Glycosyl transferase family 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glycosyl transferase family 11 - putative

Species:

Leishmania infantum

UniProt:

A4HRD1_LEIIN

TriTrypDb:

LINF_010005900

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HRD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRD1

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006486	protein glycosylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0036065	fucosylation	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0070085	glycosylation	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	7	12
GO:0008417	fucosyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0031127	alpha-(1,2)-fucosyltransferase activity	6	12
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.539
CLV_NRD_NRD_1	137	139	PF00675	0.403
CLV_NRD_NRD_1	290	292	PF00675	0.321
CLV_NRD_NRD_1	73	75	PF00675	0.547
CLV_PCSK_KEX2_1	137	139	PF00082	0.403
CLV_PCSK_KEX2_1	290	292	PF00082	0.321
CLV_PCSK_PC7_1	286	292	PF00082	0.437
CLV_PCSK_SKI1_1	162	166	PF00082	0.386
CLV_PCSK_SKI1_1	256	260	PF00082	0.386
DEG_APCC_DBOX_1	161	169	PF00400	0.475
DEG_APCC_DBOX_1	255	263	PF00400	0.381
DEG_APCC_DBOX_1	285	293	PF00400	0.449
DEG_SPOP_SBC_1	28	32	PF00917	0.529
DOC_MAPK_gen_1	219	228	PF00069	0.430
DOC_MAPK_MEF2A_6	221	230	PF00069	0.421
DOC_MAPK_MEF2A_6	256	263	PF00069	0.376
DOC_MAPK_NFAT4_5	256	264	PF00069	0.393
DOC_PP2B_LxvP_1	170	173	PF13499	0.574
DOC_USP7_MATH_1	102	106	PF00917	0.440
DOC_USP7_MATH_1	178	182	PF00917	0.705
DOC_USP7_MATH_1	244	248	PF00917	0.675
DOC_USP7_MATH_1	28	32	PF00917	0.488
DOC_WW_Pin1_4	190	195	PF00397	0.581
DOC_WW_Pin1_4	245	250	PF00397	0.666
DOC_WW_Pin1_4	56	61	PF00397	0.633
LIG_14-3-3_CanoR_1	143	151	PF00244	0.562
LIG_14-3-3_CanoR_1	209	215	PF00244	0.391
LIG_14-3-3_CanoR_1	243	249	PF00244	0.687
LIG_14-3-3_CanoR_1	286	290	PF00244	0.459
LIG_AP2alpha_1	144	148	PF02296	0.533
LIG_APCC_ABBA_1	201	206	PF00400	0.370
LIG_BRCT_BRCA1_1	295	299	PF00533	0.363
LIG_BRCT_BRCA1_1	93	97	PF00533	0.394
LIG_BRCT_BRCA1_2	295	301	PF00533	0.449
LIG_EH1_1	5	13	PF00400	0.372
LIG_FHA_1	129	135	PF00498	0.422
LIG_FHA_1	191	197	PF00498	0.562
LIG_FHA_1	68	74	PF00498	0.580
LIG_FHA_2	37	43	PF00498	0.453
LIG_FHA_2	64	70	PF00498	0.505
LIG_Integrin_RGD_1	138	140	PF01839	0.403
LIG_LIR_Apic_2	238	244	PF02991	0.431
LIG_LIR_Gen_1	140	148	PF02991	0.407
LIG_LIR_Gen_1	39	48	PF02991	0.374
LIG_LIR_Nem_3	140	144	PF02991	0.411
LIG_LIR_Nem_3	145	151	PF02991	0.393
LIG_LIR_Nem_3	155	159	PF02991	0.274
LIG_LIR_Nem_3	278	283	PF02991	0.328
LIG_LIR_Nem_3	39	44	PF02991	0.409
LIG_MYND_1	194	198	PF01753	0.488
LIG_NRBOX	164	170	PF00104	0.497
LIG_PCNA_PIPBox_1	150	159	PF02747	0.521
LIG_PCNA_yPIPBox_3	143	157	PF02747	0.541
LIG_PDZ_Class_2	313	318	PF00595	0.363
LIG_Pex14_1	279	283	PF04695	0.328
LIG_Pex14_1	41	45	PF04695	0.402
LIG_Pex14_2	144	148	PF04695	0.497
LIG_PTB_Apo_2	271	278	PF02174	0.413
LIG_SH2_GRB2like	283	286	PF00017	0.328
LIG_SH2_SRC	23	26	PF00017	0.588
LIG_SH2_STAP1	157	161	PF00017	0.345
LIG_SH2_STAT5	141	144	PF00017	0.413
LIG_SH2_STAT5	217	220	PF00017	0.398
LIG_SH2_STAT5	23	26	PF00017	0.588
LIG_SH2_STAT5	283	286	PF00017	0.344
LIG_SH2_STAT5	311	314	PF00017	0.363
LIG_SH3_3	192	198	PF00018	0.550
LIG_SH3_3	246	252	PF00018	0.610
LIG_SH3_3	289	295	PF00018	0.328
LIG_SH3_3	297	303	PF00018	0.328
LIG_SH3_3	57	63	PF00018	0.522
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.519
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.355
LIG_SUMO_SIM_par_1	63	70	PF11976	0.491
LIG_SxIP_EBH_1	101	110	PF03271	0.460
LIG_TYR_ITIM	154	159	PF00017	0.302
LIG_WW_2	60	63	PF00397	0.619
MOD_CK1_1	128	134	PF00069	0.502
MOD_CK1_1	182	188	PF00069	0.690
MOD_CK1_1	247	253	PF00069	0.633
MOD_CK1_1	275	281	PF00069	0.331
MOD_CK2_1	112	118	PF00069	0.371
MOD_CK2_1	28	34	PF00069	0.487
MOD_CK2_1	63	69	PF00069	0.510
MOD_GlcNHglycan	114	117	PF01048	0.539
MOD_GlcNHglycan	184	187	PF01048	0.746
MOD_GlcNHglycan	236	240	PF01048	0.506
MOD_GlcNHglycan	31	34	PF01048	0.591
MOD_GSK3_1	11	18	PF00069	0.519
MOD_GSK3_1	178	185	PF00069	0.703
MOD_GSK3_1	36	43	PF00069	0.506
MOD_GSK3_1	63	70	PF00069	0.532
MOD_N-GLC_1	273	278	PF02516	0.328
MOD_NEK2_1	11	16	PF00069	0.419
MOD_NEK2_1	112	117	PF00069	0.500
MOD_NEK2_1	210	215	PF00069	0.515
MOD_NEK2_1	262	267	PF00069	0.337
MOD_NEK2_1	272	277	PF00069	0.309
MOD_NEK2_1	55	60	PF00069	0.602
MOD_NEK2_2	125	130	PF00069	0.559
MOD_NEK2_2	40	45	PF00069	0.399
MOD_PIKK_1	262	268	PF00454	0.449
MOD_PKA_2	142	148	PF00069	0.484
MOD_PKA_2	242	248	PF00069	0.683
MOD_PKA_2	285	291	PF00069	0.459
MOD_PKA_2	36	42	PF00069	0.523
MOD_Plk_1	139	145	PF00069	0.553
MOD_Plk_1	235	241	PF00069	0.515
MOD_Plk_1	273	279	PF00069	0.316
MOD_Plk_4	103	109	PF00069	0.465
MOD_Plk_4	119	125	PF00069	0.487
MOD_Plk_4	171	177	PF00069	0.576
MOD_Plk_4	226	232	PF00069	0.369
MOD_Plk_4	36	42	PF00069	0.450
MOD_ProDKin_1	190	196	PF00069	0.568
MOD_ProDKin_1	245	251	PF00069	0.662
MOD_ProDKin_1	56	62	PF00069	0.628
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.622
TRG_ENDOCYTIC_2	141	144	PF00928	0.413
TRG_ENDOCYTIC_2	156	159	PF00928	0.165
TRG_ER_diArg_1	136	138	PF00400	0.386
TRG_ER_diArg_1	289	291	PF00400	0.322
TRG_NLS_MonoExtC_3	73	79	PF00514	0.290
TRG_NLS_MonoExtN_4	71	78	PF00514	0.296
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE7	Leptomonas seymouri	57%	98%
A0A0S4JMG1	Bodo saltans	37%	76%
A0A1X0P2U6	Trypanosomatidae	49%	99%
A0A3S5H4T0	Leishmania donovani	99%	100%
A0A422NY61	Trypanosoma rangeli	50%	100%
A4H325	Leishmania braziliensis	83%	100%
C9ZXG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ABZ9	Leishmania major	96%	100%
E9AJ96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5BBV1	Trypanosoma cruzi	51%	100%