Ribosomal protein L1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein L1p/L10e family, putative

Species:

Leishmania braziliensis

UniProt:

A4HQL3_LEIBR

TriTrypDb:

LbrM.35.7290 , LBRM2903_350086000

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HQL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL3

Function

Biological processes
Term	Name	Level	Count
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.387
CLV_MEL_PAP_1	187	193	PF00089	0.422
CLV_NRD_NRD_1	106	108	PF00675	0.383
CLV_NRD_NRD_1	161	163	PF00675	0.293
CLV_NRD_NRD_1	170	172	PF00675	0.352
CLV_NRD_NRD_1	181	183	PF00675	0.267
CLV_NRD_NRD_1	260	262	PF00675	0.605
CLV_NRD_NRD_1	84	86	PF00675	0.310
CLV_PCSK_FUR_1	104	108	PF00082	0.387
CLV_PCSK_KEX2_1	103	105	PF00082	0.395
CLV_PCSK_KEX2_1	106	108	PF00082	0.357
CLV_PCSK_KEX2_1	181	183	PF00082	0.336
CLV_PCSK_KEX2_1	237	239	PF00082	0.451
CLV_PCSK_KEX2_1	262	264	PF00082	0.568
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.398
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.536
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.568
CLV_PCSK_SKI1_1	144	148	PF00082	0.416
CLV_PCSK_SKI1_1	211	215	PF00082	0.395
CLV_PCSK_SKI1_1	222	226	PF00082	0.388
DEG_APCC_DBOX_1	59	67	PF00400	0.422
DEG_SPOP_SBC_1	230	234	PF00917	0.410
DEG_SPOP_SBC_1	24	28	PF00917	0.355
DOC_CKS1_1	78	83	PF01111	0.317
DOC_MAPK_gen_1	169	179	PF00069	0.445
DOC_MAPK_gen_1	237	243	PF00069	0.456
DOC_MAPK_MEF2A_6	222	229	PF00069	0.422
DOC_MAPK_MEF2A_6	39	48	PF00069	0.321
DOC_PP2B_LxvP_1	34	37	PF13499	0.607
DOC_PP2B_LxvP_1	53	56	PF13499	0.118
DOC_PP4_FxxP_1	65	68	PF00568	0.336
DOC_USP7_MATH_1	13	17	PF00917	0.459
DOC_USP7_MATH_1	230	234	PF00917	0.443
DOC_USP7_MATH_2	68	74	PF00917	0.387
DOC_USP7_UBL2_3	113	117	PF12436	0.302
DOC_USP7_UBL2_3	165	169	PF12436	0.410
DOC_WW_Pin1_4	77	82	PF00397	0.302
LIG_Actin_WH2_2	206	224	PF00022	0.422
LIG_AP2alpha_1	208	212	PF02296	0.449
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BIR_III_2	217	221	PF00653	0.351
LIG_FHA_1	174	180	PF00498	0.327
LIG_FHA_1	186	192	PF00498	0.216
LIG_FHA_1	73	79	PF00498	0.359
LIG_FHA_2	205	211	PF00498	0.196
LIG_GBD_Chelix_1	201	209	PF00786	0.422
LIG_Integrin_RGD_1	182	184	PF01839	0.422
LIG_LIR_Gen_1	130	139	PF02991	0.302
LIG_LIR_Nem_3	130	134	PF02991	0.302
LIG_LIR_Nem_3	33	38	PF02991	0.598
LIG_PDZ_Class_2	263	268	PF00595	0.680
LIG_Pex14_2	208	212	PF04695	0.391
LIG_Pex14_2	244	248	PF04695	0.438
LIG_SH2_STAP1	131	135	PF00017	0.422
LIG_SH2_STAT3	142	145	PF00017	0.317
LIG_SH2_STAT5	64	67	PF00017	0.318
LIG_SH3_3	115	121	PF00018	0.422
LIG_SH3_3	236	242	PF00018	0.566
LIG_SUMO_SIM_par_1	175	180	PF11976	0.419
LIG_WRC_WIRS_1	14	19	PF05994	0.441
LIG_WRC_WIRS_1	205	210	PF05994	0.237
MOD_CK2_1	261	267	PF00069	0.641
MOD_Cter_Amidation	235	238	PF01082	0.355
MOD_GlcNHglycan	196	199	PF01048	0.257
MOD_GlcNHglycan	72	75	PF01048	0.368
MOD_GSK3_1	13	20	PF00069	0.450
MOD_GSK3_1	173	180	PF00069	0.368
MOD_GSK3_1	68	75	PF00069	0.356
MOD_PKA_1	261	267	PF00069	0.460
MOD_PKA_2	38	44	PF00069	0.596
MOD_Plk_4	13	19	PF00069	0.461
MOD_Plk_4	173	179	PF00069	0.316
MOD_Plk_4	204	210	PF00069	0.216
MOD_ProDKin_1	77	83	PF00069	0.302
TRG_ENDOCYTIC_2	131	134	PF00928	0.422
TRG_ENDOCYTIC_2	64	67	PF00928	0.302
TRG_ENDOCYTIC_2	87	90	PF00928	0.453
TRG_ER_diArg_1	104	107	PF00400	0.422
TRG_ER_diArg_1	260	263	PF00400	0.685
TRG_NLS_Bipartite_1	85	107	PF00514	0.422
TRG_NLS_MonoExtC_3	102	107	PF00514	0.402
TRG_NLS_MonoExtC_3	260	265	PF00514	0.580
TRG_NLS_MonoExtN_4	260	266	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P809	Leptomonas seymouri	70%	100%
A0A0S4KQW6	Bodo saltans	44%	94%
A0A1X0NL61	Trypanosomatidae	53%	99%
A0A3Q8IJJ6	Leishmania donovani	87%	100%
A0A422NVW5	Trypanosoma rangeli	50%	99%
D0A3R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AI07	Leishmania infantum	87%	100%
E9AUC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q062	Leishmania major	86%	100%
Q9UT32	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	72%
V5AXP2	Trypanosoma cruzi	52%	88%