LeishMANIAdb
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Propionyl-CoA carboxylase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Propionyl-CoA carboxylase
Gene product:
carboxylase - putative
Species:
Leishmania infantum
UniProt:
A4HRC6_LEIIN
TriTrypDb:
LINF_010005400
Length:
665

Annotations

Annotations by Jardim et al.

Protein modification, carboxylase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HRC6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRC6

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 6
GO:0008152 metabolic process 1 6
GO:0009056 catabolic process 2 6
GO:0016042 lipid catabolic process 4 6
GO:0044238 primary metabolic process 2 6
GO:0071704 organic substance metabolic process 2 6
GO:1901575 organic substance catabolic process 3 6
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0003824 catalytic activity 1 8
GO:0004658 propionyl-CoA carboxylase activity 5 6
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0016421 CoA carboxylase activity 4 6
GO:0016874 ligase activity 2 8
GO:0016885 ligase activity, forming carbon-carbon bonds 3 6
GO:0017076 purine nucleotide binding 4 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0043169 cation binding 3 8
GO:0046872 metal ion binding 4 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 221 223 PF00675 0.274
CLV_NRD_NRD_1 237 239 PF00675 0.223
CLV_NRD_NRD_1 255 257 PF00675 0.221
CLV_PCSK_KEX2_1 124 126 PF00082 0.263
CLV_PCSK_KEX2_1 221 223 PF00082 0.236
CLV_PCSK_KEX2_1 237 239 PF00082 0.221
CLV_PCSK_KEX2_1 476 478 PF00082 0.265
CLV_PCSK_PC1ET2_1 124 126 PF00082 0.263
CLV_PCSK_PC1ET2_1 476 478 PF00082 0.265
CLV_PCSK_SKI1_1 193 197 PF00082 0.263
CLV_PCSK_SKI1_1 44 48 PF00082 0.267
CLV_PCSK_SKI1_1 597 601 PF00082 0.256
CLV_PCSK_SKI1_1 645 649 PF00082 0.315
DOC_MAPK_gen_1 221 228 PF00069 0.486
DOC_MAPK_gen_1 417 425 PF00069 0.421
DOC_MAPK_HePTP_8 497 509 PF00069 0.467
DOC_MAPK_MEF2A_6 318 327 PF00069 0.421
DOC_MAPK_MEF2A_6 500 509 PF00069 0.573
DOC_MAPK_MEF2A_6 535 543 PF00069 0.421
DOC_PP2B_LxvP_1 226 229 PF13499 0.463
DOC_PP2B_PxIxI_1 538 544 PF00149 0.463
DOC_PP4_FxxP_1 106 109 PF00568 0.421
DOC_USP7_MATH_1 195 199 PF00917 0.436
DOC_USP7_MATH_1 521 525 PF00917 0.458
DOC_USP7_UBL2_3 120 124 PF12436 0.421
DOC_USP7_UBL2_3 189 193 PF12436 0.441
DOC_USP7_UBL2_3 631 635 PF12436 0.306
DOC_WW_Pin1_4 598 603 PF00397 0.256
LIG_14-3-3_CanoR_1 125 135 PF00244 0.436
LIG_14-3-3_CanoR_1 20 30 PF00244 0.421
LIG_14-3-3_CanoR_1 221 227 PF00244 0.468
LIG_14-3-3_CanoR_1 358 362 PF00244 0.463
LIG_14-3-3_CanoR_1 479 488 PF00244 0.534
LIG_Actin_WH2_2 135 152 PF00022 0.463
LIG_Actin_WH2_2 303 320 PF00022 0.463
LIG_Actin_WH2_2 412 429 PF00022 0.421
LIG_APCC_ABBA_1 359 364 PF00400 0.463
LIG_APCC_ABBA_1 382 387 PF00400 0.421
LIG_APCC_ABBAyCdc20_2 358 364 PF00400 0.463
LIG_BRCT_BRCA1_1 523 527 PF00533 0.436
LIG_BRCT_BRCA1_2 523 529 PF00533 0.420
LIG_Clathr_ClatBox_1 624 628 PF01394 0.235
LIG_Clathr_ClatBox_1 661 665 PF01394 0.320
LIG_FHA_1 223 229 PF00498 0.468
LIG_FHA_1 30 36 PF00498 0.421
LIG_FHA_1 302 308 PF00498 0.445
LIG_FHA_1 399 405 PF00498 0.441
LIG_FHA_1 440 446 PF00498 0.427
LIG_FHA_1 555 561 PF00498 0.460
LIG_FHA_1 568 574 PF00498 0.346
LIG_FHA_2 142 148 PF00498 0.467
LIG_FHA_2 306 312 PF00498 0.421
LIG_FHA_2 326 332 PF00498 0.418
LIG_FHA_2 36 42 PF00498 0.421
LIG_FHA_2 457 463 PF00498 0.487
LIG_FHA_2 567 573 PF00498 0.458
LIG_FHA_2 652 658 PF00498 0.265
LIG_LIR_Apic_2 360 365 PF02991 0.421
LIG_LIR_Apic_2 383 388 PF02991 0.421
LIG_LIR_Gen_1 62 71 PF02991 0.421
LIG_LIR_Nem_3 383 389 PF02991 0.455
LIG_LIR_Nem_3 524 530 PF02991 0.446
LIG_LIR_Nem_3 537 541 PF02991 0.449
LIG_LIR_Nem_3 62 67 PF02991 0.421
LIG_LYPXL_yS_3 157 160 PF13949 0.421
LIG_LYPXL_yS_3 538 541 PF13949 0.467
LIG_Pex14_1 534 538 PF04695 0.421
LIG_SH2_CRK 386 390 PF00017 0.421
LIG_SH2_CRK 86 90 PF00017 0.421
LIG_SH2_NCK_1 36 40 PF00017 0.463
LIG_SH2_PTP2 494 497 PF00017 0.463
LIG_SH2_SRC 362 365 PF00017 0.421
LIG_SH2_STAT3 508 511 PF00017 0.467
LIG_SH2_STAT3 562 565 PF00017 0.421
LIG_SH2_STAT5 227 230 PF00017 0.435
LIG_SH2_STAT5 272 275 PF00017 0.421
LIG_SH2_STAT5 289 292 PF00017 0.463
LIG_SH2_STAT5 352 355 PF00017 0.421
LIG_SH2_STAT5 414 417 PF00017 0.421
LIG_SH2_STAT5 444 447 PF00017 0.436
LIG_SH2_STAT5 482 485 PF00017 0.522
LIG_SH2_STAT5 494 497 PF00017 0.402
LIG_SH2_STAT5 508 511 PF00017 0.467
LIG_SH2_STAT5 64 67 PF00017 0.455
LIG_SH3_1 362 368 PF00018 0.463
LIG_SH3_3 152 158 PF00018 0.463
LIG_SH3_3 278 284 PF00018 0.418
LIG_SH3_3 296 302 PF00018 0.421
LIG_SH3_3 362 368 PF00018 0.463
LIG_SH3_3 533 539 PF00018 0.487
LIG_SUMO_SIM_anti_2 308 314 PF11976 0.421
LIG_SUMO_SIM_par_1 31 38 PF11976 0.421
LIG_SUMO_SIM_par_1 322 328 PF11976 0.422
LIG_SUMO_SIM_par_1 622 628 PF11976 0.315
LIG_SUMO_SIM_par_1 656 665 PF11976 0.314
LIG_TRAF2_1 459 462 PF00917 0.377
LIG_TRAF2_1 499 502 PF00917 0.467
LIG_TRAF2_1 620 623 PF00917 0.315
LIG_TYR_ITIM 384 389 PF00017 0.421
LIG_TYR_ITIM 536 541 PF00017 0.467
LIG_UBA3_1 389 398 PF00899 0.463
LIG_UBA3_1 624 631 PF00899 0.256
MOD_CK1_1 274 280 PF00069 0.493
MOD_CK1_1 380 386 PF00069 0.427
MOD_CK1_1 60 66 PF00069 0.421
MOD_CK2_1 35 41 PF00069 0.421
MOD_CK2_1 456 462 PF00069 0.437
MOD_CK2_1 512 518 PF00069 0.463
MOD_GlcNHglycan 128 131 PF01048 0.238
MOD_GlcNHglycan 163 166 PF01048 0.242
MOD_GlcNHglycan 273 276 PF01048 0.291
MOD_GlcNHglycan 373 376 PF01048 0.268
MOD_GlcNHglycan 436 439 PF01048 0.263
MOD_GlcNHglycan 523 526 PF01048 0.239
MOD_GlcNHglycan 96 99 PF01048 0.211
MOD_GSK3_1 126 133 PF00069 0.436
MOD_GSK3_1 301 308 PF00069 0.421
MOD_GSK3_1 434 441 PF00069 0.463
MOD_GSK3_1 456 463 PF00069 0.549
MOD_GSK3_1 554 561 PF00069 0.446
MOD_GSK3_1 574 581 PF00069 0.432
MOD_GSK3_1 651 658 PF00069 0.284
MOD_N-GLC_1 438 443 PF02516 0.236
MOD_N-GLC_2 179 181 PF02516 0.181
MOD_N-GLC_2 422 424 PF02516 0.221
MOD_NEK2_1 126 131 PF00069 0.436
MOD_NEK2_1 493 498 PF00069 0.443
MOD_NEK2_1 512 517 PF00069 0.515
MOD_NEK2_1 566 571 PF00069 0.421
MOD_NEK2_2 357 362 PF00069 0.463
MOD_OFUCOSY 19 25 PF10250 0.221
MOD_PIKK_1 325 331 PF00454 0.485
MOD_PIKK_1 377 383 PF00454 0.421
MOD_PIKK_1 460 466 PF00454 0.406
MOD_PIKK_1 480 486 PF00454 0.334
MOD_PK_1 231 237 PF00069 0.421
MOD_PKA_2 357 363 PF00069 0.421
MOD_Plk_1 231 237 PF00069 0.421
MOD_Plk_1 460 466 PF00069 0.356
MOD_Plk_1 477 483 PF00069 0.381
MOD_Plk_1 512 518 PF00069 0.467
MOD_Plk_1 558 564 PF00069 0.446
MOD_Plk_1 590 596 PF00069 0.438
MOD_Plk_2-3 110 116 PF00069 0.463
MOD_Plk_2-3 623 629 PF00069 0.256
MOD_Plk_4 222 228 PF00069 0.463
MOD_Plk_4 245 251 PF00069 0.491
MOD_Plk_4 357 363 PF00069 0.483
MOD_Plk_4 547 553 PF00069 0.421
MOD_Plk_4 578 584 PF00069 0.442
MOD_Plk_4 60 66 PF00069 0.421
MOD_Plk_4 614 620 PF00069 0.291
MOD_ProDKin_1 598 604 PF00069 0.256
MOD_SUMO_for_1 475 478 PF00179 0.467
MOD_SUMO_for_1 499 502 PF00179 0.412
MOD_SUMO_rev_2 119 126 PF00179 0.463
MOD_SUMO_rev_2 186 195 PF00179 0.463
MOD_SUMO_rev_2 248 255 PF00179 0.421
MOD_SUMO_rev_2 326 334 PF00179 0.409
MOD_SUMO_rev_2 641 649 PF00179 0.262
TRG_DiLeu_BaEn_1 461 466 PF01217 0.360
TRG_DiLeu_BaEn_4 622 628 PF01217 0.315
TRG_DiLeu_BaLyEn_6 385 390 PF01217 0.421
TRG_ENDOCYTIC_2 157 160 PF00928 0.421
TRG_ENDOCYTIC_2 184 187 PF00928 0.467
TRG_ENDOCYTIC_2 386 389 PF00928 0.421
TRG_ENDOCYTIC_2 494 497 PF00928 0.463
TRG_ENDOCYTIC_2 538 541 PF00928 0.467
TRG_ENDOCYTIC_2 64 67 PF00928 0.421
TRG_ENDOCYTIC_2 86 89 PF00928 0.421
TRG_NES_CRM1_1 578 591 PF08389 0.428
TRG_Pf-PMV_PEXEL_1 200 204 PF00026 0.221
TRG_Pf-PMV_PEXEL_1 409 413 PF00026 0.292
TRG_Pf-PMV_PEXEL_1 510 514 PF00026 0.241

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P730 Leptomonas seymouri 86% 100%
A0A0N1HV47 Leptomonas seymouri 37% 97%
A0A0S4IX46 Bodo saltans 39% 98%
A0A0S4JIQ8 Bodo saltans 67% 100%
A0A1X0NJV2 Trypanosomatidae 38% 98%
A0A3Q8IKH3 Leishmania donovani 37% 97%
A0A422NEZ1 Trypanosoma rangeli 38% 98%
A0A451EJ63 Leishmania donovani 100% 100%
A4H339 Leishmania braziliensis 93% 100%
A4HJV8 Leishmania braziliensis 37% 100%
A4I7C0 Leishmania infantum 37% 97%
B9N843 Populus trichocarpa 45% 100%
C9ZWI5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 90%
D3DJ42 Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) 45% 100%
E9ABZ4 Leishmania major 97% 100%
E9AJ91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B2B3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
I3R7G3 Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) 38% 100%
O30019 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 46% 100%
O34544 Bacillus subtilis (strain 168) 48% 100%
P05165 Homo sapiens 51% 91%
P0A509 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 47% 100%
P0DTA4 Sus scrofa 51% 91%
P14882 Rattus norvegicus 51% 90%
P43873 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 49% 100%
P46392 Mycobacterium leprae (strain TN) 43% 100%
P9WPQ2 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 47% 100%
P9WPQ3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 47% 100%
Q19842 Caenorhabditis elegans 50% 92%
Q2QMG2 Oryza sativa subsp. japonica 46% 90%
Q42523 Arabidopsis thaliana 37% 91%
Q42777 Glycine max 36% 91%
Q4Q5U3 Leishmania major 37% 100%
Q58626 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 48% 100%
Q5I0C3 Rattus norvegicus 38% 93%
Q5LUF3 Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) 47% 98%
Q612F5 Caenorhabditis briggsae 50% 90%
Q91ZA3 Mus musculus 51% 92%
Q96RQ3 Homo sapiens 40% 92%
Q99MR8 Mus musculus 38% 93%
V5BDW2 Trypanosoma cruzi 36% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS