Putative DNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain factor 1

Species:

Leishmania braziliensis

UniProt:

A4HQK9_LEIBR

TriTrypDb:

LbrM.35.7250 , LBRM2903_350085600

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK9

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0070577	lysine-acetylated histone binding	4	1
GO:0140030	modification-dependent protein binding	3	1
GO:0140033	acetylation-dependent protein binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.455
CLV_C14_Caspase3-7	43	47	PF00656	0.262
CLV_NRD_NRD_1	186	188	PF00675	0.403
CLV_NRD_NRD_1	19	21	PF00675	0.468
CLV_NRD_NRD_1	218	220	PF00675	0.563
CLV_NRD_NRD_1	36	38	PF00675	0.191
CLV_NRD_NRD_1	75	77	PF00675	0.318
CLV_PCSK_FUR_1	15	19	PF00082	0.393
CLV_PCSK_KEX2_1	17	19	PF00082	0.434
CLV_PCSK_KEX2_1	186	188	PF00082	0.402
CLV_PCSK_KEX2_1	217	219	PF00082	0.551
CLV_PCSK_KEX2_1	36	38	PF00082	0.434
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.444
CLV_PCSK_PC7_1	13	19	PF00082	0.425
CLV_PCSK_PC7_1	213	219	PF00082	0.583
CLV_PCSK_SKI1_1	124	128	PF00082	0.475
CLV_PCSK_SKI1_1	152	156	PF00082	0.430
CLV_PCSK_SKI1_1	178	182	PF00082	0.438
CLV_PCSK_SKI1_1	186	190	PF00082	0.390
CLV_Separin_Metazoa	153	157	PF03568	0.469
DEG_SPOP_SBC_1	166	170	PF00917	0.405
DOC_MAPK_MEF2A_6	112	121	PF00069	0.439
DOC_USP7_MATH_1	11	15	PF00917	0.307
DOC_USP7_MATH_1	192	196	PF00917	0.477
DOC_USP7_MATH_1	209	213	PF00917	0.377
DOC_WW_Pin1_4	261	266	PF00397	0.571
DOC_WW_Pin1_4	281	286	PF00397	0.486
LIG_14-3-3_CanoR_1	124	133	PF00244	0.457
LIG_14-3-3_CanoR_1	156	161	PF00244	0.405
LIG_14-3-3_CanoR_1	178	188	PF00244	0.481
LIG_14-3-3_CanoR_1	18	27	PF00244	0.542
LIG_14-3-3_CanoR_1	53	59	PF00244	0.454
LIG_Actin_WH2_2	114	132	PF00022	0.491
LIG_BIR_III_2	241	245	PF00653	0.489
LIG_BRCT_BRCA1_1	20	24	PF00533	0.303
LIG_FHA_2	157	163	PF00498	0.260
LIG_GBD_Chelix_1	8	16	PF00786	0.476
LIG_LIR_Nem_3	159	164	PF02991	0.300
LIG_LIR_Nem_3	21	27	PF02991	0.438
LIG_PTB_Apo_2	95	102	PF02174	0.416
LIG_PTB_Phospho_1	95	101	PF10480	0.416
LIG_SH2_CRK	103	107	PF00017	0.421
LIG_SH2_SRC	26	29	PF00017	0.529
LIG_SH2_STAP1	61	65	PF00017	0.340
LIG_SH2_STAP1	81	85	PF00017	0.145
LIG_SH2_STAT5	101	104	PF00017	0.340
LIG_SH2_STAT5	158	161	PF00017	0.246
LIG_SH2_STAT5	26	29	PF00017	0.529
LIG_SH3_1	130	136	PF00018	0.531
LIG_SH3_3	130	136	PF00018	0.411
LIG_SH3_3	62	68	PF00018	0.340
LIG_WRC_WIRS_1	157	162	PF05994	0.247
MOD_CDC14_SPxK_1	264	267	PF00782	0.685
MOD_CDK_SPxK_1	261	267	PF00069	0.691
MOD_CK1_1	148	154	PF00069	0.444
MOD_CK1_1	167	173	PF00069	0.529
MOD_CK1_1	179	185	PF00069	0.369
MOD_CK1_1	212	218	PF00069	0.532
MOD_CK2_1	156	162	PF00069	0.279
MOD_CK2_1	191	197	PF00069	0.543
MOD_GlcNHglycan	147	150	PF01048	0.521
MOD_GlcNHglycan	169	172	PF01048	0.492
MOD_GlcNHglycan	178	181	PF01048	0.472
MOD_GlcNHglycan	194	197	PF01048	0.456
MOD_GSK3_1	144	151	PF00069	0.523
MOD_GSK3_1	166	173	PF00069	0.410
MOD_GSK3_1	40	47	PF00069	0.425
MOD_N-GLC_2	98	100	PF02516	0.425
MOD_NEK2_1	164	169	PF00069	0.402
MOD_NEK2_1	280	285	PF00069	0.581
MOD_PKA_1	18	24	PF00069	0.292
MOD_PKA_2	18	24	PF00069	0.292
MOD_PKA_2	192	198	PF00069	0.562
MOD_PKA_2	212	218	PF00069	0.354
MOD_Plk_2-3	40	46	PF00069	0.365
MOD_Plk_4	156	162	PF00069	0.492
MOD_ProDKin_1	261	267	PF00069	0.571
MOD_SUMO_rev_2	194	203	PF00179	0.560
TRG_DiLeu_BaEn_4	270	276	PF01217	0.480
TRG_ENDOCYTIC_2	103	106	PF00928	0.421
TRG_ENDOCYTIC_2	161	164	PF00928	0.505
TRG_ENDOCYTIC_2	70	73	PF00928	0.334
TRG_ER_diArg_1	12	15	PF00400	0.465
TRG_ER_diArg_1	18	20	PF00400	0.453
TRG_ER_diArg_1	185	187	PF00400	0.357
TRG_ER_diArg_1	217	219	PF00400	0.551
TRG_ER_diArg_1	36	38	PF00400	0.145
TRG_NLS_MonoCore_2	16	21	PF00514	0.462
TRG_NLS_MonoExtC_3	16	22	PF00514	0.566
TRG_NLS_MonoExtN_4	15	21	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD97	Leptomonas seymouri	71%	100%
A0A0S4KI88	Bodo saltans	26%	100%
A0A1X0NN00	Trypanosomatidae	37%	96%
A0A3Q8IM77	Leishmania donovani	86%	100%
A0A422NVW8	Trypanosoma rangeli	35%	97%
A4ICC9	Leishmania infantum	86%	100%
D0A3R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
E9AUC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q066	Leishmania major	87%	100%
V5DDW0	Trypanosoma cruzi	33%	97%