LeishMANIAdb
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Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin-like protein
Gene product:
Kinesin-13
Species:
Leishmania infantum
UniProt:
A4HRC5_LEIIN
TriTrypDb:
LINF_010005200
Length:
673

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 17
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 18
GO:0099080 supramolecular complex 2 18
GO:0099081 supramolecular polymer 3 18
GO:0099512 supramolecular fiber 4 18
GO:0099513 polymeric cytoskeletal fiber 5 18
GO:0110165 cellular anatomical entity 1 18
GO:0000922 spindle pole 2 1
GO:0005634 nucleus 5 1
GO:0005819 spindle 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A4HRC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRC5

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 18
GO:0007018 microtubule-based movement 3 18
GO:0009987 cellular process 1 18
GO:0000226 microtubule cytoskeleton organization 3 2
GO:0006996 organelle organization 4 2
GO:0007010 cytoskeleton organization 5 2
GO:0007019 microtubule depolymerization 5 2
GO:0007051 spindle organization 3 1
GO:0007052 mitotic spindle organization 4 1
GO:0016043 cellular component organization 3 2
GO:0022402 cell cycle process 2 1
GO:0022411 cellular component disassembly 4 2
GO:0031109 microtubule polymerization or depolymerization 4 2
GO:0032984 protein-containing complex disassembly 5 2
GO:0043933 protein-containing complex organization 4 2
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051261 protein depolymerization 6 2
GO:0051983 regulation of chromosome segregation 4 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 2
GO:0097435 supramolecular fiber organization 4 2
GO:1902850 microtubule cytoskeleton organization involved in mitosis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 18
GO:0003774 cytoskeletal motor activity 1 18
GO:0003777 microtubule motor activity 2 18
GO:0005488 binding 1 18
GO:0005515 protein binding 2 18
GO:0005524 ATP binding 5 18
GO:0008017 microtubule binding 5 18
GO:0008092 cytoskeletal protein binding 3 18
GO:0015631 tubulin binding 4 18
GO:0017076 purine nucleotide binding 4 18
GO:0030554 adenyl nucleotide binding 5 18
GO:0032553 ribonucleotide binding 3 18
GO:0032555 purine ribonucleotide binding 4 18
GO:0032559 adenyl ribonucleotide binding 5 18
GO:0035639 purine ribonucleoside triphosphate binding 4 18
GO:0036094 small molecule binding 2 18
GO:0043167 ion binding 2 18
GO:0043168 anion binding 3 18
GO:0097159 organic cyclic compound binding 2 18
GO:0097367 carbohydrate derivative binding 2 18
GO:0140657 ATP-dependent activity 1 18
GO:1901265 nucleoside phosphate binding 3 18
GO:1901363 heterocyclic compound binding 2 18

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 153 157 PF00656 0.322
CLV_C14_Caspase3-7 80 84 PF00656 0.735
CLV_NRD_NRD_1 106 108 PF00675 0.739
CLV_NRD_NRD_1 128 130 PF00675 0.460
CLV_NRD_NRD_1 137 139 PF00675 0.334
CLV_NRD_NRD_1 174 176 PF00675 0.374
CLV_NRD_NRD_1 18 20 PF00675 0.520
CLV_NRD_NRD_1 278 280 PF00675 0.388
CLV_NRD_NRD_1 397 399 PF00675 0.252
CLV_NRD_NRD_1 458 460 PF00675 0.503
CLV_NRD_NRD_1 482 484 PF00675 0.683
CLV_NRD_NRD_1 633 635 PF00675 0.484
CLV_PCSK_KEX2_1 105 107 PF00082 0.751
CLV_PCSK_KEX2_1 128 130 PF00082 0.459
CLV_PCSK_KEX2_1 139 141 PF00082 0.329
CLV_PCSK_KEX2_1 18 20 PF00082 0.520
CLV_PCSK_KEX2_1 278 280 PF00082 0.395
CLV_PCSK_KEX2_1 343 345 PF00082 0.405
CLV_PCSK_KEX2_1 452 454 PF00082 0.482
CLV_PCSK_KEX2_1 458 460 PF00082 0.493
CLV_PCSK_KEX2_1 482 484 PF00082 0.683
CLV_PCSK_KEX2_1 546 548 PF00082 0.595
CLV_PCSK_KEX2_1 570 572 PF00082 0.717
CLV_PCSK_KEX2_1 632 634 PF00082 0.512
CLV_PCSK_PC1ET2_1 128 130 PF00082 0.462
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.354
CLV_PCSK_PC1ET2_1 343 345 PF00082 0.247
CLV_PCSK_PC1ET2_1 452 454 PF00082 0.453
CLV_PCSK_PC1ET2_1 546 548 PF00082 0.595
CLV_PCSK_PC1ET2_1 570 572 PF00082 0.638
CLV_PCSK_PC1ET2_1 632 634 PF00082 0.480
CLV_PCSK_PC7_1 478 484 PF00082 0.668
CLV_PCSK_PC7_1 566 572 PF00082 0.647
CLV_PCSK_SKI1_1 182 186 PF00082 0.230
CLV_PCSK_SKI1_1 247 251 PF00082 0.356
CLV_PCSK_SKI1_1 294 298 PF00082 0.374
CLV_PCSK_SKI1_1 36 40 PF00082 0.471
CLV_PCSK_SKI1_1 382 386 PF00082 0.316
CLV_PCSK_SKI1_1 449 453 PF00082 0.450
CLV_Separin_Metazoa 410 414 PF03568 0.277
DEG_APCC_DBOX_1 277 285 PF00400 0.223
DEG_SPOP_SBC_1 668 672 PF00917 0.465
DOC_CKS1_1 528 533 PF01111 0.530
DOC_CYCLIN_RxL_1 379 389 PF00134 0.316
DOC_MAPK_gen_1 128 137 PF00069 0.405
DOC_MAPK_gen_1 166 174 PF00069 0.363
DOC_MAPK_MEF2A_6 128 137 PF00069 0.410
DOC_MAPK_MEF2A_6 166 174 PF00069 0.363
DOC_MAPK_MEF2A_6 331 340 PF00069 0.359
DOC_USP7_MATH_1 504 508 PF00917 0.634
DOC_USP7_MATH_1 548 552 PF00917 0.709
DOC_USP7_MATH_1 561 565 PF00917 0.598
DOC_USP7_MATH_1 581 585 PF00917 0.519
DOC_USP7_MATH_1 635 639 PF00917 0.474
DOC_USP7_MATH_1 668 672 PF00917 0.465
DOC_USP7_MATH_1 74 78 PF00917 0.607
DOC_USP7_UBL2_3 339 343 PF12436 0.371
DOC_USP7_UBL2_3 347 351 PF12436 0.188
DOC_WW_Pin1_4 426 431 PF00397 0.316
DOC_WW_Pin1_4 516 521 PF00397 0.669
DOC_WW_Pin1_4 527 532 PF00397 0.676
DOC_WW_Pin1_4 536 541 PF00397 0.679
DOC_WW_Pin1_4 91 96 PF00397 0.645
LIG_14-3-3_CanoR_1 106 116 PF00244 0.528
LIG_14-3-3_CanoR_1 175 184 PF00244 0.366
LIG_14-3-3_CanoR_1 24 30 PF00244 0.331
LIG_14-3-3_CanoR_1 252 261 PF00244 0.357
LIG_14-3-3_CanoR_1 453 461 PF00244 0.678
LIG_14-3-3_CanoR_1 482 488 PF00244 0.550
LIG_14-3-3_CanoR_1 513 519 PF00244 0.704
LIG_14-3-3_CanoR_1 626 636 PF00244 0.483
LIG_Actin_WH2_1 48 63 PF00022 0.322
LIG_BRCT_BRCA1_1 348 352 PF00533 0.233
LIG_BRCT_BRCA1_1 669 673 PF00533 0.476
LIG_FHA_1 112 118 PF00498 0.445
LIG_FHA_1 255 261 PF00498 0.219
LIG_FHA_1 407 413 PF00498 0.307
LIG_FHA_1 420 426 PF00498 0.275
LIG_FHA_1 458 464 PF00498 0.636
LIG_FHA_1 483 489 PF00498 0.601
LIG_FHA_2 121 127 PF00498 0.420
LIG_FHA_2 207 213 PF00498 0.324
LIG_FHA_2 300 306 PF00498 0.219
LIG_FHA_2 307 313 PF00498 0.188
LIG_FHA_2 32 38 PF00498 0.513
LIG_FHA_2 351 357 PF00498 0.286
LIG_FHA_2 371 377 PF00498 0.226
LIG_FHA_2 618 624 PF00498 0.312
LIG_FHA_2 639 645 PF00498 0.490
LIG_Integrin_isoDGR_2 276 278 PF01839 0.230
LIG_LIR_Gen_1 148 157 PF02991 0.437
LIG_LIR_Gen_1 248 256 PF02991 0.308
LIG_LIR_Gen_1 349 358 PF02991 0.322
LIG_LIR_Nem_3 148 154 PF02991 0.437
LIG_LIR_Nem_3 248 253 PF02991 0.311
LIG_LIR_Nem_3 262 267 PF02991 0.336
LIG_LIR_Nem_3 349 355 PF02991 0.320
LIG_LIR_Nem_3 44 49 PF02991 0.424
LIG_LIR_Nem_3 568 572 PF02991 0.567
LIG_LIR_Nem_3 588 593 PF02991 0.461
LIG_NRBOX 270 276 PF00104 0.286
LIG_PCNA_TLS_4 633 640 PF02747 0.483
LIG_PDZ_Class_1 668 673 PF00595 0.470
LIG_Pex14_2 185 189 PF04695 0.277
LIG_Pex14_2 25 29 PF04695 0.473
LIG_RPA_C_Fungi 621 633 PF08784 0.483
LIG_SH2_NCK_1 199 203 PF00017 0.458
LIG_SH2_NCK_1 242 246 PF00017 0.277
LIG_SH2_STAP1 242 246 PF00017 0.277
LIG_SH2_STAP1 444 448 PF00017 0.316
LIG_SH2_STAT5 109 112 PF00017 0.480
LIG_SH2_STAT5 12 15 PF00017 0.485
LIG_SH2_STAT5 177 180 PF00017 0.316
LIG_SH2_STAT5 593 596 PF00017 0.342
LIG_SH2_STAT5 66 69 PF00017 0.371
LIG_SH3_3 458 464 PF00018 0.619
LIG_SH3_3 557 563 PF00018 0.532
LIG_SH3_3 662 668 PF00018 0.429
LIG_SUMO_SIM_par_1 383 389 PF11976 0.277
LIG_TRAF2_1 123 126 PF00917 0.409
LIG_UBA3_1 133 139 PF00899 0.405
LIG_UBA3_1 335 343 PF00899 0.247
LIG_UBA3_1 384 388 PF00899 0.315
LIG_WRC_WIRS_1 260 265 PF05994 0.277
LIG_WRC_WIRS_1 636 641 PF05994 0.486
MOD_CDK_SPK_2 527 532 PF00069 0.667
MOD_CDK_SPxxK_3 91 98 PF00069 0.648
MOD_CK1_1 120 126 PF00069 0.499
MOD_CK1_1 226 232 PF00069 0.316
MOD_CK1_1 28 34 PF00069 0.445
MOD_CK1_1 319 325 PF00069 0.284
MOD_CK1_1 329 335 PF00069 0.363
MOD_CK1_1 346 352 PF00069 0.233
MOD_CK1_1 406 412 PF00069 0.316
MOD_CK1_1 481 487 PF00069 0.599
MOD_CK1_1 496 502 PF00069 0.594
MOD_CK1_1 511 517 PF00069 0.607
MOD_CK1_1 519 525 PF00069 0.585
MOD_CK1_1 551 557 PF00069 0.697
MOD_CK1_1 638 644 PF00069 0.540
MOD_CK2_1 120 126 PF00069 0.431
MOD_CK2_1 140 146 PF00069 0.187
MOD_CK2_1 259 265 PF00069 0.316
MOD_CK2_1 299 305 PF00069 0.247
MOD_CK2_1 370 376 PF00069 0.316
MOD_CK2_1 617 623 PF00069 0.498
MOD_CK2_1 90 96 PF00069 0.610
MOD_Cter_Amidation 276 279 PF01082 0.390
MOD_GlcNHglycan 142 145 PF01048 0.471
MOD_GlcNHglycan 2 5 PF01048 0.694
MOD_GlcNHglycan 225 228 PF01048 0.311
MOD_GlcNHglycan 267 270 PF01048 0.234
MOD_GlcNHglycan 314 317 PF01048 0.310
MOD_GlcNHglycan 348 351 PF01048 0.267
MOD_GlcNHglycan 488 491 PF01048 0.631
MOD_GlcNHglycan 495 498 PF01048 0.572
MOD_GlcNHglycan 552 556 PF01048 0.685
MOD_GlcNHglycan 563 566 PF01048 0.694
MOD_GlcNHglycan 76 79 PF01048 0.717
MOD_GSK3_1 107 114 PF00069 0.474
MOD_GSK3_1 145 152 PF00069 0.265
MOD_GSK3_1 24 31 PF00069 0.341
MOD_GSK3_1 294 301 PF00069 0.284
MOD_GSK3_1 312 319 PF00069 0.155
MOD_GSK3_1 325 332 PF00069 0.217
MOD_GSK3_1 342 349 PF00069 0.230
MOD_GSK3_1 453 460 PF00069 0.649
MOD_GSK3_1 474 481 PF00069 0.674
MOD_GSK3_1 482 489 PF00069 0.613
MOD_GSK3_1 493 500 PF00069 0.606
MOD_GSK3_1 504 511 PF00069 0.652
MOD_GSK3_1 514 521 PF00069 0.647
MOD_GSK3_1 523 530 PF00069 0.664
MOD_GSK3_1 532 539 PF00069 0.599
MOD_GSK3_1 561 568 PF00069 0.698
MOD_GSK3_1 663 670 PF00069 0.461
MOD_GSK3_1 72 79 PF00069 0.574
MOD_N-GLC_1 325 330 PF02516 0.230
MOD_N-GLC_1 380 385 PF02516 0.313
MOD_N-GLC_1 453 458 PF02516 0.454
MOD_NEK2_1 206 211 PF00069 0.427
MOD_NEK2_1 25 30 PF00069 0.459
MOD_NEK2_1 403 408 PF00069 0.306
MOD_NEK2_1 412 417 PF00069 0.298
MOD_NEK2_1 495 500 PF00069 0.624
MOD_NEK2_1 509 514 PF00069 0.652
MOD_NEK2_2 214 219 PF00069 0.316
MOD_PIKK_1 519 525 PF00454 0.552
MOD_PIKK_1 6 12 PF00454 0.471
MOD_PIKK_1 638 644 PF00454 0.517
MOD_PIKK_1 663 669 PF00454 0.670
MOD_PKA_1 128 134 PF00069 0.396
MOD_PKA_1 175 181 PF00069 0.342
MOD_PKA_1 343 349 PF00069 0.363
MOD_PKA_1 482 488 PF00069 0.664
MOD_PKA_2 111 117 PF00069 0.453
MOD_PKA_2 128 134 PF00069 0.388
MOD_PKA_2 251 257 PF00069 0.410
MOD_PKA_2 343 349 PF00069 0.433
MOD_PKA_2 370 376 PF00069 0.230
MOD_PKA_2 403 409 PF00069 0.310
MOD_PKA_2 412 418 PF00069 0.293
MOD_PKA_2 457 463 PF00069 0.657
MOD_PKA_2 481 487 PF00069 0.573
MOD_PKA_2 548 554 PF00069 0.650
MOD_PKA_2 561 567 PF00069 0.540
MOD_PKB_1 105 113 PF00069 0.501
MOD_PKB_1 138 146 PF00069 0.305
MOD_Plk_1 380 386 PF00069 0.316
MOD_Plk_1 435 441 PF00069 0.286
MOD_Plk_2-3 306 312 PF00069 0.219
MOD_Plk_4 112 118 PF00069 0.445
MOD_Plk_4 206 212 PF00069 0.303
MOD_Plk_4 228 234 PF00069 0.316
MOD_Plk_4 259 265 PF00069 0.305
MOD_Plk_4 306 312 PF00069 0.375
MOD_Plk_4 380 386 PF00069 0.316
MOD_Plk_4 412 418 PF00069 0.259
MOD_Plk_4 505 511 PF00069 0.653
MOD_Plk_4 524 530 PF00069 0.649
MOD_Plk_4 635 641 PF00069 0.475
MOD_ProDKin_1 426 432 PF00069 0.316
MOD_ProDKin_1 516 522 PF00069 0.668
MOD_ProDKin_1 527 533 PF00069 0.675
MOD_ProDKin_1 536 542 PF00069 0.680
MOD_ProDKin_1 91 97 PF00069 0.646
MOD_SUMO_for_1 601 604 PF00179 0.441
MOD_SUMO_rev_2 162 170 PF00179 0.367
MOD_SUMO_rev_2 332 340 PF00179 0.230
TRG_DiLeu_BaEn_1 623 628 PF01217 0.369
TRG_DiLeu_BaEn_2 388 394 PF01217 0.363
TRG_DiLeu_LyEn_5 623 628 PF01217 0.369
TRG_ENDOCYTIC_2 177 180 PF00928 0.345
TRG_ENDOCYTIC_2 49 52 PF00928 0.443
TRG_ER_diArg_1 105 107 PF00400 0.642
TRG_ER_diArg_1 137 140 PF00400 0.298
TRG_ER_diArg_1 17 19 PF00400 0.515
TRG_ER_diArg_1 278 280 PF00400 0.405
TRG_ER_diArg_1 58 61 PF00400 0.365
TRG_ER_diArg_1 583 586 PF00400 0.506
TRG_ER_diArg_1 624 627 PF00400 0.545
TRG_NLS_Bipartite_1 128 142 PF00514 0.390
TRG_NLS_MonoExtC_3 127 132 PF00514 0.528
TRG_NLS_MonoExtN_4 128 133 PF00514 0.398
TRG_Pf-PMV_PEXEL_1 204 208 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.242
TRG_Pf-PMV_PEXEL_1 294 298 PF00026 0.206
TRG_Pf-PMV_PEXEL_1 392 396 PF00026 0.410
TRG_Pf-PMV_PEXEL_1 585 589 PF00026 0.586
TRG_Pf-PMV_PEXEL_1 626 631 PF00026 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6P6 Leptomonas seymouri 73% 100%
A0A0S4IP49 Bodo saltans 27% 83%
A0A1X0P2U1 Trypanosomatidae 46% 96%
A0A3S5H4S8 Leishmania donovani 100% 100%
A0A3S7WST0 Leishmania donovani 46% 92%
A0A3S7X9Y1 Leishmania donovani 34% 100%
A0A422NY45 Trypanosoma rangeli 51% 96%
A4H337 Leishmania braziliensis 88% 100%
A4H7F1 Leishmania braziliensis 46% 100%
A4HAQ7 Leishmania braziliensis 26% 100%
A4HDC2 Leishmania braziliensis 41% 100%
A4HND6 Leishmania braziliensis 34% 100%
A4HSA6 Leishmania infantum 32% 100%
A4HVT9 Leishmania infantum 46% 92%
A4IC09 Leishmania infantum 34% 100%
C9ZXH0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 97%
E9ABZ2 Leishmania major 97% 100%
E9AFU7 Leishmania major 34% 100%
E9AJ89 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9API5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AWQ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B6Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
Q4QFZ3 Leishmania major 46% 100%
Q940Y8 Arabidopsis thaliana 40% 98%
V5D311 Trypanosoma cruzi 47% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS