Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQL1_LEIBR

TriTrypDb:

LbrM.35.7270 , LBRM2903_350085800

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0000164	protein phosphatase type 1 complex	5	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4HQL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL1

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	1
GO:0010562	positive regulation of phosphorus metabolic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031399	regulation of protein modification process	6	1
GO:0031401	positive regulation of protein modification process	7	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035304	regulation of protein dephosphorylation	7	1
GO:0035306	positive regulation of dephosphorylation	8	1
GO:0035307	positive regulation of protein dephosphorylation	8	1
GO:0045937	positive regulation of phosphate metabolic process	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	1
GO:0004864	protein phosphatase inhibitor activity	5	1
GO:0004865	protein serine/threonine phosphatase inhibitor activity	6	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.579
CLV_C14_Caspase3-7	668	672	PF00656	0.568
CLV_C14_Caspase3-7	703	707	PF00656	0.704
CLV_MEL_PAP_1	692	698	PF00089	0.549
CLV_NRD_NRD_1	150	152	PF00675	0.519
CLV_NRD_NRD_1	158	160	PF00675	0.560
CLV_NRD_NRD_1	204	206	PF00675	0.636
CLV_NRD_NRD_1	21	23	PF00675	0.623
CLV_NRD_NRD_1	457	459	PF00675	0.676
CLV_NRD_NRD_1	597	599	PF00675	0.708
CLV_PCSK_KEX2_1	120	122	PF00082	0.555
CLV_PCSK_KEX2_1	150	152	PF00082	0.527
CLV_PCSK_KEX2_1	158	160	PF00082	0.535
CLV_PCSK_KEX2_1	204	206	PF00082	0.534
CLV_PCSK_KEX2_1	432	434	PF00082	0.558
CLV_PCSK_KEX2_1	457	459	PF00082	0.601
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.555
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.558
CLV_PCSK_SKI1_1	121	125	PF00082	0.460
CLV_PCSK_SKI1_1	169	173	PF00082	0.520
CLV_PCSK_SKI1_1	314	318	PF00082	0.599
CLV_PCSK_SKI1_1	343	347	PF00082	0.488
CLV_PCSK_SKI1_1	433	437	PF00082	0.552
CLV_PCSK_SKI1_1	47	51	PF00082	0.380
CLV_PCSK_SKI1_1	621	625	PF00082	0.560
CLV_PCSK_SKI1_1	63	67	PF00082	0.500
CLV_Separin_Metazoa	711	715	PF03568	0.568
DEG_APCC_DBOX_1	296	304	PF00400	0.606
DEG_SCF_FBW7_1	415	420	PF00400	0.703
DEG_SCF_FBW7_1	605	612	PF00400	0.562
DEG_SIAH_1	216	224	PF03145	0.504
DEG_SPOP_SBC_1	240	244	PF00917	0.663
DOC_CDC14_PxL_1	332	340	PF14671	0.587
DOC_CYCLIN_RxL_1	309	322	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	224	227	PF00134	0.788
DOC_CYCLIN_yCln2_LP_2	352	355	PF00134	0.441
DOC_CYCLIN_yCln2_LP_2	644	650	PF00134	0.568
DOC_MAPK_DCC_7	479	487	PF00069	0.545
DOC_MAPK_gen_1	120	126	PF00069	0.465
DOC_MAPK_gen_1	22	30	PF00069	0.598
DOC_MAPK_gen_1	297	305	PF00069	0.597
DOC_MAPK_gen_1	309	318	PF00069	0.428
DOC_MAPK_gen_1	511	519	PF00069	0.670
DOC_MAPK_gen_1	598	607	PF00069	0.607
DOC_MAPK_MEF2A_6	23	32	PF00069	0.539
DOC_MAPK_MEF2A_6	297	305	PF00069	0.597
DOC_MAPK_MEF2A_6	88	97	PF00069	0.439
DOC_PP1_RVXF_1	341	348	PF00149	0.325
DOC_PP2B_LxvP_1	224	227	PF13499	0.788
DOC_PP2B_LxvP_1	352	355	PF13499	0.441
DOC_USP7_MATH_1	106	110	PF00917	0.513
DOC_USP7_MATH_1	304	308	PF00917	0.348
DOC_USP7_MATH_1	393	397	PF00917	0.722
DOC_USP7_MATH_1	417	421	PF00917	0.730
DOC_USP7_MATH_1	521	525	PF00917	0.682
DOC_USP7_MATH_1	630	634	PF00917	0.604
DOC_USP7_MATH_1	640	644	PF00917	0.537
DOC_USP7_MATH_1	684	688	PF00917	0.722
DOC_WW_Pin1_4	213	218	PF00397	0.569
DOC_WW_Pin1_4	376	381	PF00397	0.727
DOC_WW_Pin1_4	413	418	PF00397	0.695
DOC_WW_Pin1_4	480	485	PF00397	0.540
DOC_WW_Pin1_4	506	511	PF00397	0.544
DOC_WW_Pin1_4	528	533	PF00397	0.525
DOC_WW_Pin1_4	564	569	PF00397	0.535
DOC_WW_Pin1_4	579	584	PF00397	0.506
DOC_WW_Pin1_4	586	591	PF00397	0.554
DOC_WW_Pin1_4	605	610	PF00397	0.483
DOC_WW_Pin1_4	636	641	PF00397	0.714
DOC_WW_Pin1_4	643	648	PF00397	0.613
LIG_14-3-3_CanoR_1	158	166	PF00244	0.511
LIG_14-3-3_CanoR_1	314	319	PF00244	0.516
LIG_14-3-3_CanoR_1	34	43	PF00244	0.515
LIG_14-3-3_CanoR_1	405	415	PF00244	0.569
LIG_14-3-3_CanoR_1	433	438	PF00244	0.718
LIG_14-3-3_CanoR_1	457	465	PF00244	0.693
LIG_14-3-3_CanoR_1	472	476	PF00244	0.765
LIG_14-3-3_CanoR_1	563	568	PF00244	0.633
LIG_14-3-3_CanoR_1	58	63	PF00244	0.440
LIG_14-3-3_CanoR_1	689	699	PF00244	0.551
LIG_14-3-3_CanoR_1	714	718	PF00244	0.761
LIG_BIR_III_2	629	633	PF00653	0.560
LIG_BIR_III_4	230	234	PF00653	0.647
LIG_BRCT_BRCA1_1	243	247	PF00533	0.671
LIG_BRCT_BRCA1_1	256	260	PF00533	0.294
LIG_BRCT_BRCA1_1	38	42	PF00533	0.471
LIG_BRCT_BRCA1_1	523	527	PF00533	0.627
LIG_BRCT_BRCA1_1	538	542	PF00533	0.567
LIG_BRCT_BRCA1_1	566	570	PF00533	0.540
LIG_BRCT_BRCA1_1	661	665	PF00533	0.653
LIG_BRCT_BRCA1_1	692	696	PF00533	0.762
LIG_CaM_IQ_9	187	203	PF13499	0.663
LIG_DLG_GKlike_1	58	65	PF00625	0.556
LIG_eIF4E_1	87	93	PF01652	0.434
LIG_FHA_1	185	191	PF00498	0.525
LIG_FHA_1	325	331	PF00498	0.570
LIG_FHA_1	377	383	PF00498	0.634
LIG_FHA_1	429	435	PF00498	0.554
LIG_FHA_1	472	478	PF00498	0.606
LIG_FHA_1	606	612	PF00498	0.814
LIG_FHA_1	64	70	PF00498	0.452
LIG_FHA_2	106	112	PF00498	0.620
LIG_FHA_2	136	142	PF00498	0.595
LIG_FHA_2	358	364	PF00498	0.544
LIG_FHA_2	36	42	PF00498	0.496
LIG_FHA_2	399	405	PF00498	0.825
LIG_FHA_2	637	643	PF00498	0.650
LIG_FHA_2	668	674	PF00498	0.568
LIG_LIR_Apic_2	349	354	PF02991	0.410
LIG_LIR_Gen_1	139	149	PF02991	0.501
LIG_LIR_Gen_1	24	32	PF02991	0.578
LIG_LIR_Gen_1	275	284	PF02991	0.505
LIG_LIR_Gen_1	329	340	PF02991	0.586
LIG_LIR_Gen_1	38	48	PF02991	0.262
LIG_LIR_Gen_1	524	535	PF02991	0.735
LIG_LIR_Gen_1	548	559	PF02991	0.643
LIG_LIR_Nem_3	127	131	PF02991	0.459
LIG_LIR_Nem_3	139	145	PF02991	0.488
LIG_LIR_Nem_3	148	152	PF02991	0.487
LIG_LIR_Nem_3	24	30	PF02991	0.520
LIG_LIR_Nem_3	275	280	PF02991	0.532
LIG_LIR_Nem_3	329	335	PF02991	0.590
LIG_LIR_Nem_3	38	43	PF02991	0.269
LIG_LIR_Nem_3	524	530	PF02991	0.614
LIG_LIR_Nem_3	548	554	PF02991	0.630
LIG_LIR_Nem_3	61	65	PF02991	0.547
LIG_LIR_Nem_3	693	699	PF02991	0.802
LIG_LRP6_Inhibitor_1	683	689	PF00058	0.556
LIG_MYND_1	223	227	PF01753	0.784
LIG_NRBOX	208	214	PF00104	0.416
LIG_NRBOX	88	94	PF00104	0.534
LIG_SH2_CRK	142	146	PF00017	0.473
LIG_SH2_CRK	312	316	PF00017	0.395
LIG_SH2_CRK	342	346	PF00017	0.580
LIG_SH2_NCK_1	543	547	PF00017	0.535
LIG_SH2_NCK_1	551	555	PF00017	0.516
LIG_SH2_SRC	534	537	PF00017	0.524
LIG_SH2_STAP1	142	146	PF00017	0.473
LIG_SH2_STAT5	294	297	PF00017	0.378
LIG_SH2_STAT5	351	354	PF00017	0.434
LIG_SH2_STAT5	48	51	PF00017	0.573
LIG_SH2_STAT5	534	537	PF00017	0.588
LIG_SH3_2	593	598	PF14604	0.568
LIG_SH3_3	212	218	PF00018	0.537
LIG_SH3_3	220	226	PF00018	0.622
LIG_SH3_3	298	304	PF00018	0.346
LIG_SH3_3	441	447	PF00018	0.615
LIG_SH3_3	504	510	PF00018	0.618
LIG_SH3_3	587	593	PF00018	0.577
LIG_SUMO_SIM_anti_2	251	257	PF11976	0.627
LIG_SUMO_SIM_par_1	164	170	PF11976	0.508
LIG_SUMO_SIM_par_1	210	216	PF11976	0.436
LIG_SUMO_SIM_par_1	354	360	PF11976	0.590
LIG_SUMO_SIM_par_1	473	478	PF11976	0.558
LIG_SUMO_SIM_par_1	483	488	PF11976	0.512
LIG_TYR_ITIM	126	131	PF00017	0.454
LIG_WRC_WIRS_1	37	42	PF05994	0.431
LIG_WRC_WIRS_1	59	64	PF05994	0.467
LIG_WRC_WIRS_1	631	636	PF05994	0.703
LIG_WW_2	444	447	PF00397	0.709
LIG_WW_3	595	599	PF00397	0.716
MOD_CDK_SPK_2	506	511	PF00069	0.544
MOD_CDK_SPxxK_3	506	513	PF00069	0.548
MOD_CDK_SPxxK_3	579	586	PF00069	0.572
MOD_CK1_1	241	247	PF00069	0.625
MOD_CK1_1	293	299	PF00069	0.585
MOD_CK1_1	357	363	PF00069	0.609
MOD_CK1_1	398	404	PF00069	0.826
MOD_CK1_1	406	412	PF00069	0.683
MOD_CK1_1	459	465	PF00069	0.668
MOD_CK1_1	471	477	PF00069	0.640
MOD_CK1_1	488	494	PF00069	0.512
MOD_CK1_1	509	515	PF00069	0.770
MOD_CK1_1	528	534	PF00069	0.679
MOD_CK1_1	564	570	PF00069	0.579
MOD_CK1_1	574	580	PF00069	0.532
MOD_CK1_1	610	616	PF00069	0.821
MOD_CK1_1	643	649	PF00069	0.787
MOD_CK1_1	687	693	PF00069	0.606
MOD_CK1_1	70	76	PF00069	0.460
MOD_CK1_1	704	710	PF00069	0.551
MOD_CK2_1	105	111	PF00069	0.624
MOD_CK2_1	135	141	PF00069	0.604
MOD_CK2_1	245	251	PF00069	0.581
MOD_CK2_1	35	41	PF00069	0.478
MOD_CK2_1	357	363	PF00069	0.546
MOD_CK2_1	370	376	PF00069	0.611
MOD_CK2_1	398	404	PF00069	0.716
MOD_CK2_1	702	708	PF00069	0.552
MOD_Cter_Amidation	118	121	PF01082	0.606
MOD_GlcNHglycan	247	250	PF01048	0.647
MOD_GlcNHglycan	273	277	PF01048	0.634
MOD_GlcNHglycan	348	351	PF01048	0.620
MOD_GlcNHglycan	395	398	PF01048	0.719
MOD_GlcNHglycan	408	411	PF01048	0.683
MOD_GlcNHglycan	419	422	PF01048	0.811
MOD_GlcNHglycan	502	505	PF01048	0.788
MOD_GlcNHglycan	681	684	PF01048	0.765
MOD_GlcNHglycan	689	692	PF01048	0.675
MOD_GSK3_1	236	243	PF00069	0.734
MOD_GSK3_1	366	373	PF00069	0.634
MOD_GSK3_1	395	402	PF00069	0.685
MOD_GSK3_1	413	420	PF00069	0.831
MOD_GSK3_1	452	459	PF00069	0.664
MOD_GSK3_1	461	468	PF00069	0.613
MOD_GSK3_1	471	478	PF00069	0.689
MOD_GSK3_1	491	498	PF00069	0.484
MOD_GSK3_1	521	528	PF00069	0.627
MOD_GSK3_1	541	548	PF00069	0.703
MOD_GSK3_1	562	569	PF00069	0.563
MOD_GSK3_1	571	578	PF00069	0.537
MOD_GSK3_1	605	612	PF00069	0.777
MOD_GSK3_1	63	70	PF00069	0.486
MOD_GSK3_1	630	637	PF00069	0.743
MOD_GSK3_1	653	660	PF00069	0.759
MOD_GSK3_1	687	694	PF00069	0.792
MOD_GSK3_1	700	707	PF00069	0.784
MOD_GSK3_1	712	719	PF00069	0.654
MOD_LATS_1	450	456	PF00433	0.573
MOD_LATS_1	56	62	PF00433	0.420
MOD_N-GLC_1	184	189	PF02516	0.549
MOD_N-GLC_1	236	241	PF02516	0.536
MOD_NEK2_1	124	129	PF00069	0.434
MOD_NEK2_1	175	180	PF00069	0.652
MOD_NEK2_1	254	259	PF00069	0.370
MOD_NEK2_1	346	351	PF00069	0.511
MOD_NEK2_1	370	375	PF00069	0.662
MOD_NEK2_1	42	47	PF00069	0.481
MOD_NEK2_1	453	458	PF00069	0.741
MOD_NEK2_1	465	470	PF00069	0.639
MOD_NEK2_1	634	639	PF00069	0.674
MOD_NEK2_1	648	653	PF00069	0.640
MOD_NEK2_1	700	705	PF00069	0.673
MOD_NEK2_1	712	717	PF00069	0.545
MOD_NEK2_2	304	309	PF00069	0.356
MOD_NEK2_2	395	400	PF00069	0.557
MOD_NEK2_2	684	689	PF00069	0.553
MOD_PIKK_1	157	163	PF00454	0.663
MOD_PIKK_1	175	181	PF00454	0.630
MOD_PIKK_1	357	363	PF00454	0.623
MOD_PIKK_1	465	471	PF00454	0.558
MOD_PKA_2	157	163	PF00069	0.449
MOD_PKA_2	35	41	PF00069	0.519
MOD_PKA_2	451	457	PF00069	0.668
MOD_PKA_2	471	477	PF00069	0.784
MOD_PKA_2	562	568	PF00069	0.583
MOD_PKA_2	653	659	PF00069	0.650
MOD_PKA_2	713	719	PF00069	0.567
MOD_PKB_1	34	42	PF00069	0.425
MOD_Plk_1	236	242	PF00069	0.532
MOD_Plk_1	284	290	PF00069	0.321
MOD_Plk_1	403	409	PF00069	0.567
MOD_Plk_1	495	501	PF00069	0.590
MOD_Plk_2-3	164	170	PF00069	0.361
MOD_Plk_2-3	550	556	PF00069	0.544
MOD_Plk_2-3	702	708	PF00069	0.552
MOD_Plk_4	290	296	PF00069	0.502
MOD_Plk_4	314	320	PF00069	0.568
MOD_Plk_4	354	360	PF00069	0.559
MOD_Plk_4	495	501	PF00069	0.551
MOD_ProDKin_1	213	219	PF00069	0.573
MOD_ProDKin_1	376	382	PF00069	0.727
MOD_ProDKin_1	413	419	PF00069	0.694
MOD_ProDKin_1	480	486	PF00069	0.541
MOD_ProDKin_1	506	512	PF00069	0.546
MOD_ProDKin_1	528	534	PF00069	0.527
MOD_ProDKin_1	564	570	PF00069	0.538
MOD_ProDKin_1	579	585	PF00069	0.509
MOD_ProDKin_1	586	592	PF00069	0.549
MOD_ProDKin_1	605	611	PF00069	0.485
MOD_ProDKin_1	636	642	PF00069	0.714
MOD_ProDKin_1	643	649	PF00069	0.614
TRG_DiLeu_BaEn_1	708	713	PF01217	0.563
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.411
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.776
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.494
TRG_ENDOCYTIC_2	128	131	PF00928	0.460
TRG_ENDOCYTIC_2	142	145	PF00928	0.479
TRG_ENDOCYTIC_2	342	345	PF00928	0.570
TRG_ENDOCYTIC_2	551	554	PF00928	0.543
TRG_ENDOCYTIC_2	86	89	PF00928	0.434
TRG_ER_diArg_1	149	151	PF00400	0.606
TRG_ER_diArg_1	157	159	PF00400	0.524
TRG_ER_diArg_1	204	206	PF00400	0.636
TRG_ER_diArg_1	297	300	PF00400	0.533
TRG_ER_diArg_1	308	311	PF00400	0.516
TRG_ER_diArg_1	34	37	PF00400	0.515
TRG_ER_diArg_1	652	655	PF00400	0.563
TRG_ER_diLys_1	721	726	PF00400	0.569
TRG_NLS_MonoExtC_3	597	603	PF00514	0.563
TRG_NLS_MonoExtN_4	596	602	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KNZ5	Bodo saltans	30%	100%
A0A3S7XCG9	Leishmania donovani	59%	100%
A4ICD1	Leishmania infantum	59%	100%
E9AUC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q064	Leishmania major	59%	100%