SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HQK1_LEIBR

TriTrypDb:

LbrM.35.7140 , LBRM2903_350084600

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.591
CLV_NRD_NRD_1	153	155	PF00675	0.288
CLV_NRD_NRD_1	243	245	PF00675	0.288
CLV_NRD_NRD_1	93	95	PF00675	0.310
CLV_PCSK_KEX2_1	153	155	PF00082	0.340
CLV_PCSK_KEX2_1	93	95	PF00082	0.340
CLV_PCSK_SKI1_1	343	347	PF00082	0.299
CLV_PCSK_SKI1_1	393	397	PF00082	0.340
CLV_PCSK_SKI1_1	96	100	PF00082	0.306
DOC_ANK_TNKS_1	430	437	PF00023	0.538
DOC_CDC14_PxL_1	110	118	PF14671	0.540
DOC_CKS1_1	81	86	PF01111	0.485
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.519
DOC_MAPK_gen_1	244	251	PF00069	0.512
DOC_MAPK_gen_1	393	403	PF00069	0.516
DOC_MAPK_gen_1	93	101	PF00069	0.466
DOC_PP2B_LxvP_1	106	109	PF13499	0.509
DOC_PP2B_LxvP_1	99	102	PF13499	0.506
DOC_USP7_MATH_1	210	214	PF00917	0.497
DOC_USP7_MATH_1	89	93	PF00917	0.516
DOC_WW_Pin1_4	206	211	PF00397	0.509
DOC_WW_Pin1_4	307	312	PF00397	0.448
DOC_WW_Pin1_4	80	85	PF00397	0.465
LIG_14-3-3_CanoR_1	193	197	PF00244	0.462
LIG_14-3-3_CanoR_1	294	302	PF00244	0.459
LIG_14-3-3_CanoR_1	330	339	PF00244	0.540
LIG_14-3-3_CanoR_1	343	352	PF00244	0.378
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BRCT_BRCA1_1	212	216	PF00533	0.509
LIG_BRCT_BRCA1_1	408	412	PF00533	0.535
LIG_eIF4E_1	361	367	PF01652	0.425
LIG_FHA_1	172	178	PF00498	0.420
LIG_FHA_1	215	221	PF00498	0.478
LIG_FHA_1	30	36	PF00498	0.537
LIG_FHA_1	384	390	PF00498	0.449
LIG_FHA_1	73	79	PF00498	0.540
LIG_FHA_2	24	30	PF00498	0.540
LIG_FHA_2	49	55	PF00498	0.540
LIG_LIR_Gen_1	201	211	PF02991	0.504
LIG_LIR_Gen_1	213	224	PF02991	0.465
LIG_LIR_Gen_1	376	387	PF02991	0.540
LIG_LIR_Nem_3	197	203	PF02991	0.437
LIG_LIR_Nem_3	212	218	PF02991	0.434
LIG_LIR_Nem_3	376	382	PF02991	0.540
LIG_LYPXL_yS_3	103	106	PF13949	0.540
LIG_MLH1_MIPbox_1	212	216	PF16413	0.509
LIG_MYND_1	248	252	PF01753	0.540
LIG_PCNA_PIPBox_1	416	425	PF02747	0.377
LIG_PCNA_yPIPBox_3	415	424	PF02747	0.531
LIG_SH2_CRK	203	207	PF00017	0.456
LIG_SH2_CRK	379	383	PF00017	0.485
LIG_SH2_SRC	405	408	PF00017	0.528
LIG_SH2_STAP1	156	160	PF00017	0.443
LIG_SH2_STAP1	171	175	PF00017	0.407
LIG_SH2_STAP1	19	23	PF00017	0.495
LIG_SH2_STAP1	203	207	PF00017	0.488
LIG_SH2_STAP1	258	262	PF00017	0.540
LIG_SH2_STAT5	218	221	PF00017	0.438
LIG_SH2_STAT5	405	408	PF00017	0.353
LIG_SH2_STAT5	423	426	PF00017	0.373
LIG_SH3_3	106	112	PF00018	0.512
LIG_SH3_3	308	314	PF00018	0.485
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.486
LIG_SUMO_SIM_anti_2	384	391	PF11976	0.451
LIG_SUMO_SIM_par_1	388	394	PF11976	0.442
LIG_TRAF2_1	397	400	PF00917	0.465
LIG_TYR_ITIM	101	106	PF00017	0.465
LIG_TYR_ITIM	377	382	PF00017	0.485
LIG_WRC_WIRS_1	211	216	PF05994	0.509
LIG_WRC_WIRS_1	73	78	PF05994	0.540
MOD_CDK_SPK_2	80	85	PF00069	0.485
MOD_CK1_1	209	215	PF00069	0.499
MOD_CK1_1	310	316	PF00069	0.443
MOD_CK1_1	80	86	PF00069	0.485
MOD_CK2_1	23	29	PF00069	0.536
MOD_CK2_1	310	316	PF00069	0.509
MOD_CK2_1	330	336	PF00069	0.290
MOD_CK2_1	48	54	PF00069	0.540
MOD_GlcNHglycan	127	130	PF01048	0.294
MOD_GlcNHglycan	133	136	PF01048	0.298
MOD_GlcNHglycan	230	233	PF01048	0.322
MOD_GlcNHglycan	332	335	PF01048	0.340
MOD_GlcNHglycan	45	49	PF01048	0.340
MOD_GSK3_1	19	26	PF00069	0.484
MOD_GSK3_1	206	213	PF00069	0.474
MOD_GSK3_1	223	230	PF00069	0.382
MOD_GSK3_1	335	342	PF00069	0.515
MOD_GSK3_1	373	380	PF00069	0.491
MOD_GSK3_1	40	47	PF00069	0.540
MOD_GSK3_1	401	408	PF00069	0.491
MOD_N-GLC_1	367	372	PF02516	0.225
MOD_N-GLC_1	373	378	PF02516	0.225
MOD_NEK2_1	148	153	PF00069	0.540
MOD_NEK2_1	21	26	PF00069	0.526
MOD_NEK2_1	214	219	PF00069	0.435
MOD_NEK2_1	31	36	PF00069	0.502
MOD_NEK2_1	335	340	PF00069	0.491
MOD_NEK2_1	351	356	PF00069	0.342
MOD_NEK2_1	401	406	PF00069	0.425
MOD_NEK2_1	58	63	PF00069	0.504
MOD_NEK2_1	88	93	PF00069	0.521
MOD_NEK2_2	210	215	PF00069	0.509
MOD_NEK2_2	48	53	PF00069	0.540
MOD_OFUCOSY	365	371	PF10250	0.225
MOD_PIKK_1	148	154	PF00454	0.510
MOD_PIKK_1	58	64	PF00454	0.465
MOD_PIKK_1	83	89	PF00454	0.540
MOD_PKA_2	131	137	PF00069	0.516
MOD_PKA_2	192	198	PF00069	0.485
MOD_PKA_2	293	299	PF00069	0.454
MOD_PKA_2	89	95	PF00069	0.469
MOD_Plk_1	335	341	PF00069	0.519
MOD_Plk_1	373	379	PF00069	0.465
MOD_Plk_1	383	389	PF00069	0.376
MOD_Plk_1	399	405	PF00069	0.445
MOD_Plk_1	406	412	PF00069	0.339
MOD_Plk_1	53	59	PF00069	0.465
MOD_Plk_4	210	216	PF00069	0.454
MOD_Plk_4	335	341	PF00069	0.540
MOD_Plk_4	385	391	PF00069	0.439
MOD_ProDKin_1	206	212	PF00069	0.509
MOD_ProDKin_1	307	313	PF00069	0.448
MOD_ProDKin_1	80	86	PF00069	0.465
TRG_DiLeu_BaEn_1	271	276	PF01217	0.501
TRG_DiLeu_BaEn_2	284	290	PF01217	0.540
TRG_ENDOCYTIC_2	103	106	PF00928	0.465
TRG_ENDOCYTIC_2	156	159	PF00928	0.436
TRG_ENDOCYTIC_2	162	165	PF00928	0.436
TRG_ENDOCYTIC_2	18	21	PF00928	0.532
TRG_ENDOCYTIC_2	203	206	PF00928	0.444
TRG_ENDOCYTIC_2	218	221	PF00928	0.473
TRG_ENDOCYTIC_2	379	382	PF00928	0.485
TRG_NES_CRM1_1	271	286	PF08389	0.521
TRG_NLS_MonoExtN_4	93	98	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER3	Leptomonas seymouri	65%	100%
A0A0S4JT57	Bodo saltans	46%	85%
A0A1X0NMZ6	Trypanosomatidae	46%	100%
A0A422NVU9	Trypanosoma rangeli	45%	100%
D0A3Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
Q5PP37	Arabidopsis thaliana	23%	93%
V5BM67	Trypanosoma cruzi	46%	100%