Putative nuclear lim interactor-interacting factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear lim interactor-interacting factor, putative

Species:

Leishmania braziliensis

UniProt:

A4HQK0_LEIBR

TriTrypDb:

LbrM.35.7130 , LBRM2903_350084500

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0004721	phosphoprotein phosphatase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.408
CLV_NRD_NRD_1	281	283	PF00675	0.721
CLV_NRD_NRD_1	36	38	PF00675	0.640
CLV_NRD_NRD_1	6	8	PF00675	0.652
CLV_PCSK_FUR_1	127	131	PF00082	0.449
CLV_PCSK_KEX2_1	129	131	PF00082	0.449
CLV_PCSK_KEX2_1	281	283	PF00082	0.705
CLV_PCSK_KEX2_1	36	38	PF00082	0.637
CLV_PCSK_KEX2_1	5	7	PF00082	0.631
DEG_COP1_1	199	208	PF00400	0.427
DEG_SCF_FBW7_1	209	216	PF00400	0.463
DEG_SPOP_SBC_1	99	103	PF00917	0.449
DOC_CYCLIN_RxL_1	136	147	PF00134	0.449
DOC_MAPK_gen_1	197	205	PF00069	0.449
DOC_MAPK_gen_1	57	66	PF00069	0.322
DOC_MAPK_MEF2A_6	57	66	PF00069	0.281
DOC_PP4_FxxP_1	262	265	PF00568	0.541
DOC_USP7_MATH_1	274	278	PF00917	0.798
DOC_USP7_MATH_1	51	55	PF00917	0.357
DOC_WW_Pin1_4	154	159	PF00397	0.316
DOC_WW_Pin1_4	209	214	PF00397	0.531
DOC_WW_Pin1_4	35	40	PF00397	0.593
LIG_14-3-3_CanoR_1	214	221	PF00244	0.404
LIG_14-3-3_CanoR_1	59	63	PF00244	0.308
LIG_14-3-3_CanoR_1	6	12	PF00244	0.481
LIG_BRCT_BRCA1_1	258	262	PF00533	0.417
LIG_FHA_1	136	142	PF00498	0.350
LIG_FHA_1	148	154	PF00498	0.233
LIG_FHA_1	210	216	PF00498	0.524
LIG_FHA_1	29	35	PF00498	0.626
LIG_FHA_1	59	65	PF00498	0.281
LIG_FHA_2	202	208	PF00498	0.440
LIG_GBD_Chelix_1	62	70	PF00786	0.337
LIG_LIR_Apic_2	259	265	PF02991	0.529
LIG_LIR_Apic_2	46	50	PF02991	0.426
LIG_LIR_Nem_3	10	14	PF02991	0.559
LIG_NRBOX	183	189	PF00104	0.428
LIG_PCNA_PIPBox_1	84	93	PF02747	0.369
LIG_Pex14_2	258	262	PF04695	0.417
LIG_SH2_PTP2	79	82	PF00017	0.356
LIG_SH2_SRC	107	110	PF00017	0.356
LIG_SH2_STAP1	107	111	PF00017	0.316
LIG_SH2_STAP1	164	168	PF00017	0.445
LIG_SH2_STAT3	72	75	PF00017	0.449
LIG_SH2_STAT5	15	18	PF00017	0.575
LIG_SH2_STAT5	208	211	PF00017	0.452
LIG_SH2_STAT5	231	234	PF00017	0.427
LIG_SH2_STAT5	250	253	PF00017	0.418
LIG_SH2_STAT5	47	50	PF00017	0.502
LIG_SH2_STAT5	79	82	PF00017	0.319
LIG_SH2_STAT5	94	97	PF00017	0.273
LIG_SH3_1	47	53	PF00018	0.538
LIG_SH3_3	11	17	PF00018	0.601
LIG_SH3_3	47	53	PF00018	0.512
LIG_SUMO_SIM_par_1	149	155	PF11976	0.339
LIG_SUMO_SIM_par_1	60	65	PF11976	0.309
MOD_CDK_SPK_2	209	214	PF00069	0.547
MOD_CK1_1	245	251	PF00069	0.674
MOD_CK1_1	277	283	PF00069	0.475
MOD_CK2_1	201	207	PF00069	0.433
MOD_CK2_1	24	30	PF00069	0.633
MOD_GlcNHglycan	135	138	PF01048	0.375
MOD_GlcNHglycan	251	254	PF01048	0.559
MOD_GlcNHglycan	259	262	PF01048	0.662
MOD_GSK3_1	209	216	PF00069	0.499
MOD_GSK3_1	219	226	PF00069	0.552
MOD_GSK3_1	24	31	PF00069	0.586
MOD_GSK3_1	245	252	PF00069	0.594
MOD_GSK3_1	35	42	PF00069	0.637
MOD_GSK3_1	94	101	PF00069	0.331
MOD_N-GLC_1	132	137	PF02516	0.415
MOD_N-GLC_1	256	261	PF02516	0.723
MOD_NEK2_1	132	137	PF00069	0.404
MOD_NEK2_1	148	153	PF00069	0.216
MOD_NEK2_1	24	29	PF00069	0.595
MOD_NEK2_1	66	71	PF00069	0.311
MOD_NEK2_2	180	185	PF00069	0.388
MOD_PIKK_1	213	219	PF00454	0.392
MOD_PK_1	37	43	PF00069	0.642
MOD_PKA_2	213	219	PF00069	0.422
MOD_PKA_2	58	64	PF00069	0.340
MOD_PKB_1	5	13	PF00069	0.526
MOD_Plk_1	148	154	PF00069	0.342
MOD_Plk_1	180	186	PF00069	0.314
MOD_Plk_1	24	30	PF00069	0.653
MOD_Plk_1	66	72	PF00069	0.314
MOD_Plk_2-3	201	207	PF00069	0.466
MOD_Plk_4	121	127	PF00069	0.319
MOD_Plk_4	148	154	PF00069	0.361
MOD_Plk_4	58	64	PF00069	0.321
MOD_Plk_4	66	72	PF00069	0.303
MOD_Plk_4	83	89	PF00069	0.356
MOD_Plk_4	94	100	PF00069	0.253
MOD_ProDKin_1	154	160	PF00069	0.316
MOD_ProDKin_1	209	215	PF00069	0.525
MOD_ProDKin_1	35	41	PF00069	0.584
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.456
TRG_ER_diArg_1	126	129	PF00400	0.429
TRG_ER_diArg_1	270	273	PF00400	0.749
TRG_ER_diArg_1	35	37	PF00400	0.607
TRG_ER_diArg_1	5	7	PF00400	0.530
TRG_NES_CRM1_1	55	68	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	74%	100%
A0A0N1IKD3	Leptomonas seymouri	42%	100%
A0A0S4IUQ9	Bodo saltans	35%	81%
A0A0S4JU61	Bodo saltans	52%	100%
A0A0S4JWE2	Bodo saltans	41%	100%
A0A1X0NJT2	Trypanosomatidae	42%	100%
A0A1X0NLU1	Trypanosomatidae	52%	100%
A0A1X0P5T3	Trypanosomatidae	34%	92%
A0A1X0PA23	Trypanosomatidae	32%	83%
A0A3R7NSE5	Trypanosoma rangeli	40%	100%
A0A3S7X8P8	Leishmania donovani	43%	100%
A0A3S7XCG7	Leishmania donovani	88%	100%
A0A422NVW2	Trypanosoma rangeli	52%	100%
A4HM58	Leishmania braziliensis	43%	100%
A4IAS0	Leishmania infantum	43%	100%
A4ICB8	Leishmania infantum	88%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	69%
C9ZL07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	80%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A2E1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A3Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AEA2	Leishmania major	37%	100%
E9AEJ6	Leishmania major	43%	100%
E9AUB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
Q4Q077	Leishmania major	88%	100%
V5BHN4	Trypanosoma cruzi	53%	100%
V5BSW0	Trypanosoma cruzi	40%	100%
V5BX67	Trypanosoma cruzi	36%	79%