PF00454 0.311
MOD_PIKK_1 60 66 PF00454 0.425
MOD_PKA_2 185 191 PF00069 0.411
MOD_Plk_1 153 159 PF00069 0.298
MOD_Plk_1 249 255 PF00069 0.280
MOD_Plk_1 272 278 PF00069 0.190
MOD_Plk_1 68 74 PF00069 0.789
MOD_Plk_4 108 114 PF00069 0.301
MOD_Plk_4 197 203 PF00069 0.339
MOD_Plk_4 213 219 PF00069 0.200
MOD_Plk_4 282 288 PF00069 0.250
MOD_Plk_4 318 324 PF00069 0.295
MOD_Plk_4 88 94 PF00069 0.297
MOD_SUMO_for_1 40 43 PF00179 0.306
TRG_DiLeu_BaEn_1 102 107 PF01217 0.354
TRG_DiLeu_LyEn_5 102 107 PF01217 0.332
TRG_ENDOCYTIC_2 10 13 PF00928 0.383
TRG_ENDOCYTIC_2 150 153 PF00928 0.269
TRG_ENDOCYTIC_2 170 173 PF00928 0.224
TRG_ENDOCYTIC_2 278 281 PF00928 0.225
TRG_ENDOCYTIC_2 291 294 PF00928 0.252
TRG_ENDOCYTIC_2 36 39 PF00928 0.306
TRG_Pf-PMV_PEXEL_1 105 110 PF00026 0.329
TRG_Pf-PMV_PEXEL_1 219 223 PF00026 0.344

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL84 Leptomonas seymouri 55% 100%
A0A0N1PDY0 Leptomonas seymouri 24% 100%
A0A0S4IKA5 Bodo saltans 39% 100%
A0A3Q8ICB3 Leishmania donovani 29% 100%
A0A3R7M7E5 Trypanosoma rangeli 43% 100%
A0A3S5H7U6 Leishmania donovani 38% 100%
A0A3S5IQL2 Trypanosoma rangeli 27% 100%
A0A3S7X325 Leishmania donovani 26% 100%
A0A3S7X410 Leishmania donovani 36% 100%
A0A3S7XB52 Leishmania donovani 34% 100%
A0A451EJ79 Leishmania donovani 100% 100%
A4H346 Leishmania braziliensis 83% 100%
A4HCI8 Leishmania braziliensis 28% 100%
A4HHU7 Leishmania braziliensis 24% 100%
A4HIW9 Leishmania braziliensis 35% 100%
A4I004 Leishmania infantum 29% 100%
A4I4Z7 Leishmania infantum 25% 100%
A4I698 Leishmania infantum 36% 100%
A4I935 Leishmania infantum 38% 100%
A4IDA1 Leishmania infantum 34% 100%
C9ZXF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AC11 Leishmania major 94% 100%
E9AJA8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AT91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AVX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B0C7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1F3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B400 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
Q4Q1A6 Leishmania major 34% 100%
Q4Q6Q9 Leishmania major 36% 100%
Q4Q7V7 Leishmania major 26% 100%
Q4QBK2 Leishmania major 29% 100%
Q8IXY8 Homo sapiens 29% 100%
V5B9Y6 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS