RNA editing comple protein MP63

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing comple protein MP63

Species:

Leishmania braziliensis

UniProt:

A4HQL4_LEIBR

TriTrypDb:

LbrM.35.7300 , LBRM2903_350086100

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.418
CLV_C14_Caspase3-7	312	316	PF00656	0.707
CLV_NRD_NRD_1	135	137	PF00675	0.600
CLV_NRD_NRD_1	19	21	PF00675	0.634
CLV_NRD_NRD_1	260	262	PF00675	0.614
CLV_NRD_NRD_1	3	5	PF00675	0.579
CLV_NRD_NRD_1	479	481	PF00675	0.655
CLV_NRD_NRD_1	59	61	PF00675	0.602
CLV_PCSK_KEX2_1	135	137	PF00082	0.600
CLV_PCSK_KEX2_1	169	171	PF00082	0.573
CLV_PCSK_KEX2_1	19	21	PF00082	0.634
CLV_PCSK_KEX2_1	3	5	PF00082	0.576
CLV_PCSK_KEX2_1	483	485	PF00082	0.650
CLV_PCSK_KEX2_1	59	61	PF00082	0.540
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.624
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.657
CLV_PCSK_PC7_1	15	21	PF00082	0.607
CLV_PCSK_SKI1_1	135	139	PF00082	0.741
CLV_PCSK_SKI1_1	15	19	PF00082	0.624
CLV_PCSK_SKI1_1	261	265	PF00082	0.698
CLV_PCSK_SKI1_1	269	273	PF00082	0.693
CLV_PCSK_SKI1_1	455	459	PF00082	0.356
DEG_APCC_DBOX_1	14	22	PF00400	0.579
DEG_COP1_1	479	489	PF00400	0.461
DEG_Nend_UBRbox_3	1	3	PF02207	0.568
DEG_SPOP_SBC_1	369	373	PF00917	0.479
DEG_SPOP_SBC_1	397	401	PF00917	0.634
DEG_SPOP_SBC_1	415	419	PF00917	0.526
DEG_SPOP_SBC_1	443	447	PF00917	0.406
DOC_CKS1_1	104	109	PF01111	0.682
DOC_CKS1_1	283	288	PF01111	0.526
DOC_MAPK_MEF2A_6	149	156	PF00069	0.557
DOC_USP7_MATH_1	187	191	PF00917	0.600
DOC_USP7_MATH_1	240	244	PF00917	0.555
DOC_USP7_MATH_1	303	307	PF00917	0.705
DOC_USP7_MATH_1	325	329	PF00917	0.507
DOC_USP7_MATH_1	34	38	PF00917	0.749
DOC_USP7_MATH_1	347	351	PF00917	0.648
DOC_USP7_MATH_1	365	369	PF00917	0.636
DOC_USP7_MATH_1	404	408	PF00917	0.567
DOC_USP7_MATH_1	415	419	PF00917	0.594
DOC_USP7_MATH_1	420	424	PF00917	0.596
DOC_USP7_MATH_1	436	440	PF00917	0.502
DOC_USP7_MATH_1	476	480	PF00917	0.535
DOC_USP7_MATH_1	504	508	PF00917	0.669
DOC_USP7_MATH_1	509	513	PF00917	0.664
DOC_USP7_MATH_1	587	591	PF00917	0.387
DOC_USP7_UBL2_3	138	142	PF12436	0.709
DOC_USP7_UBL2_3	265	269	PF12436	0.623
DOC_USP7_UBL2_3	473	477	PF12436	0.442
DOC_USP7_UBL2_3	599	603	PF12436	0.454
DOC_WW_Pin1_4	103	108	PF00397	0.612
DOC_WW_Pin1_4	120	125	PF00397	0.583
DOC_WW_Pin1_4	282	287	PF00397	0.529
DOC_WW_Pin1_4	318	323	PF00397	0.579
DOC_WW_Pin1_4	327	332	PF00397	0.558
DOC_WW_Pin1_4	343	348	PF00397	0.576
DOC_WW_Pin1_4	374	379	PF00397	0.555
DOC_WW_Pin1_4	386	391	PF00397	0.538
DOC_WW_Pin1_4	393	398	PF00397	0.541
DOC_WW_Pin1_4	424	429	PF00397	0.587
DOC_WW_Pin1_4	492	497	PF00397	0.505
DOC_WW_Pin1_4	500	505	PF00397	0.491
DOC_WW_Pin1_4	517	522	PF00397	0.479
LIG_14-3-3_CanoR_1	511	521	PF00244	0.557
LIG_14-3-3_CanoR_1	566	575	PF00244	0.528
LIG_14-3-3_CanoR_1	60	66	PF00244	0.431
LIG_APCC_ABBA_1	593	598	PF00400	0.436
LIG_BRCT_BRCA1_1	235	239	PF00533	0.452
LIG_BRCT_BRCA1_1	319	323	PF00533	0.659
LIG_BRCT_BRCA1_1	417	421	PF00533	0.625
LIG_CSK_EPIYA_1	194	198	PF00017	0.681
LIG_CtBP_PxDLS_1	496	500	PF00389	0.488
LIG_EH_1	205	209	PF12763	0.518
LIG_EH_1	256	260	PF12763	0.587
LIG_EVH1_2	387	391	PF00568	0.535
LIG_FHA_1	262	268	PF00498	0.621
LIG_FHA_1	279	285	PF00498	0.603
LIG_FHA_1	333	339	PF00498	0.519
LIG_FHA_1	614	620	PF00498	0.371
LIG_FHA_2	232	238	PF00498	0.518
LIG_FHA_2	270	276	PF00498	0.650
LIG_FHA_2	513	519	PF00498	0.650
LIG_FHA_2	53	59	PF00498	0.534
LIG_LIR_Gen_1	407	416	PF02991	0.444
LIG_LIR_Gen_1	512	522	PF02991	0.662
LIG_LIR_Nem_3	194	200	PF02991	0.524
LIG_LIR_Nem_3	285	290	PF02991	0.525
LIG_LIR_Nem_3	346	351	PF02991	0.680
LIG_LIR_Nem_3	407	411	PF02991	0.475
LIG_LIR_Nem_3	512	517	PF02991	0.670
LIG_PTB_Apo_2	451	458	PF02174	0.314
LIG_SH2_CRK	197	201	PF00017	0.576
LIG_SH2_NCK_1	408	412	PF00017	0.447
LIG_SH2_STAP1	522	526	PF00017	0.612
LIG_SH2_STAP1	605	609	PF00017	0.406
LIG_SH2_STAT5	551	554	PF00017	0.515
LIG_SH3_1	484	490	PF00018	0.547
LIG_SH3_2	249	254	PF14604	0.608
LIG_SH3_3	113	119	PF00018	0.632
LIG_SH3_3	121	127	PF00018	0.657
LIG_SH3_3	246	252	PF00018	0.602
LIG_SH3_3	280	286	PF00018	0.558
LIG_SH3_3	316	322	PF00018	0.600
LIG_SH3_3	348	354	PF00018	0.653
LIG_SH3_3	372	378	PF00018	0.662
LIG_SH3_3	384	390	PF00018	0.533
LIG_SH3_3	484	490	PF00018	0.561
LIG_SH3_3	609	615	PF00018	0.385
LIG_SH3_4	138	145	PF00018	0.589
LIG_SUMO_SIM_par_1	157	166	PF11976	0.501
LIG_SUMO_SIM_par_1	495	500	PF11976	0.540
LIG_SUMO_SIM_par_1	534	539	PF11976	0.295
MOD_CK1_1	243	249	PF00069	0.744
MOD_CK1_1	367	373	PF00069	0.746
MOD_CK1_1	396	402	PF00069	0.605
MOD_CK1_1	427	433	PF00069	0.627
MOD_CK1_1	512	518	PF00069	0.591
MOD_CK1_1	527	533	PF00069	0.283
MOD_CK1_1	86	92	PF00069	0.494
MOD_CK2_1	269	275	PF00069	0.648
MOD_CK2_1	303	309	PF00069	0.775
MOD_CK2_1	436	442	PF00069	0.535
MOD_CK2_1	476	482	PF00069	0.452
MOD_CK2_1	512	518	PF00069	0.505
MOD_GlcNHglycan	131	135	PF01048	0.644
MOD_GlcNHglycan	305	308	PF01048	0.710
MOD_GlcNHglycan	31	34	PF01048	0.734
MOD_GlcNHglycan	418	421	PF01048	0.609
MOD_GlcNHglycan	431	434	PF01048	0.664
MOD_GlcNHglycan	436	439	PF01048	0.692
MOD_GlcNHglycan	507	510	PF01048	0.575
MOD_GlcNHglycan	554	557	PF01048	0.445
MOD_GlcNHglycan	606	609	PF01048	0.453
MOD_GSK3_1	126	133	PF00069	0.494
MOD_GSK3_1	278	285	PF00069	0.575
MOD_GSK3_1	310	317	PF00069	0.705
MOD_GSK3_1	333	340	PF00069	0.565
MOD_GSK3_1	343	350	PF00069	0.662
MOD_GSK3_1	364	371	PF00069	0.646
MOD_GSK3_1	393	400	PF00069	0.606
MOD_GSK3_1	416	423	PF00069	0.615
MOD_GSK3_1	444	451	PF00069	0.558
MOD_GSK3_1	500	507	PF00069	0.543
MOD_GSK3_1	546	553	PF00069	0.510
MOD_GSK3_1	571	578	PF00069	0.503
MOD_GSK3_1	594	601	PF00069	0.584
MOD_N-GLC_1	453	458	PF02516	0.378
MOD_N-GLC_1	51	56	PF02516	0.603
MOD_N-GLC_1	527	532	PF02516	0.368
MOD_NEK2_1	175	180	PF00069	0.513
MOD_NEK2_1	293	298	PF00069	0.736
MOD_NEK2_1	332	337	PF00069	0.624
MOD_NEK2_1	398	403	PF00069	0.710
MOD_NEK2_1	499	504	PF00069	0.488
MOD_NEK2_1	505	510	PF00069	0.505
MOD_NEK2_1	546	551	PF00069	0.477
MOD_NEK2_1	61	66	PF00069	0.395
MOD_NEK2_2	453	458	PF00069	0.310
MOD_NEK2_2	587	592	PF00069	0.476
MOD_NEK2_2	66	71	PF00069	0.452
MOD_PIKK_1	598	604	PF00454	0.448
MOD_PK_1	158	164	PF00069	0.584
MOD_PKA_1	261	267	PF00069	0.478
MOD_PKA_2	187	193	PF00069	0.679
MOD_PKA_2	250	256	PF00069	0.464
MOD_PKA_2	565	571	PF00069	0.423
MOD_Plk_1	243	249	PF00069	0.471
MOD_Plk_1	314	320	PF00069	0.622
MOD_Plk_1	453	459	PF00069	0.476
MOD_Plk_1	497	503	PF00069	0.612
MOD_Plk_1	51	57	PF00069	0.597
MOD_Plk_1	527	533	PF00069	0.376
MOD_Plk_4	117	123	PF00069	0.656
MOD_Plk_4	158	164	PF00069	0.538
MOD_Plk_4	176	182	PF00069	0.411
MOD_Plk_4	314	320	PF00069	0.693
MOD_Plk_4	453	459	PF00069	0.311
MOD_Plk_4	546	552	PF00069	0.414
MOD_ProDKin_1	103	109	PF00069	0.611
MOD_ProDKin_1	120	126	PF00069	0.581
MOD_ProDKin_1	282	288	PF00069	0.526
MOD_ProDKin_1	318	324	PF00069	0.578
MOD_ProDKin_1	327	333	PF00069	0.558
MOD_ProDKin_1	343	349	PF00069	0.577
MOD_ProDKin_1	374	380	PF00069	0.557
MOD_ProDKin_1	386	392	PF00069	0.540
MOD_ProDKin_1	393	399	PF00069	0.540
MOD_ProDKin_1	424	430	PF00069	0.588
MOD_ProDKin_1	492	498	PF00069	0.503
MOD_ProDKin_1	500	506	PF00069	0.494
MOD_ProDKin_1	517	523	PF00069	0.477
TRG_DiLeu_BaEn_1	150	155	PF01217	0.578
TRG_DiLeu_BaEn_1	543	548	PF01217	0.265
TRG_ENDOCYTIC_2	197	200	PF00928	0.567
TRG_ENDOCYTIC_2	408	411	PF00928	0.445
TRG_ER_diArg_1	18	20	PF00400	0.596
TRG_ER_diArg_1	3	5	PF00400	0.595
TRG_ER_diArg_1	59	61	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D6	Leptomonas seymouri	54%	99%
A0A0S4KI33	Bodo saltans	37%	97%
A0A1X0NLZ8	Trypanosomatidae	40%	100%
A0A3S7XCC6	Leishmania donovani	74%	100%
A0A422NVX1	Trypanosoma rangeli	39%	100%
A4ICD3	Leishmania infantum	74%	100%
D0A3R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AUC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q6T448	Leishmania major	75%	100%
V5DDW7	Trypanosoma cruzi	40%	100%