CCT-theta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CCT-theta

Gene product:

T-complex protein 1, theta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HQL2_LEIBR

TriTrypDb:

LbrM.35.7280 , LBRM2903_350085900

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005832	chaperonin-containing T-complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A4HQL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044183	protein folding chaperone	1	12
GO:0051082	unfolded protein binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:0140662	ATP-dependent protein folding chaperone	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.472
CLV_C14_Caspase3-7	481	485	PF00656	0.443
CLV_C14_Caspase3-7	90	94	PF00656	0.358
CLV_NRD_NRD_1	149	151	PF00675	0.394
CLV_NRD_NRD_1	264	266	PF00675	0.402
CLV_NRD_NRD_1	317	319	PF00675	0.358
CLV_NRD_NRD_1	433	435	PF00675	0.390
CLV_PCSK_KEX2_1	317	319	PF00082	0.358
CLV_PCSK_KEX2_1	401	403	PF00082	0.358
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.358
CLV_PCSK_SKI1_1	198	202	PF00082	0.358
CLV_PCSK_SKI1_1	227	231	PF00082	0.381
CLV_PCSK_SKI1_1	326	330	PF00082	0.456
CLV_PCSK_SKI1_1	353	357	PF00082	0.443
CLV_PCSK_SKI1_1	373	377	PF00082	0.175
CLV_PCSK_SKI1_1	395	399	PF00082	0.358
CLV_PCSK_SKI1_1	416	420	PF00082	0.358
CLV_PCSK_SKI1_1	502	506	PF00082	0.478
DOC_ANK_TNKS_1	213	220	PF00023	0.443
DOC_CYCLIN_RxL_1	413	423	PF00134	0.443
DOC_MAPK_gen_1	227	236	PF00069	0.358
DOC_MAPK_gen_1	470	477	PF00069	0.478
DOC_MAPK_MEF2A_6	302	310	PF00069	0.358
DOC_PP2B_LxvP_1	331	334	PF13499	0.392
DOC_USP7_MATH_1	341	345	PF00917	0.522
DOC_USP7_MATH_1	448	452	PF00917	0.349
DOC_USP7_UBL2_3	128	132	PF12436	0.373
DOC_USP7_UBL2_3	395	399	PF12436	0.358
LIG_14-3-3_CanoR_1	220	226	PF00244	0.503
LIG_14-3-3_CanoR_1	373	380	PF00244	0.415
LIG_14-3-3_CanoR_1	38	42	PF00244	0.358
LIG_14-3-3_CanoR_1	434	443	PF00244	0.389
LIG_14-3-3_CanoR_1	502	511	PF00244	0.478
LIG_APCC_ABBA_1	418	423	PF00400	0.443
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_FHA_1	208	214	PF00498	0.503
LIG_FHA_1	249	255	PF00498	0.345
LIG_FHA_1	354	360	PF00498	0.360
LIG_FHA_1	367	373	PF00498	0.356
LIG_FHA_1	374	380	PF00498	0.353
LIG_FHA_1	454	460	PF00498	0.358
LIG_FHA_1	503	509	PF00498	0.373
LIG_FHA_1	93	99	PF00498	0.358
LIG_FHA_2	289	295	PF00498	0.261
LIG_FHA_2	327	333	PF00498	0.383
LIG_FHA_2	444	450	PF00498	0.358
LIG_FHA_2	458	464	PF00498	0.358
LIG_FHA_2	479	485	PF00498	0.443
LIG_LIR_Gen_1	438	448	PF02991	0.358
LIG_LIR_Nem_3	290	295	PF02991	0.362
LIG_LIR_Nem_3	438	443	PF02991	0.358
LIG_LIR_Nem_3	496	501	PF02991	0.238
LIG_MYND_3	243	247	PF01753	0.478
LIG_PTB_Apo_2	286	293	PF02174	0.373
LIG_SH2_CRK	472	476	PF00017	0.299
LIG_SH2_NCK_1	421	425	PF00017	0.415
LIG_SH2_SRC	421	424	PF00017	0.403
LIG_SH2_STAP1	169	173	PF00017	0.392
LIG_SH2_STAP1	237	241	PF00017	0.443
LIG_SH2_STAP1	436	440	PF00017	0.478
LIG_SH3_3	16	22	PF00018	0.487
LIG_SH3_3	238	244	PF00018	0.373
LIG_SH3_3	305	311	PF00018	0.443
LIG_SH3_3	69	75	PF00018	0.358
LIG_Sin3_3	77	84	PF02671	0.503
LIG_SUMO_SIM_anti_2	133	139	PF11976	0.392
LIG_SUMO_SIM_anti_2	343	349	PF11976	0.478
LIG_SUMO_SIM_anti_2	505	513	PF11976	0.478
LIG_SUMO_SIM_par_1	505	513	PF11976	0.478
LIG_TRAF2_1	86	89	PF00917	0.373
LIG_TRAF2_2	530	535	PF00917	0.661
LIG_UBA3_1	136	143	PF00899	0.472
LIG_UBA3_1	274	280	PF00899	0.313
LIG_WRC_WIRS_1	189	194	PF05994	0.384
MOD_CK1_1	161	167	PF00069	0.483
MOD_CK1_1	206	212	PF00069	0.443
MOD_CK1_1	245	251	PF00069	0.358
MOD_CK1_1	288	294	PF00069	0.373
MOD_CK1_1	34	40	PF00069	0.503
MOD_CK1_1	365	371	PF00069	0.358
MOD_CK2_1	104	110	PF00069	0.350
MOD_CK2_1	261	267	PF00069	0.369
MOD_CK2_1	309	315	PF00069	0.238
MOD_CK2_1	435	441	PF00069	0.372
MOD_CK2_1	443	449	PF00069	0.358
MOD_CK2_1	457	463	PF00069	0.358
MOD_Cter_Amidation	468	471	PF01082	0.478
MOD_GlcNHglycan	14	18	PF01048	0.400
MOD_GlcNHglycan	230	233	PF01048	0.240
MOD_GlcNHglycan	280	283	PF01048	0.416
MOD_GlcNHglycan	449	453	PF01048	0.358
MOD_GSK3_1	104	111	PF00069	0.391
MOD_GSK3_1	157	164	PF00069	0.358
MOD_GSK3_1	184	191	PF00069	0.373
MOD_GSK3_1	203	210	PF00069	0.247
MOD_GSK3_1	3	10	PF00069	0.576
MOD_GSK3_1	362	369	PF00069	0.358
MOD_GSK3_1	453	460	PF00069	0.358
MOD_N-GLC_1	288	293	PF02516	0.373
MOD_N-GLC_1	353	358	PF02516	0.478
MOD_N-GLC_1	453	458	PF02516	0.358
MOD_N-GLC_2	183	185	PF02516	0.247
MOD_NEK2_1	136	141	PF00069	0.475
MOD_NEK2_1	285	290	PF00069	0.373
MOD_NEK2_1	3	8	PF00069	0.607
MOD_NEK2_1	97	102	PF00069	0.392
MOD_PIKK_1	104	110	PF00454	0.373
MOD_PIKK_1	373	379	PF00454	0.439
MOD_PIKK_1	457	463	PF00454	0.358
MOD_PKA_2	158	164	PF00069	0.502
MOD_PKA_2	219	225	PF00069	0.503
MOD_PKA_2	37	43	PF00069	0.358
MOD_Plk_1	288	294	PF00069	0.373
MOD_Plk_1	353	359	PF00069	0.458
MOD_Plk_1	416	422	PF00069	0.443
MOD_Plk_2-3	242	248	PF00069	0.478
MOD_Plk_2-3	332	338	PF00069	0.358
MOD_Plk_2-3	479	485	PF00069	0.443
MOD_Plk_4	108	114	PF00069	0.392
MOD_Plk_4	136	142	PF00069	0.441
MOD_Plk_4	203	209	PF00069	0.369
MOD_Plk_4	366	372	PF00069	0.389
MOD_Plk_4	416	422	PF00069	0.478
MOD_Plk_4	504	510	PF00069	0.369
MOD_Plk_4	62	68	PF00069	0.358
MOD_Plk_4	7	13	PF00069	0.525
MOD_SUMO_rev_2	242	251	PF00179	0.352
MOD_SUMO_rev_2	361	368	PF00179	0.373
TRG_ENDOCYTIC_2	169	172	PF00928	0.358
TRG_ENDOCYTIC_2	472	475	PF00928	0.299
TRG_ER_diArg_1	316	318	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	68	73	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U4	Leptomonas seymouri	27%	98%
A0A0N1HUM6	Leptomonas seymouri	28%	100%
A0A0N1HUW6	Leptomonas seymouri	27%	97%
A0A0N1HXN1	Leptomonas seymouri	28%	100%
A0A0N1I104	Leptomonas seymouri	28%	94%
A0A0N1I2L2	Leptomonas seymouri	29%	100%
A0A0N1II94	Leptomonas seymouri	30%	98%
A0A0N1IM41	Leptomonas seymouri	90%	100%
A0A0S4IWM5	Bodo saltans	26%	98%
A0A0S4J048	Bodo saltans	28%	94%
A0A0S4J2A3	Bodo saltans	28%	93%
A0A0S4JDP9	Bodo saltans	28%	98%
A0A0S4JFF0	Bodo saltans	29%	94%
A0A0S4KI45	Bodo saltans	75%	100%
A0A0S4KIR9	Bodo saltans	30%	100%
A0A0S4KJ28	Bodo saltans	27%	100%
A0A0S4KQ13	Bodo saltans	27%	99%
A0A1X0NJG5	Trypanosomatidae	26%	99%
A0A1X0NL95	Trypanosomatidae	78%	100%
A0A1X0NSG8	Trypanosomatidae	30%	99%
A0A1X0NUN9	Trypanosomatidae	30%	100%
A0A1X0NWR4	Trypanosomatidae	27%	97%
A0A1X0NXT3	Trypanosomatidae	28%	100%
A0A1X0P4G0	Trypanosomatidae	28%	100%
A0A1X0P560	Trypanosomatidae	28%	94%
A0A3Q8IFF2	Leishmania donovani	28%	94%
A0A3Q8II90	Leishmania donovani	95%	100%
A0A3Q8IJL9	Leishmania donovani	30%	98%
A0A3R7KZ57	Trypanosoma rangeli	27%	100%
A0A3R7N205	Trypanosoma rangeli	29%	100%
A0A3R7NPP8	Trypanosoma rangeli	79%	100%
A0A3R7NRL8	Trypanosoma rangeli	30%	98%
A0A3R7RBS2	Trypanosoma rangeli	27%	95%
A0A3R7RTF6	Trypanosoma rangeli	26%	99%
A0A3S5H7C3	Leishmania donovani	28%	97%
A0A3S7WSR3	Leishmania donovani	27%	100%
A0A3S7WWK8	Leishmania donovani	28%	97%
A0A3S7X0N9	Leishmania donovani	28%	100%
A0A3S7X5D6	Leishmania donovani	29%	100%
A0A422NW95	Trypanosoma rangeli	28%	100%
A0A422NY11	Trypanosoma rangeli	27%	96%
A0LRS7	Acidothermus cellulolyticus (strain ATCC 43068 / DSM 8971 / 11B)	23%	99%
A0Q838	Francisella tularensis subsp. novicida (strain U112)	21%	99%
A1W0K4	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	20%	99%
A2C0Q8	Prochlorococcus marinus (strain NATL1A)	22%	95%
A4H7F6	Leishmania braziliensis	27%	100%
A4HCZ3	Leishmania braziliensis	28%	100%
A4HFQ1	Leishmania braziliensis	27%	100%
A4HK82	Leishmania braziliensis	30%	100%
A4HKX2	Leishmania braziliensis	30%	100%
A4HN57	Leishmania braziliensis	28%	100%
A4I0H8	Leishmania infantum	28%	97%
A4I2S6	Leishmania infantum	28%	100%
A4I7R7	Leishmania infantum	29%	100%
A4I8F2	Leishmania infantum	30%	98%
A4IBS4	Leishmania infantum	28%	94%
A4ICD2	Leishmania infantum	95%	100%
A4IJV3	Geobacillus thermodenitrificans (strain NG80-2)	22%	99%
A4IWC4	Francisella tularensis subsp. tularensis (strain WY96-3418)	22%	99%
A5G9I2	Geotalea uraniireducens (strain Rf4)	21%	98%
A5GMX4	Synechococcus sp. (strain WH7803)	23%	97%
A6LQ87	Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)	22%	99%
A6NM43	Homo sapiens	27%	96%
A6Q2B4	Nitratiruptor sp. (strain SB155-2)	21%	98%
A6QBP8	Sulfurovum sp. (strain NBC37-1)	23%	99%
A7GZ43	Campylobacter curvus (strain 525.92)	20%	99%
A7H2F8	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	21%	99%
A7NE88	Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)	22%	99%
A7NIK8	Roseiflexus castenholzii (strain DSM 13941 / HLO8)	21%	99%
A7ZCV2	Campylobacter concisus (strain 13826)	20%	99%
A8FMS6	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	20%	99%
A8X6I9	Caenorhabditis briggsae	45%	98%
A8YTH8	Lactobacillus helveticus (strain DPC 4571)	21%	99%
A9NHL6	Acholeplasma laidlawii (strain PG-8A)	22%	100%
B1HT15	Lysinibacillus sphaericus (strain C3-41)	20%	99%
B1YEP6	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	23%	99%
B2GAI0	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	21%	99%
B2SFF8	Francisella tularensis subsp. mediasiatica (strain FSC147)	22%	99%
B3DZP5	Methylacidiphilum infernorum (isolate V4)	21%	99%
B3E8G0	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	23%	98%
B5Y894	Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT)	22%	100%
B7GFR6	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	22%	100%
B8I5W0	Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)	20%	99%
B9KCR7	Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)	20%	99%
B9L698	Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)	21%	99%
B9LZ35	Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32)	21%	98%
C3KUC8	Clostridium botulinum (strain 657 / Type Ba4)	22%	99%
C4ZD46	Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)	20%	99%
C5D4F4	Geobacillus sp. (strain WCH70)	22%	100%
C9ZVA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
C9ZYU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
D0A1B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A3R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0A5Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A6E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	99%
D0A9X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0AAR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
E9ADA4	Leishmania major	28%	100%
E9AFL0	Leishmania major	28%	100%
E9AGK2	Leishmania infantum	27%	100%
E9AGX7	Leishmania infantum	28%	97%
E9AIQ3	Leishmania braziliensis	27%	97%
E9APJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AUC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AV93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	97%
E9AWE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	97%
E9AZ29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B3B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	98%
E9B6R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
O00782	Oxytricha granulifera	26%	96%
O04450	Arabidopsis thaliana	29%	100%
O15891	Tetrahymena pyriformis	31%	98%
O24730	Thermococcus sp. (strain JCM 11816 / KS-1)	34%	98%
O24731	Thermococcus sp. (strain KS-8)	32%	98%
O24732	Thermococcus sp. (strain KS-8)	33%	99%
O24734	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	31%	96%
O24735	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	32%	97%
O26320	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	33%	99%
O26885	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	34%	100%
O28045	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	33%	99%
O28821	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	34%	99%
O30560	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	32%	96%
O30561	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	31%	96%
O57762	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	98%
O68324	Lactobacillus helveticus	21%	99%
O69289	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	20%	99%
O74341	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O77323	Plasmodium falciparum (isolate 3D7)	26%	100%
O77622	Oryctolagus cuniculus	26%	100%
O93624	Methanothermococcus thermolithotrophicus	34%	99%
O94501	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	97%
O94515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P0C0N7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	22%	100%
P11983	Mus musculus	31%	97%
P12612	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	96%
P12613	Drosophila melanogaster	31%	96%
P17987	Homo sapiens	31%	97%
P18279	Cricetulus griseus	31%	97%
P26209	Bacillus sp. (strain PS3)	23%	100%
P28480	Rattus norvegicus	31%	97%
P28488	Saccharolobus shibatae	33%	97%
P28769	Arabidopsis thaliana	31%	99%
P39076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P39077	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P39078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P39079	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	98%
P40227	Homo sapiens	26%	100%
P40412	Avena sativa	28%	100%
P40413	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	96%
P41988	Caenorhabditis elegans	32%	98%
P42932	Mus musculus	48%	98%
P42943	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	98%
P46219	Saccharolobus shibatae	32%	96%
P46550	Caenorhabditis elegans	27%	100%
P47079	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	95%
P47207	Caenorhabditis elegans	27%	100%
P47208	Caenorhabditis elegans	28%	99%
P47209	Caenorhabditis elegans	31%	99%
P47828	Candida albicans	40%	99%
P48424	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	33%	99%
P48425	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	32%	99%
P48605	Drosophila melanogaster	29%	99%
P48643	Homo sapiens	29%	99%
P49368	Homo sapiens	29%	99%
P50016	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	34%	99%
P50143	Xenopus laevis	30%	98%
P50990	Homo sapiens	48%	98%
P50991	Homo sapiens	29%	100%
P50999	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P53451	Takifugu rubripes	29%	100%
P54408	Tetrahymena pyriformis	26%	96%
P54409	Tetrahymena pyriformis	27%	96%
P54411	Avena sativa	28%	100%
P61111	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	32%	98%
P61112	Thermococcus sp. (strain JCM 11816 / KS-1)	32%	98%
P78371	Homo sapiens	28%	100%
P78921	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	98%
P80313	Mus musculus	29%	99%
P80314	Mus musculus	28%	100%
P80315	Mus musculus	30%	100%
P80316	Mus musculus	29%	99%
P80317	Mus musculus	26%	100%
P80318	Mus musculus	30%	99%
P87153	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	96%
P94798	Francisella tularensis subsp. holarctica (strain LVS)	22%	99%
Q03H05	Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)	22%	100%
Q03SQ9	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	21%	99%
Q048Y3	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18)	21%	100%
Q07201	Geobacillus stearothermophilus	23%	100%
Q0BKF7	Francisella tularensis subsp. holarctica (strain OSU18)	22%	99%
Q0I885	Synechococcus sp. (strain CC9311)	24%	97%
Q10147	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q14FU4	Francisella tularensis subsp. tularensis (strain FSC 198)	22%	99%
Q1G937	Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)	21%	100%
Q2LPJ8	Syntrophus aciditrophicus (strain SB)	21%	99%
Q2NKZ1	Bos taurus	29%	99%
Q2T9X2	Bos taurus	29%	99%
Q32L40	Bos taurus	31%	97%
Q39ZP5	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	21%	98%
Q3MHL7	Bos taurus	27%	100%
Q3T084	Bos taurus	27%	100%
Q3T0K2	Bos taurus	30%	99%
Q3ZBH0	Bos taurus	28%	100%
Q3ZCI9	Bos taurus	48%	98%
Q46GW7	Prochlorococcus marinus (strain NATL2A)	22%	96%
Q49YY5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	23%	99%
Q4Q063	Leishmania major	95%	100%
Q4Q4U5	Leishmania major	30%	100%
Q4Q5I2	Leishmania major	29%	100%
Q4QB32	Leishmania major	27%	100%
Q4QC87	Leishmania major	28%	100%
Q4QFY8	Leishmania major	27%	100%
Q4R5G2	Macaca fascicularis	31%	97%
Q4R5J0	Macaca fascicularis	48%	98%
Q4R6F8	Macaca fascicularis	28%	100%
Q4R6V2	Macaca fascicularis	29%	99%
Q4R963	Macaca fascicularis	29%	99%
Q52500	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	34%	98%
Q53546	Desulfurococcus sp. (strain SY)	33%	99%
Q54CL2	Dictyostelium discoideum	29%	100%
Q54ER7	Dictyostelium discoideum	28%	97%
Q54ES9	Dictyostelium discoideum	28%	100%
Q54TD3	Dictyostelium discoideum	29%	100%
Q54TH8	Dictyostelium discoideum	30%	100%
Q552J0	Dictyostelium discoideum	48%	100%
Q55BM4	Dictyostelium discoideum	30%	98%
Q58405	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	99%
Q5HMZ1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	22%	100%
Q5HTP2	Campylobacter jejuni (strain RM1221)	20%	99%
Q5L3E6	Geobacillus kaustophilus (strain HTA426)	23%	100%
Q5NEE1	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)	22%	99%
Q5NVF9	Pongo abelii	30%	99%
Q5R5C8	Pongo abelii	29%	99%
Q5R637	Pongo abelii	29%	100%
Q5RAP1	Pongo abelii	48%	98%
Q5RCD2	Pongo abelii	25%	100%
Q5RF02	Pongo abelii	29%	99%
Q5XIM9	Rattus norvegicus	28%	100%
Q5ZJ54	Gallus gallus	26%	100%
Q5ZJK8	Gallus gallus	29%	97%
Q61390	Mus musculus	27%	100%
Q68FQ0	Rattus norvegicus	29%	99%
Q6BXF6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	100%
Q6C100	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	100%
Q6CL82	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	100%
Q6EE31	Gallus gallus	48%	98%
Q6FQT2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6MBZ5	Protochlamydia amoebophila (strain UWE25)	21%	99%
Q6P502	Rattus norvegicus	30%	99%
Q747C7	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	21%	99%
Q75A36	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	100%
Q76NU3	Dictyostelium discoideum	25%	100%
Q7MBB2	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	24%	100%
Q7TPB1	Rattus norvegicus	29%	100%
Q7TVA6	Prochlorococcus marinus (strain SARG / CCMP1375 / SS120)	23%	95%
Q84WV1	Arabidopsis thaliana	28%	97%
Q85G22	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	21%	100%
Q8GJ00	Fusobacterium nucleatum subsp. polymorphum	21%	100%
Q8KJ24	Clostridium botulinum	22%	99%
Q8L7N0	Arabidopsis thaliana	26%	100%
Q8R5X7	Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)	22%	100%
Q8SQP2	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q8SR53	Encephalitozoon cuniculi (strain GB-M1)	24%	100%
Q8SR76	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q8SRP9	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q8SS33	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q8SSC9	Encephalitozoon cuniculi (strain GB-M1)	26%	99%
Q8SSH3	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8TGX7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	22%	100%
Q92526	Homo sapiens	26%	100%
Q93G07	Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)	22%	99%
Q93GT6	Tetragenococcus halophilus	22%	98%
Q940P8	Arabidopsis thaliana	27%	100%
Q94757	Schistosoma mansoni	28%	99%
Q94K05	Arabidopsis thaliana	49%	98%
Q96SF2	Homo sapiens	27%	96%
Q99832	Homo sapiens	29%	99%
Q9HH21	Saccharolobus shibatae	30%	100%
Q9HHA2	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	31%	100%
Q9HN70	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	33%	96%
Q9HNI0	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	31%	97%
Q9LKI7	Thalassiosira weissflogii	27%	96%
Q9LV21	Arabidopsis thaliana	27%	100%
Q9M888	Arabidopsis thaliana	26%	100%
Q9N358	Caenorhabditis elegans	45%	98%
Q9N4J8	Caenorhabditis elegans	26%	99%
Q9NB32	Ochlerotatus triseriatus	29%	100%
Q9SF16	Arabidopsis thaliana	29%	96%
Q9UTM4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	98%
Q9V2Q7	Pyrococcus abyssi (strain GE5 / Orsay)	34%	98%
Q9V2S9	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	32%	96%
Q9V2T3	Desulfurococcus mucosus	31%	100%
Q9V2T4	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	32%	97%
Q9V2T5	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	31%	96%
Q9V2T7	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
Q9V2T8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	33%	97%
Q9W790	Paleosuchus palpebrosus	31%	96%
Q9XT06	Monodelphis domestica	31%	96%
Q9YA66	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	31%	98%
Q9YDK6	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	33%	97%
V5AR01	Trypanosoma cruzi	27%	100%
V5B209	Trypanosoma cruzi	26%	100%
V5B5Q0	Trypanosoma cruzi	30%	98%
V5BD32	Trypanosoma cruzi	79%	100%
V5BL37	Trypanosoma cruzi	28%	100%
V5BNS0	Trypanosoma cruzi	27%	97%
V5C2S4	Trypanosoma cruzi	28%	95%
V5DHJ5	Trypanosoma cruzi	29%	100%