Putative eukaryotic translation initiation factor 3 subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit c

Species:

Leishmania braziliensis

UniProt:

A4HQM0_LEIBR

TriTrypDb:

LbrM.35.7360 , LBRM2903_350086700 , LBRM2903_350086800

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQM0

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0003743	translation initiation factor activity	4	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0031369	translation initiation factor binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.557
CLV_C14_Caspase3-7	7	11	PF00656	0.652
CLV_NRD_NRD_1	208	210	PF00675	0.647
CLV_NRD_NRD_1	229	231	PF00675	0.616
CLV_NRD_NRD_1	232	234	PF00675	0.659
CLV_NRD_NRD_1	330	332	PF00675	0.320
CLV_NRD_NRD_1	351	353	PF00675	0.335
CLV_NRD_NRD_1	599	601	PF00675	0.580
CLV_NRD_NRD_1	642	644	PF00675	0.594
CLV_NRD_NRD_1	93	95	PF00675	0.653
CLV_PCSK_KEX2_1	229	231	PF00082	0.608
CLV_PCSK_KEX2_1	332	334	PF00082	0.320
CLV_PCSK_KEX2_1	351	353	PF00082	0.336
CLV_PCSK_KEX2_1	599	601	PF00082	0.575
CLV_PCSK_KEX2_1	642	644	PF00082	0.594
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.336
CLV_PCSK_SKI1_1	132	136	PF00082	0.500
CLV_PCSK_SKI1_1	17	21	PF00082	0.827
CLV_PCSK_SKI1_1	233	237	PF00082	0.630
CLV_PCSK_SKI1_1	244	248	PF00082	0.534
CLV_PCSK_SKI1_1	485	489	PF00082	0.376
CLV_PCSK_SKI1_1	498	502	PF00082	0.257
DEG_APCC_DBOX_1	599	607	PF00400	0.308
DEG_Nend_UBRbox_3	1	3	PF02207	0.704
DEG_SPOP_SBC_1	5	9	PF00917	0.786
DOC_CYCLIN_yClb1_LxF_4	126	131	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	501	504	PF00134	0.536
DOC_MAPK_gen_1	132	140	PF00069	0.570
DOC_MAPK_gen_1	209	217	PF00069	0.538
DOC_MAPK_gen_1	229	237	PF00069	0.338
DOC_MAPK_MEF2A_6	338	345	PF00069	0.590
DOC_MAPK_MEF2A_6	381	390	PF00069	0.610
DOC_MAPK_RevD_3	339	352	PF00069	0.619
DOC_PP1_RVXF_1	126	132	PF00149	0.670
DOC_PP1_RVXF_1	307	314	PF00149	0.590
DOC_PP2B_LxvP_1	500	503	PF13499	0.519
DOC_USP7_MATH_1	5	9	PF00917	0.786
DOC_USP7_MATH_1	55	59	PF00917	0.586
DOC_USP7_UBL2_3	146	150	PF12436	0.592
DOC_USP7_UBL2_3	247	251	PF12436	0.544
DOC_WW_Pin1_4	478	483	PF00397	0.594
DOC_WW_Pin1_4	547	552	PF00397	0.657
LIG_14-3-3_CanoR_1	331	336	PF00244	0.501
LIG_14-3-3_CanoR_1	466	472	PF00244	0.501
LIG_14-3-3_CanoR_1	619	627	PF00244	0.509
LIG_14-3-3_CanoR_1	642	646	PF00244	0.405
LIG_Actin_WH2_2	295	311	PF00022	0.590
LIG_Actin_WH2_2	451	468	PF00022	0.559
LIG_Actin_WH2_2	557	574	PF00022	0.453
LIG_Actin_WH2_2	683	701	PF00022	0.486
LIG_deltaCOP1_diTrp_1	240	248	PF00928	0.537
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.493
LIG_EH_1	29	33	PF12763	0.751
LIG_eIF4E_1	288	294	PF01652	0.619
LIG_FHA_1	142	148	PF00498	0.605
LIG_FHA_1	289	295	PF00498	0.612
LIG_FHA_1	332	338	PF00498	0.498
LIG_FHA_1	364	370	PF00498	0.526
LIG_FHA_1	548	554	PF00498	0.677
LIG_FHA_1	622	628	PF00498	0.475
LIG_FHA_2	175	181	PF00498	0.572
LIG_FHA_2	211	217	PF00498	0.567
LIG_FHA_2	35	41	PF00498	0.621
LIG_FHA_2	429	435	PF00498	0.533
LIG_FHA_2	585	591	PF00498	0.588
LIG_FHA_2	603	609	PF00498	0.523
LIG_IBAR_NPY_1	532	534	PF08397	0.607
LIG_LIR_Gen_1	178	188	PF02991	0.607
LIG_LIR_Gen_1	297	307	PF02991	0.540
LIG_LIR_Gen_1	374	383	PF02991	0.612
LIG_LIR_Gen_1	587	593	PF02991	0.517
LIG_LIR_Gen_1	620	630	PF02991	0.577
LIG_LIR_Gen_1	662	673	PF02991	0.474
LIG_LIR_Nem_3	130	134	PF02991	0.480
LIG_LIR_Nem_3	178	184	PF02991	0.618
LIG_LIR_Nem_3	297	302	PF02991	0.537
LIG_LIR_Nem_3	304	310	PF02991	0.498
LIG_LIR_Nem_3	374	380	PF02991	0.577
LIG_LIR_Nem_3	494	500	PF02991	0.505
LIG_LIR_Nem_3	587	592	PF02991	0.588
LIG_LIR_Nem_3	662	668	PF02991	0.453
LIG_NRP_CendR_1	728	731	PF00754	0.789
LIG_PCNA_PIPBox_1	110	119	PF02747	0.663
LIG_PCNA_PIPBox_1	407	416	PF02747	0.590
LIG_PCNA_yPIPBox_3	407	418	PF02747	0.590
LIG_PCNA_yPIPBox_3	443	454	PF02747	0.590
LIG_PCNA_yPIPBox_3	652	661	PF02747	0.529
LIG_Pex14_1	242	246	PF04695	0.427
LIG_Pex14_1	248	252	PF04695	0.432
LIG_Pex14_2	32	36	PF04695	0.761
LIG_Rb_pABgroove_1	339	347	PF01858	0.619
LIG_REV1ctd_RIR_1	250	259	PF16727	0.596
LIG_SH2_CRK	181	185	PF00017	0.589
LIG_SH2_CRK	360	364	PF00017	0.590
LIG_SH2_CRK	507	511	PF00017	0.568
LIG_SH2_CRK	544	548	PF00017	0.474
LIG_SH2_GRB2like	212	215	PF00017	0.570
LIG_SH2_GRB2like	616	619	PF00017	0.534
LIG_SH2_NCK_1	544	548	PF00017	0.586
LIG_SH2_SRC	116	119	PF00017	0.450
LIG_SH2_SRC	406	409	PF00017	0.570
LIG_SH2_STAP1	181	185	PF00017	0.591
LIG_SH2_STAT5	116	119	PF00017	0.450
LIG_SH2_STAT5	212	215	PF00017	0.527
LIG_SH2_STAT5	288	291	PF00017	0.585
LIG_SH2_STAT5	307	310	PF00017	0.402
LIG_SH2_STAT5	420	423	PF00017	0.585
LIG_SH2_STAT5	542	545	PF00017	0.477
LIG_SH2_STAT5	576	579	PF00017	0.485
LIG_SH2_STAT5	602	605	PF00017	0.514
LIG_SH2_STAT5	665	668	PF00017	0.448
LIG_SUMO_SIM_anti_2	136	145	PF11976	0.617
LIG_SUMO_SIM_anti_2	316	322	PF11976	0.590
LIG_SUMO_SIM_anti_2	364	375	PF11976	0.587
LIG_SUMO_SIM_anti_2	608	613	PF11976	0.499
LIG_SUMO_SIM_anti_2	683	691	PF11976	0.362
LIG_SUMO_SIM_par_1	136	145	PF11976	0.579
LIG_SUMO_SIM_par_1	364	375	PF11976	0.428
LIG_TRAF2_1	303	306	PF00917	0.619
LIG_TRAF2_1	37	40	PF00917	0.689
LIG_TYR_ITAM	494	510	PF00017	0.428
LIG_TYR_ITIM	325	330	PF00017	0.428
LIG_TYR_ITIM	358	363	PF00017	0.590
LIG_TYR_ITIM	566	571	PF00017	0.536
LIG_WRC_WIRS_1	586	591	PF05994	0.570
LIG_WRC_WIRS_1	79	84	PF05994	0.415
MOD_CDK_SPxxK_3	478	485	PF00069	0.619
MOD_CK1_1	15	21	PF00069	0.677
MOD_CK1_1	238	244	PF00069	0.528
MOD_CK1_1	269	275	PF00069	0.543
MOD_CK1_1	362	368	PF00069	0.590
MOD_CK1_1	470	476	PF00069	0.428
MOD_CK1_1	517	523	PF00069	0.619
MOD_CK1_1	617	623	PF00069	0.571
MOD_CK1_1	650	656	PF00069	0.558
MOD_CK1_1	8	14	PF00069	0.655
MOD_CK2_1	174	180	PF00069	0.669
MOD_CK2_1	210	216	PF00069	0.621
MOD_CK2_1	294	300	PF00069	0.590
MOD_CK2_1	34	40	PF00069	0.603
MOD_CK2_1	556	562	PF00069	0.632
MOD_CK2_1	575	581	PF00069	0.487
MOD_CK2_1	591	597	PF00069	0.612
MOD_CK2_1	602	608	PF00069	0.338
MOD_CK2_1	641	647	PF00069	0.590
MOD_CK2_1	71	77	PF00069	0.513
MOD_CK2_1	8	14	PF00069	0.648
MOD_CMANNOS	33	36	PF00535	0.762
MOD_Cter_Amidation	207	210	PF01082	0.518
MOD_GlcNHglycan	186	191	PF01048	0.606
MOD_GlcNHglycan	216	220	PF01048	0.533
MOD_GlcNHglycan	271	274	PF01048	0.273
MOD_GlcNHglycan	392	395	PF01048	0.368
MOD_GlcNHglycan	398	401	PF01048	0.351
MOD_GlcNHglycan	519	522	PF01048	0.390
MOD_GlcNHglycan	577	580	PF01048	0.447
MOD_GlcNHglycan	593	596	PF01048	0.492
MOD_GlcNHglycan	655	658	PF01048	0.584
MOD_GSK3_1	265	272	PF00069	0.341
MOD_GSK3_1	284	291	PF00069	0.624
MOD_GSK3_1	359	366	PF00069	0.558
MOD_GSK3_1	372	379	PF00069	0.466
MOD_GSK3_1	390	397	PF00069	0.519
MOD_GSK3_1	4	11	PF00069	0.740
MOD_GSK3_1	543	550	PF00069	0.561
MOD_GSK3_1	584	591	PF00069	0.545
MOD_GSK3_1	614	621	PF00069	0.561
MOD_GSK3_1	647	654	PF00069	0.524
MOD_GSK3_1	681	688	PF00069	0.632
MOD_N-GLC_1	294	299	PF02516	0.390
MOD_N-GLC_1	617	622	PF02516	0.575
MOD_N-GLC_1	651	656	PF02516	0.554
MOD_N-GLC_1	671	676	PF02516	0.526
MOD_N-GLC_1	71	76	PF02516	0.609
MOD_NEK2_1	215	220	PF00069	0.434
MOD_NEK2_1	359	364	PF00069	0.576
MOD_NEK2_1	396	401	PF00069	0.594
MOD_NEK2_1	4	9	PF00069	0.737
MOD_NEK2_1	421	426	PF00069	0.561
MOD_NEK2_1	464	469	PF00069	0.624
MOD_NEK2_1	614	619	PF00069	0.510
MOD_NEK2_2	602	607	PF00069	0.459
MOD_NEK2_2	78	83	PF00069	0.356
MOD_PIKK_1	24	30	PF00454	0.490
MOD_PIKK_1	301	307	PF00454	0.569
MOD_PKA_1	229	235	PF00069	0.642
MOD_PKA_1	331	337	PF00069	0.501
MOD_PKA_2	229	235	PF00069	0.614
MOD_PKA_2	618	624	PF00069	0.340
MOD_PKA_2	641	647	PF00069	0.402
MOD_Plk_1	15	21	PF00069	0.704
MOD_Plk_1	215	221	PF00069	0.506
MOD_Plk_1	266	272	PF00069	0.561
MOD_Plk_1	617	623	PF00069	0.569
MOD_Plk_1	650	656	PF00069	0.560
MOD_Plk_1	671	677	PF00069	0.524
MOD_Plk_1	71	77	PF00069	0.605
MOD_Plk_2-3	10	16	PF00069	0.800
MOD_Plk_2-3	130	136	PF00069	0.623
MOD_Plk_4	15	21	PF00069	0.823
MOD_Plk_4	223	229	PF00069	0.556
MOD_Plk_4	284	290	PF00069	0.631
MOD_Plk_4	367	373	PF00069	0.530
MOD_Plk_4	483	489	PF00069	0.619
MOD_Plk_4	514	520	PF00069	0.529
MOD_ProDKin_1	478	484	PF00069	0.594
MOD_ProDKin_1	547	553	PF00069	0.666
MOD_SUMO_for_1	50	53	PF00179	0.691
MOD_SUMO_for_1	526	529	PF00179	0.547
MOD_SUMO_rev_2	115	121	PF00179	0.602
MOD_SUMO_rev_2	124	134	PF00179	0.615
TRG_DiLeu_BaEn_1	496	501	PF01217	0.566
TRG_DiLeu_BaEn_1	608	613	PF01217	0.509
TRG_DiLeu_BaEn_2	87	93	PF01217	0.576
TRG_DiLeu_BaEn_4	142	148	PF01217	0.564
TRG_ENDOCYTIC_2	181	184	PF00928	0.596
TRG_ENDOCYTIC_2	212	215	PF00928	0.551
TRG_ENDOCYTIC_2	307	310	PF00928	0.519
TRG_ENDOCYTIC_2	327	330	PF00928	0.384
TRG_ENDOCYTIC_2	360	363	PF00928	0.519
TRG_ENDOCYTIC_2	497	500	PF00928	0.519
TRG_ENDOCYTIC_2	507	510	PF00928	0.519
TRG_ENDOCYTIC_2	544	547	PF00928	0.468
TRG_ENDOCYTIC_2	568	571	PF00928	0.442
TRG_ENDOCYTIC_2	665	668	PF00928	0.454
TRG_ER_diArg_1	228	230	PF00400	0.630
TRG_ER_diArg_1	330	333	PF00400	0.590
TRG_ER_diArg_1	599	601	PF00400	0.563
TRG_ER_diArg_1	641	643	PF00400	0.585
TRG_NES_CRM1_1	335	350	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I262	Leptomonas seymouri	76%	99%
A0A1X0NL84	Trypanosomatidae	39%	100%
A0A3Q8IWP7	Leishmania donovani	93%	100%
A0A422NVW4	Trypanosoma rangeli	39%	100%
A4ICD8	Leishmania infantum	93%	100%
A7E471	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	21%	84%
E9AUD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q1DP77	Coccidioides immitis (strain RS)	24%	85%
Q4Q055	Leishmania major	93%	100%
Q6P1V4	Xenopus tropicalis	22%	79%
Q6PFQ2	Danio rerio	23%	79%
V5DDW8	Trypanosoma cruzi	39%	100%