Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13

Species:

Leishmania infantum

UniProt:

A4HRC5_LEIIN

TriTrypDb:

LINF_010005200

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

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Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0005874	microtubule	6	18
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

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Expansion

Sequence features

A4HRC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRC5

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	18
GO:0007018	microtubule-based movement	3	18
GO:0007019	microtubule depolymerization	5	2
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	18
GO:0016043	cellular component organization	3	2

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003774	cytoskeletal motor activity	1	18
GO:0003777	microtubule motor activity	2	18
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0005524	ATP binding	5	18
GO:0008017	microtubule binding	5	18
GO:0008092	cytoskeletal protein binding	3	18
GO:0015631	tubulin binding	4	18
GO:0017076	purine nucleotide binding	4	18

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.322
CLV_C14_Caspase3-7	80	84	PF00656	0.735
CLV_NRD_NRD_1	106	108	PF00675	0.739
CLV_NRD_NRD_1	128	130	PF00675	0.460
CLV_NRD_NRD_1	137	139	PF00675	0.334
CLV_NRD_NRD_1	174	176	PF00675	0.374
CLV_NRD_NRD_1	18	20	PF00675	0.520
CLV_NRD_NRD_1	278	280	PF00675	0.388
CLV_NRD_NRD_1	397	399	PF00675	0.252
CLV_NRD_NRD_1	458	460	PF00675	0.503

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	73%	100%
A0A0S4IP49	Bodo saltans	27%	83%
A0A1X0P2U1	Trypanosomatidae	46%	96%
A0A3S5H4S8	Leishmania donovani	100%	100%
A0A3S7WST0	Leishmania donovani	46%	92%
A0A3S7X9Y1	Leishmania donovani	34%	100%
A0A422NY45	Trypanosoma rangeli	51%	96%
A4H337	Leishmania braziliensis	88%	100%
A4H7F1	Leishmania braziliensis	46%	100%
A4HAQ7	Leishmania braziliensis	26%	100%

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