Nocturnin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nocturnin

Gene product:

Endonuclease/Exonuclease/phosphatase family

Species:

Leishmania infantum

UniProt:

A4HRC4_LEIIN

TriTrypDb:

LINF_010005100

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HRC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HRC4

Function

Biological processes
Term	Name	Level	Count
GO:0007623	circadian rhythm	2	11
GO:0010468	regulation of gene expression	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0032501	multicellular organismal process	1	11
GO:0032922	circadian regulation of gene expression	2	11
GO:0048511	rhythmic process	1	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004527	exonuclease activity	5	11
GO:0004532	RNA exonuclease activity	5	11
GO:0004535	poly(A)-specific ribonuclease activity	8	11
GO:0004540	RNA nuclease activity	4	11
GO:0008408	3'-5' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0004519	endonuclease activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.426
CLV_C14_Caspase3-7	36	40	PF00656	0.583
CLV_C14_Caspase3-7	529	533	PF00656	0.384
CLV_NRD_NRD_1	156	158	PF00675	0.289
CLV_NRD_NRD_1	210	212	PF00675	0.272
CLV_NRD_NRD_1	3	5	PF00675	0.551
CLV_NRD_NRD_1	395	397	PF00675	0.331
CLV_NRD_NRD_1	471	473	PF00675	0.311
CLV_NRD_NRD_1	73	75	PF00675	0.555
CLV_NRD_NRD_1	90	92	PF00675	0.307
CLV_PCSK_FUR_1	393	397	PF00082	0.270
CLV_PCSK_KEX2_1	156	158	PF00082	0.290
CLV_PCSK_KEX2_1	178	180	PF00082	0.370
CLV_PCSK_KEX2_1	3	5	PF00082	0.551
CLV_PCSK_KEX2_1	395	397	PF00082	0.303
CLV_PCSK_KEX2_1	73	75	PF00082	0.508
CLV_PCSK_KEX2_1	90	92	PF00082	0.319
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.370
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.499
CLV_PCSK_SKI1_1	179	183	PF00082	0.289
CLV_PCSK_SKI1_1	297	301	PF00082	0.349
CLV_PCSK_SKI1_1	472	476	PF00082	0.396
CLV_PCSK_SKI1_1	540	544	PF00082	0.613
CLV_PCSK_SKI1_1	75	79	PF00082	0.424
CLV_Separin_Metazoa	162	166	PF03568	0.335
CLV_Separin_Metazoa	335	339	PF03568	0.404
DEG_APCC_DBOX_1	296	304	PF00400	0.349
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DOC_CKS1_1	150	155	PF01111	0.270
DOC_CKS1_1	428	433	PF01111	0.459
DOC_MAPK_gen_1	156	163	PF00069	0.404
DOC_MAPK_gen_1	265	273	PF00069	0.271
DOC_MAPK_MEF2A_6	267	275	PF00069	0.271
DOC_PP2B_LxvP_1	245	248	PF13499	0.404
DOC_PP2B_LxvP_1	498	501	PF13499	0.271
DOC_PP4_FxxP_1	150	153	PF00568	0.279
DOC_PP4_FxxP_1	486	489	PF00568	0.289
DOC_USP7_MATH_1	13	17	PF00917	0.606
DOC_USP7_MATH_1	311	315	PF00917	0.323
DOC_USP7_MATH_1	378	382	PF00917	0.396
DOC_USP7_MATH_1	49	53	PF00917	0.524
DOC_USP7_UBL2_3	469	473	PF12436	0.314
DOC_WW_Pin1_4	109	114	PF00397	0.517
DOC_WW_Pin1_4	149	154	PF00397	0.371
DOC_WW_Pin1_4	427	432	PF00397	0.368
DOC_WW_Pin1_4	445	450	PF00397	0.384
LIG_14-3-3_CanoR_1	3	12	PF00244	0.524
LIG_14-3-3_CanoR_1	352	358	PF00244	0.345
LIG_14-3-3_CanoR_1	393	402	PF00244	0.356
LIG_14-3-3_CanoR_1	95	100	PF00244	0.364
LIG_APCC_ABBA_1	522	527	PF00400	0.347
LIG_BIR_III_4	104	108	PF00653	0.523
LIG_BIR_III_4	304	308	PF00653	0.335
LIG_BIR_III_4	398	402	PF00653	0.292
LIG_deltaCOP1_diTrp_1	527	534	PF00928	0.495
LIG_deltaCOP1_diTrp_1	92	99	PF00928	0.357
LIG_FHA_1	109	115	PF00498	0.523
LIG_FHA_1	270	276	PF00498	0.273
LIG_FHA_1	342	348	PF00498	0.349
LIG_FHA_1	489	495	PF00498	0.289
LIG_FHA_2	110	116	PF00498	0.450
LIG_FHA_2	299	305	PF00498	0.363
LIG_LIR_Apic_2	483	489	PF02991	0.289
LIG_LIR_Gen_1	98	105	PF02991	0.400
LIG_LIR_Nem_3	184	190	PF02991	0.319
LIG_LIR_Nem_3	481	487	PF02991	0.271
LIG_LIR_Nem_3	532	537	PF02991	0.485
LIG_LIR_Nem_3	92	96	PF02991	0.366
LIG_MYND_1	149	153	PF01753	0.279
LIG_PCNA_yPIPBox_3	178	190	PF02747	0.317
LIG_Pex14_1	530	534	PF04695	0.531
LIG_SH2_CRK	195	199	PF00017	0.271
LIG_SH2_CRK	402	406	PF00017	0.335
LIG_SH2_SRC	139	142	PF00017	0.404
LIG_SH2_SRC	487	490	PF00017	0.335
LIG_SH2_STAP1	367	371	PF00017	0.407
LIG_SH2_STAT3	479	482	PF00017	0.326
LIG_SH2_STAT5	189	192	PF00017	0.305
LIG_SH2_STAT5	274	277	PF00017	0.406
LIG_SH2_STAT5	371	374	PF00017	0.351
LIG_SH3_3	116	122	PF00018	0.385
LIG_SH3_3	345	351	PF00018	0.289
LIG_SH3_3	74	80	PF00018	0.433
LIG_SUMO_SIM_anti_2	463	471	PF11976	0.335
LIG_SUMO_SIM_par_1	298	304	PF11976	0.404
LIG_SUMO_SIM_par_1	496	505	PF11976	0.271
LIG_TRAF2_1	226	229	PF00917	0.404
LIG_TRAF2_1	387	390	PF00917	0.334
LIG_TYR_ITIM	193	198	PF00017	0.349
LIG_WRC_WIRS_1	96	101	PF05994	0.378
MOD_CDK_SPxxK_3	149	156	PF00069	0.371
MOD_CK1_1	109	115	PF00069	0.482
MOD_CK1_1	314	320	PF00069	0.314
MOD_CK1_1	82	88	PF00069	0.437
MOD_CK2_1	109	115	PF00069	0.436
MOD_CK2_1	42	48	PF00069	0.677
MOD_CMANNOS	353	356	PF00535	0.271
MOD_GlcNHglycan	15	18	PF01048	0.640
MOD_GlcNHglycan	44	47	PF01048	0.648
MOD_GlcNHglycan	5	8	PF01048	0.567
MOD_GSK3_1	177	184	PF00069	0.412
MOD_GSK3_1	194	201	PF00069	0.234
MOD_GSK3_1	24	31	PF00069	0.728
MOD_GSK3_1	278	285	PF00069	0.271
MOD_GSK3_1	526	533	PF00069	0.407
MOD_GSK3_1	79	86	PF00069	0.461
MOD_N-GLC_1	269	274	PF02516	0.311
MOD_NEK2_1	198	203	PF00069	0.303
MOD_NEK2_1	24	29	PF00069	0.751
MOD_NEK2_1	455	460	PF00069	0.463
MOD_NEK2_1	468	473	PF00069	0.373
MOD_NEK2_1	84	89	PF00069	0.455
MOD_NEK2_2	194	199	PF00069	0.289
MOD_NEK2_2	538	543	PF00069	0.567
MOD_PIKK_1	40	46	PF00454	0.483
MOD_PIKK_1	478	484	PF00454	0.271
MOD_PIKK_1	79	85	PF00454	0.572
MOD_PKA_1	3	9	PF00069	0.584
MOD_PKA_2	24	30	PF00069	0.676
MOD_PKA_2	266	272	PF00069	0.284
MOD_PKA_2	3	9	PF00069	0.541
MOD_PKA_2	33	39	PF00069	0.463
MOD_PKA_2	351	357	PF00069	0.294
MOD_PKA_2	394	400	PF00069	0.344
MOD_Plk_1	269	275	PF00069	0.311
MOD_Plk_1	526	532	PF00069	0.326
MOD_Plk_4	194	200	PF00069	0.281
MOD_Plk_4	269	275	PF00069	0.408
MOD_Plk_4	298	304	PF00069	0.390
MOD_Plk_4	33	39	PF00069	0.700
MOD_Plk_4	366	372	PF00069	0.397
MOD_Plk_4	50	56	PF00069	0.526
MOD_ProDKin_1	109	115	PF00069	0.514
MOD_ProDKin_1	149	155	PF00069	0.371
MOD_ProDKin_1	427	433	PF00069	0.368
MOD_ProDKin_1	445	451	PF00069	0.384
MOD_SUMO_rev_2	170	180	PF00179	0.292
MOD_SUMO_rev_2	45	52	PF00179	0.568
TRG_DiLeu_BaEn_2	145	151	PF01217	0.314
TRG_ENDOCYTIC_2	195	198	PF00928	0.254
TRG_ENDOCYTIC_2	402	405	PF00928	0.335
TRG_ER_diArg_1	117	120	PF00400	0.480
TRG_ER_diArg_1	2	4	PF00400	0.559
TRG_ER_diArg_1	394	396	PF00400	0.318
TRG_NLS_MonoExtN_4	469	476	PF00514	0.292
TRG_NLS_MonoExtN_4	70	77	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q6	Leptomonas seymouri	65%	98%
A0A0S4JIK0	Bodo saltans	41%	85%
A0A1X0P355	Trypanosomatidae	47%	98%
A0A3S5H4S7	Leishmania donovani	97%	98%
A4H336	Leishmania braziliensis	83%	100%
C9ZXH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ABZ1	Leishmania major	94%	100%
E9AJ88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5B795	Trypanosoma cruzi	51%	97%