LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HQL9_LEIBR
TriTrypDb:
LbrM.35.7350 , LBRM2903_350086600
Length:
298

Annotations

LeishMANIAdb annotations

Might be part of a yet-unknown kinetoplastid enzyme

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4HQL9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 131 133 PF00675 0.566
CLV_NRD_NRD_1 267 269 PF00675 0.610
CLV_NRD_NRD_1 70 72 PF00675 0.543
CLV_PCSK_KEX2_1 129 131 PF00082 0.577
CLV_PCSK_PC1ET2_1 129 131 PF00082 0.661
CLV_PCSK_SKI1_1 132 136 PF00082 0.556
CLV_PCSK_SKI1_1 187 191 PF00082 0.538
CLV_PCSK_SKI1_1 254 258 PF00082 0.551
CLV_PCSK_SKI1_1 39 43 PF00082 0.276
DEG_APCC_DBOX_1 174 182 PF00400 0.293
DEG_APCC_DBOX_1 38 46 PF00400 0.497
DEG_Nend_Nbox_1 1 3 PF02207 0.754
DOC_CYCLIN_RxL_1 184 192 PF00134 0.431
DOC_CYCLIN_RxL_1 71 82 PF00134 0.324
DOC_MAPK_gen_1 129 138 PF00069 0.366
DOC_MAPK_MEF2A_6 129 138 PF00069 0.378
DOC_MAPK_MEF2A_6 198 206 PF00069 0.395
DOC_MAPK_NFAT4_5 131 139 PF00069 0.358
DOC_USP7_MATH_1 16 20 PF00917 0.725
DOC_USP7_MATH_1 226 230 PF00917 0.434
DOC_USP7_MATH_1 44 48 PF00917 0.223
DOC_WW_Pin1_4 268 273 PF00397 0.355
DOC_WW_Pin1_4 79 84 PF00397 0.325
LIG_14-3-3_CanoR_1 117 123 PF00244 0.467
LIG_14-3-3_CanoR_1 131 137 PF00244 0.349
LIG_14-3-3_CanoR_1 39 48 PF00244 0.420
LIG_14-3-3_CterR_2 294 298 PF00244 0.402
LIG_deltaCOP1_diTrp_1 143 153 PF00928 0.335
LIG_IRF3_LxIS_1 48 55 PF10401 0.475
LIG_LIR_Gen_1 150 159 PF02991 0.335
LIG_LIR_Gen_1 200 211 PF02991 0.328
LIG_LIR_Gen_1 28 34 PF02991 0.583
LIG_LIR_Nem_3 150 156 PF02991 0.332
LIG_LIR_Nem_3 164 169 PF02991 0.335
LIG_LIR_Nem_3 212 216 PF02991 0.389
LIG_LIR_Nem_3 28 33 PF02991 0.557
LIG_LYPXL_yS_3 213 216 PF13949 0.439
LIG_MYND_1 10 14 PF01753 0.729
LIG_PCNA_PIPBox_1 253 262 PF02747 0.413
LIG_PCNA_yPIPBox_3 250 260 PF02747 0.421
LIG_SH2_CRK 169 173 PF00017 0.301
LIG_SH2_CRK 261 265 PF00017 0.363
LIG_SH2_SRC 20 23 PF00017 0.681
LIG_SH2_STAP1 169 173 PF00017 0.301
LIG_SH2_STAP1 261 265 PF00017 0.306
LIG_SH2_STAP1 30 34 PF00017 0.599
LIG_SH2_STAT5 196 199 PF00017 0.337
LIG_SH2_STAT5 73 76 PF00017 0.315
LIG_SH3_1 269 275 PF00018 0.401
LIG_SH3_2 272 277 PF14604 0.425
LIG_SH3_3 261 267 PF00018 0.397
LIG_SH3_3 269 275 PF00018 0.459
LIG_SUMO_SIM_par_1 77 82 PF11976 0.311
LIG_TRAF2_1 123 126 PF00917 0.433
LIG_UBA3_1 178 185 PF00899 0.257
LIG_UBA3_1 202 210 PF00899 0.367
MOD_CDK_SPK_2 79 84 PF00069 0.325
MOD_CK1_1 4 10 PF00069 0.754
MOD_GlcNHglycan 163 166 PF01048 0.632
MOD_GlcNHglycan 191 194 PF01048 0.573
MOD_GlcNHglycan 295 298 PF01048 0.784
MOD_GlcNHglycan 3 6 PF01048 0.542
MOD_GSK3_1 289 296 PF00069 0.441
MOD_GSK3_1 40 47 PF00069 0.421
MOD_N-GLC_1 181 186 PF02516 0.582
MOD_N-GLC_1 224 229 PF02516 0.643
MOD_N-GLC_2 230 232 PF02516 0.470
MOD_NEK2_1 1 6 PF00069 0.720
MOD_NEK2_1 181 186 PF00069 0.427
MOD_NEK2_1 189 194 PF00069 0.396
MOD_NEK2_1 40 45 PF00069 0.328
MOD_NEK2_1 52 57 PF00069 0.399
MOD_PIKK_1 158 164 PF00454 0.414
MOD_PKA_2 116 122 PF00069 0.511
MOD_PKB_1 130 138 PF00069 0.413
MOD_Plk_4 152 158 PF00069 0.372
MOD_Plk_4 241 247 PF00069 0.350
MOD_ProDKin_1 268 274 PF00069 0.363
MOD_ProDKin_1 79 85 PF00069 0.331
MOD_SUMO_for_1 10 13 PF00179 0.760
MOD_SUMO_for_1 249 252 PF00179 0.409
MOD_SUMO_rev_2 177 186 PF00179 0.388
MOD_SUMO_rev_2 82 91 PF00179 0.410
TRG_DiLeu_BaEn_2 198 204 PF01217 0.418
TRG_ENDOCYTIC_2 169 172 PF00928 0.301
TRG_ENDOCYTIC_2 213 216 PF00928 0.406
TRG_ENDOCYTIC_2 260 263 PF00928 0.339
TRG_ENDOCYTIC_2 30 33 PF00928 0.569
TRG_ER_diArg_1 130 132 PF00400 0.414
TRG_ER_diArg_1 37 40 PF00400 0.583
TRG_NES_CRM1_1 95 108 PF08389 0.328
TRG_Pf-PMV_PEXEL_1 187 191 PF00026 0.608

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8V1 Leptomonas seymouri 74% 100%
A0A0S4KJI8 Bodo saltans 36% 100%
A0A1X0NLH2 Trypanosomatidae 52% 100%
A0A3Q8IKF0 Leishmania donovani 82% 100%
A0A422NVW1 Trypanosoma rangeli 54% 100%
A4ICD7 Leishmania infantum 82% 100%
D0A3S2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AUD4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q056 Leishmania major 81% 100%
V5AXP5 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS