Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13

Species:

Leishmania infantum

UniProt:

A4HRC5_LEIIN

TriTrypDb:

LINF_010005200

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	18
GO:0099080	supramolecular complex	2	18
GO:0099081	supramolecular polymer	3	18
GO:0099512	supramolecular fiber	4	18
GO:0099513	polymeric cytoskeletal fiber	5	18
GO:0110165	cellular anatomical entity	1	18
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HRC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRC5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	18
GO:0007018	microtubule-based movement	3	18
GO:0009987	cellular process	1	18
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007019	microtubule depolymerization	5	2
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	1
GO:0022411	cellular component disassembly	4	2
GO:0031109	microtubule polymerization or depolymerization	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051261	protein depolymerization	6	2
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003774	cytoskeletal motor activity	1	18
GO:0003777	microtubule motor activity	2	18
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0005524	ATP binding	5	18
GO:0008017	microtubule binding	5	18
GO:0008092	cytoskeletal protein binding	3	18
GO:0015631	tubulin binding	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140657	ATP-dependent activity	1	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.322
CLV_C14_Caspase3-7	80	84	PF00656	0.735
CLV_NRD_NRD_1	106	108	PF00675	0.739
CLV_NRD_NRD_1	128	130	PF00675	0.460
CLV_NRD_NRD_1	137	139	PF00675	0.334
CLV_NRD_NRD_1	174	176	PF00675	0.374
CLV_NRD_NRD_1	18	20	PF00675	0.520
CLV_NRD_NRD_1	278	280	PF00675	0.388
CLV_NRD_NRD_1	397	399	PF00675	0.252
CLV_NRD_NRD_1	458	460	PF00675	0.503
CLV_NRD_NRD_1	482	484	PF00675	0.683
CLV_NRD_NRD_1	633	635	PF00675	0.484
CLV_PCSK_KEX2_1	105	107	PF00082	0.751
CLV_PCSK_KEX2_1	128	130	PF00082	0.459
CLV_PCSK_KEX2_1	139	141	PF00082	0.329
CLV_PCSK_KEX2_1	18	20	PF00082	0.520
CLV_PCSK_KEX2_1	278	280	PF00082	0.395
CLV_PCSK_KEX2_1	343	345	PF00082	0.405
CLV_PCSK_KEX2_1	452	454	PF00082	0.482
CLV_PCSK_KEX2_1	458	460	PF00082	0.493
CLV_PCSK_KEX2_1	482	484	PF00082	0.683
CLV_PCSK_KEX2_1	546	548	PF00082	0.595
CLV_PCSK_KEX2_1	570	572	PF00082	0.717
CLV_PCSK_KEX2_1	632	634	PF00082	0.512
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.462
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.354
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.247
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.453
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.595
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.638
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.480
CLV_PCSK_PC7_1	478	484	PF00082	0.668
CLV_PCSK_PC7_1	566	572	PF00082	0.647
CLV_PCSK_SKI1_1	182	186	PF00082	0.230
CLV_PCSK_SKI1_1	247	251	PF00082	0.356
CLV_PCSK_SKI1_1	294	298	PF00082	0.374
CLV_PCSK_SKI1_1	36	40	PF00082	0.471
CLV_PCSK_SKI1_1	382	386	PF00082	0.316
CLV_PCSK_SKI1_1	449	453	PF00082	0.450
CLV_Separin_Metazoa	410	414	PF03568	0.277
DEG_APCC_DBOX_1	277	285	PF00400	0.223
DEG_SPOP_SBC_1	668	672	PF00917	0.465
DOC_CKS1_1	528	533	PF01111	0.530
DOC_CYCLIN_RxL_1	379	389	PF00134	0.316
DOC_MAPK_gen_1	128	137	PF00069	0.405
DOC_MAPK_gen_1	166	174	PF00069	0.363
DOC_MAPK_MEF2A_6	128	137	PF00069	0.410
DOC_MAPK_MEF2A_6	166	174	PF00069	0.363
DOC_MAPK_MEF2A_6	331	340	PF00069	0.359
DOC_USP7_MATH_1	504	508	PF00917	0.634
DOC_USP7_MATH_1	548	552	PF00917	0.709
DOC_USP7_MATH_1	561	565	PF00917	0.598
DOC_USP7_MATH_1	581	585	PF00917	0.519
DOC_USP7_MATH_1	635	639	PF00917	0.474
DOC_USP7_MATH_1	668	672	PF00917	0.465
DOC_USP7_MATH_1	74	78	PF00917	0.607
DOC_USP7_UBL2_3	339	343	PF12436	0.371
DOC_USP7_UBL2_3	347	351	PF12436	0.188
DOC_WW_Pin1_4	426	431	PF00397	0.316
DOC_WW_Pin1_4	516	521	PF00397	0.669
DOC_WW_Pin1_4	527	532	PF00397	0.676
DOC_WW_Pin1_4	536	541	PF00397	0.679
DOC_WW_Pin1_4	91	96	PF00397	0.645
LIG_14-3-3_CanoR_1	106	116	PF00244	0.528
LIG_14-3-3_CanoR_1	175	184	PF00244	0.366
LIG_14-3-3_CanoR_1	24	30	PF00244	0.331
LIG_14-3-3_CanoR_1	252	261	PF00244	0.357
LIG_14-3-3_CanoR_1	453	461	PF00244	0.678
LIG_14-3-3_CanoR_1	482	488	PF00244	0.550
LIG_14-3-3_CanoR_1	513	519	PF00244	0.704
LIG_14-3-3_CanoR_1	626	636	PF00244	0.483
LIG_Actin_WH2_1	48	63	PF00022	0.322
LIG_BRCT_BRCA1_1	348	352	PF00533	0.233
LIG_BRCT_BRCA1_1	669	673	PF00533	0.476
LIG_FHA_1	112	118	PF00498	0.445
LIG_FHA_1	255	261	PF00498	0.219
LIG_FHA_1	407	413	PF00498	0.307
LIG_FHA_1	420	426	PF00498	0.275
LIG_FHA_1	458	464	PF00498	0.636
LIG_FHA_1	483	489	PF00498	0.601
LIG_FHA_2	121	127	PF00498	0.420
LIG_FHA_2	207	213	PF00498	0.324
LIG_FHA_2	300	306	PF00498	0.219
LIG_FHA_2	307	313	PF00498	0.188
LIG_FHA_2	32	38	PF00498	0.513
LIG_FHA_2	351	357	PF00498	0.286
LIG_FHA_2	371	377	PF00498	0.226
LIG_FHA_2	618	624	PF00498	0.312
LIG_FHA_2	639	645	PF00498	0.490
LIG_Integrin_isoDGR_2	276	278	PF01839	0.230
LIG_LIR_Gen_1	148	157	PF02991	0.437
LIG_LIR_Gen_1	248	256	PF02991	0.308
LIG_LIR_Gen_1	349	358	PF02991	0.322
LIG_LIR_Nem_3	148	154	PF02991	0.437
LIG_LIR_Nem_3	248	253	PF02991	0.311
LIG_LIR_Nem_3	262	267	PF02991	0.336
LIG_LIR_Nem_3	349	355	PF02991	0.320
LIG_LIR_Nem_3	44	49	PF02991	0.424
LIG_LIR_Nem_3	568	572	PF02991	0.567
LIG_LIR_Nem_3	588	593	PF02991	0.461
LIG_NRBOX	270	276	PF00104	0.286
LIG_PCNA_TLS_4	633	640	PF02747	0.483
LIG_PDZ_Class_1	668	673	PF00595	0.470
LIG_Pex14_2	185	189	PF04695	0.277
LIG_Pex14_2	25	29	PF04695	0.473
LIG_RPA_C_Fungi	621	633	PF08784	0.483
LIG_SH2_NCK_1	199	203	PF00017	0.458
LIG_SH2_NCK_1	242	246	PF00017	0.277
LIG_SH2_STAP1	242	246	PF00017	0.277
LIG_SH2_STAP1	444	448	PF00017	0.316
LIG_SH2_STAT5	109	112	PF00017	0.480
LIG_SH2_STAT5	12	15	PF00017	0.485
LIG_SH2_STAT5	177	180	PF00017	0.316
LIG_SH2_STAT5	593	596	PF00017	0.342
LIG_SH2_STAT5	66	69	PF00017	0.371
LIG_SH3_3	458	464	PF00018	0.619
LIG_SH3_3	557	563	PF00018	0.532
LIG_SH3_3	662	668	PF00018	0.429
LIG_SUMO_SIM_par_1	383	389	PF11976	0.277
LIG_TRAF2_1	123	126	PF00917	0.409
LIG_UBA3_1	133	139	PF00899	0.405
LIG_UBA3_1	335	343	PF00899	0.247
LIG_UBA3_1	384	388	PF00899	0.315
LIG_WRC_WIRS_1	260	265	PF05994	0.277
LIG_WRC_WIRS_1	636	641	PF05994	0.486
MOD_CDK_SPK_2	527	532	PF00069	0.667
MOD_CDK_SPxxK_3	91	98	PF00069	0.648
MOD_CK1_1	120	126	PF00069	0.499
MOD_CK1_1	226	232	PF00069	0.316
MOD_CK1_1	28	34	PF00069	0.445
MOD_CK1_1	319	325	PF00069	0.284
MOD_CK1_1	329	335	PF00069	0.363
MOD_CK1_1	346	352	PF00069	0.233
MOD_CK1_1	406	412	PF00069	0.316
MOD_CK1_1	481	487	PF00069	0.599
MOD_CK1_1	496	502	PF00069	0.594
MOD_CK1_1	511	517	PF00069	0.607
MOD_CK1_1	519	525	PF00069	0.585
MOD_CK1_1	551	557	PF00069	0.697
MOD_CK1_1	638	644	PF00069	0.540
MOD_CK2_1	120	126	PF00069	0.431
MOD_CK2_1	140	146	PF00069	0.187
MOD_CK2_1	259	265	PF00069	0.316
MOD_CK2_1	299	305	PF00069	0.247
MOD_CK2_1	370	376	PF00069	0.316
MOD_CK2_1	617	623	PF00069	0.498
MOD_CK2_1	90	96	PF00069	0.610
MOD_Cter_Amidation	276	279	PF01082	0.390
MOD_GlcNHglycan	142	145	PF01048	0.471
MOD_GlcNHglycan	2	5	PF01048	0.694
MOD_GlcNHglycan	225	228	PF01048	0.311
MOD_GlcNHglycan	267	270	PF01048	0.234
MOD_GlcNHglycan	314	317	PF01048	0.310
MOD_GlcNHglycan	348	351	PF01048	0.267
MOD_GlcNHglycan	488	491	PF01048	0.631
MOD_GlcNHglycan	495	498	PF01048	0.572
MOD_GlcNHglycan	552	556	PF01048	0.685
MOD_GlcNHglycan	563	566	PF01048	0.694
MOD_GlcNHglycan	76	79	PF01048	0.717
MOD_GSK3_1	107	114	PF00069	0.474
MOD_GSK3_1	145	152	PF00069	0.265
MOD_GSK3_1	24	31	PF00069	0.341
MOD_GSK3_1	294	301	PF00069	0.284
MOD_GSK3_1	312	319	PF00069	0.155
MOD_GSK3_1	325	332	PF00069	0.217
MOD_GSK3_1	342	349	PF00069	0.230
MOD_GSK3_1	453	460	PF00069	0.649
MOD_GSK3_1	474	481	PF00069	0.674
MOD_GSK3_1	482	489	PF00069	0.613
MOD_GSK3_1	493	500	PF00069	0.606
MOD_GSK3_1	504	511	PF00069	0.652
MOD_GSK3_1	514	521	PF00069	0.647
MOD_GSK3_1	523	530	PF00069	0.664
MOD_GSK3_1	532	539	PF00069	0.599
MOD_GSK3_1	561	568	PF00069	0.698
MOD_GSK3_1	663	670	PF00069	0.461
MOD_GSK3_1	72	79	PF00069	0.574
MOD_N-GLC_1	325	330	PF02516	0.230
MOD_N-GLC_1	380	385	PF02516	0.313
MOD_N-GLC_1	453	458	PF02516	0.454
MOD_NEK2_1	206	211	PF00069	0.427
MOD_NEK2_1	25	30	PF00069	0.459
MOD_NEK2_1	403	408	PF00069	0.306
MOD_NEK2_1	412	417	PF00069	0.298
MOD_NEK2_1	495	500	PF00069	0.624
MOD_NEK2_1	509	514	PF00069	0.652
MOD_NEK2_2	214	219	PF00069	0.316
MOD_PIKK_1	519	525	PF00454	0.552
MOD_PIKK_1	6	12	PF00454	0.471
MOD_PIKK_1	638	644	PF00454	0.517
MOD_PIKK_1	663	669	PF00454	0.670
MOD_PKA_1	128	134	PF00069	0.396
MOD_PKA_1	175	181	PF00069	0.342
MOD_PKA_1	343	349	PF00069	0.363
MOD_PKA_1	482	488	PF00069	0.664
MOD_PKA_2	111	117	PF00069	0.453
MOD_PKA_2	128	134	PF00069	0.388
MOD_PKA_2	251	257	PF00069	0.410
MOD_PKA_2	343	349	PF00069	0.433
MOD_PKA_2	370	376	PF00069	0.230
MOD_PKA_2	403	409	PF00069	0.310
MOD_PKA_2	412	418	PF00069	0.293
MOD_PKA_2	457	463	PF00069	0.657
MOD_PKA_2	481	487	PF00069	0.573
MOD_PKA_2	548	554	PF00069	0.650
MOD_PKA_2	561	567	PF00069	0.540
MOD_PKB_1	105	113	PF00069	0.501
MOD_PKB_1	138	146	PF00069	0.305
MOD_Plk_1	380	386	PF00069	0.316
MOD_Plk_1	435	441	PF00069	0.286
MOD_Plk_2-3	306	312	PF00069	0.219
MOD_Plk_4	112	118	PF00069	0.445
MOD_Plk_4	206	212	PF00069	0.303
MOD_Plk_4	228	234	PF00069	0.316
MOD_Plk_4	259	265	PF00069	0.305
MOD_Plk_4	306	312	PF00069	0.375
MOD_Plk_4	380	386	PF00069	0.316
MOD_Plk_4	412	418	PF00069	0.259
MOD_Plk_4	505	511	PF00069	0.653
MOD_Plk_4	524	530	PF00069	0.649
MOD_Plk_4	635	641	PF00069	0.475
MOD_ProDKin_1	426	432	PF00069	0.316
MOD_ProDKin_1	516	522	PF00069	0.668
MOD_ProDKin_1	527	533	PF00069	0.675
MOD_ProDKin_1	536	542	PF00069	0.680
MOD_ProDKin_1	91	97	PF00069	0.646
MOD_SUMO_for_1	601	604	PF00179	0.441
MOD_SUMO_rev_2	162	170	PF00179	0.367
MOD_SUMO_rev_2	332	340	PF00179	0.230
TRG_DiLeu_BaEn_1	623	628	PF01217	0.369
TRG_DiLeu_BaEn_2	388	394	PF01217	0.363
TRG_DiLeu_LyEn_5	623	628	PF01217	0.369
TRG_ENDOCYTIC_2	177	180	PF00928	0.345
TRG_ENDOCYTIC_2	49	52	PF00928	0.443
TRG_ER_diArg_1	105	107	PF00400	0.642
TRG_ER_diArg_1	137	140	PF00400	0.298
TRG_ER_diArg_1	17	19	PF00400	0.515
TRG_ER_diArg_1	278	280	PF00400	0.405
TRG_ER_diArg_1	58	61	PF00400	0.365
TRG_ER_diArg_1	583	586	PF00400	0.506
TRG_ER_diArg_1	624	627	PF00400	0.545
TRG_NLS_Bipartite_1	128	142	PF00514	0.390
TRG_NLS_MonoExtC_3	127	132	PF00514	0.528
TRG_NLS_MonoExtN_4	128	133	PF00514	0.398
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.206
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	626	631	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	73%	100%
A0A0S4IP49	Bodo saltans	27%	83%
A0A1X0P2U1	Trypanosomatidae	46%	96%
A0A3S5H4S8	Leishmania donovani	100%	100%
A0A3S7WST0	Leishmania donovani	46%	92%
A0A3S7X9Y1	Leishmania donovani	34%	100%
A0A422NY45	Trypanosoma rangeli	51%	96%
A4H337	Leishmania braziliensis	88%	100%
A4H7F1	Leishmania braziliensis	46%	100%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HDC2	Leishmania braziliensis	41%	100%
A4HND6	Leishmania braziliensis	34%	100%
A4HSA6	Leishmania infantum	32%	100%
A4HVT9	Leishmania infantum	46%	92%
A4IC09	Leishmania infantum	34%	100%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	97%
E9ABZ2	Leishmania major	97%	100%
E9AFU7	Leishmania major	34%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AWQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QFZ3	Leishmania major	46%	100%
Q940Y8	Arabidopsis thaliana	40%	98%
V5D311	Trypanosoma cruzi	47%	99%