RNA_lig_T4_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA ligase/AAA domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQK6_LEIBR

TriTrypDb:

LbrM.35.7220 , LBRM2903_350085300

Length:

904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016874	ligase activity	2	10
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.444
CLV_C14_Caspase3-7	372	376	PF00656	0.413
CLV_C14_Caspase3-7	75	79	PF00656	0.492
CLV_MEL_PAP_1	152	158	PF00089	0.259
CLV_MEL_PAP_1	693	699	PF00089	0.369
CLV_NRD_NRD_1	115	117	PF00675	0.271
CLV_NRD_NRD_1	181	183	PF00675	0.400
CLV_NRD_NRD_1	207	209	PF00675	0.335
CLV_NRD_NRD_1	340	342	PF00675	0.512
CLV_NRD_NRD_1	459	461	PF00675	0.273
CLV_NRD_NRD_1	534	536	PF00675	0.304
CLV_NRD_NRD_1	555	557	PF00675	0.569
CLV_NRD_NRD_1	612	614	PF00675	0.525
CLV_NRD_NRD_1	878	880	PF00675	0.669
CLV_PCSK_KEX2_1	181	183	PF00082	0.404
CLV_PCSK_KEX2_1	207	209	PF00082	0.271
CLV_PCSK_KEX2_1	339	341	PF00082	0.525
CLV_PCSK_KEX2_1	459	461	PF00082	0.318
CLV_PCSK_KEX2_1	5	7	PF00082	0.471
CLV_PCSK_KEX2_1	534	536	PF00082	0.304
CLV_PCSK_KEX2_1	555	557	PF00082	0.453
CLV_PCSK_KEX2_1	612	614	PF00082	0.432
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.521
CLV_PCSK_SKI1_1	138	142	PF00082	0.399
CLV_PCSK_SKI1_1	601	605	PF00082	0.439
CLV_PCSK_SKI1_1	691	695	PF00082	0.501
CLV_PCSK_SKI1_1	70	74	PF00082	0.271
DEG_APCC_DBOX_1	34	42	PF00400	0.444
DEG_APCC_DBOX_1	717	725	PF00400	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.399
DEG_SPOP_SBC_1	766	770	PF00917	0.431
DOC_CKS1_1	14	19	PF01111	0.480
DOC_CKS1_1	296	301	PF01111	0.319
DOC_CYCLIN_RxL_1	415	426	PF00134	0.314
DOC_CYCLIN_RxL_1	688	698	PF00134	0.515
DOC_MAPK_DCC_7	823	833	PF00069	0.351
DOC_MAPK_gen_1	295	304	PF00069	0.365
DOC_MAPK_gen_1	534	542	PF00069	0.335
DOC_MAPK_gen_1	646	655	PF00069	0.412
DOC_MAPK_MEF2A_6	287	296	PF00069	0.449
DOC_MAPK_MEF2A_6	391	400	PF00069	0.339
DOC_MAPK_MEF2A_6	535	544	PF00069	0.193
DOC_MAPK_MEF2A_6	649	657	PF00069	0.375
DOC_MAPK_MEF2A_6	785	794	PF00069	0.502
DOC_PP1_RVXF_1	689	695	PF00149	0.554
DOC_PP1_RVXF_1	700	707	PF00149	0.592
DOC_PP2B_LxvP_1	603	606	PF13499	0.285
DOC_PP4_FxxP_1	558	561	PF00568	0.376
DOC_USP7_MATH_1	243	247	PF00917	0.428
DOC_USP7_MATH_1	250	254	PF00917	0.409
DOC_USP7_MATH_1	306	310	PF00917	0.458
DOC_USP7_MATH_1	349	353	PF00917	0.259
DOC_USP7_MATH_1	407	411	PF00917	0.404
DOC_USP7_MATH_1	451	455	PF00917	0.193
DOC_USP7_MATH_1	579	583	PF00917	0.521
DOC_USP7_MATH_1	645	649	PF00917	0.460
DOC_USP7_MATH_1	663	667	PF00917	0.221
DOC_USP7_MATH_1	679	683	PF00917	0.551
DOC_USP7_MATH_1	752	756	PF00917	0.413
DOC_USP7_MATH_1	77	81	PF00917	0.307
DOC_USP7_MATH_2	737	743	PF00917	0.413
DOC_WW_Pin1_4	13	18	PF00397	0.472
DOC_WW_Pin1_4	256	261	PF00397	0.390
DOC_WW_Pin1_4	295	300	PF00397	0.284
DOC_WW_Pin1_4	423	428	PF00397	0.348
DOC_WW_Pin1_4	641	646	PF00397	0.585
LIG_14-3-3_CanoR_1	181	189	PF00244	0.370
LIG_14-3-3_CanoR_1	305	311	PF00244	0.340
LIG_14-3-3_CanoR_1	316	321	PF00244	0.379
LIG_14-3-3_CanoR_1	33	39	PF00244	0.492
LIG_14-3-3_CanoR_1	382	390	PF00244	0.469
LIG_14-3-3_CanoR_1	612	620	PF00244	0.513
LIG_14-3-3_CanoR_1	649	654	PF00244	0.432
LIG_14-3-3_CanoR_1	680	686	PF00244	0.525
LIG_14-3-3_CanoR_1	696	704	PF00244	0.560
LIG_14-3-3_CanoR_1	761	767	PF00244	0.610
LIG_14-3-3_CanoR_1	793	798	PF00244	0.324
LIG_14-3-3_CanoR_1	801	807	PF00244	0.365
LIG_Actin_WH2_2	458	476	PF00022	0.193
LIG_Actin_WH2_2	650	667	PF00022	0.419
LIG_Actin_WH2_2	85	103	PF00022	0.193
LIG_Actin_WH2_2	882	898	PF00022	0.275
LIG_APCC_ABBA_1	142	147	PF00400	0.259
LIG_APCC_Cbox_2	28	34	PF00515	0.330
LIG_BRCT_BRCA1_1	214	218	PF00533	0.404
LIG_Clathr_ClatBox_1	125	129	PF01394	0.273
LIG_Clathr_ClatBox_1	488	492	PF01394	0.271
LIG_deltaCOP1_diTrp_1	252	261	PF00928	0.284
LIG_deltaCOP1_diTrp_1	98	106	PF00928	0.310
LIG_DLG_GKlike_1	212	220	PF00625	0.193
LIG_FHA_1	38	44	PF00498	0.441
LIG_FHA_1	381	387	PF00498	0.540
LIG_FHA_1	395	401	PF00498	0.378
LIG_FHA_1	440	446	PF00498	0.193
LIG_FHA_1	642	648	PF00498	0.484
LIG_FHA_1	659	665	PF00498	0.439
LIG_FHA_1	711	717	PF00498	0.418
LIG_FHA_1	793	799	PF00498	0.344
LIG_FHA_2	129	135	PF00498	0.193
LIG_FHA_2	18	24	PF00498	0.538
LIG_FHA_2	221	227	PF00498	0.404
LIG_FHA_2	370	376	PF00498	0.457
LIG_FHA_2	466	472	PF00498	0.281
LIG_FHA_2	583	589	PF00498	0.375
LIG_FHA_2	767	773	PF00498	0.474
LIG_LIR_Gen_1	147	156	PF02991	0.284
LIG_LIR_Gen_1	215	225	PF02991	0.404
LIG_LIR_Gen_1	269	278	PF02991	0.270
LIG_LIR_Gen_1	298	307	PF02991	0.393
LIG_LIR_Gen_1	426	434	PF02991	0.349
LIG_LIR_Nem_3	147	153	PF02991	0.284
LIG_LIR_Nem_3	215	221	PF02991	0.454
LIG_LIR_Nem_3	269	274	PF02991	0.239
LIG_LIR_Nem_3	298	304	PF02991	0.323
LIG_LIR_Nem_3	426	431	PF02991	0.272
LIG_LIR_Nem_3	870	874	PF02991	0.614
LIG_NRBOX	619	625	PF00104	0.480
LIG_PCNA_yPIPBox_3	455	465	PF02747	0.308
LIG_Pex14_1	106	110	PF04695	0.335
LIG_Pex14_1	254	258	PF04695	0.404
LIG_Pex14_1	504	508	PF04695	0.404
LIG_Pex14_1	706	710	PF04695	0.507
LIG_PTB_Apo_2	633	640	PF02174	0.360
LIG_Rb_pABgroove_1	847	855	PF01858	0.279
LIG_SH2_GRB2like	881	884	PF00017	0.489
LIG_SH2_NCK_1	515	519	PF00017	0.335
LIG_SH2_PTP2	301	304	PF00017	0.426
LIG_SH2_SRC	320	323	PF00017	0.441
LIG_SH2_STAP1	515	519	PF00017	0.335
LIG_SH2_STAP1	802	806	PF00017	0.384
LIG_SH2_STAT3	11	14	PF00017	0.305
LIG_SH2_STAT3	778	781	PF00017	0.442
LIG_SH2_STAT5	258	261	PF00017	0.378
LIG_SH2_STAT5	30	33	PF00017	0.469
LIG_SH2_STAT5	301	304	PF00017	0.426
LIG_SH2_STAT5	320	323	PF00017	0.308
LIG_SH2_STAT5	507	510	PF00017	0.315
LIG_SH2_STAT5	778	781	PF00017	0.399
LIG_SH3_3	705	711	PF00018	0.584
LIG_SH3_3	746	752	PF00018	0.434
LIG_SH3_3	813	819	PF00018	0.330
LIG_Sin3_3	271	278	PF02671	0.404
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.193
LIG_SUMO_SIM_anti_2	197	204	PF11976	0.193
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.390
LIG_SUMO_SIM_anti_2	486	492	PF11976	0.428
LIG_SUMO_SIM_anti_2	754	761	PF11976	0.269
LIG_SUMO_SIM_par_1	121	127	PF11976	0.300
LIG_SUMO_SIM_par_1	271	277	PF11976	0.282
LIG_SUMO_SIM_par_1	39	45	PF11976	0.397
LIG_SUMO_SIM_par_1	418	424	PF11976	0.271
LIG_SUMO_SIM_par_1	440	446	PF11976	0.193
LIG_SUMO_SIM_par_1	486	492	PF11976	0.398
LIG_SUMO_SIM_par_1	539	546	PF11976	0.193
LIG_SxIP_EBH_1	823	835	PF03271	0.335
LIG_TRAF2_1	421	424	PF00917	0.281
LIG_TRAF2_1	496	499	PF00917	0.193
LIG_TRAF2_1	561	564	PF00917	0.547
LIG_TRAF2_1	575	578	PF00917	0.514
LIG_WW_3	591	595	PF00397	0.363
MOD_CDK_SPK_2	295	300	PF00069	0.319
MOD_CDK_SPK_2	641	646	PF00069	0.415
MOD_CK1_1	104	110	PF00069	0.446
MOD_CK1_1	410	416	PF00069	0.266
MOD_CK1_1	426	432	PF00069	0.476
MOD_CK1_1	480	486	PF00069	0.335
MOD_CK1_1	50	56	PF00069	0.367
MOD_CK1_1	523	529	PF00069	0.335
MOD_CK1_1	568	574	PF00069	0.480
MOD_CK1_1	582	588	PF00069	0.516
MOD_CK1_1	615	621	PF00069	0.473
MOD_CK1_1	627	633	PF00069	0.571
MOD_CK1_1	648	654	PF00069	0.562
MOD_CK1_1	682	688	PF00069	0.598
MOD_CK1_1	755	761	PF00069	0.322
MOD_CK1_1	765	771	PF00069	0.365
MOD_CK2_1	128	134	PF00069	0.193
MOD_CK2_1	220	226	PF00069	0.404
MOD_CK2_1	349	355	PF00069	0.275
MOD_CK2_1	540	546	PF00069	0.493
MOD_CK2_1	571	577	PF00069	0.370
MOD_CK2_1	582	588	PF00069	0.299
MOD_CK2_1	766	772	PF00069	0.408
MOD_GlcNHglycan	279	282	PF01048	0.223
MOD_GlcNHglycan	44	47	PF01048	0.430
MOD_GlcNHglycan	485	488	PF01048	0.293
MOD_GlcNHglycan	630	633	PF01048	0.495
MOD_GlcNHglycan	665	668	PF01048	0.378
MOD_GlcNHglycan	681	684	PF01048	0.421
MOD_GlcNHglycan	687	690	PF01048	0.429
MOD_GlcNHglycan	697	700	PF01048	0.467
MOD_GlcNHglycan	741	744	PF01048	0.412
MOD_GlcNHglycan	769	772	PF01048	0.554
MOD_GSK3_1	100	107	PF00069	0.453
MOD_GSK3_1	124	131	PF00069	0.252
MOD_GSK3_1	13	20	PF00069	0.559
MOD_GSK3_1	212	219	PF00069	0.368
MOD_GSK3_1	256	263	PF00069	0.293
MOD_GSK3_1	312	319	PF00069	0.458
MOD_GSK3_1	349	356	PF00069	0.272
MOD_GSK3_1	37	44	PF00069	0.305
MOD_GSK3_1	380	387	PF00069	0.354
MOD_GSK3_1	447	454	PF00069	0.335
MOD_GSK3_1	522	529	PF00069	0.193
MOD_GSK3_1	568	575	PF00069	0.339
MOD_GSK3_1	615	622	PF00069	0.343
MOD_GSK3_1	624	631	PF00069	0.444
MOD_GSK3_1	641	648	PF00069	0.430
MOD_GSK3_1	702	709	PF00069	0.608
MOD_GSK3_1	710	717	PF00069	0.547
MOD_GSK3_1	751	758	PF00069	0.300
MOD_GSK3_1	761	768	PF00069	0.420
MOD_GSK3_1	802	809	PF00069	0.474
MOD_N-GLC_1	494	499	PF02516	0.404
MOD_N-GLC_1	762	767	PF02516	0.387
MOD_N-GLC_1	859	864	PF02516	0.452
MOD_N-GLC_1	874	879	PF02516	0.404
MOD_NEK2_1	100	105	PF00069	0.335
MOD_NEK2_1	121	126	PF00069	0.282
MOD_NEK2_1	128	133	PF00069	0.296
MOD_NEK2_1	216	221	PF00069	0.284
MOD_NEK2_1	274	279	PF00069	0.388
MOD_NEK2_1	380	385	PF00069	0.526
MOD_NEK2_1	619	624	PF00069	0.293
MOD_NEK2_1	671	676	PF00069	0.490
MOD_NEK2_1	779	784	PF00069	0.524
MOD_NEK2_1	806	811	PF00069	0.425
MOD_NEK2_1	831	836	PF00069	0.288
MOD_NEK2_2	243	248	PF00069	0.374
MOD_NEK2_2	579	584	PF00069	0.423
MOD_PIKK_1	180	186	PF00454	0.215
MOD_PIKK_1	206	212	PF00454	0.404
MOD_PIKK_1	216	222	PF00454	0.404
MOD_PIKK_1	494	500	PF00454	0.404
MOD_PIKK_1	526	532	PF00454	0.193
MOD_PIKK_1	55	61	PF00454	0.555
MOD_PIKK_1	874	880	PF00454	0.630
MOD_PK_1	572	578	PF00069	0.310
MOD_PKA_1	612	618	PF00069	0.354
MOD_PKA_2	154	160	PF00069	0.259
MOD_PKA_2	180	186	PF00069	0.215
MOD_PKA_2	206	212	PF00069	0.335
MOD_PKA_2	34	40	PF00069	0.334
MOD_PKA_2	381	387	PF00069	0.462
MOD_PKA_2	612	618	PF00069	0.448
MOD_PKA_2	648	654	PF00069	0.529
MOD_PKA_2	679	685	PF00069	0.526
MOD_PKA_2	695	701	PF00069	0.470
MOD_PKA_2	731	737	PF00069	0.350
MOD_PKA_2	792	798	PF00069	0.238
MOD_PKA_2	867	873	PF00069	0.675
MOD_Plk_1	101	107	PF00069	0.335
MOD_Plk_1	212	218	PF00069	0.349
MOD_Plk_1	47	53	PF00069	0.481
MOD_Plk_1	523	529	PF00069	0.382
MOD_Plk_1	762	768	PF00069	0.428
MOD_Plk_1	859	865	PF00069	0.459
MOD_Plk_2-3	23	29	PF00069	0.336
MOD_Plk_2-3	859	865	PF00069	0.459
MOD_Plk_4	101	107	PF00069	0.428
MOD_Plk_4	243	249	PF00069	0.340
MOD_Plk_4	316	322	PF00069	0.478
MOD_Plk_4	394	400	PF00069	0.423
MOD_Plk_4	523	529	PF00069	0.374
MOD_Plk_4	615	621	PF00069	0.425
MOD_Plk_4	755	761	PF00069	0.360
MOD_Plk_4	77	83	PF00069	0.335
MOD_Plk_4	793	799	PF00069	0.331
MOD_Plk_4	824	830	PF00069	0.522
MOD_ProDKin_1	13	19	PF00069	0.471
MOD_ProDKin_1	256	262	PF00069	0.390
MOD_ProDKin_1	295	301	PF00069	0.284
MOD_ProDKin_1	423	429	PF00069	0.348
MOD_ProDKin_1	641	647	PF00069	0.583
MOD_SUMO_for_1	4	7	PF00179	0.478
MOD_SUMO_rev_2	564	574	PF00179	0.469
MOD_SUMO_rev_2	58	65	PF00179	0.392
TRG_DiLeu_BaEn_1	198	203	PF01217	0.193
TRG_DiLeu_BaEn_1	269	274	PF01217	0.349
TRG_DiLeu_BaEn_1	355	360	PF01217	0.278
TRG_DiLeu_BaLyEn_6	688	693	PF01217	0.517
TRG_ENDOCYTIC_2	258	261	PF00928	0.333
TRG_ENDOCYTIC_2	301	304	PF00928	0.293
TRG_ENDOCYTIC_2	881	884	PF00928	0.489
TRG_ER_diArg_1	161	164	PF00400	0.374
TRG_ER_diArg_1	180	182	PF00400	0.176
TRG_ER_diArg_1	33	36	PF00400	0.428
TRG_ER_diArg_1	338	341	PF00400	0.515
TRG_ER_diArg_1	364	367	PF00400	0.412
TRG_ER_diArg_1	459	462	PF00400	0.349
TRG_ER_diArg_1	554	556	PF00400	0.425
TRG_ER_diArg_1	729	732	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	418	423	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	462	467	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8U3	Leptomonas seymouri	53%	95%
A0A1X0NM11	Trypanosomatidae	35%	100%
A0A3Q8IWN9	Leishmania donovani	79%	100%
A0A422NVW3	Trypanosoma rangeli	34%	100%
A4ICC6	Leishmania infantum	79%	100%
D0A3Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AUC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q069	Leishmania major	79%	100%
V5BM71	Trypanosoma cruzi	35%	100%