LMWPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low molecular weight phosphotyrosine protein phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4HRE1_LEIIN

TriTrypDb:

LINF_010006900

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HRE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRE1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004725	protein tyrosine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.435
CLV_NRD_NRD_1	108	110	PF00675	0.290
CLV_NRD_NRD_1	134	136	PF00675	0.573
CLV_NRD_NRD_1	205	207	PF00675	0.447
CLV_NRD_NRD_1	227	229	PF00675	0.491
CLV_NRD_NRD_1	235	237	PF00675	0.444
CLV_PCSK_KEX2_1	108	110	PF00082	0.289
CLV_PCSK_KEX2_1	134	136	PF00082	0.556
CLV_PCSK_KEX2_1	235	237	PF00082	0.478
CLV_PCSK_SKI1_1	245	249	PF00082	0.553
CLV_PCSK_SKI1_1	262	266	PF00082	0.285
CLV_PCSK_SKI1_1	61	65	PF00082	0.297
DEG_APCC_DBOX_1	261	269	PF00400	0.446
DEG_SPOP_SBC_1	157	161	PF00917	0.594
DOC_MAPK_gen_1	108	118	PF00069	0.389
DOC_MAPK_MEF2A_6	111	120	PF00069	0.389
DOC_PP4_FxxP_1	163	166	PF00568	0.553
DOC_USP7_MATH_1	142	146	PF00917	0.667
DOC_WW_Pin1_4	169	174	PF00397	0.507
DOC_WW_Pin1_4	190	195	PF00397	0.410
LIG_14-3-3_CanoR_1	186	192	PF00244	0.546
LIG_14-3-3_CanoR_1	35	44	PF00244	0.467
LIG_14-3-3_CanoR_1	98	107	PF00244	0.424
LIG_Actin_WH2_2	215	230	PF00022	0.534
LIG_APCC_ABBAyCdc20_2	21	27	PF00400	0.492
LIG_CSL_BTD_1	191	194	PF09270	0.402
LIG_eIF4E_1	213	219	PF01652	0.393
LIG_FHA_1	111	117	PF00498	0.333
LIG_FHA_1	203	209	PF00498	0.598
LIG_FHA_2	248	254	PF00498	0.546
LIG_FHA_2	281	287	PF00498	0.560
LIG_FHA_2	86	92	PF00498	0.320
LIG_GBD_Chelix_1	268	276	PF00786	0.465
LIG_HCF-1_HBM_1	210	213	PF13415	0.433
LIG_LIR_Apic_2	160	166	PF02991	0.546
LIG_LIR_Gen_1	115	124	PF02991	0.333
LIG_LIR_Gen_1	216	227	PF02991	0.419
LIG_LIR_Nem_3	112	117	PF02991	0.314
LIG_LIR_Nem_3	216	222	PF02991	0.404
LIG_Pex14_2	59	63	PF04695	0.433
LIG_RPA_C_Fungi	93	105	PF08784	0.351
LIG_SH2_NCK_1	293	297	PF00017	0.537
LIG_SH2_PTP2	117	120	PF00017	0.313
LIG_SH2_SRC	25	28	PF00017	0.502
LIG_SH2_STAP1	114	118	PF00017	0.338
LIG_SH2_STAP1	293	297	PF00017	0.575
LIG_SH2_STAT5	117	120	PF00017	0.313
LIG_SH2_STAT5	124	127	PF00017	0.313
LIG_SH3_3	117	123	PF00018	0.415
LIG_SH3_3	191	197	PF00018	0.416
LIG_SUMO_SIM_par_1	82	88	PF11976	0.383
MOD_CDK_SPK_2	190	195	PF00069	0.410
MOD_CK1_1	150	156	PF00069	0.700
MOD_CK1_1	158	164	PF00069	0.545
MOD_CK1_1	179	185	PF00069	0.443
MOD_CK1_1	97	103	PF00069	0.312
MOD_CK2_1	247	253	PF00069	0.489
MOD_CK2_1	85	91	PF00069	0.320
MOD_CMANNOS	189	192	PF00535	0.413
MOD_GlcNHglycan	149	152	PF01048	0.702
MOD_GlcNHglycan	169	172	PF01048	0.484
MOD_GlcNHglycan	71	74	PF01048	0.301
MOD_GSK3_1	122	129	PF00069	0.338
MOD_GSK3_1	143	150	PF00069	0.651
MOD_GSK3_1	152	159	PF00069	0.696
MOD_GSK3_1	176	183	PF00069	0.573
MOD_GSK3_1	296	303	PF00069	0.403
MOD_GSK3_1	94	101	PF00069	0.357
MOD_LATS_1	33	39	PF00433	0.370
MOD_NEK2_1	147	152	PF00069	0.507
MOD_NEK2_1	167	172	PF00069	0.552
MOD_NEK2_1	264	269	PF00069	0.526
MOD_NEK2_1	69	74	PF00069	0.333
MOD_NEK2_1	84	89	PF00069	0.333
MOD_NMyristoyl	1	7	PF02799	0.448
MOD_OFUCOSY	34	39	PF10250	0.264
MOD_PIKK_1	136	142	PF00454	0.584
MOD_PIKK_1	176	182	PF00454	0.485
MOD_PIKK_1	19	25	PF00454	0.475
MOD_PIKK_1	240	246	PF00454	0.499
MOD_PIKK_1	50	56	PF00454	0.297
MOD_PKA_2	110	116	PF00069	0.242
MOD_PKA_2	126	132	PF00069	0.448
MOD_PKA_2	185	191	PF00069	0.554
MOD_PKA_2	202	208	PF00069	0.567
MOD_PKA_2	34	40	PF00069	0.327
MOD_PKA_2	97	103	PF00069	0.446
MOD_Plk_1	26	32	PF00069	0.446
MOD_Plk_1	286	292	PF00069	0.442
MOD_Plk_4	280	286	PF00069	0.506
MOD_ProDKin_1	169	175	PF00069	0.509
MOD_ProDKin_1	190	196	PF00069	0.409
MOD_SUMO_rev_2	249	256	PF00179	0.517
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.473
TRG_ENDOCYTIC_2	117	120	PF00928	0.332
TRG_ENDOCYTIC_2	293	296	PF00928	0.543
TRG_ER_diArg_1	107	109	PF00400	0.315
TRG_ER_diArg_1	134	136	PF00400	0.609
TRG_ER_diArg_1	220	223	PF00400	0.460
TRG_ER_diArg_1	235	237	PF00400	0.354
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ3	Leptomonas seymouri	61%	100%
A0A0S4ING3	Bodo saltans	45%	100%
A0A1X0P2S0	Trypanosomatidae	46%	91%
A0A422NY87	Trypanosoma rangeli	48%	100%
A0A451EJ77	Leishmania donovani	98%	100%
A4H344	Leishmania braziliensis	85%	100%
C9ZXF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AC09	Leishmania major	90%	100%
E9AJA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5AQ10	Trypanosoma cruzi	49%	100%