Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prolyl endopeptidase

Species:

Leishmania braziliensis

UniProt:

A4HQJ7_LEIBR

TriTrypDb:

LbrM.35.7100 , LBRM2903_350084200

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4HQJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004252	serine-type endopeptidase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008236	serine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0017171	serine hydrolase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0070012	oligopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.428
CLV_C14_Caspase3-7	438	442	PF00656	0.388
CLV_NRD_NRD_1	309	311	PF00675	0.277
CLV_NRD_NRD_1	358	360	PF00675	0.359
CLV_NRD_NRD_1	9	11	PF00675	0.299
CLV_PCSK_KEX2_1	9	11	PF00082	0.300
CLV_PCSK_SKI1_1	353	357	PF00082	0.249
DEG_Nend_UBRbox_1	1	4	PF02207	0.517
DOC_CDC14_PxL_1	186	194	PF14671	0.495
DOC_CYCLIN_yClb5_NLxxxL_5	484	493	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	653	659	PF00134	0.432
DOC_MAPK_gen_1	106	114	PF00069	0.409
DOC_MAPK_gen_1	310	318	PF00069	0.464
DOC_MAPK_gen_1	385	391	PF00069	0.437
DOC_MAPK_MEF2A_6	106	114	PF00069	0.510
DOC_MAPK_MEF2A_6	310	318	PF00069	0.520
DOC_MAPK_MEF2A_6	341	349	PF00069	0.495
DOC_MAPK_NFAT4_5	311	319	PF00069	0.424
DOC_MAPK_RevD_3	345	360	PF00069	0.409
DOC_PP1_RVXF_1	165	171	PF00149	0.520
DOC_PP1_RVXF_1	273	280	PF00149	0.618
DOC_PP2B_LxvP_1	226	229	PF13499	0.477
DOC_PP2B_LxvP_1	493	496	PF13499	0.317
DOC_PP2B_PxIxI_1	620	626	PF00149	0.317
DOC_PP4_FxxP_1	113	116	PF00568	0.464
DOC_PP4_FxxP_1	396	399	PF00568	0.464
DOC_PP4_FxxP_1	669	672	PF00568	0.432
DOC_USP7_MATH_1	399	403	PF00917	0.487
DOC_USP7_MATH_1	410	414	PF00917	0.477
DOC_USP7_MATH_1	636	640	PF00917	0.299
DOC_USP7_MATH_1	73	77	PF00917	0.495
DOC_USP7_UBL2_3	603	607	PF12436	0.318
DOC_USP7_UBL2_3	671	675	PF12436	0.312
DOC_WW_Pin1_4	457	462	PF00397	0.340
DOC_WW_Pin1_4	472	477	PF00397	0.325
DOC_WW_Pin1_4	535	540	PF00397	0.329
DOC_WW_Pin1_4	606	611	PF00397	0.299
LIG_14-3-3_CanoR_1	10	16	PF00244	0.484
LIG_14-3-3_CanoR_1	65	72	PF00244	0.505
LIG_APCC_ABBA_1	345	350	PF00400	0.495
LIG_APCC_ABBA_1	414	419	PF00400	0.392
LIG_APCC_ABBAyCdc20_2	109	115	PF00400	0.409
LIG_BRCT_BRCA1_1	314	318	PF00533	0.567
LIG_CSL_BTD_1	588	591	PF09270	0.221
LIG_deltaCOP1_diTrp_1	175	185	PF00928	0.423
LIG_FHA_1	12	18	PF00498	0.559
LIG_FHA_1	122	128	PF00498	0.423
LIG_FHA_1	539	545	PF00498	0.299
LIG_FHA_1	65	71	PF00498	0.522
LIG_FHA_2	19	25	PF00498	0.500
LIG_FHA_2	318	324	PF00498	0.534
LIG_FHA_2	366	372	PF00498	0.474
LIG_FHA_2	419	425	PF00498	0.560
LIG_FHA_2	647	653	PF00498	0.287
LIG_FHA_2	674	680	PF00498	0.232
LIG_LIR_Apic_2	111	116	PF02991	0.477
LIG_LIR_Apic_2	394	399	PF02991	0.464
LIG_LIR_Apic_2	592	596	PF02991	0.299
LIG_LIR_Gen_1	148	158	PF02991	0.477
LIG_LIR_Gen_1	24	32	PF02991	0.478
LIG_LIR_Gen_1	243	252	PF02991	0.482
LIG_LIR_Gen_1	387	396	PF02991	0.559
LIG_LIR_Gen_1	481	489	PF02991	0.221
LIG_LIR_Gen_1	507	514	PF02991	0.221
LIG_LIR_Gen_1	563	572	PF02991	0.432
LIG_LIR_Gen_1	681	691	PF02991	0.302
LIG_LIR_Nem_3	148	153	PF02991	0.454
LIG_LIR_Nem_3	171	176	PF02991	0.467
LIG_LIR_Nem_3	24	29	PF02991	0.496
LIG_LIR_Nem_3	243	249	PF02991	0.482
LIG_LIR_Nem_3	269	273	PF02991	0.554
LIG_LIR_Nem_3	289	293	PF02991	0.456
LIG_LIR_Nem_3	378	384	PF02991	0.537
LIG_LIR_Nem_3	387	391	PF02991	0.497
LIG_LIR_Nem_3	46	51	PF02991	0.511
LIG_LIR_Nem_3	481	485	PF02991	0.221
LIG_LIR_Nem_3	507	511	PF02991	0.273
LIG_LIR_Nem_3	563	568	PF02991	0.332
LIG_LIR_Nem_3	600	605	PF02991	0.317
LIG_LIR_Nem_3	606	611	PF02991	0.300
LIG_LIR_Nem_3	83	89	PF02991	0.437
LIG_LYPXL_yS_3	189	192	PF13949	0.495
LIG_LYPXL_yS_3	620	623	PF13949	0.299
LIG_PAM2_1	76	88	PF00658	0.559
LIG_PCNA_yPIPBox_3	275	287	PF02747	0.483
LIG_PCNA_yPIPBox_3	571	582	PF02747	0.312
LIG_Pex14_1	589	593	PF04695	0.299
LIG_REV1ctd_RIR_1	182	189	PF16727	0.464
LIG_SH2_CRK	290	294	PF00017	0.447
LIG_SH2_CRK	358	362	PF00017	0.510
LIG_SH2_NCK_1	437	441	PF00017	0.326
LIG_SH2_PTP2	152	155	PF00017	0.559
LIG_SH2_SRC	152	155	PF00017	0.474
LIG_SH2_STAP1	684	688	PF00017	0.317
LIG_SH2_STAT5	152	155	PF00017	0.523
LIG_SH2_STAT5	209	212	PF00017	0.564
LIG_SH2_STAT5	246	249	PF00017	0.495
LIG_SH2_STAT5	28	31	PF00017	0.523
LIG_SH2_STAT5	292	295	PF00017	0.463
LIG_SH2_STAT5	348	351	PF00017	0.470
LIG_SH2_STAT5	403	406	PF00017	0.520
LIG_SH2_STAT5	482	485	PF00017	0.221
LIG_SH2_STAT5	642	645	PF00017	0.299
LIG_SH3_3	226	232	PF00018	0.475
LIG_SH3_3	615	621	PF00018	0.377
LIG_SH3_4	671	678	PF00018	0.299
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.495
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.409
LIG_SUMO_SIM_par_1	312	317	PF11976	0.437
LIG_SUMO_SIM_par_1	622	629	PF11976	0.299
LIG_TRAF2_1	320	323	PF00917	0.520
LIG_TRAF2_1	676	679	PF00917	0.221
LIG_TYR_ITIM	356	361	PF00017	0.437
LIG_TYR_ITIM	618	623	PF00017	0.317
LIG_UBA3_1	260	265	PF00899	0.520
LIG_UBA3_1	345	353	PF00899	0.453
LIG_WRC_WIRS_1	283	288	PF05994	0.570
LIG_WRC_WIRS_1	388	393	PF05994	0.483
MOD_CDK_SPxxK_3	472	479	PF00069	0.261
MOD_CK1_1	171	177	PF00069	0.561
MOD_CK1_1	238	244	PF00069	0.409
MOD_CK1_1	332	338	PF00069	0.421
MOD_CK1_1	457	463	PF00069	0.477
MOD_CK1_1	538	544	PF00069	0.317
MOD_CK1_1	55	61	PF00069	0.480
MOD_CK1_1	76	82	PF00069	0.520
MOD_CK2_1	130	136	PF00069	0.470
MOD_CK2_1	18	24	PF00069	0.495
MOD_CK2_1	30	36	PF00069	0.495
MOD_CK2_1	301	307	PF00069	0.518
MOD_CK2_1	317	323	PF00069	0.465
MOD_CK2_1	51	57	PF00069	0.530
MOD_CK2_1	646	652	PF00069	0.442
MOD_CK2_1	673	679	PF00069	0.488
MOD_GlcNHglycan	119	122	PF01048	0.354
MOD_GlcNHglycan	249	252	PF01048	0.271
MOD_GlcNHglycan	456	459	PF01048	0.552
MOD_GlcNHglycan	525	528	PF01048	0.423
MOD_GSK3_1	117	124	PF00069	0.520
MOD_GSK3_1	141	148	PF00069	0.523
MOD_GSK3_1	296	303	PF00069	0.560
MOD_GSK3_1	30	37	PF00069	0.474
MOD_GSK3_1	376	383	PF00069	0.477
MOD_GSK3_1	387	394	PF00069	0.450
MOD_GSK3_1	436	443	PF00069	0.383
MOD_GSK3_1	452	459	PF00069	0.403
MOD_GSK3_1	47	54	PF00069	0.508
MOD_GSK3_1	470	477	PF00069	0.351
MOD_GSK3_1	519	526	PF00069	0.423
MOD_GSK3_1	535	542	PF00069	0.317
MOD_GSK3_1	642	649	PF00069	0.380
MOD_GSK3_1	673	680	PF00069	0.295
MOD_GSK3_1	687	694	PF00069	0.267
MOD_GSK3_1	72	79	PF00069	0.550
MOD_N-GLC_1	168	173	PF02516	0.209
MOD_N-GLC_1	94	99	PF02516	0.322
MOD_NEK2_1	100	105	PF00069	0.521
MOD_NEK2_1	139	144	PF00069	0.527
MOD_NEK2_1	168	173	PF00069	0.471
MOD_NEK2_1	247	252	PF00069	0.408
MOD_NEK2_1	300	305	PF00069	0.553
MOD_NEK2_1	380	385	PF00069	0.489
MOD_NEK2_1	391	396	PF00069	0.478
MOD_NEK2_1	456	461	PF00069	0.360
MOD_NEK2_1	470	475	PF00069	0.360
MOD_NEK2_1	478	483	PF00069	0.329
MOD_NEK2_1	545	550	PF00069	0.301
MOD_NEK2_1	646	651	PF00069	0.315
MOD_NEK2_1	687	692	PF00069	0.287
MOD_NEK2_1	80	85	PF00069	0.505
MOD_NEK2_2	412	417	PF00069	0.579
MOD_NEK2_2	636	641	PF00069	0.317
MOD_PIKK_1	202	208	PF00454	0.538
MOD_PKA_1	452	458	PF00069	0.451
MOD_PKA_2	512	518	PF00069	0.432
MOD_PKA_2	64	70	PF00069	0.506
MOD_PKA_2	73	79	PF00069	0.458
MOD_Plk_1	174	180	PF00069	0.409
MOD_Plk_1	418	424	PF00069	0.342
MOD_Plk_1	94	100	PF00069	0.495
MOD_Plk_4	108	114	PF00069	0.496
MOD_Plk_4	282	288	PF00069	0.501
MOD_Plk_4	296	302	PF00069	0.421
MOD_Plk_4	329	335	PF00069	0.477
MOD_Plk_4	340	346	PF00069	0.461
MOD_Plk_4	376	382	PF00069	0.490
MOD_Plk_4	392	398	PF00069	0.422
MOD_Plk_4	412	418	PF00069	0.444
MOD_Plk_4	47	53	PF00069	0.466
MOD_Plk_4	478	484	PF00069	0.221
MOD_Plk_4	94	100	PF00069	0.495
MOD_ProDKin_1	457	463	PF00069	0.335
MOD_ProDKin_1	472	478	PF00069	0.323
MOD_ProDKin_1	535	541	PF00069	0.329
MOD_ProDKin_1	606	612	PF00069	0.299
MOD_SUMO_rev_2	104	111	PF00179	0.480
MOD_SUMO_rev_2	30	40	PF00179	0.495
MOD_SUMO_rev_2	350	355	PF00179	0.464
MOD_SUMO_rev_2	597	605	PF00179	0.348
TRG_DiLeu_BaEn_1	256	261	PF01217	0.432
TRG_DiLeu_BaEn_1	322	327	PF01217	0.500
TRG_DiLeu_BaEn_2	35	41	PF01217	0.495
TRG_ENDOCYTIC_2	152	155	PF00928	0.559
TRG_ENDOCYTIC_2	189	192	PF00928	0.487
TRG_ENDOCYTIC_2	209	212	PF00928	0.378
TRG_ENDOCYTIC_2	246	249	PF00928	0.495
TRG_ENDOCYTIC_2	26	29	PF00928	0.477
TRG_ENDOCYTIC_2	270	273	PF00928	0.587
TRG_ENDOCYTIC_2	290	293	PF00928	0.471
TRG_ENDOCYTIC_2	358	361	PF00928	0.495
TRG_ENDOCYTIC_2	437	440	PF00928	0.376
TRG_ENDOCYTIC_2	467	470	PF00928	0.320
TRG_ENDOCYTIC_2	482	485	PF00928	0.299
TRG_ENDOCYTIC_2	620	623	PF00928	0.324
TRG_ENDOCYTIC_2	684	687	PF00928	0.299
TRG_NLS_MonoExtN_4	309	314	PF00514	0.405
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.281
TRG_PTS2	1	17	PF00400	0.221

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P803	Leptomonas seymouri	76%	100%
A0A0N1PDP3	Leptomonas seymouri	21%	80%
A0A0S4IIS9	Bodo saltans	58%	100%
A0A0S4J065	Bodo saltans	23%	75%
A0A1X0NKN5	Trypanosomatidae	23%	76%
A0A1X0NLB6	Trypanosomatidae	63%	100%
A0A1X0NMH6	Trypanosomatidae	25%	97%
A0A3Q8IJI4	Leishmania donovani	82%	100%
A0A3S5H5P5	Leishmania donovani	21%	77%
A4H4J9	Leishmania braziliensis	22%	77%
A4HSS5	Leishmania infantum	21%	77%
A4ICB5	Leishmania infantum	82%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	77%
D0A3P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A9G2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E2JFG1	Amanita bisporigera	38%	92%
E2JFG2	Amanita bisporigera	36%	95%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	77%
E9AUB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
H2E7Q7	Galerina marginata (strain CBS 339.88)	38%	94%
H2E7Q8	Galerina marginata (strain CBS 339.88)	36%	95%
O70196	Rattus norvegicus	43%	98%
P23687	Sus scrofa	43%	98%
P24555	Escherichia coli (strain K12)	26%	100%
P27028	Elizabethkingia meningoseptica	36%	99%
P27195	Elizabethkingia miricola	34%	99%
P48147	Homo sapiens	43%	98%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	22%	92%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	23%	99%
Q06903	Aeromonas hydrophila	38%	100%
Q4Q080	Leishmania major	83%	100%
Q4QJ45	Leishmania major	21%	100%
Q59536	Moraxella lacunata	25%	100%
Q86AS5	Dictyostelium discoideum	35%	92%
Q9QUR6	Mus musculus	43%	98%
Q9XTA2	Bos taurus	43%	98%
V5B5S3	Trypanosoma cruzi	22%	81%
V5B860	Trypanosoma cruzi	24%	97%
V5BM62	Trypanosoma cruzi	66%	100%