LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HQL1_LEIBR
TriTrypDb:
LbrM.35.7270 , LBRM2903_350085800 *
Length:
726

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005929 cilium 4 7
GO:0042995 cell projection 2 7
GO:0043226 organelle 2 7
GO:0043227 membrane-bounded organelle 3 7
GO:0110165 cellular anatomical entity 1 7
GO:0120025 plasma membrane bounded cell projection 3 7
GO:0000164 protein phosphatase type 1 complex 5 1
GO:0008287 protein serine/threonine phosphatase complex 4 1
GO:0032991 protein-containing complex 1 1
GO:1902494 catalytic complex 2 1
GO:1903293 phosphatase complex 3 1

Expansion

Sequence features

A4HQL1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQL1

Function

Biological processes
Term Name Level Count
GO:0009893 positive regulation of metabolic process 4 1
GO:0010562 positive regulation of phosphorus metabolic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0031401 positive regulation of protein modification process 7 1
GO:0035303 regulation of dephosphorylation 7 1
GO:0035304 regulation of protein dephosphorylation 7 1
GO:0035306 positive regulation of dephosphorylation 8 1
GO:0035307 positive regulation of protein dephosphorylation 8 1
GO:0045937 positive regulation of phosphate metabolic process 7 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
Molecular functions
Term Name Level Count
GO:0004857 enzyme inhibitor activity 3 1
GO:0004864 protein phosphatase inhibitor activity 5 1
GO:0004865 protein serine/threonine phosphatase inhibitor activity 6 1
GO:0019208 phosphatase regulator activity 3 1
GO:0019212 phosphatase inhibitor activity 4 1
GO:0019888 protein phosphatase regulator activity 4 1
GO:0030234 enzyme regulator activity 2 1
GO:0098772 molecular function regulator activity 1 1
GO:0140678 molecular function inhibitor activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.579
CLV_C14_Caspase3-7 668 672 PF00656 0.568
CLV_C14_Caspase3-7 703 707 PF00656 0.704
CLV_MEL_PAP_1 692 698 PF00089 0.549
CLV_NRD_NRD_1 150 152 PF00675 0.519
CLV_NRD_NRD_1 158 160 PF00675 0.560
CLV_NRD_NRD_1 204 206 PF00675 0.636
CLV_NRD_NRD_1 21 23 PF00675 0.623
CLV_NRD_NRD_1 457 459 PF00675 0.676
CLV_NRD_NRD_1 597 599 PF00675 0.708
CLV_PCSK_KEX2_1 120 122 PF00082 0.555
CLV_PCSK_KEX2_1 150 152 PF00082 0.527
CLV_PCSK_KEX2_1 158 160 PF00082 0.535
CLV_PCSK_KEX2_1 204 206 PF00082 0.534
CLV_PCSK_KEX2_1 432 434 PF00082 0.558
CLV_PCSK_KEX2_1 457 459 PF00082 0.601
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.555
CLV_PCSK_PC1ET2_1 432 434 PF00082 0.558
CLV_PCSK_SKI1_1 121 125 PF00082 0.460
CLV_PCSK_SKI1_1 169 173 PF00082 0.520
CLV_PCSK_SKI1_1 314 318 PF00082 0.599
CLV_PCSK_SKI1_1 343 347 PF00082 0.488
CLV_PCSK_SKI1_1 433 437 PF00082 0.552
CLV_PCSK_SKI1_1 47 51 PF00082 0.380
CLV_PCSK_SKI1_1 621 625 PF00082 0.560
CLV_PCSK_SKI1_1 63 67 PF00082 0.500
CLV_Separin_Metazoa 711 715 PF03568 0.568
DEG_APCC_DBOX_1 296 304 PF00400 0.606
DEG_SCF_FBW7_1 415 420 PF00400 0.703
DEG_SCF_FBW7_1 605 612 PF00400 0.562
DEG_SIAH_1 216 224 PF03145 0.504
DEG_SPOP_SBC_1 240 244 PF00917 0.663
DOC_CDC14_PxL_1 332 340 PF14671 0.587
DOC_CYCLIN_RxL_1 309 322 PF00134 0.610
DOC_CYCLIN_yCln2_LP_2 224 227 PF00134 0.788
DOC_CYCLIN_yCln2_LP_2 352 355 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 644 650 PF00134 0.568
DOC_MAPK_DCC_7 479 487 PF00069 0.545
DOC_MAPK_gen_1 120 126 PF00069 0.465
DOC_MAPK_gen_1 22 30 PF00069 0.598
DOC_MAPK_gen_1 297 305 PF00069 0.597
DOC_MAPK_gen_1 309 318 PF00069 0.428
DOC_MAPK_gen_1 511 519 PF00069 0.670
DOC_MAPK_gen_1 598 607 PF00069 0.607
DOC_MAPK_MEF2A_6 23 32 PF00069 0.539
DOC_MAPK_MEF2A_6 297 305 PF00069 0.597
DOC_MAPK_MEF2A_6 88 97 PF00069 0.439
DOC_PP1_RVXF_1 341 348 PF00149 0.325
DOC_PP2B_LxvP_1 224 227 PF13499 0.788
DOC_PP2B_LxvP_1 352 355 PF13499 0.441
DOC_USP7_MATH_1 106 110 PF00917 0.513
DOC_USP7_MATH_1 304 308 PF00917 0.348
DOC_USP7_MATH_1 393 397 PF00917 0.722
DOC_USP7_MATH_1 417 421 PF00917 0.730
DOC_USP7_MATH_1 521 525 PF00917 0.682
DOC_USP7_MATH_1 630 634 PF00917 0.604
DOC_USP7_MATH_1 640 644 PF00917 0.537
DOC_USP7_MATH_1 684 688 PF00917 0.722
DOC_WW_Pin1_4 213 218 PF00397 0.569
DOC_WW_Pin1_4 376 381 PF00397 0.727
DOC_WW_Pin1_4 413 418 PF00397 0.695
DOC_WW_Pin1_4 480 485 PF00397 0.540
DOC_WW_Pin1_4 506 511 PF00397 0.544
DOC_WW_Pin1_4 528 533 PF00397 0.525
DOC_WW_Pin1_4 564 569 PF00397 0.535
DOC_WW_Pin1_4 579 584 PF00397 0.506
DOC_WW_Pin1_4 586 591 PF00397 0.554
DOC_WW_Pin1_4 605 610 PF00397 0.483
DOC_WW_Pin1_4 636 641 PF00397 0.714
DOC_WW_Pin1_4 643 648 PF00397 0.613
LIG_14-3-3_CanoR_1 158 166 PF00244 0.511
LIG_14-3-3_CanoR_1 314 319 PF00244 0.516
LIG_14-3-3_CanoR_1 34 43 PF00244 0.515
LIG_14-3-3_CanoR_1 405 415 PF00244 0.569
LIG_14-3-3_CanoR_1 433 438 PF00244 0.718
LIG_14-3-3_CanoR_1 457 465 PF00244 0.693
LIG_14-3-3_CanoR_1 472 476 PF00244 0.765
LIG_14-3-3_CanoR_1 563 568 PF00244 0.633
LIG_14-3-3_CanoR_1 58 63 PF00244 0.440
LIG_14-3-3_CanoR_1 689 699 PF00244 0.551
LIG_14-3-3_CanoR_1 714 718 PF00244 0.761
LIG_BIR_III_2 629 633 PF00653 0.560
LIG_BIR_III_4 230 234 PF00653 0.647
LIG_BRCT_BRCA1_1 243 247 PF00533 0.671
LIG_BRCT_BRCA1_1 256 260 PF00533 0.294
LIG_BRCT_BRCA1_1 38 42 PF00533 0.471
LIG_BRCT_BRCA1_1 523 527 PF00533 0.627
LIG_BRCT_BRCA1_1 538 542 PF00533 0.567
LIG_BRCT_BRCA1_1 566 570 PF00533 0.540
LIG_BRCT_BRCA1_1 661 665 PF00533 0.653
LIG_BRCT_BRCA1_1 692 696 PF00533 0.762
LIG_CaM_IQ_9 187 203 PF13499 0.663
LIG_DLG_GKlike_1 58 65 PF00625 0.556
LIG_eIF4E_1 87 93 PF01652 0.434
LIG_FHA_1 185 191 PF00498 0.525
LIG_FHA_1 325 331 PF00498 0.570
LIG_FHA_1 377 383 PF00498 0.634
LIG_FHA_1 429 435 PF00498 0.554
LIG_FHA_1 472 478 PF00498 0.606
LIG_FHA_1 606 612 PF00498 0.814
LIG_FHA_1 64 70 PF00498 0.452
LIG_FHA_2 106 112 PF00498 0.620
LIG_FHA_2 136 142 PF00498 0.595
LIG_FHA_2 358 364 PF00498 0.544
LIG_FHA_2 36 42 PF00498 0.496
LIG_FHA_2 399 405 PF00498 0.825
LIG_FHA_2 637 643 PF00498 0.650
LIG_FHA_2 668 674 PF00498 0.568
LIG_LIR_Apic_2 349 354 PF02991 0.410
LIG_LIR_Gen_1 139 149 PF02991 0.501
LIG_LIR_Gen_1 24 32 PF02991 0.578
LIG_LIR_Gen_1 275 284 PF02991 0.505
LIG_LIR_Gen_1 329 340 PF02991 0.586
LIG_LIR_Gen_1 38 48 PF02991 0.262
LIG_LIR_Gen_1 524 535 PF02991 0.735
LIG_LIR_Gen_1 548 559 PF02991 0.643
LIG_LIR_Nem_3 127 131 PF02991 0.459
LIG_LIR_Nem_3 139 145 PF02991 0.488
LIG_LIR_Nem_3 148 152 PF02991 0.487
LIG_LIR_Nem_3 24 30 PF02991 0.520
LIG_LIR_Nem_3 275 280 PF02991 0.532
LIG_LIR_Nem_3 329 335 PF02991 0.590
LIG_LIR_Nem_3 38 43 PF02991 0.269
LIG_LIR_Nem_3 524 530 PF02991 0.614
LIG_LIR_Nem_3 548 554 PF02991 0.630
LIG_LIR_Nem_3 61 65 PF02991 0.547
LIG_LIR_Nem_3 693 699 PF02991 0.802
LIG_LRP6_Inhibitor_1 683 689 PF00058 0.556
LIG_MYND_1 223 227 PF01753 0.784
LIG_NRBOX 208 214 PF00104 0.416
LIG_NRBOX 88 94 PF00104 0.534
LIG_SH2_CRK 142 146 PF00017 0.473
LIG_SH2_CRK 312 316 PF00017 0.395
LIG_SH2_CRK 342 346 PF00017 0.580
LIG_SH2_NCK_1 543 547 PF00017 0.535
LIG_SH2_NCK_1 551 555 PF00017 0.516
LIG_SH2_SRC 534 537 PF00017 0.524
LIG_SH2_STAP1 142 146 PF00017 0.473
LIG_SH2_STAT5 294 297 PF00017 0.378
LIG_SH2_STAT5 351 354 PF00017 0.434
LIG_SH2_STAT5 48 51 PF00017 0.573
LIG_SH2_STAT5 534 537 PF00017 0.588
LIG_SH3_2 593 598 PF14604 0.568
LIG_SH3_3 212 218 PF00018 0.537
LIG_SH3_3 220 226 PF00018 0.622
LIG_SH3_3 298 304 PF00018 0.346
LIG_SH3_3 441 447 PF00018 0.615
LIG_SH3_3 504 510 PF00018 0.618
LIG_SH3_3 587 593 PF00018 0.577
LIG_SUMO_SIM_anti_2 251 257 PF11976 0.627
LIG_SUMO_SIM_par_1 164 170 PF11976 0.508
LIG_SUMO_SIM_par_1 210 216 PF11976 0.436
LIG_SUMO_SIM_par_1 354 360 PF11976 0.590
LIG_SUMO_SIM_par_1 473 478 PF11976 0.558
LIG_SUMO_SIM_par_1 483 488 PF11976 0.512
LIG_TYR_ITIM 126 131 PF00017 0.454
LIG_WRC_WIRS_1 37 42 PF05994 0.431
LIG_WRC_WIRS_1 59 64 PF05994 0.467
LIG_WRC_WIRS_1 631 636 PF05994 0.703
LIG_WW_2 444 447 PF00397 0.709
LIG_WW_3 595 599 PF00397 0.716
MOD_CDK_SPK_2 506 511 PF00069 0.544
MOD_CDK_SPxxK_3 506 513 PF00069 0.548
MOD_CDK_SPxxK_3 579 586 PF00069 0.572
MOD_CK1_1 241 247 PF00069 0.625
MOD_CK1_1 293 299 PF00069 0.585
MOD_CK1_1 357 363 PF00069 0.609
MOD_CK1_1 398 404 PF00069 0.826
MOD_CK1_1 406 412 PF00069 0.683
MOD_CK1_1 459 465 PF00069 0.668
MOD_CK1_1 471 477 PF00069 0.640
MOD_CK1_1 488 494 PF00069 0.512
MOD_CK1_1 509 515 PF00069 0.770
MOD_CK1_1 528 534 PF00069 0.679
MOD_CK1_1 564 570 PF00069 0.579
MOD_CK1_1 574 580 PF00069 0.532
MOD_CK1_1 610 616 PF00069 0.821
MOD_CK1_1 643 649 PF00069 0.787
MOD_CK1_1 687 693 PF00069 0.606
MOD_CK1_1 70 76 PF00069 0.460
MOD_CK1_1 704 710 PF00069 0.551
MOD_CK2_1 105 111 PF00069 0.624
MOD_CK2_1 135 141 PF00069 0.604
MOD_CK2_1 245 251 PF00069 0.581
MOD_CK2_1 35 41 PF00069 0.478
MOD_CK2_1 357 363 PF00069 0.546
MOD_CK2_1 370 376 PF00069 0.611
MOD_CK2_1 398 404 PF00069 0.716
MOD_CK2_1 702 708 PF00069 0.552
MOD_Cter_Amidation 118 121 PF01082 0.606
MOD_GlcNHglycan 247 250 PF01048 0.647
MOD_GlcNHglycan 273 277 PF01048 0.634
MOD_GlcNHglycan 348 351 PF01048 0.620
MOD_GlcNHglycan 395 398 PF01048 0.719
MOD_GlcNHglycan 408 411 PF01048 0.683
MOD_GlcNHglycan 419 422 PF01048 0.811
MOD_GlcNHglycan 502 505 PF01048 0.788
MOD_GlcNHglycan 681 684 PF01048 0.765
MOD_GlcNHglycan 689 692 PF01048 0.675
MOD_GSK3_1 236 243 PF00069 0.734
MOD_GSK3_1 366 373 PF00069 0.634
MOD_GSK3_1 395 402 PF00069 0.685
MOD_GSK3_1 413 420 PF00069 0.831
MOD_GSK3_1 452 459 PF00069 0.664
MOD_GSK3_1 461 468 PF00069 0.613
MOD_GSK3_1 471 478 PF00069 0.689
MOD_GSK3_1 491 498 PF00069 0.484
MOD_GSK3_1 521 528 PF00069 0.627
MOD_GSK3_1 541 548 PF00069 0.703
MOD_GSK3_1 562 569 PF00069 0.563
MOD_GSK3_1 571 578 PF00069 0.537
MOD_GSK3_1 605 612 PF00069 0.777
MOD_GSK3_1 63 70 PF00069 0.486
MOD_GSK3_1 630 637 PF00069 0.743
MOD_GSK3_1 653 660 PF00069 0.759
MOD_GSK3_1 687 694 PF00069 0.792
MOD_GSK3_1 700 707 PF00069 0.784
MOD_GSK3_1 712 719 PF00069 0.654
MOD_LATS_1 450 456 PF00433 0.573
MOD_LATS_1 56 62 PF00433 0.420
MOD_N-GLC_1 184 189 PF02516 0.549
MOD_N-GLC_1 236 241 PF02516 0.536
MOD_NEK2_1 124 129 PF00069 0.434
MOD_NEK2_1 175 180 PF00069 0.652
MOD_NEK2_1 254 259 PF00069 0.370
MOD_NEK2_1 346 351 PF00069 0.511
MOD_NEK2_1 370 375 PF00069 0.662
MOD_NEK2_1 42 47 PF00069 0.481
MOD_NEK2_1 453 458 PF00069 0.741
MOD_NEK2_1 465 470 PF00069 0.639
MOD_NEK2_1 634 639 PF00069 0.674
MOD_NEK2_1 648 653 PF00069 0.640
MOD_NEK2_1 700 705 PF00069 0.673
MOD_NEK2_1 712 717 PF00069 0.545
MOD_NEK2_2 304 309 PF00069 0.356
MOD_NEK2_2 395 400 PF00069 0.557
MOD_NEK2_2 684 689 PF00069 0.553
MOD_PIKK_1 157 163 PF00454 0.663
MOD_PIKK_1 175 181 PF00454 0.630
MOD_PIKK_1 357 363 PF00454 0.623
MOD_PIKK_1 465 471 PF00454 0.558
MOD_PKA_2 157 163 PF00069 0.449
MOD_PKA_2 35 41 PF00069 0.519
MOD_PKA_2 451 457 PF00069 0.668
MOD_PKA_2 471 477 PF00069 0.784
MOD_PKA_2 562 568 PF00069 0.583
MOD_PKA_2 653 659 PF00069 0.650
MOD_PKA_2 713 719 PF00069 0.567
MOD_PKB_1 34 42 PF00069 0.425
MOD_Plk_1 236 242 PF00069 0.532
MOD_Plk_1 284 290 PF00069 0.321
MOD_Plk_1 403 409 PF00069 0.567
MOD_Plk_1 495 501 PF00069 0.590
MOD_Plk_2-3 164 170 PF00069 0.361
MOD_Plk_2-3 550 556 PF00069 0.544
MOD_Plk_2-3 702 708 PF00069 0.552
MOD_Plk_4 290 296 PF00069 0.502
MOD_Plk_4 314 320 PF00069 0.568
MOD_Plk_4 354 360 PF00069 0.559
MOD_Plk_4 495 501 PF00069 0.551
MOD_ProDKin_1 213 219 PF00069 0.573
MOD_ProDKin_1 376 382 PF00069 0.727
MOD_ProDKin_1 413 419 PF00069 0.694
MOD_ProDKin_1 480 486 PF00069 0.541
MOD_ProDKin_1 506 512 PF00069 0.546
MOD_ProDKin_1 528 534 PF00069 0.527
MOD_ProDKin_1 564 570 PF00069 0.538
MOD_ProDKin_1 579 585 PF00069 0.509
MOD_ProDKin_1 586 592 PF00069 0.549
MOD_ProDKin_1 605 611 PF00069 0.485
MOD_ProDKin_1 636 642 PF00069 0.714
MOD_ProDKin_1 643 649 PF00069 0.614
TRG_DiLeu_BaEn_1 708 713 PF01217 0.563
TRG_DiLeu_BaLyEn_6 208 213 PF01217 0.411
TRG_DiLeu_BaLyEn_6 220 225 PF01217 0.776
TRG_DiLeu_BaLyEn_6 333 338 PF01217 0.494
TRG_ENDOCYTIC_2 128 131 PF00928 0.460
TRG_ENDOCYTIC_2 142 145 PF00928 0.479
TRG_ENDOCYTIC_2 342 345 PF00928 0.570
TRG_ENDOCYTIC_2 551 554 PF00928 0.543
TRG_ENDOCYTIC_2 86 89 PF00928 0.434
TRG_ER_diArg_1 149 151 PF00400 0.606
TRG_ER_diArg_1 157 159 PF00400 0.524
TRG_ER_diArg_1 204 206 PF00400 0.636
TRG_ER_diArg_1 297 300 PF00400 0.533
TRG_ER_diArg_1 308 311 PF00400 0.516
TRG_ER_diArg_1 34 37 PF00400 0.515
TRG_ER_diArg_1 652 655 PF00400 0.563
TRG_ER_diLys_1 721 726 PF00400 0.569
TRG_NLS_MonoExtC_3 597 603 PF00514 0.563
TRG_NLS_MonoExtN_4 596 602 PF00514 0.562
TRG_Pf-PMV_PEXEL_1 150 155 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 63 68 PF00026 0.579

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4KNZ5 Bodo saltans 30% 100%
A0A3S7XCG9 Leishmania donovani 59% 100%
A4ICD1 Leishmania infantum 59% 100%
E9AUC6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 100%
Q4Q064 Leishmania major 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS