Putative U1A small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 14

Species:

Leishmania braziliensis

UniProt:

A4HQM1_LEIBR

TriTrypDb:

LbrM.35.7370 , LBRM2903_350087000

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:1990904	ribonucleoprotein complex	2	7
GO:0005634	nucleus	5	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HQM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQM1

Function

Biological processes
Term	Name	Level	Count
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0017069	snRNA binding	5	1
GO:0030619	U1 snRNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.448
CLV_NRD_NRD_1	19	21	PF00675	0.425
CLV_PCSK_KEX2_1	19	21	PF00082	0.425
CLV_PCSK_SKI1_1	141	145	PF00082	0.360
CLV_PCSK_SKI1_1	20	24	PF00082	0.452
CLV_PCSK_SKI1_1	94	98	PF00082	0.432
DEG_APCC_DBOX_1	18	26	PF00400	0.410
DEG_Nend_UBRbox_2	1	3	PF02207	0.362
DEG_SCF_FBW7_1	98	105	PF00400	0.273
DOC_CYCLIN_RxL_1	17	27	PF00134	0.416
DOC_CYCLIN_RxL_1	66	76	PF00134	0.420
DOC_CYCLIN_RxL_1	91	101	PF00134	0.389
DOC_MAPK_gen_1	19	25	PF00069	0.508
DOC_MAPK_gen_1	40	48	PF00069	0.421
DOC_MAPK_HePTP_8	96	108	PF00069	0.378
DOC_MAPK_MEF2A_6	99	108	PF00069	0.389
DOC_USP7_MATH_1	118	122	PF00917	0.414
DOC_WW_Pin1_4	73	78	PF00397	0.571
DOC_WW_Pin1_4	98	103	PF00397	0.391
LIG_14-3-3_CanoR_1	19	23	PF00244	0.440
LIG_14-3-3_CanoR_1	28	33	PF00244	0.422
LIG_14-3-3_CanoR_1	43	49	PF00244	0.284
LIG_Actin_WH2_2	127	143	PF00022	0.264
LIG_Clathr_ClatBox_1	58	62	PF01394	0.426
LIG_FHA_1	135	141	PF00498	0.526
LIG_FHA_1	99	105	PF00498	0.403
LIG_LIR_Gen_1	2	11	PF02991	0.399
LIG_LIR_Gen_1	93	103	PF02991	0.352
LIG_LIR_Nem_3	101	106	PF02991	0.363
LIG_LIR_Nem_3	153	159	PF02991	0.430
LIG_LIR_Nem_3	2	6	PF02991	0.529
LIG_LIR_Nem_3	62	67	PF02991	0.422
LIG_LIR_Nem_3	93	98	PF02991	0.378
LIG_LYPXL_SIV_4	102	110	PF13949	0.419
LIG_PTB_Apo_2	5	12	PF02174	0.433
LIG_PTB_Apo_2	97	104	PF02174	0.415
LIG_PTB_Phospho_1	97	103	PF10480	0.408
LIG_SH2_STAT5	103	106	PF00017	0.332
LIG_SH2_STAT5	159	162	PF00017	0.420
LIG_SH2_STAT5	86	89	PF00017	0.481
LIG_SH2_STAT5	95	98	PF00017	0.359
LIG_SH3_2	79	84	PF14604	0.461
LIG_SH3_3	6	12	PF00018	0.408
LIG_SH3_3	72	78	PF00018	0.433
LIG_SUMO_SIM_anti_2	56	62	PF11976	0.379
LIG_SUMO_SIM_par_1	115	121	PF11976	0.461
LIG_SUMO_SIM_par_1	135	142	PF11976	0.507
LIG_SUMO_SIM_par_1	56	62	PF11976	0.440
LIG_TRAF2_1	53	56	PF00917	0.441
LIG_TYR_ITSM	99	106	PF00017	0.397
LIG_WRC_WIRS_1	45	50	PF05994	0.419
MOD_CDC14_SPxK_1	81	84	PF00782	0.465
MOD_CDK_SPxK_1	78	84	PF00069	0.459
MOD_CK1_1	146	152	PF00069	0.618
MOD_CK2_1	44	50	PF00069	0.357
MOD_GlcNHglycan	120	123	PF01048	0.552
MOD_GlcNHglycan	50	54	PF01048	0.361
MOD_GSK3_1	130	137	PF00069	0.462
MOD_GSK3_1	146	153	PF00069	0.600
MOD_GSK3_1	44	51	PF00069	0.400
MOD_GSK3_1	98	105	PF00069	0.347
MOD_N-GLC_2	125	127	PF02516	0.407
MOD_NEK2_1	15	20	PF00069	0.362
MOD_NEK2_1	48	53	PF00069	0.570
MOD_NEK2_2	123	128	PF00069	0.424
MOD_PK_1	28	34	PF00069	0.423
MOD_PKA_2	18	24	PF00069	0.382
MOD_PKA_2	39	45	PF00069	0.292
MOD_Plk_1	134	140	PF00069	0.470
MOD_Plk_4	102	108	PF00069	0.337
MOD_Plk_4	134	140	PF00069	0.469
MOD_Plk_4	155	161	PF00069	0.385
MOD_ProDKin_1	73	79	PF00069	0.567
MOD_ProDKin_1	98	104	PF00069	0.398
TRG_DiLeu_BaEn_1	135	140	PF01217	0.415
TRG_DiLeu_BaEn_1	56	61	PF01217	0.271
TRG_ENDOCYTIC_2	103	106	PF00928	0.481
TRG_ENDOCYTIC_2	95	98	PF00928	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NL51	Trypanosomatidae	34%	100%
A0A3R7MQF7	Trypanosoma rangeli	35%	100%
A0A3S7XCG8	Leishmania donovani	90%	100%
A4ICD9	Leishmania infantum	90%	100%
D0A3S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AUD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q054	Leishmania major	90%	100%