AP complex subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta adaptin, putative

Species:

Leishmania braziliensis

UniProt:

A4HQJ9_LEIBR

TriTrypDb:

LbrM.35.7120 , LBRM2903_350084400

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	10
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0030119	AP-type membrane coat adaptor complex	3	2
GO:0030131	clathrin adaptor complex	4	2

Expansion

Sequence features

A4HQJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQJ9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0030276	clathrin binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	569	573	PF00656	0.426
CLV_NRD_NRD_1	13	15	PF00675	0.441
CLV_NRD_NRD_1	146	148	PF00675	0.251
CLV_NRD_NRD_1	156	158	PF00675	0.233
CLV_NRD_NRD_1	30	32	PF00675	0.346
CLV_NRD_NRD_1	308	310	PF00675	0.170
CLV_NRD_NRD_1	415	417	PF00675	0.315
CLV_NRD_NRD_1	432	434	PF00675	0.165
CLV_NRD_NRD_1	47	49	PF00675	0.277
CLV_NRD_NRD_1	5	7	PF00675	0.408
CLV_NRD_NRD_1	553	555	PF00675	0.451
CLV_PCSK_KEX2_1	146	148	PF00082	0.277
CLV_PCSK_KEX2_1	30	32	PF00082	0.506
CLV_PCSK_KEX2_1	308	310	PF00082	0.389
CLV_PCSK_KEX2_1	54	56	PF00082	0.243
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.243
CLV_PCSK_SKI1_1	102	106	PF00082	0.389
CLV_PCSK_SKI1_1	355	359	PF00082	0.243
CLV_PCSK_SKI1_1	504	508	PF00082	0.259
CLV_PCSK_SKI1_1	546	550	PF00082	0.539
CLV_PCSK_SKI1_1	721	725	PF00082	0.500
CLV_Separin_Fungi	716	722	PF03568	0.492
CLV_Separin_Metazoa	143	147	PF03568	0.258
CLV_Separin_Metazoa	387	391	PF03568	0.326
DEG_APCC_DBOX_1	332	340	PF00400	0.170
DEG_APCC_DBOX_1	492	500	PF00400	0.389
DEG_Nend_UBRbox_2	1	3	PF02207	0.444
DOC_CDC14_PxL_1	690	698	PF14671	0.515
DOC_CKS1_1	360	365	PF01111	0.259
DOC_CKS1_1	622	627	PF01111	0.684
DOC_CYCLIN_RxL_1	350	362	PF00134	0.258
DOC_CYCLIN_RxL_1	97	109	PF00134	0.305
DOC_MAPK_DCC_7	342	351	PF00069	0.243
DOC_MAPK_gen_1	157	164	PF00069	0.268
DOC_MAPK_gen_1	181	187	PF00069	0.389
DOC_MAPK_gen_1	350	360	PF00069	0.243
DOC_MAPK_gen_1	433	441	PF00069	0.243
DOC_MAPK_gen_1	85	92	PF00069	0.243
DOC_MAPK_HePTP_8	316	328	PF00069	0.243
DOC_MAPK_HePTP_8	339	351	PF00069	0.170
DOC_MAPK_MEF2A_6	127	134	PF00069	0.282
DOC_MAPK_MEF2A_6	319	328	PF00069	0.243
DOC_MAPK_MEF2A_6	342	351	PF00069	0.243
DOC_MAPK_MEF2A_6	353	360	PF00069	0.243
DOC_MAPK_MEF2A_6	390	399	PF00069	0.247
DOC_MAPK_MEF2A_6	433	440	PF00069	0.277
DOC_MAPK_MEF2A_6	64	73	PF00069	0.292
DOC_MAPK_MEF2A_6	85	92	PF00069	0.277
DOC_MAPK_NFAT4_5	353	361	PF00069	0.243
DOC_MAPK_RevD_3	71	86	PF00069	0.243
DOC_PP2B_LxvP_1	679	682	PF13499	0.467
DOC_PP2B_LxvP_1	696	699	PF13499	0.473
DOC_PP4_FxxP_1	590	593	PF00568	0.370
DOC_PP4_FxxP_1	597	600	PF00568	0.389
DOC_USP7_MATH_1	263	267	PF00917	0.466
DOC_USP7_MATH_1	458	462	PF00917	0.243
DOC_USP7_MATH_1	593	597	PF00917	0.370
DOC_USP7_MATH_1	634	638	PF00917	0.659
DOC_USP7_UBL2_3	20	24	PF12436	0.550
DOC_USP7_UBL2_3	50	54	PF12436	0.246
DOC_WW_Pin1_4	115	120	PF00397	0.243
DOC_WW_Pin1_4	285	290	PF00397	0.170
DOC_WW_Pin1_4	359	364	PF00397	0.259
DOC_WW_Pin1_4	621	626	PF00397	0.612
DOC_WW_Pin1_4	630	635	PF00397	0.568
DOC_WW_Pin1_4	684	689	PF00397	0.652
DOC_WW_Pin1_4	698	703	PF00397	0.651
LIG_14-3-3_CanoR_1	133	138	PF00244	0.450
LIG_14-3-3_CanoR_1	157	164	PF00244	0.268
LIG_14-3-3_CanoR_1	264	272	PF00244	0.246
LIG_14-3-3_CanoR_1	294	298	PF00244	0.256
LIG_14-3-3_CanoR_1	342	346	PF00244	0.256
LIG_14-3-3_CanoR_1	568	576	PF00244	0.555
LIG_14-3-3_CanoR_1	592	598	PF00244	0.456
LIG_14-3-3_CanoR_1	721	726	PF00244	0.764
LIG_Actin_WH2_2	130	148	PF00022	0.258
LIG_Actin_WH2_2	344	361	PF00022	0.305
LIG_Actin_WH2_2	567	582	PF00022	0.431
LIG_BRCT_BRCA1_1	22	26	PF00533	0.444
LIG_BRCT_BRCA1_1	66	70	PF00533	0.258
LIG_BRCT_BRCA1_1	686	690	PF00533	0.632
LIG_Clathr_ClatBox_1	438	442	PF01394	0.337
LIG_EVH1_1	621	625	PF00568	0.509
LIG_FHA_1	257	263	PF00498	0.337
LIG_FHA_1	294	300	PF00498	0.363
LIG_FHA_1	311	317	PF00498	0.169
LIG_FHA_1	583	589	PF00498	0.387
LIG_FHA_1	704	710	PF00498	0.798
LIG_FHA_1	93	99	PF00498	0.389
LIG_FHA_2	332	338	PF00498	0.380
LIG_FHA_2	484	490	PF00498	0.368
LIG_FHA_2	567	573	PF00498	0.489
LIG_FHA_2	611	617	PF00498	0.686
LIG_FHA_2	706	712	PF00498	0.655
LIG_FHA_2	78	84	PF00498	0.337
LIG_GBD_Chelix_1	134	142	PF00786	0.170
LIG_LIR_Apic_2	596	600	PF02991	0.402
LIG_LIR_Gen_1	345	356	PF02991	0.312
LIG_LIR_Gen_1	468	473	PF02991	0.243
LIG_LIR_Gen_1	591	601	PF02991	0.293
LIG_LIR_Gen_1	65	76	PF02991	0.246
LIG_LIR_Gen_1	674	684	PF02991	0.616
LIG_LIR_Nem_3	337	343	PF02991	0.295
LIG_LIR_Nem_3	345	351	PF02991	0.296
LIG_LIR_Nem_3	372	376	PF02991	0.370
LIG_LIR_Nem_3	468	472	PF02991	0.249
LIG_LIR_Nem_3	591	597	PF02991	0.415
LIG_LIR_Nem_3	65	71	PF02991	0.265
LIG_LIR_Nem_3	674	679	PF02991	0.672
LIG_LYPXL_yS_3	435	438	PF13949	0.246
LIG_MAD2	555	563	PF02301	0.514
LIG_MLH1_MIPbox_1	22	26	PF16413	0.444
LIG_MYND_1	418	422	PF01753	0.258
LIG_NRBOX	183	189	PF00104	0.258
LIG_NRBOX	353	359	PF00104	0.258
LIG_NRBOX	516	522	PF00104	0.312
LIG_PCNA_yPIPBox_3	294	307	PF02747	0.296
LIG_Pex14_1	234	238	PF04695	0.302
LIG_SH2_NCK_1	343	347	PF00017	0.305
LIG_SH2_SRC	89	92	PF00017	0.243
LIG_SH2_STAT3	25	28	PF00017	0.582
LIG_SH2_STAT5	140	143	PF00017	0.291
LIG_SH2_STAT5	155	158	PF00017	0.301
LIG_SH2_STAT5	238	241	PF00017	0.382
LIG_SH2_STAT5	25	28	PF00017	0.582
LIG_SH2_STAT5	315	318	PF00017	0.258
LIG_SH2_STAT5	340	343	PF00017	0.245
LIG_SH2_STAT5	469	472	PF00017	0.386
LIG_SH2_STAT5	68	71	PF00017	0.302
LIG_SH2_STAT5	89	92	PF00017	0.243
LIG_SH3_3	146	152	PF00018	0.304
LIG_SH3_3	323	329	PF00018	0.243
LIG_SH3_3	619	625	PF00018	0.612
LIG_SH3_3	675	681	PF00018	0.462
LIG_SH3_3	696	702	PF00018	0.740
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.341
LIG_SUMO_SIM_anti_2	334	340	PF11976	0.170
LIG_SUMO_SIM_par_1	103	109	PF11976	0.389
LIG_SUMO_SIM_par_1	437	443	PF11976	0.294
LIG_TRAF2_1	454	457	PF00917	0.170
LIG_TRFH_1	140	144	PF08558	0.258
LIG_TYR_ITIM	66	71	PF00017	0.389
LIG_TYR_ITIM	87	92	PF00017	0.243
LIG_UBA3_1	174	182	PF00899	0.337
LIG_UBA3_1	394	398	PF00899	0.277
LIG_UBA3_1	409	417	PF00899	0.139
LIG_UBA3_1	520	526	PF00899	0.170
LIG_WRC_WIRS_1	107	112	PF05994	0.243
LIG_WRC_WIRS_1	594	599	PF05994	0.368
MOD_CDK_SPxxK_3	115	122	PF00069	0.243
MOD_CK1_1	253	259	PF00069	0.333
MOD_CK1_1	285	291	PF00069	0.348
MOD_CK1_1	497	503	PF00069	0.277
MOD_CK1_1	582	588	PF00069	0.415
MOD_CK1_1	701	707	PF00069	0.663
MOD_CK2_1	133	139	PF00069	0.316
MOD_CK2_1	213	219	PF00069	0.389
MOD_CK2_1	483	489	PF00069	0.341
MOD_CK2_1	77	83	PF00069	0.337
MOD_GlcNHglycan	252	255	PF01048	0.337
MOD_GlcNHglycan	363	366	PF01048	0.337
MOD_GlcNHglycan	377	380	PF01048	0.395
MOD_GlcNHglycan	499	502	PF01048	0.243
MOD_GlcNHglycan	636	639	PF01048	0.690
MOD_GlcNHglycan	660	663	PF01048	0.641
MOD_GlcNHglycan	729	732	PF01048	0.706
MOD_GSK3_1	111	118	PF00069	0.258
MOD_GSK3_1	16	23	PF00069	0.467
MOD_GSK3_1	298	305	PF00069	0.255
MOD_GSK3_1	542	549	PF00069	0.389
MOD_GSK3_1	568	575	PF00069	0.466
MOD_GSK3_1	626	633	PF00069	0.577
MOD_GSK3_1	701	708	PF00069	0.729
MOD_N-GLC_1	115	120	PF02516	0.266
MOD_N-GLC_1	41	46	PF02516	0.337
MOD_N-GLC_1	58	63	PF02516	0.337
MOD_NEK2_1	111	116	PF00069	0.258
MOD_NEK2_1	16	21	PF00069	0.473
MOD_NEK2_1	194	199	PF00069	0.189
MOD_NEK2_1	26	31	PF00069	0.420
MOD_NEK2_1	331	336	PF00069	0.326
MOD_NEK2_1	358	363	PF00069	0.170
MOD_NEK2_1	440	445	PF00069	0.170
MOD_NEK2_1	483	488	PF00069	0.395
MOD_NEK2_1	544	549	PF00069	0.170
MOD_NEK2_1	579	584	PF00069	0.361
MOD_PIKK_1	310	316	PF00454	0.277
MOD_PIKK_1	626	632	PF00454	0.749
MOD_PIKK_1	736	742	PF00454	0.618
MOD_PK_1	133	139	PF00069	0.302
MOD_PKA_2	156	162	PF00069	0.258
MOD_PKA_2	263	269	PF00069	0.216
MOD_PKA_2	293	299	PF00069	0.350
MOD_PKA_2	341	347	PF00069	0.256
MOD_PKA_2	736	742	PF00069	0.618
MOD_PKB_1	719	727	PF00069	0.499
MOD_Plk_1	138	144	PF00069	0.243
MOD_Plk_1	566	572	PF00069	0.450
MOD_Plk_1	58	64	PF00069	0.275
MOD_Plk_2-3	572	578	PF00069	0.415
MOD_Plk_2-3	610	616	PF00069	0.590
MOD_Plk_4	106	112	PF00069	0.243
MOD_Plk_4	133	139	PF00069	0.389
MOD_Plk_4	253	259	PF00069	0.311
MOD_Plk_4	302	308	PF00069	0.277
MOD_Plk_4	440	446	PF00069	0.200
MOD_Plk_4	458	464	PF00069	0.316
MOD_Plk_4	483	489	PF00069	0.374
MOD_Plk_4	494	500	PF00069	0.325
MOD_Plk_4	593	599	PF00069	0.402
MOD_Plk_4	64	70	PF00069	0.302
MOD_ProDKin_1	115	121	PF00069	0.243
MOD_ProDKin_1	285	291	PF00069	0.170
MOD_ProDKin_1	359	365	PF00069	0.259
MOD_ProDKin_1	621	627	PF00069	0.614
MOD_ProDKin_1	630	636	PF00069	0.565
MOD_ProDKin_1	684	690	PF00069	0.656
MOD_ProDKin_1	698	704	PF00069	0.652
MOD_SUMO_for_1	349	352	PF00179	0.243
MOD_SUMO_rev_2	451	461	PF00179	0.284
MOD_SUMO_rev_2	572	582	PF00179	0.413
MOD_SUMO_rev_2	79	87	PF00179	0.389
TRG_AP2beta_CARGO_1	345	355	PF09066	0.305
TRG_DiLeu_BaEn_1	352	357	PF01217	0.243
TRG_DiLeu_BaEn_1	83	88	PF01217	0.243
TRG_DiLeu_BaEn_2	467	473	PF01217	0.243
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.243
TRG_DiLeu_LyEn_5	352	357	PF01217	0.258
TRG_ENDOCYTIC_2	435	438	PF00928	0.246
TRG_ENDOCYTIC_2	469	472	PF00928	0.389
TRG_ENDOCYTIC_2	540	543	PF00928	0.291
TRG_ENDOCYTIC_2	594	597	PF00928	0.372
TRG_ENDOCYTIC_2	643	646	PF00928	0.767
TRG_ENDOCYTIC_2	68	71	PF00928	0.302
TRG_ENDOCYTIC_2	89	92	PF00928	0.243
TRG_ER_diArg_1	145	147	PF00400	0.277
TRG_ER_diArg_1	307	309	PF00400	0.170
TRG_NES_CRM1_1	495	509	PF08389	0.352
TRG_NLS_Bipartite_1	30	52	PF00514	0.389
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	707	711	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B0	Leptomonas seymouri	80%	100%
A0A0N1IC81	Leptomonas seymouri	26%	96%
A0A0S4IS43	Bodo saltans	32%	79%
A0A0S4J8G3	Bodo saltans	26%	100%
A0A0S4JSJ9	Bodo saltans	58%	76%
A0A1X0NL72	Trypanosomatidae	64%	77%
A0A1X0NUY1	Trypanosomatidae	31%	81%
A0A1X0P0E5	Trypanosomatidae	26%	95%
A0A3Q8I939	Leishmania donovani	28%	75%
A0A3Q8IK57	Leishmania donovani	87%	100%
A0A3R7L5L0	Trypanosoma rangeli	29%	82%
A0A3S5IS14	Trypanosoma rangeli	58%	78%
A0A422NKG4	Trypanosoma rangeli	27%	96%
A4HV08	Leishmania infantum	28%	75%
A4ICB7	Leishmania infantum	86%	100%
D0A3P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
D0A442	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
E9AUB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O00203	Homo sapiens	25%	68%
O13939	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O35643	Mus musculus	37%	79%
O43005	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O43079	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O81742	Arabidopsis thaliana	37%	84%
P27351	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P36000	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P46682	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	92%
P52303	Rattus norvegicus	37%	79%
P62944	Rattus norvegicus	36%	80%
P63009	Bos taurus	36%	80%
P63010	Homo sapiens	36%	80%
Q08DS7	Bos taurus	36%	78%
Q10567	Homo sapiens	38%	79%
Q13367	Homo sapiens	26%	69%
Q22498	Caenorhabditis elegans	20%	86%
Q32PG1	Bos taurus	25%	69%
Q4Q078	Leishmania major	85%	100%
Q54R84	Dictyostelium discoideum	26%	89%
Q54X82	Dictyostelium discoideum	38%	79%
Q759E2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	96%
Q7YRF1	Canis lupus familiaris	25%	68%
Q9DBG3	Mus musculus	36%	80%
Q9JME5	Mus musculus	26%	69%
Q9LDK9	Arabidopsis thaliana	27%	89%
Q9SUS3	Arabidopsis thaliana	37%	83%
Q9WV76	Mus musculus	28%	100%
Q9Y6B7	Homo sapiens	27%	100%
Q9Z1T1	Mus musculus	25%	68%
V5BRU9	Trypanosoma cruzi	31%	82%
V5BTB0	Trypanosoma cruzi	25%	96%
V5DDV1	Trypanosoma cruzi	58%	78%