4HBT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioesterase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HQK3_LEIBR

TriTrypDb:

LbrM.35.7170 , LBRM2903_350084900

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016289	CoA hydrolase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0047617	acyl-CoA hydrolase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.349
CLV_PCSK_KEX2_1	60	62	PF00082	0.591
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.666
CLV_PCSK_SKI1_1	36	40	PF00082	0.560
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.622
DOC_MAPK_gen_1	120	130	PF00069	0.408
DOC_PP1_RVXF_1	34	41	PF00149	0.477
DOC_USP7_MATH_1	74	78	PF00917	0.495
DOC_WW_Pin1_4	38	43	PF00397	0.596
LIG_BRCT_BRCA1_1	106	110	PF00533	0.331
LIG_BRCT_BRCA1_1	97	101	PF00533	0.256
LIG_Clathr_ClatBox_1	121	125	PF01394	0.248
LIG_FHA_1	117	123	PF00498	0.309
LIG_FHA_1	129	135	PF00498	0.353
LIG_FHA_1	146	152	PF00498	0.531
LIG_FHA_1	2	8	PF00498	0.650
LIG_LIR_Gen_1	127	135	PF02991	0.296
LIG_LIR_Gen_1	80	90	PF02991	0.319
LIG_LIR_Nem_3	127	133	PF02991	0.296
LIG_LIR_Nem_3	80	85	PF02991	0.319
LIG_Pex14_2	101	105	PF04695	0.233
LIG_SH2_STAP1	30	34	PF00017	0.652
LIG_SH2_STAT3	90	93	PF00017	0.193
LIG_SH2_STAT5	90	93	PF00017	0.386
LIG_UBA3_1	7	14	PF00899	0.403
MOD_CDC14_SPxK_1	41	44	PF00782	0.648
MOD_CDK_SPxK_1	38	44	PF00069	0.647
MOD_CK1_1	104	110	PF00069	0.363
MOD_CK1_1	49	55	PF00069	0.526
MOD_GlcNHglycan	106	109	PF01048	0.400
MOD_GlcNHglycan	30	33	PF01048	0.632
MOD_GSK3_1	124	131	PF00069	0.433
MOD_GSK3_1	145	152	PF00069	0.548
MOD_GSK3_1	34	41	PF00069	0.642
MOD_GSK3_1	97	104	PF00069	0.301
MOD_N-GLC_1	28	33	PF02516	0.561
MOD_NEK2_1	10	15	PF00069	0.390
MOD_NEK2_1	101	106	PF00069	0.314
MOD_NEK2_1	124	129	PF00069	0.319
MOD_NEK2_1	34	39	PF00069	0.736
MOD_NEK2_2	66	71	PF00069	0.566
MOD_PIKK_1	60	66	PF00454	0.561
MOD_PKA_1	60	66	PF00069	0.660
MOD_PKA_2	145	151	PF00069	0.559
MOD_PKA_2	60	66	PF00069	0.670
MOD_Plk_1	101	107	PF00069	0.303
MOD_Plk_1	124	130	PF00069	0.307
MOD_Plk_2-3	97	103	PF00069	0.335
MOD_Plk_4	124	130	PF00069	0.351
MOD_Plk_4	49	55	PF00069	0.599
MOD_ProDKin_1	38	44	PF00069	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU0	Leptomonas seymouri	68%	100%
A0A0S4JPU2	Bodo saltans	33%	100%
A0A1X0NLI9	Trypanosomatidae	45%	100%
A0A3S7XCF9	Leishmania donovani	77%	100%
A0A422NVU3	Trypanosoma rangeli	49%	100%
A4ICC1	Leishmania infantum	78%	100%
D0A3Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AUB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q074	Leishmania major	77%	100%