Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQK7_LEIBR

TriTrypDb:

LbrM.35.7230 , LBRM2903_350085400

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.731
CLV_NRD_NRD_1	16	18	PF00675	0.658
CLV_NRD_NRD_1	221	223	PF00675	0.608
CLV_NRD_NRD_1	299	301	PF00675	0.435
CLV_PCSK_KEX2_1	188	190	PF00082	0.723
CLV_PCSK_KEX2_1	221	223	PF00082	0.608
CLV_PCSK_KEX2_1	298	300	PF00082	0.461
CLV_PCSK_KEX2_1	305	307	PF00082	0.602
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.723
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.625
CLV_PCSK_SKI1_1	147	151	PF00082	0.472
CLV_PCSK_SKI1_1	17	21	PF00082	0.681
CLV_PCSK_SKI1_1	221	225	PF00082	0.763
CLV_PCSK_SKI1_1	28	32	PF00082	0.738
CLV_PCSK_SKI1_1	351	355	PF00082	0.631
DEG_APCC_DBOX_1	146	154	PF00400	0.476
DEG_APCC_DBOX_1	297	305	PF00400	0.367
DOC_CKS1_1	135	140	PF01111	0.505
DOC_CKS1_1	50	55	PF01111	0.554
DOC_MAPK_MEF2A_6	310	317	PF00069	0.368
DOC_MAPK_MEF2A_6	330	338	PF00069	0.588
DOC_MAPK_MEF2A_6	374	383	PF00069	0.562
DOC_MAPK_NFAT4_5	310	318	PF00069	0.369
DOC_PP1_RVXF_1	15	22	PF00149	0.649
DOC_PP1_RVXF_1	187	194	PF00149	0.551
DOC_PP1_RVXF_1	199	205	PF00149	0.587
DOC_PP2B_LxvP_1	56	59	PF13499	0.809
DOC_PP4_FxxP_1	21	24	PF00568	0.556
DOC_PP4_FxxP_1	270	273	PF00568	0.610
DOC_PP4_MxPP_1	156	159	PF00568	0.463
DOC_USP7_MATH_1	13	17	PF00917	0.550
DOC_USP7_MATH_1	57	61	PF00917	0.603
DOC_USP7_MATH_1	63	67	PF00917	0.561
DOC_WW_Pin1_4	117	122	PF00397	0.772
DOC_WW_Pin1_4	134	139	PF00397	0.434
DOC_WW_Pin1_4	269	274	PF00397	0.614
DOC_WW_Pin1_4	31	36	PF00397	0.749
DOC_WW_Pin1_4	344	349	PF00397	0.400
DOC_WW_Pin1_4	387	392	PF00397	0.656
DOC_WW_Pin1_4	409	414	PF00397	0.737
DOC_WW_Pin1_4	49	54	PF00397	0.521
DOC_WW_Pin1_4	9	14	PF00397	0.800
DOC_WW_Pin1_4	94	99	PF00397	0.570
LIG_14-3-3_CanoR_1	143	150	PF00244	0.730
LIG_14-3-3_CanoR_1	17	22	PF00244	0.657
LIG_14-3-3_CanoR_1	228	234	PF00244	0.794
LIG_14-3-3_CanoR_1	396	406	PF00244	0.532
LIG_BIR_II_1	1	5	PF00653	0.800
LIG_BRCT_BRCA1_1	65	69	PF00533	0.553
LIG_EVH1_1	49	53	PF00568	0.551
LIG_EVH1_2	121	125	PF00568	0.779
LIG_FHA_1	126	132	PF00498	0.660
LIG_FHA_1	18	24	PF00498	0.804
LIG_FHA_1	254	260	PF00498	0.515
LIG_FHA_1	345	351	PF00498	0.401
LIG_FHA_1	388	394	PF00498	0.620
LIG_FHA_2	170	176	PF00498	0.471
LIG_FHA_2	243	249	PF00498	0.730
LIG_FHA_2	73	79	PF00498	0.810
LIG_LIR_Apic_2	105	110	PF02991	0.485
LIG_LIR_Apic_2	20	24	PF02991	0.554
LIG_LIR_Gen_1	160	169	PF02991	0.626
LIG_LIR_Gen_1	235	246	PF02991	0.531
LIG_LIR_Nem_3	160	164	PF02991	0.531
LIG_LIR_Nem_3	235	241	PF02991	0.535
LIG_LIR_Nem_3	291	297	PF02991	0.597
LIG_LIR_Nem_3	66	72	PF02991	0.597
LIG_LYPXL_S_1	108	112	PF13949	0.752
LIG_LYPXL_yS_3	109	112	PF13949	0.761
LIG_PCNA_PIPBox_1	208	217	PF02747	0.647
LIG_Pex14_1	265	269	PF04695	0.578
LIG_SH2_CRK	238	242	PF00017	0.529
LIG_SH2_NCK_1	238	242	PF00017	0.529
LIG_SH2_STAP1	104	108	PF00017	0.473
LIG_SH2_STAT5	161	164	PF00017	0.520
LIG_SH2_STAT5	215	218	PF00017	0.683
LIG_SH2_STAT5	238	241	PF00017	0.537
LIG_SH2_STAT5	269	272	PF00017	0.603
LIG_SH2_STAT5	294	297	PF00017	0.596
LIG_SH3_3	1	7	PF00018	0.743
LIG_SH3_3	127	133	PF00018	0.527
LIG_SH3_3	174	180	PF00018	0.705
LIG_SH3_3	33	39	PF00018	0.648
LIG_SH3_3	362	368	PF00018	0.610
LIG_SH3_3	40	46	PF00018	0.653
LIG_SH3_3	47	53	PF00018	0.687
LIG_SH3_3	56	62	PF00018	0.534
LIG_SH3_3	92	98	PF00018	0.557
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.522
LIG_SUMO_SIM_anti_2	332	340	PF11976	0.453
LIG_SUMO_SIM_par_1	179	186	PF11976	0.755
LIG_SUMO_SIM_par_1	332	340	PF11976	0.453
LIG_SUMO_SIM_par_1	38	44	PF11976	0.546
LIG_TRAF2_1	74	77	PF00917	0.811
LIG_TRAF2_1	90	93	PF00917	0.574
LIG_TRAF2_1	97	100	PF00917	0.497
LIG_WW_1	158	161	PF00397	0.689
MOD_CDK_SPK_2	344	349	PF00069	0.400
MOD_CDK_SPxxK_3	117	124	PF00069	0.525
MOD_CDK_SPxxK_3	344	351	PF00069	0.399
MOD_CDK_SPxxK_3	409	416	PF00069	0.535
MOD_CK1_1	117	123	PF00069	0.668
MOD_CK1_1	12	18	PF00069	0.571
MOD_CK1_1	170	176	PF00069	0.574
MOD_CK1_1	231	237	PF00069	0.774
MOD_CK1_1	253	259	PF00069	0.507
MOD_CK1_1	355	361	PF00069	0.629
MOD_CK1_1	387	393	PF00069	0.572
MOD_CK2_1	142	148	PF00069	0.591
MOD_CK2_1	72	78	PF00069	0.814
MOD_CK2_1	87	93	PF00069	0.574
MOD_CK2_1	94	100	PF00069	0.478
MOD_GlcNHglycan	116	119	PF01048	0.628
MOD_GlcNHglycan	252	255	PF01048	0.567
MOD_GlcNHglycan	265	268	PF01048	0.326
MOD_GlcNHglycan	339	342	PF01048	0.562
MOD_GlcNHglycan	354	357	PF01048	0.394
MOD_GSK3_1	113	120	PF00069	0.768
MOD_GSK3_1	183	190	PF00069	0.532
MOD_GSK3_1	228	235	PF00069	0.784
MOD_GSK3_1	259	266	PF00069	0.403
MOD_GSK3_1	383	390	PF00069	0.642
MOD_GSK3_1	9	16	PF00069	0.700
MOD_LATS_1	375	381	PF00433	0.561
MOD_NEK2_1	113	118	PF00069	0.764
MOD_NEK2_1	317	322	PF00069	0.439
MOD_NEK2_1	337	342	PF00069	0.494
MOD_NEK2_1	383	388	PF00069	0.572
MOD_NEK2_1	394	399	PF00069	0.695
MOD_PKA_1	17	23	PF00069	0.806
MOD_PKA_1	221	227	PF00069	0.617
MOD_PKA_2	142	148	PF00069	0.738
MOD_PKA_2	221	227	PF00069	0.722
MOD_PKA_2	317	323	PF00069	0.329
MOD_PKA_2	342	348	PF00069	0.543
MOD_PKA_2	415	421	PF00069	0.524
MOD_Plk_1	394	400	PF00069	0.533
MOD_Plk_4	152	158	PF00069	0.474
MOD_Plk_4	17	23	PF00069	0.556
MOD_Plk_4	317	323	PF00069	0.429
MOD_Plk_4	79	85	PF00069	0.567
MOD_ProDKin_1	117	123	PF00069	0.773
MOD_ProDKin_1	134	140	PF00069	0.432
MOD_ProDKin_1	269	275	PF00069	0.613
MOD_ProDKin_1	31	37	PF00069	0.751
MOD_ProDKin_1	344	350	PF00069	0.394
MOD_ProDKin_1	387	393	PF00069	0.656
MOD_ProDKin_1	409	415	PF00069	0.736
MOD_ProDKin_1	49	55	PF00069	0.520
MOD_ProDKin_1	9	15	PF00069	0.601
MOD_ProDKin_1	94	100	PF00069	0.566
MOD_SUMO_for_1	216	219	PF00179	0.647
MOD_SUMO_rev_2	90	96	PF00179	0.571
TRG_ENDOCYTIC_2	109	112	PF00928	0.636
TRG_ENDOCYTIC_2	161	164	PF00928	0.553
TRG_ENDOCYTIC_2	215	218	PF00928	0.674
TRG_ENDOCYTIC_2	238	241	PF00928	0.534
TRG_ER_diArg_1	221	223	PF00400	0.608
TRG_ER_diArg_1	297	300	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGY1	Leishmania donovani	68%	100%
A4ICC7	Leishmania infantum	67%	100%
E9AUC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q068	Leishmania major	68%	100%