EVE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EVE domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQK8_LEIBR

TriTrypDb:

LbrM.35.7240 , LBRM2903_350085500

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK8

PDB structure(s): 2ar1_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.342
CLV_NRD_NRD_1	2	4	PF00675	0.541
CLV_PCSK_KEX2_1	127	129	PF00082	0.342
CLV_PCSK_KEX2_1	4	6	PF00082	0.489
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.489
CLV_PCSK_SKI1_1	132	136	PF00082	0.394
CLV_PCSK_SKI1_1	56	60	PF00082	0.261
CLV_Separin_Metazoa	74	78	PF03568	0.342
DEG_APCC_DBOX_1	126	134	PF00400	0.342
DEG_MDM2_SWIB_1	111	119	PF02201	0.392
DOC_MAPK_gen_1	125	135	PF00069	0.311
DOC_USP7_MATH_1	123	127	PF00917	0.167
DOC_USP7_UBL2_3	110	114	PF12436	0.195
LIG_14-3-3_CanoR_1	140	144	PF00244	0.254
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BRCT_BRCA1_1	89	93	PF00533	0.342
LIG_FHA_2	82	88	PF00498	0.277
LIG_LIR_Apic_2	89	95	PF02991	0.392
LIG_LIR_Gen_1	113	123	PF02991	0.181
LIG_LIR_Gen_1	150	157	PF02991	0.286
LIG_LIR_Gen_1	81	87	PF02991	0.392
LIG_LIR_Nem_3	10	16	PF02991	0.342
LIG_LIR_Nem_3	113	118	PF02991	0.212
LIG_LIR_Nem_3	150	154	PF02991	0.286
LIG_LIR_Nem_3	33	39	PF02991	0.255
LIG_LIR_Nem_3	81	86	PF02991	0.392
LIG_MLH1_MIPbox_1	89	93	PF16413	0.342
LIG_Pex14_2	111	115	PF04695	0.251
LIG_SH2_CRK	151	155	PF00017	0.342
LIG_SH2_SRC	151	154	PF00017	0.311
LIG_SH2_STAP1	151	155	PF00017	0.286
LIG_SH2_STAT5	153	156	PF00017	0.342
LIG_SH2_STAT5	92	95	PF00017	0.422
LIG_TRAF2_2	103	108	PF00917	0.281
LIG_TYR_ITIM	11	16	PF00017	0.342
MOD_CK1_1	139	145	PF00069	0.347
MOD_CK2_1	123	129	PF00069	0.167
MOD_GlcNHglycan	33	36	PF01048	0.306
MOD_NEK2_1	136	141	PF00069	0.311
MOD_NEK2_1	59	64	PF00069	0.251
MOD_PIKK_1	134	140	PF00454	0.345
MOD_PKA_2	139	145	PF00069	0.251
MOD_Plk_1	81	87	PF00069	0.286
MOD_SUMO_for_1	16	19	PF00179	0.254
MOD_SUMO_rev_2	90	98	PF00179	0.259
TRG_ENDOCYTIC_2	13	16	PF00928	0.307
TRG_ENDOCYTIC_2	151	154	PF00928	0.286
TRG_ENDOCYTIC_2	80	83	PF00928	0.400
TRG_ER_diArg_1	3	6	PF00400	0.528
TRG_NLS_MonoExtC_3	2	7	PF00514	0.528
TRG_NLS_MonoExtN_4	3	8	PF00514	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I255	Leptomonas seymouri	77%	94%
A0A0S4JQP8	Bodo saltans	54%	93%
A0A0S4KI49	Bodo saltans	54%	93%
A0A1X0NLS9	Trypanosomatidae	60%	100%
A0A3R7KTV7	Trypanosoma rangeli	63%	99%
A0A3S7XCF0	Leishmania donovani	88%	80%
A4ICC8	Leishmania infantum	89%	80%
D0A3R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AUC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O94645	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	69%
Q4Q067	Leishmania major	89%	100%
Q6P3E0	Rattus norvegicus	43%	73%
Q6PFL8	Danio rerio	44%	71%
Q90679	Gallus gallus	42%	68%
Q91YJ3	Mus musculus	43%	73%
Q9P016	Homo sapiens	45%	73%