LeishMANIAdb
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E3 UFM1-protein ligase 1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
E3 UFM1-protein ligase 1 homolog
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HQK2_LEIBR
TriTrypDb:
LbrM.35.7160 , LBRM2903_350084800 *
Length:
737

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HQK2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK2

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0032446 protein modification by small protein conjugation 6 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0070647 protein modification by small protein conjugation or removal 5 12
GO:0071569 protein ufmylation 7 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0006950 response to stress 2 1
GO:0009894 regulation of catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0019222 regulation of metabolic process 3 1
GO:0030162 regulation of proteolysis 6 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0042176 regulation of protein catabolic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050896 response to stimulus 1 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061136 regulation of proteasomal protein catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903050 regulation of proteolysis involved in protein catabolic process 7 1
GO:1990564 protein polyufmylation 8 1
GO:1990592 protein K69-linked ufmylation 9 1
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12
GO:0019787 ubiquitin-like protein transferase activity 3 12
GO:0061659 ubiquitin-like protein ligase activity 4 12
GO:0061666 UFM1 ligase activity 5 12
GO:0071568 UFM1 transferase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 204 206 PF00675 0.370
CLV_NRD_NRD_1 304 306 PF00675 0.665
CLV_NRD_NRD_1 307 309 PF00675 0.644
CLV_NRD_NRD_1 430 432 PF00675 0.466
CLV_NRD_NRD_1 585 587 PF00675 0.482
CLV_PCSK_KEX2_1 11 13 PF00082 0.449
CLV_PCSK_KEX2_1 204 206 PF00082 0.415
CLV_PCSK_KEX2_1 242 244 PF00082 0.415
CLV_PCSK_KEX2_1 585 587 PF00082 0.483
CLV_PCSK_KEX2_1 61 63 PF00082 0.328
CLV_PCSK_KEX2_1 652 654 PF00082 0.543
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.449
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.475
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.449
CLV_PCSK_PC1ET2_1 652 654 PF00082 0.543
CLV_PCSK_SKI1_1 152 156 PF00082 0.435
CLV_PCSK_SKI1_1 420 424 PF00082 0.535
CLV_Separin_Metazoa 195 199 PF03568 0.475
CLV_Separin_Metazoa 458 462 PF03568 0.545
DEG_APCC_DBOX_1 585 593 PF00400 0.428
DEG_Nend_UBRbox_2 1 3 PF02207 0.614
DOC_CDC14_PxL_1 352 360 PF14671 0.586
DOC_CYCLIN_RxL_1 149 156 PF00134 0.262
DOC_MAPK_gen_1 40 47 PF00069 0.349
DOC_MAPK_gen_1 431 437 PF00069 0.616
DOC_MAPK_gen_1 585 592 PF00069 0.556
DOC_MAPK_gen_1 597 605 PF00069 0.370
DOC_MAPK_gen_1 673 680 PF00069 0.442
DOC_MAPK_MEF2A_6 321 329 PF00069 0.685
DOC_MAPK_MEF2A_6 364 371 PF00069 0.501
DOC_MAPK_MEF2A_6 40 47 PF00069 0.413
DOC_MAPK_MEF2A_6 597 605 PF00069 0.524
DOC_MAPK_NFAT4_5 40 48 PF00069 0.433
DOC_MIT_MIM_1 8 16 PF04212 0.449
DOC_PP1_RVXF_1 511 518 PF00149 0.403
DOC_PP2B_LxvP_1 208 211 PF13499 0.344
DOC_PP4_FxxP_1 622 625 PF00568 0.476
DOC_USP7_MATH_1 298 302 PF00917 0.721
DOC_USP7_MATH_1 430 434 PF00917 0.572
DOC_USP7_MATH_1 618 622 PF00917 0.455
DOC_USP7_MATH_1 646 650 PF00917 0.611
DOC_USP7_UBL2_3 306 310 PF12436 0.795
DOC_WW_Pin1_4 621 626 PF00397 0.344
LIG_14-3-3_CanoR_1 12 17 PF00244 0.423
LIG_14-3-3_CanoR_1 271 281 PF00244 0.398
LIG_14-3-3_CanoR_1 455 463 PF00244 0.476
LIG_14-3-3_CanoR_1 532 542 PF00244 0.426
LIG_14-3-3_CanoR_1 585 590 PF00244 0.503
LIG_14-3-3_CanoR_1 691 699 PF00244 0.617
LIG_APCC_ABBA_1 375 380 PF00400 0.554
LIG_APCC_ABBA_1 578 583 PF00400 0.451
LIG_APCC_ABBA_1 601 606 PF00400 0.440
LIG_BRCT_BRCA1_1 146 150 PF00533 0.413
LIG_BRCT_BRCA1_1 342 346 PF00533 0.306
LIG_BRCT_BRCA1_1 347 351 PF00533 0.292
LIG_BRCT_BRCA1_2 146 152 PF00533 0.475
LIG_CaM_IQ_9 10 26 PF13499 0.383
LIG_eIF4E_1 203 209 PF01652 0.449
LIG_FHA_1 242 248 PF00498 0.458
LIG_FHA_1 315 321 PF00498 0.642
LIG_FHA_1 364 370 PF00498 0.427
LIG_FHA_1 406 412 PF00498 0.524
LIG_FHA_1 501 507 PF00498 0.540
LIG_FHA_1 524 530 PF00498 0.372
LIG_FHA_1 665 671 PF00498 0.476
LIG_FHA_1 729 735 PF00498 0.564
LIG_FHA_1 86 92 PF00498 0.437
LIG_FHA_2 54 60 PF00498 0.449
LIG_FHA_2 605 611 PF00498 0.501
LIG_FHA_2 715 721 PF00498 0.615
LIG_FHA_2 723 729 PF00498 0.548
LIG_GBD_Chelix_1 470 478 PF00786 0.519
LIG_LIR_Apic_2 275 281 PF02991 0.650
LIG_LIR_Apic_2 621 625 PF02991 0.471
LIG_LIR_Gen_1 138 146 PF02991 0.371
LIG_LIR_Gen_1 258 267 PF02991 0.228
LIG_LIR_Gen_1 454 464 PF02991 0.419
LIG_LIR_Gen_1 503 512 PF02991 0.467
LIG_LIR_Gen_1 56 65 PF02991 0.328
LIG_LIR_Gen_1 632 642 PF02991 0.531
LIG_LIR_Nem_3 138 143 PF02991 0.276
LIG_LIR_Nem_3 227 231 PF02991 0.423
LIG_LIR_Nem_3 232 237 PF02991 0.446
LIG_LIR_Nem_3 253 259 PF02991 0.325
LIG_LIR_Nem_3 382 388 PF02991 0.516
LIG_LIR_Nem_3 394 399 PF02991 0.472
LIG_LIR_Nem_3 454 459 PF02991 0.497
LIG_LIR_Nem_3 465 470 PF02991 0.389
LIG_LIR_Nem_3 503 508 PF02991 0.475
LIG_LIR_Nem_3 56 60 PF02991 0.328
LIG_LIR_Nem_3 632 637 PF02991 0.576
LIG_LYPXL_S_1 395 399 PF13949 0.567
LIG_LYPXL_yS_3 396 399 PF13949 0.570
LIG_NRBOX 41 47 PF00104 0.314
LIG_NRBOX 660 666 PF00104 0.463
LIG_PCNA_yPIPBox_3 39 52 PF02747 0.223
LIG_PCNA_yPIPBox_3 652 665 PF02747 0.322
LIG_SH2_CRK 259 263 PF00017 0.328
LIG_SH2_CRK 634 638 PF00017 0.339
LIG_SH2_NCK_1 278 282 PF00017 0.647
LIG_SH2_PTP2 234 237 PF00017 0.475
LIG_SH2_SRC 117 120 PF00017 0.328
LIG_SH2_STAP1 174 178 PF00017 0.368
LIG_SH2_STAP1 456 460 PF00017 0.392
LIG_SH2_STAT3 174 177 PF00017 0.385
LIG_SH2_STAT5 117 120 PF00017 0.328
LIG_SH2_STAT5 174 177 PF00017 0.344
LIG_SH2_STAT5 234 237 PF00017 0.323
LIG_SH2_STAT5 256 259 PF00017 0.297
LIG_SH2_STAT5 273 276 PF00017 0.541
LIG_SH2_STAT5 54 57 PF00017 0.351
LIG_SH3_3 565 571 PF00018 0.528
LIG_SH3_3 675 681 PF00018 0.417
LIG_SH3_3 75 81 PF00018 0.344
LIG_SUMO_SIM_par_1 365 370 PF11976 0.389
LIG_SUMO_SIM_par_1 407 412 PF11976 0.559
LIG_SUMO_SIM_par_1 614 621 PF11976 0.548
LIG_SUMO_SIM_par_1 731 737 PF11976 0.457
LIG_TRAF2_1 192 195 PF00917 0.475
LIG_TRAF2_1 414 417 PF00917 0.580
LIG_TRAF2_1 725 728 PF00917 0.577
LIG_TYR_ITIM 257 262 PF00017 0.328
LIG_UBA3_1 589 597 PF00899 0.569
LIG_WRC_WIRS_1 619 624 PF05994 0.479
LIG_WRC_WIRS_1 86 91 PF05994 0.444
MOD_CDC14_SPxK_1 624 627 PF00782 0.357
MOD_CDK_SPxK_1 621 627 PF00069 0.349
MOD_CDK_SPxxK_3 621 628 PF00069 0.353
MOD_CK1_1 153 159 PF00069 0.425
MOD_CK1_1 172 178 PF00069 0.404
MOD_CK1_1 296 302 PF00069 0.777
MOD_CK1_1 314 320 PF00069 0.575
MOD_CK1_1 525 531 PF00069 0.305
MOD_CK1_1 551 557 PF00069 0.532
MOD_CK1_1 621 627 PF00069 0.349
MOD_CK2_1 53 59 PF00069 0.449
MOD_CK2_1 604 610 PF00069 0.481
MOD_CK2_1 691 697 PF00069 0.600
MOD_CK2_1 714 720 PF00069 0.545
MOD_CK2_1 722 728 PF00069 0.474
MOD_Cter_Amidation 306 309 PF01082 0.664
MOD_GlcNHglycan 296 299 PF01048 0.764
MOD_GlcNHglycan 300 303 PF01048 0.786
MOD_GlcNHglycan 400 403 PF01048 0.611
MOD_GlcNHglycan 411 414 PF01048 0.501
MOD_GlcNHglycan 480 483 PF01048 0.598
MOD_GlcNHglycan 610 614 PF01048 0.463
MOD_GSK3_1 131 138 PF00069 0.357
MOD_GSK3_1 19 26 PF00069 0.428
MOD_GSK3_1 211 218 PF00069 0.223
MOD_GSK3_1 289 296 PF00069 0.697
MOD_GSK3_1 405 412 PF00069 0.483
MOD_GSK3_1 435 442 PF00069 0.573
MOD_GSK3_1 551 558 PF00069 0.582
MOD_GSK3_1 581 588 PF00069 0.490
MOD_GSK3_1 660 667 PF00069 0.493
MOD_GSK3_1 728 735 PF00069 0.501
MOD_N-GLC_1 548 553 PF02516 0.424
MOD_NEK2_1 135 140 PF00069 0.404
MOD_NEK2_1 150 155 PF00069 0.303
MOD_NEK2_1 250 255 PF00069 0.381
MOD_NEK2_1 436 441 PF00069 0.440
MOD_NEK2_1 478 483 PF00069 0.575
MOD_NEK2_1 508 513 PF00069 0.427
MOD_NEK2_1 522 527 PF00069 0.369
MOD_NEK2_1 581 586 PF00069 0.547
MOD_NEK2_1 604 609 PF00069 0.429
MOD_NEK2_1 611 616 PF00069 0.386
MOD_NEK2_1 664 669 PF00069 0.385
MOD_NEK2_2 618 623 PF00069 0.478
MOD_PIKK_1 551 557 PF00454 0.338
MOD_PIKK_1 566 572 PF00454 0.579
MOD_PK_1 139 145 PF00069 0.329
MOD_PK_1 597 603 PF00069 0.580
MOD_PKA_1 585 591 PF00069 0.508
MOD_PKA_2 314 320 PF00069 0.728
MOD_PKA_2 363 369 PF00069 0.362
MOD_PKA_2 430 436 PF00069 0.443
MOD_PKA_2 454 460 PF00069 0.534
MOD_PKA_2 585 591 PF00069 0.510
MOD_Plk_1 548 554 PF00069 0.431
MOD_Plk_2-3 53 59 PF00069 0.328
MOD_Plk_4 117 123 PF00069 0.464
MOD_Plk_4 145 151 PF00069 0.328
MOD_Plk_4 169 175 PF00069 0.413
MOD_Plk_4 230 236 PF00069 0.342
MOD_Plk_4 400 406 PF00069 0.502
MOD_Plk_4 436 442 PF00069 0.573
MOD_Plk_4 444 450 PF00069 0.478
MOD_Plk_4 525 531 PF00069 0.425
MOD_Plk_4 585 591 PF00069 0.578
MOD_Plk_4 660 666 PF00069 0.410
MOD_Plk_4 94 100 PF00069 0.427
MOD_ProDKin_1 621 627 PF00069 0.349
MOD_SUMO_for_1 60 63 PF00179 0.449
MOD_SUMO_for_1 692 695 PF00179 0.606
TRG_DiLeu_BaEn_1 108 113 PF01217 0.344
TRG_DiLeu_BaEn_1 400 405 PF01217 0.566
TRG_DiLeu_BaEn_1 5 10 PF01217 0.333
TRG_DiLeu_BaEn_4 194 200 PF01217 0.475
TRG_DiLeu_BaLyEn_6 208 213 PF01217 0.223
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.487
TRG_DiLeu_BaLyEn_6 588 593 PF01217 0.534
TRG_ENDOCYTIC_2 234 237 PF00928 0.457
TRG_ENDOCYTIC_2 259 262 PF00928 0.328
TRG_ENDOCYTIC_2 396 399 PF00928 0.570
TRG_ENDOCYTIC_2 456 459 PF00928 0.515
TRG_ENDOCYTIC_2 634 637 PF00928 0.566
TRG_ER_diArg_1 161 164 PF00400 0.475
TRG_ER_diArg_1 181 184 PF00400 0.145
TRG_ER_diArg_1 203 205 PF00400 0.417
TRG_NES_CRM1_1 365 380 PF08389 0.527
TRG_NLS_MonoExtC_3 304 309 PF00514 0.675
TRG_NLS_MonoExtN_4 303 309 PF00514 0.648
TRG_Pf-PMV_PEXEL_1 461 465 PF00026 0.525
TRG_Pf-PMV_PEXEL_1 62 66 PF00026 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM39 Leptomonas seymouri 66% 100%
A0A0S4JTJ6 Bodo saltans 34% 95%
A0A1X0NLV8 Trypanosomatidae 41% 98%
A0A3S7XCH5 Leishmania donovani 82% 100%
A0A422NVV8 Trypanosoma rangeli 42% 99%
A4ICC0 Leishmania infantum 81% 100%
D0A3Q3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AUB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4Q075 Leishmania major 82% 100%
V5AXN4 Trypanosoma cruzi 40% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS