Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBA/TS-N domain/CUE domain/Domain of unknown function (DUF1771)/Smr domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HRE2_LEIIN

TriTrypDb:

LINF_010007000

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRE2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	10
GO:0032182	ubiquitin-like protein binding	3	10
GO:0043130	ubiquitin binding	4	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.630
CLV_C14_Caspase3-7	397	401	PF00656	0.705
CLV_C14_Caspase3-7	435	439	PF00656	0.677
CLV_C14_Caspase3-7	768	772	PF00656	0.292
CLV_NRD_NRD_1	100	102	PF00675	0.537
CLV_NRD_NRD_1	222	224	PF00675	0.645
CLV_NRD_NRD_1	328	330	PF00675	0.736
CLV_NRD_NRD_1	365	367	PF00675	0.580
CLV_NRD_NRD_1	404	406	PF00675	0.745
CLV_NRD_NRD_1	743	745	PF00675	0.277
CLV_NRD_NRD_1	783	785	PF00675	0.469
CLV_NRD_NRD_1	829	831	PF00675	0.271
CLV_PCSK_KEX2_1	100	102	PF00082	0.562
CLV_PCSK_KEX2_1	2	4	PF00082	0.722
CLV_PCSK_KEX2_1	222	224	PF00082	0.645
CLV_PCSK_KEX2_1	328	330	PF00082	0.718
CLV_PCSK_KEX2_1	365	367	PF00082	0.551
CLV_PCSK_KEX2_1	743	745	PF00082	0.271
CLV_PCSK_KEX2_1	783	785	PF00082	0.444
CLV_PCSK_KEX2_1	829	831	PF00082	0.274
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.722
CLV_PCSK_SKI1_1	391	395	PF00082	0.532
CLV_PCSK_SKI1_1	668	672	PF00082	0.381
CLV_PCSK_SKI1_1	843	847	PF00082	0.318
CLV_PCSK_SKI1_1	880	884	PF00082	0.387
DEG_Nend_UBRbox_1	1	4	PF02207	0.680
DEG_SPOP_SBC_1	313	317	PF00917	0.705
DEG_SPOP_SBC_1	63	67	PF00917	0.632
DEG_SPOP_SBC_1	83	87	PF00917	0.435
DOC_CYCLIN_RxL_1	665	675	PF00134	0.392
DOC_MAPK_gen_1	629	637	PF00069	0.544
DOC_MAPK_gen_1	791	800	PF00069	0.289
DOC_MAPK_gen_1	836	844	PF00069	0.311
DOC_MAPK_gen_1	880	889	PF00069	0.422
DOC_MAPK_MEF2A_6	354	362	PF00069	0.364
DOC_MAPK_MEF2A_6	629	637	PF00069	0.420
DOC_MAPK_MEF2A_6	883	891	PF00069	0.397
DOC_PP2B_LxvP_1	224	227	PF13499	0.575
DOC_PP2B_LxvP_1	305	308	PF13499	0.651
DOC_PP2B_LxvP_1	444	447	PF13499	0.630
DOC_USP7_MATH_1	263	267	PF00917	0.748
DOC_USP7_MATH_1	311	315	PF00917	0.725
DOC_USP7_MATH_1	422	426	PF00917	0.803
DOC_USP7_MATH_1	428	432	PF00917	0.762
DOC_USP7_MATH_1	445	449	PF00917	0.740
DOC_USP7_MATH_1	63	67	PF00917	0.740
DOC_USP7_MATH_1	73	77	PF00917	0.699
DOC_USP7_MATH_1	766	770	PF00917	0.292
DOC_WW_Pin1_4	248	253	PF00397	0.572
DOC_WW_Pin1_4	287	292	PF00397	0.672
DOC_WW_Pin1_4	317	322	PF00397	0.684
DOC_WW_Pin1_4	620	625	PF00397	0.540
DOC_WW_Pin1_4	90	95	PF00397	0.626
LIG_14-3-3_CanoR_1	14	20	PF00244	0.436
LIG_14-3-3_CanoR_1	366	376	PF00244	0.486
LIG_14-3-3_CanoR_1	64	74	PF00244	0.783
LIG_14-3-3_CanoR_1	658	666	PF00244	0.484
LIG_14-3-3_CanoR_1	776	785	PF00244	0.468
LIG_14-3-3_CanoR_1	804	813	PF00244	0.450
LIG_Actin_WH2_2	445	462	PF00022	0.565
LIG_BIR_III_2	169	173	PF00653	0.522
LIG_BIR_III_4	270	274	PF00653	0.733
LIG_BIR_III_4	400	404	PF00653	0.615
LIG_BRCT_BRCA1_1	341	345	PF00533	0.511
LIG_BRCT_BRCA1_1	85	89	PF00533	0.576
LIG_Clathr_ClatBox_1	670	674	PF01394	0.508
LIG_EVH1_2	252	256	PF00568	0.586
LIG_FHA_1	24	30	PF00498	0.405
LIG_FHA_1	527	533	PF00498	0.563
LIG_FHA_1	658	664	PF00498	0.457
LIG_FHA_1	665	671	PF00498	0.484
LIG_FHA_1	698	704	PF00498	0.548
LIG_FHA_1	752	758	PF00498	0.292
LIG_FHA_1	772	778	PF00498	0.193
LIG_FHA_1	808	814	PF00498	0.394
LIG_FHA_1	83	89	PF00498	0.705
LIG_FHA_1	888	894	PF00498	0.500
LIG_FHA_2	378	384	PF00498	0.555
LIG_FHA_2	433	439	PF00498	0.655
LIG_FHA_2	526	532	PF00498	0.552
LIG_FHA_2	621	627	PF00498	0.599
LIG_FHA_2	715	721	PF00498	0.563
LIG_FHA_2	860	866	PF00498	0.425
LIG_LIR_Apic_2	243	247	PF02991	0.596
LIG_LIR_Apic_2	688	694	PF02991	0.614
LIG_LIR_Gen_1	232	242	PF02991	0.715
LIG_LIR_Gen_1	597	605	PF02991	0.348
LIG_LIR_Gen_1	788	797	PF02991	0.292
LIG_LIR_Nem_3	115	121	PF02991	0.457
LIG_LIR_Nem_3	232	237	PF02991	0.719
LIG_LIR_Nem_3	290	295	PF02991	0.741
LIG_LIR_Nem_3	492	497	PF02991	0.464
LIG_LIR_Nem_3	574	579	PF02991	0.337
LIG_LIR_Nem_3	597	602	PF02991	0.288
LIG_LIR_Nem_3	724	729	PF02991	0.482
LIG_LIR_Nem_3	741	745	PF02991	0.187
LIG_LIR_Nem_3	788	792	PF02991	0.292
LIG_LIR_Nem_3	858	863	PF02991	0.318
LIG_LYPXL_S_1	859	863	PF13949	0.314
LIG_LYPXL_yS_3	860	863	PF13949	0.314
LIG_SH2_CRK	121	125	PF00017	0.428
LIG_SH2_CRK	599	603	PF00017	0.271
LIG_SH2_CRK	789	793	PF00017	0.314
LIG_SH2_PTP2	886	889	PF00017	0.401
LIG_SH2_SRC	886	889	PF00017	0.401
LIG_SH2_STAT3	254	257	PF00017	0.575
LIG_SH2_STAT5	121	124	PF00017	0.487
LIG_SH2_STAT5	160	163	PF00017	0.533
LIG_SH2_STAT5	244	247	PF00017	0.633
LIG_SH2_STAT5	649	652	PF00017	0.475
LIG_SH2_STAT5	750	753	PF00017	0.271
LIG_SH2_STAT5	886	889	PF00017	0.389
LIG_SH3_3	283	289	PF00018	0.578
LIG_SH3_3	300	306	PF00018	0.555
LIG_SH3_3	632	638	PF00018	0.392
LIG_SH3_3	690	696	PF00018	0.677
LIG_SH3_3	888	894	PF00018	0.501
LIG_SUMO_SIM_par_1	568	574	PF11976	0.411
LIG_SUMO_SIM_par_1	580	585	PF11976	0.422
LIG_SUMO_SIM_par_1	669	675	PF11976	0.578
LIG_SUMO_SIM_par_1	796	801	PF11976	0.271
LIG_TRAF2_1	543	546	PF00917	0.498
LIG_TRAF2_1	717	720	PF00917	0.574
LIG_TYR_ITIM	787	792	PF00017	0.349
MOD_CDK_SPxK_1	287	293	PF00069	0.615
MOD_CK1_1	240	246	PF00069	0.546
MOD_CK1_1	314	320	PF00069	0.665
MOD_CK1_1	479	485	PF00069	0.593
MOD_CK1_1	616	622	PF00069	0.539
MOD_CK1_1	657	663	PF00069	0.422
MOD_CK1_1	66	72	PF00069	0.630
MOD_CK1_1	672	678	PF00069	0.586
MOD_CK2_1	240	246	PF00069	0.687
MOD_CK2_1	367	373	PF00069	0.570
MOD_CK2_1	377	383	PF00069	0.431
MOD_CK2_1	477	483	PF00069	0.607
MOD_CK2_1	525	531	PF00069	0.536
MOD_CK2_1	714	720	PF00069	0.627
MOD_CK2_1	859	865	PF00069	0.292
MOD_Cter_Amidation	781	784	PF01082	0.335
MOD_GlcNHglycan	298	301	PF01048	0.703
MOD_GlcNHglycan	369	372	PF01048	0.537
MOD_GlcNHglycan	424	427	PF01048	0.590
MOD_GlcNHglycan	428	431	PF01048	0.594
MOD_GlcNHglycan	479	482	PF01048	0.603
MOD_GlcNHglycan	5	8	PF01048	0.552
MOD_GlcNHglycan	508	511	PF01048	0.476
MOD_GlcNHglycan	611	614	PF01048	0.595
MOD_GlcNHglycan	615	618	PF01048	0.627
MOD_GlcNHglycan	646	649	PF01048	0.389
MOD_GlcNHglycan	70	73	PF01048	0.728
MOD_GlcNHglycan	706	711	PF01048	0.664
MOD_GlcNHglycan	719	724	PF01048	0.466
MOD_GlcNHglycan	726	729	PF01048	0.322
MOD_GlcNHglycan	768	771	PF01048	0.373
MOD_GlcNHglycan	873	876	PF01048	0.454
MOD_GSK3_1	311	318	PF00069	0.719
MOD_GSK3_1	395	402	PF00069	0.553
MOD_GSK3_1	420	427	PF00069	0.804
MOD_GSK3_1	428	435	PF00069	0.685
MOD_GSK3_1	609	616	PF00069	0.515
MOD_GSK3_1	62	69	PF00069	0.713
MOD_GSK3_1	714	721	PF00069	0.676
MOD_GSK3_1	73	80	PF00069	0.654
MOD_GSK3_1	761	768	PF00069	0.292
MOD_GSK3_1	804	811	PF00069	0.454
MOD_GSK3_1	84	91	PF00069	0.634
MOD_GSK3_1	855	862	PF00069	0.348
MOD_LATS_1	841	847	PF00433	0.292
MOD_N-GLC_1	77	82	PF02516	0.596
MOD_NEK2_1	136	141	PF00069	0.410
MOD_NEK2_1	389	394	PF00069	0.684
MOD_NEK2_1	506	511	PF00069	0.472
MOD_NEK2_1	751	756	PF00069	0.292
MOD_NEK2_1	77	82	PF00069	0.708
MOD_NEK2_1	88	93	PF00069	0.680
MOD_NEK2_2	142	147	PF00069	0.373
MOD_NEK2_2	84	89	PF00069	0.574
MOD_NEK2_2	855	860	PF00069	0.349
MOD_OFUCOSY	109	116	PF10250	0.504
MOD_OFUCOSY	140	146	PF10250	0.407
MOD_OFUCOSY	336	343	PF10250	0.371
MOD_PIKK_1	23	29	PF00454	0.463
MOD_PIKK_1	586	592	PF00454	0.404
MOD_PIKK_1	751	757	PF00454	0.335
MOD_PK_1	878	884	PF00069	0.405
MOD_PKA_2	13	19	PF00069	0.434
MOD_PKA_2	148	154	PF00069	0.476
MOD_PKA_2	237	243	PF00069	0.678
MOD_PKA_2	367	373	PF00069	0.445
MOD_PKA_2	408	414	PF00069	0.763
MOD_PKA_2	432	438	PF00069	0.693
MOD_PKA_2	506	512	PF00069	0.512
MOD_PKA_2	514	520	PF00069	0.472
MOD_PKA_2	63	69	PF00069	0.510
MOD_PKA_2	657	663	PF00069	0.477
MOD_PKB_1	375	383	PF00069	0.459
MOD_Plk_1	887	893	PF00069	0.565
MOD_Plk_2-3	669	675	PF00069	0.580
MOD_Plk_4	176	182	PF00069	0.472
MOD_Plk_4	568	574	PF00069	0.284
MOD_Plk_4	84	90	PF00069	0.632
MOD_Plk_4	855	861	PF00069	0.368
MOD_ProDKin_1	248	254	PF00069	0.575
MOD_ProDKin_1	287	293	PF00069	0.671
MOD_ProDKin_1	317	323	PF00069	0.683
MOD_ProDKin_1	620	626	PF00069	0.527
MOD_ProDKin_1	90	96	PF00069	0.618
MOD_SUMO_rev_2	400	408	PF00179	0.596
TRG_DiLeu_BaEn_1	747	752	PF01217	0.464
TRG_DiLeu_BaEn_2	482	488	PF01217	0.533
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.574
TRG_ENDOCYTIC_2	121	124	PF00928	0.392
TRG_ENDOCYTIC_2	599	602	PF00928	0.271
TRG_ENDOCYTIC_2	789	792	PF00928	0.290
TRG_ENDOCYTIC_2	860	863	PF00928	0.293
TRG_ENDOCYTIC_2	886	889	PF00928	0.365
TRG_ER_diArg_1	181	184	PF00400	0.438
TRG_ER_diArg_1	222	224	PF00400	0.651
TRG_ER_diArg_1	328	331	PF00400	0.708
TRG_ER_diArg_1	365	368	PF00400	0.542
TRG_ER_diArg_1	414	417	PF00400	0.774
TRG_ER_diArg_1	742	744	PF00400	0.271
TRG_ER_diArg_1	756	759	PF00400	0.271
TRG_ER_diArg_1	783	785	PF00400	0.475
TRG_ER_diArg_1	828	830	PF00400	0.274
TRG_ER_diArg_1	836	839	PF00400	0.276
TRG_ER_diArg_1	99	101	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	776	781	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	783	788	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE15	Leptomonas seymouri	46%	99%
A0A1X0P3G2	Trypanosomatidae	33%	100%
A0A3R7KV90	Trypanosoma rangeli	34%	100%
A0A3S5H4T8	Leishmania donovani	100%	100%
A4H345	Leishmania braziliensis	74%	98%
C9ZXF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AC10	Leishmania major	92%	100%
E9AJA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D5T7	Trypanosoma cruzi	34%	100%