Appears to be a family of secreted proteins, probably ER-localized, like its homologs in other Eukaryotes.. Seems to carry a putative KDEL-like signal on its C-terminus.. Localization: Secreted (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | yes | yes: 1 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 20 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 7 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 10, no: 1 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005788 | endoplasmic reticulum lumen | 5 | 10 |
| GO:0031974 | membrane-enclosed lumen | 2 | 10 |
| GO:0043233 | organelle lumen | 3 | 10 |
| GO:0070013 | intracellular organelle lumen | 4 | 10 |
| GO:0110165 | cellular anatomical entity | 1 | 11 |
| GO:0005783 | endoplasmic reticulum | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0016020 | membrane | 2 | 1 |
Related structures:
AlphaFold database: A4HQL6
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006457 | protein folding | 2 | 1 |
| GO:0006950 | response to stress | 2 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0033554 | cellular response to stress | 3 | 1 |
| GO:0034976 | response to endoplasmic reticulum stress | 4 | 1 |
| GO:0050896 | response to stimulus | 1 | 1 |
| GO:0051716 | cellular response to stimulus | 2 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003756 | protein disulfide isomerase activity | 3 | 12 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0016853 | isomerase activity | 2 | 12 |
| GO:0016860 | intramolecular oxidoreductase activity | 3 | 12 |
| GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | 4 | 12 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 278 | 282 | PF00656 | 0.555 |
| CLV_NRD_NRD_1 | 195 | 197 | PF00675 | 0.432 |
| CLV_NRD_NRD_1 | 309 | 311 | PF00675 | 0.519 |
| CLV_PCSK_KEX2_1 | 309 | 311 | PF00082 | 0.528 |
| CLV_PCSK_SKI1_1 | 216 | 220 | PF00082 | 0.440 |
| CLV_PCSK_SKI1_1 | 331 | 335 | PF00082 | 0.574 |
| CLV_PCSK_SKI1_1 | 445 | 449 | PF00082 | 0.489 |
| DEG_APCC_KENBOX_2 | 140 | 144 | PF00400 | 0.413 |
| DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.543 |
| DOC_MAPK_DCC_7 | 309 | 318 | PF00069 | 0.437 |
| DOC_MAPK_gen_1 | 243 | 252 | PF00069 | 0.555 |
| DOC_MAPK_gen_1 | 309 | 316 | PF00069 | 0.510 |
| DOC_MAPK_MEF2A_6 | 309 | 318 | PF00069 | 0.510 |
| DOC_MAPK_MEF2A_6 | 370 | 377 | PF00069 | 0.442 |
| DOC_MAPK_MEF2A_6 | 89 | 96 | PF00069 | 0.443 |
| DOC_PP1_RVXF_1 | 243 | 250 | PF00149 | 0.470 |
| DOC_PP2B_LxvP_1 | 292 | 295 | PF13499 | 0.493 |
| DOC_PP4_FxxP_1 | 377 | 380 | PF00568 | 0.408 |
| DOC_PP4_FxxP_1 | 43 | 46 | PF00568 | 0.443 |
| DOC_USP7_MATH_1 | 188 | 192 | PF00917 | 0.523 |
| DOC_USP7_MATH_1 | 203 | 207 | PF00917 | 0.523 |
| DOC_USP7_UBL2_3 | 128 | 132 | PF12436 | 0.570 |
| DOC_USP7_UBL2_3 | 334 | 338 | PF12436 | 0.635 |
| DOC_USP7_UBL2_3 | 85 | 89 | PF12436 | 0.452 |
| DOC_WW_Pin1_4 | 181 | 186 | PF00397 | 0.555 |
| DOC_WW_Pin1_4 | 205 | 210 | PF00397 | 0.439 |
| LIG_EH1_1 | 7 | 15 | PF00400 | 0.625 |
| LIG_eIF4E_1 | 271 | 277 | PF01652 | 0.528 |
| LIG_FHA_1 | 10 | 16 | PF00498 | 0.658 |
| LIG_FHA_1 | 219 | 225 | PF00498 | 0.528 |
| LIG_FHA_1 | 324 | 330 | PF00498 | 0.362 |
| LIG_FHA_1 | 347 | 353 | PF00498 | 0.548 |
| LIG_FHA_1 | 354 | 360 | PF00498 | 0.470 |
| LIG_FHA_1 | 91 | 97 | PF00498 | 0.394 |
| LIG_FHA_2 | 16 | 22 | PF00498 | 0.569 |
| LIG_FHA_2 | 276 | 282 | PF00498 | 0.531 |
| LIG_FHA_2 | 410 | 416 | PF00498 | 0.486 |
| LIG_FHA_2 | 68 | 74 | PF00498 | 0.555 |
| LIG_GBD_Chelix_1 | 165 | 173 | PF00786 | 0.480 |
| LIG_LIR_Apic_2 | 428 | 433 | PF02991 | 0.408 |
| LIG_LIR_Gen_1 | 172 | 183 | PF02991 | 0.302 |
| LIG_LIR_Gen_1 | 28 | 38 | PF02991 | 0.468 |
| LIG_LIR_Gen_1 | 391 | 399 | PF02991 | 0.297 |
| LIG_LIR_Nem_3 | 172 | 178 | PF02991 | 0.442 |
| LIG_LIR_Nem_3 | 225 | 230 | PF02991 | 0.457 |
| LIG_LIR_Nem_3 | 234 | 238 | PF02991 | 0.454 |
| LIG_LIR_Nem_3 | 28 | 33 | PF02991 | 0.468 |
| LIG_LIR_Nem_3 | 283 | 288 | PF02991 | 0.487 |
| LIG_LIR_Nem_3 | 299 | 303 | PF02991 | 0.315 |
| LIG_LIR_Nem_3 | 424 | 429 | PF02991 | 0.424 |
| LIG_Pex14_2 | 377 | 381 | PF04695 | 0.405 |
| LIG_Pex14_2 | 43 | 47 | PF04695 | 0.427 |
| LIG_SH2_CRK | 106 | 110 | PF00017 | 0.528 |
| LIG_SH2_CRK | 285 | 289 | PF00017 | 0.555 |
| LIG_SH2_NCK_1 | 204 | 208 | PF00017 | 0.302 |
| LIG_SH2_SRC | 279 | 282 | PF00017 | 0.439 |
| LIG_SH2_STAP1 | 392 | 396 | PF00017 | 0.465 |
| LIG_SH2_STAT3 | 271 | 274 | PF00017 | 0.528 |
| LIG_SH2_STAT5 | 279 | 282 | PF00017 | 0.439 |
| LIG_SH2_STAT5 | 332 | 335 | PF00017 | 0.615 |
| LIG_SH2_STAT5 | 366 | 369 | PF00017 | 0.541 |
| LIG_SH2_STAT5 | 430 | 433 | PF00017 | 0.420 |
| LIG_SH2_STAT5 | 5 | 8 | PF00017 | 0.506 |
| LIG_SH2_STAT5 | 95 | 98 | PF00017 | 0.555 |
| LIG_SH3_3 | 313 | 319 | PF00018 | 0.553 |
| LIG_SUMO_SIM_anti_2 | 37 | 42 | PF11976 | 0.467 |
| LIG_SUMO_SIM_par_1 | 317 | 324 | PF11976 | 0.544 |
| MOD_CK1_1 | 160 | 166 | PF00069 | 0.335 |
| MOD_CK1_1 | 168 | 174 | PF00069 | 0.437 |
| MOD_CK1_1 | 208 | 214 | PF00069 | 0.398 |
| MOD_CK1_1 | 364 | 370 | PF00069 | 0.441 |
| MOD_CK1_1 | 456 | 462 | PF00069 | 0.674 |
| MOD_CK2_1 | 15 | 21 | PF00069 | 0.641 |
| MOD_CK2_1 | 321 | 327 | PF00069 | 0.357 |
| MOD_CK2_1 | 443 | 449 | PF00069 | 0.497 |
| MOD_CK2_1 | 461 | 467 | PF00069 | 0.796 |
| MOD_CK2_1 | 67 | 73 | PF00069 | 0.545 |
| MOD_GlcNHglycan | 18 | 21 | PF01048 | 0.692 |
| MOD_GlcNHglycan | 205 | 208 | PF01048 | 0.442 |
| MOD_GlcNHglycan | 34 | 37 | PF01048 | 0.528 |
| MOD_GlcNHglycan | 423 | 426 | PF01048 | 0.432 |
| MOD_GlcNHglycan | 445 | 448 | PF01048 | 0.302 |
| MOD_GlcNHglycan | 461 | 464 | PF01048 | 0.770 |
| MOD_GSK3_1 | 114 | 121 | PF00069 | 0.461 |
| MOD_GSK3_1 | 153 | 160 | PF00069 | 0.430 |
| MOD_GSK3_1 | 256 | 263 | PF00069 | 0.397 |
| MOD_GSK3_1 | 32 | 39 | PF00069 | 0.515 |
| MOD_GSK3_1 | 421 | 428 | PF00069 | 0.421 |
| MOD_GSK3_1 | 453 | 460 | PF00069 | 0.660 |
| MOD_GSK3_1 | 63 | 70 | PF00069 | 0.547 |
| MOD_NEK2_1 | 15 | 20 | PF00069 | 0.605 |
| MOD_NEK2_1 | 165 | 170 | PF00069 | 0.363 |
| MOD_NEK2_1 | 218 | 223 | PF00069 | 0.430 |
| MOD_NEK2_1 | 409 | 414 | PF00069 | 0.459 |
| MOD_NEK2_1 | 421 | 426 | PF00069 | 0.383 |
| MOD_NEK2_1 | 453 | 458 | PF00069 | 0.674 |
| MOD_NEK2_1 | 9 | 14 | PF00069 | 0.658 |
| MOD_PIKK_1 | 23 | 29 | PF00454 | 0.302 |
| MOD_PIKK_1 | 270 | 276 | PF00454 | 0.512 |
| MOD_Plk_1 | 211 | 217 | PF00069 | 0.419 |
| MOD_Plk_1 | 36 | 42 | PF00069 | 0.505 |
| MOD_Plk_4 | 114 | 120 | PF00069 | 0.506 |
| MOD_Plk_4 | 157 | 163 | PF00069 | 0.542 |
| MOD_Plk_4 | 190 | 196 | PF00069 | 0.423 |
| MOD_Plk_4 | 275 | 281 | PF00069 | 0.434 |
| MOD_Plk_4 | 337 | 343 | PF00069 | 0.626 |
| MOD_Plk_4 | 354 | 360 | PF00069 | 0.481 |
| MOD_Plk_4 | 36 | 42 | PF00069 | 0.460 |
| MOD_Plk_4 | 425 | 431 | PF00069 | 0.422 |
| MOD_Plk_4 | 9 | 15 | PF00069 | 0.593 |
| MOD_Plk_4 | 90 | 96 | PF00069 | 0.409 |
| MOD_ProDKin_1 | 181 | 187 | PF00069 | 0.555 |
| MOD_ProDKin_1 | 205 | 211 | PF00069 | 0.439 |
| MOD_SUMO_for_1 | 131 | 134 | PF00179 | 0.580 |
| MOD_SUMO_for_1 | 333 | 336 | PF00179 | 0.643 |
| MOD_SUMO_rev_2 | 330 | 340 | PF00179 | 0.574 |
| MOD_SUMO_rev_2 | 84 | 91 | PF00179 | 0.539 |
| TRG_DiLeu_BaEn_1 | 135 | 140 | PF01217 | 0.390 |
| TRG_DiLeu_BaEn_2 | 298 | 304 | PF01217 | 0.302 |
| TRG_DiLeu_BaEn_2 | 448 | 454 | PF01217 | 0.497 |
| TRG_ENDOCYTIC_2 | 285 | 288 | PF00928 | 0.493 |
| TRG_ENDOCYTIC_2 | 392 | 395 | PF00928 | 0.465 |
| TRG_ENDOCYTIC_2 | 5 | 8 | PF00928 | 0.506 |
| TRG_Pf-PMV_PEXEL_1 | 80 | 84 | PF00026 | 0.302 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P805 | Leptomonas seymouri | 64% | 98% |
| A0A0S4KL52 | Bodo saltans | 39% | 99% |
| A0A1X0NMX9 | Trypanosomatidae | 45% | 97% |
| A0A3Q8IS34 | Leishmania donovani | 77% | 99% |
| A0A3R7L858 | Trypanosoma rangeli | 42% | 98% |
| A3KPF5 | Arabidopsis thaliana | 25% | 88% |
| A4ICD5 | Leishmania infantum | 78% | 99% |
| D0A3S0 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 95% |
| D3Z6P0 | Mus musculus | 30% | 89% |
| D4B2L8 | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) | 34% | 90% |
| E9AUD1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 77% | 99% |
| P04785 | Rattus norvegicus | 29% | 92% |
| P05307 | Bos taurus | 30% | 92% |
| P07237 | Homo sapiens | 30% | 93% |
| P08003 | Mus musculus | 30% | 74% |
| P09102 | Gallus gallus | 29% | 91% |
| P09103 | Mus musculus | 29% | 92% |
| P11598 | Rattus norvegicus | 33% | 93% |
| P12865 | Trypanosoma brucei brucei | 35% | 95% |
| P13667 | Homo sapiens | 32% | 73% |
| P17967 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 90% |
| P21195 | Oryctolagus cuniculus | 29% | 92% |
| P27773 | Mus musculus | 32% | 93% |
| P29828 | Medicago sativa | 32% | 92% |
| P30101 | Homo sapiens | 32% | 93% |
| P32474 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 23% | 91% |
| P34329 | Caenorhabditis elegans | 32% | 76% |
| P38657 | Bos taurus | 33% | 93% |
| P38658 | Schistosoma mansoni | 29% | 97% |
| P38659 | Rattus norvegicus | 30% | 73% |
| P52588 | Zea mays | 32% | 92% |
| P52589 | Triticum aestivum | 33% | 91% |
| P54399 | Drosophila melanogaster | 32% | 95% |
| P55059 | Humicola insolens | 32% | 93% |
| P80284 | Hordeum vulgare | 34% | 92% |
| Q00002 | Alternaria alternata | 25% | 100% |
| Q00248 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 32% | 91% |
| Q0E0I1 | Oryza sativa subsp. japonica | 26% | 100% |
| Q0JD42 | Oryza sativa subsp. japonica | 24% | 100% |
| Q10057 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 32% | 96% |
| Q12730 | Aspergillus niger | 30% | 91% |
| Q13087 | Homo sapiens | 31% | 90% |
| Q14554 | Homo sapiens | 20% | 91% |
| Q17770 | Caenorhabditis elegans | 30% | 95% |
| Q17967 | Caenorhabditis elegans | 30% | 97% |
| Q29RV1 | Bos taurus | 32% | 73% |
| Q2HWU2 | Macaca fuscata fuscata | 29% | 92% |
| Q43116 | Ricinus communis | 29% | 94% |
| Q4Q059 | Leishmania major | 77% | 100% |
| Q4VIT4 | Chlorocebus aethiops | 33% | 93% |
| Q53LQ0 | Oryza sativa subsp. japonica | 31% | 92% |
| Q54EN4 | Dictyostelium discoideum | 30% | 92% |
| Q5R5B6 | Pongo abelii | 30% | 93% |
| Q5RCH2 | Pongo abelii | 32% | 90% |
| Q5RDG4 | Pongo abelii | 32% | 93% |
| Q5WA72 | Oryza sativa subsp. japonica | 23% | 88% |
| Q5XI02 | Rattus norvegicus | 23% | 80% |
| Q66GQ3 | Arabidopsis thaliana | 25% | 88% |
| Q67IX6 | Oryza sativa subsp. japonica | 30% | 83% |
| Q69ST6 | Oryza sativa subsp. japonica | 29% | 86% |
| Q7XRB5 | Oryza sativa subsp. japonica | 30% | 91% |
| Q8JG64 | Gallus gallus | 32% | 93% |
| Q8N807 | Homo sapiens | 22% | 80% |
| Q8R4U2 | Cricetulus griseus | 29% | 92% |
| Q8VX13 | Arabidopsis thaliana | 30% | 81% |
| Q94F09 | Arabidopsis thaliana | 25% | 100% |
| Q95LM0 | Macaca fascicularis | 22% | 81% |
| Q9DAN1 | Mus musculus | 23% | 80% |
| Q9FF55 | Arabidopsis thaliana | 28% | 79% |
| Q9SRG3 | Arabidopsis thaliana | 32% | 93% |
| Q9XF61 | Datisca glomerata | 30% | 93% |
| Q9XI01 | Arabidopsis thaliana | 32% | 94% |
| V5BHP7 | Trypanosoma cruzi | 41% | 100% |