LeishMANIAdb
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Elks delta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Elks delta-like protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HQL8_LEIBR
TriTrypDb:
LbrM.35.7340 , LBRM2903_350086500
Length:
366

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQL8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 215 219 PF00656 0.507
CLV_C14_Caspase3-7 43 47 PF00656 0.437
CLV_NRD_NRD_1 304 306 PF00675 0.538
CLV_NRD_NRD_1 332 334 PF00675 0.482
CLV_PCSK_KEX2_1 130 132 PF00082 0.450
CLV_PCSK_KEX2_1 25 27 PF00082 0.544
CLV_PCSK_KEX2_1 304 306 PF00082 0.528
CLV_PCSK_KEX2_1 33 35 PF00082 0.570
CLV_PCSK_PC1ET2_1 130 132 PF00082 0.526
CLV_PCSK_PC1ET2_1 25 27 PF00082 0.432
CLV_PCSK_PC1ET2_1 33 35 PF00082 0.479
CLV_PCSK_SKI1_1 119 123 PF00082 0.491
CLV_PCSK_SKI1_1 130 134 PF00082 0.390
CLV_PCSK_SKI1_1 222 226 PF00082 0.384
CLV_PCSK_SKI1_1 334 338 PF00082 0.440
CLV_PCSK_SKI1_1 351 355 PF00082 0.309
CLV_PCSK_SKI1_1 72 76 PF00082 0.542
DEG_APCC_DBOX_1 12 20 PF00400 0.515
DEG_APCC_KENBOX_2 347 351 PF00400 0.524
DOC_MAPK_gen_1 175 183 PF00069 0.526
DOC_MAPK_RevD_3 135 151 PF00069 0.583
DOC_PP1_RVXF_1 177 184 PF00149 0.331
DOC_USP7_MATH_1 103 107 PF00917 0.335
DOC_USP7_MATH_1 327 331 PF00917 0.393
DOC_USP7_MATH_1 5 9 PF00917 0.515
DOC_USP7_MATH_1 59 63 PF00917 0.572
DOC_USP7_MATH_1 80 84 PF00917 0.633
DOC_USP7_UBL2_3 348 352 PF12436 0.302
LIG_14-3-3_CanoR_1 131 135 PF00244 0.439
LIG_14-3-3_CanoR_1 136 141 PF00244 0.434
LIG_14-3-3_CanoR_1 211 217 PF00244 0.553
LIG_Actin_WH2_2 224 242 PF00022 0.305
LIG_BIR_II_1 1 5 PF00653 0.565
LIG_BRCT_BRCA1_1 342 346 PF00533 0.389
LIG_BRCT_BRCA1_2 342 348 PF00533 0.394
LIG_FHA_1 208 214 PF00498 0.524
LIG_FHA_1 309 315 PF00498 0.407
LIG_FHA_2 167 173 PF00498 0.570
LIG_FHA_2 213 219 PF00498 0.424
LIG_LIR_Nem_3 335 339 PF02991 0.314
LIG_NRBOX 143 149 PF00104 0.589
LIG_NRBOX 18 24 PF00104 0.332
LIG_PCNA_yPIPBox_3 244 256 PF02747 0.490
LIG_SH2_SRC 216 219 PF00017 0.465
LIG_SH2_STAP1 325 329 PF00017 0.293
LIG_SH2_STAT3 93 96 PF00017 0.574
LIG_SH2_STAT5 261 264 PF00017 0.542
LIG_SH2_STAT5 93 96 PF00017 0.444
LIG_SH3_3 149 155 PF00018 0.658
LIG_SUMO_SIM_par_1 251 259 PF11976 0.327
LIG_TRAF2_1 169 172 PF00917 0.521
LIG_TRAF2_1 52 55 PF00917 0.476
LIG_UBA3_1 140 149 PF00899 0.528
LIG_UBA3_1 194 198 PF00899 0.397
MOD_CK1_1 106 112 PF00069 0.542
MOD_CK1_1 207 213 PF00069 0.427
MOD_CK1_1 275 281 PF00069 0.693
MOD_CK1_1 82 88 PF00069 0.660
MOD_CK2_1 153 159 PF00069 0.628
MOD_CK2_1 166 172 PF00069 0.409
MOD_CK2_1 182 188 PF00069 0.542
MOD_CK2_1 5 11 PF00069 0.488
MOD_GlcNHglycan 113 117 PF01048 0.416
MOD_GlcNHglycan 155 158 PF01048 0.705
MOD_GlcNHglycan 264 267 PF01048 0.535
MOD_GlcNHglycan 274 277 PF01048 0.535
MOD_GlcNHglycan 325 328 PF01048 0.295
MOD_GSK3_1 207 214 PF00069 0.477
MOD_GSK3_1 256 263 PF00069 0.505
MOD_GSK3_1 319 326 PF00069 0.559
MOD_GSK3_1 50 57 PF00069 0.540
MOD_LATS_1 32 38 PF00433 0.350
MOD_N-GLC_1 211 216 PF02516 0.504
MOD_NEK2_1 166 171 PF00069 0.576
MOD_NEK2_1 256 261 PF00069 0.442
MOD_NEK2_1 280 285 PF00069 0.587
MOD_NEK2_1 323 328 PF00069 0.480
MOD_NEK2_1 360 365 PF00069 0.470
MOD_PIKK_1 233 239 PF00454 0.301
MOD_PIKK_1 34 40 PF00454 0.454
MOD_PIKK_1 50 56 PF00454 0.600
MOD_PIKK_1 80 86 PF00454 0.654
MOD_PIKK_1 92 98 PF00454 0.573
MOD_PKA_1 130 136 PF00069 0.483
MOD_PKA_2 130 136 PF00069 0.452
MOD_PKA_2 269 275 PF00069 0.671
MOD_PKB_1 175 183 PF00069 0.500
MOD_Plk_1 177 183 PF00069 0.487
MOD_Plk_1 211 217 PF00069 0.462
MOD_Plk_1 233 239 PF00069 0.403
MOD_Plk_1 319 325 PF00069 0.457
MOD_Plk_1 340 346 PF00069 0.511
MOD_Plk_4 136 142 PF00069 0.459
MOD_Plk_4 275 281 PF00069 0.436
MOD_SUMO_for_1 24 27 PF00179 0.342
MOD_SUMO_for_1 309 312 PF00179 0.472
MOD_SUMO_rev_2 254 262 PF00179 0.449
MOD_SUMO_rev_2 343 353 PF00179 0.523
TRG_DiLeu_BaEn_1 190 195 PF01217 0.444
TRG_DiLeu_BaEn_1 234 239 PF01217 0.526
TRG_ER_diArg_1 304 306 PF00400 0.553
TRG_NES_CRM1_1 15 28 PF08389 0.564
TRG_Pf-PMV_PEXEL_1 119 123 PF00026 0.538
TRG_Pf-PMV_PEXEL_1 362 366 PF00026 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAJ8 Leptomonas seymouri 63% 100%
A0A0S4KNY7 Bodo saltans 26% 95%
A0A1X0NLT9 Trypanosomatidae 35% 98%
A0A3Q8IQ67 Leishmania donovani 76% 99%
A0A422NVX8 Trypanosoma rangeli 37% 98%
A4ICD6 Leishmania infantum 76% 99%
D0A3S1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 98%
E9AUD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4Q057 Leishmania major 74% 100%
V5BD37 Trypanosoma cruzi 32% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS