Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQM2_LEIBR

TriTrypDb:

LbrM.35.7380 , LBRM2903_350087100

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000123	histone acetyltransferase complex	4	6
GO:0031248	protein acetyltransferase complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0072487	MSL complex	6	6
GO:0140535	intracellular protein-containing complex	2	6
GO:1902493	acetyltransferase complex	4	6
GO:1902494	catalytic complex	2	6
GO:1902562	H4 histone acetyltransferase complex	5	6
GO:1990234	transferase complex	3	6

Expansion

Sequence features

A4HQM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQM2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	10
GO:0009889	regulation of biosynthetic process	4	10
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051252	regulation of RNA metabolic process	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1903506	regulation of nucleic acid-templated transcription	7	10
GO:2001141	regulation of RNA biosynthetic process	6	10
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004402	histone acetyltransferase activity	4	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0010485	histone H4 acetyltransferase activity	5	1
GO:0042393	histone binding	3	1
GO:0046972	histone H4K16 acetyltransferase activity	6	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.265
CLV_NRD_NRD_1	209	211	PF00675	0.357
CLV_NRD_NRD_1	279	281	PF00675	0.474
CLV_NRD_NRD_1	96	98	PF00675	0.265
CLV_PCSK_KEX2_1	106	108	PF00082	0.265
CLV_PCSK_KEX2_1	209	211	PF00082	0.204
CLV_PCSK_KEX2_1	279	281	PF00082	0.435
CLV_PCSK_PC7_1	275	281	PF00082	0.409
CLV_PCSK_SKI1_1	113	117	PF00082	0.265
CLV_PCSK_SKI1_1	38	42	PF00082	0.479
CLV_PCSK_SKI1_1	71	75	PF00082	0.399
DEG_MDM2_SWIB_1	208	216	PF02201	0.465
DEG_Nend_Nbox_1	1	3	PF02207	0.376
DEG_SPOP_SBC_1	199	203	PF00917	0.385
DOC_CKS1_1	193	198	PF01111	0.566
DOC_MAPK_gen_1	209	218	PF00069	0.576
DOC_MAPK_gen_1	97	104	PF00069	0.476
DOC_MAPK_MEF2A_6	261	268	PF00069	0.538
DOC_PP1_RVXF_1	283	289	PF00149	0.508
DOC_PP4_FxxP_1	74	77	PF00568	0.435
DOC_SPAK_OSR1_1	88	92	PF12202	0.486
DOC_USP7_MATH_1	169	173	PF00917	0.505
DOC_WW_Pin1_4	192	197	PF00397	0.465
DOC_WW_Pin1_4	21	26	PF00397	0.527
LIG_14-3-3_CanoR_1	181	185	PF00244	0.566
LIG_14-3-3_CanoR_1	198	208	PF00244	0.384
LIG_14-3-3_CanoR_1	26	30	PF00244	0.505
LIG_14-3-3_CanoR_1	4	11	PF00244	0.700
LIG_BRCT_BRCA1_1	111	115	PF00533	0.526
LIG_Clathr_ClatBox_1	114	118	PF01394	0.572
LIG_Clathr_ClatBox_1	133	137	PF01394	0.348
LIG_CSL_BTD_1	74	77	PF09270	0.435
LIG_FHA_1	13	19	PF00498	0.596
LIG_FHA_1	153	159	PF00498	0.428
LIG_FHA_1	272	278	PF00498	0.500
LIG_FHA_1	44	50	PF00498	0.514
LIG_FHA_2	119	125	PF00498	0.455
LIG_FHA_2	229	235	PF00498	0.536
LIG_LIR_Gen_1	129	136	PF02991	0.515
LIG_LIR_Gen_1	138	147	PF02991	0.446
LIG_LIR_Gen_1	215	223	PF02991	0.554
LIG_LIR_Gen_1	86	94	PF02991	0.413
LIG_LIR_Nem_3	124	130	PF02991	0.465
LIG_LIR_Nem_3	138	144	PF02991	0.465
LIG_LIR_Nem_3	172	178	PF02991	0.505
LIG_LIR_Nem_3	215	221	PF02991	0.554
LIG_LIR_Nem_3	28	32	PF02991	0.428
LIG_LIR_Nem_3	86	92	PF02991	0.413
LIG_Pex14_2	130	134	PF04695	0.476
LIG_Pex14_2	143	147	PF04695	0.441
LIG_Pex14_2	208	212	PF04695	0.453
LIG_SH2_STAT5	146	149	PF00017	0.465
LIG_SH3_3	163	169	PF00018	0.465
LIG_SH3_3	19	25	PF00018	0.533
LIG_SH3_3	190	196	PF00018	0.470
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.465
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.455
LIG_SUMO_SIM_par_1	228	234	PF11976	0.482
LIG_SUMO_SIM_par_1	244	252	PF11976	0.482
LIG_TRAF2_1	222	225	PF00917	0.385
LIG_UBA3_1	110	119	PF00899	0.460
LIG_WRC_WIRS_1	127	132	PF05994	0.460
MOD_CDK_SPK_2	21	26	PF00069	0.527
MOD_CDK_SPxK_1	192	198	PF00069	0.319
MOD_CK1_1	14	20	PF00069	0.436
MOD_CK1_1	153	159	PF00069	0.460
MOD_CK1_1	236	242	PF00069	0.290
MOD_CK1_1	271	277	PF00069	0.458
MOD_CK1_1	52	58	PF00069	0.247
MOD_CK2_1	228	234	PF00069	0.377
MOD_Cter_Amidation	95	98	PF01082	0.319
MOD_DYRK1A_RPxSP_1	21	25	PF00069	0.271
MOD_GlcNHglycan	202	205	PF01048	0.335
MOD_GlcNHglycan	289	292	PF01048	0.636
MOD_GSK3_1	12	19	PF00069	0.538
MOD_GSK3_1	145	152	PF00069	0.395
MOD_GSK3_1	153	160	PF00069	0.356
MOD_GSK3_1	21	28	PF00069	0.467
MOD_GSK3_1	233	240	PF00069	0.351
MOD_GSK3_1	286	293	PF00069	0.577
MOD_N-GLC_1	268	273	PF02516	0.569
MOD_NEK2_1	200	205	PF00069	0.418
MOD_NEK2_1	286	291	PF00069	0.491
MOD_NEK2_1	49	54	PF00069	0.448
MOD_OFUCOSY	157	163	PF10250	0.319
MOD_PK_1	16	22	PF00069	0.327
MOD_PKA_2	180	186	PF00069	0.460
MOD_PKA_2	25	31	PF00069	0.532
MOD_PKA_2	3	9	PF00069	0.461
MOD_PKA_2	43	49	PF00069	0.232
MOD_Plk_1	271	277	PF00069	0.584
MOD_Plk_2-3	118	124	PF00069	0.319
MOD_Plk_4	237	243	PF00069	0.421
MOD_Plk_4	43	49	PF00069	0.447
MOD_Plk_4	52	58	PF00069	0.331
MOD_ProDKin_1	192	198	PF00069	0.319
MOD_ProDKin_1	21	27	PF00069	0.526
TRG_DiLeu_BaEn_1	272	277	PF01217	0.575
TRG_DiLeu_BaEn_2	138	144	PF01217	0.460
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.542
TRG_DiLeu_LyEn_5	272	277	PF01217	0.323
TRG_ENDOCYTIC_2	175	178	PF00928	0.299
TRG_ER_diArg_1	106	108	PF00400	0.300
TRG_ER_diArg_1	208	210	PF00400	0.207
TRG_ER_diArg_1	279	281	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	279	284	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KI17	Bodo saltans	31%	100%
A0A1X0NLZ1	Trypanosomatidae	54%	100%
A0A3R7KL17	Trypanosoma rangeli	50%	100%
A4ICE0	Leishmania infantum	84%	100%
D0A3S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AUD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P40963	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	87%
Q10325	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	72%
Q4Q053	Leishmania major	84%	100%
Q6CKE9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	67%
Q75BY2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	67%
V5BHQ1	Trypanosoma cruzi	56%	100%
W0G5Y6	Leishmania donovani	84%	100%