Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQJ6_LEIBR

TriTrypDb:

LbrM.35.7090 , LBRM2903_350084100

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HQJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.301
CLV_NRD_NRD_1	254	256	PF00675	0.436
CLV_PCSK_FUR_1	131	135	PF00082	0.387
CLV_PCSK_KEX2_1	111	113	PF00082	0.415
CLV_PCSK_KEX2_1	125	127	PF00082	0.240
CLV_PCSK_KEX2_1	133	135	PF00082	0.359
CLV_PCSK_KEX2_1	216	218	PF00082	0.353
CLV_PCSK_KEX2_1	254	256	PF00082	0.433
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.462
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.235
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.433
CLV_PCSK_SKI1_1	133	137	PF00082	0.381
CLV_PCSK_SKI1_1	177	181	PF00082	0.400
CLV_PCSK_SKI1_1	200	204	PF00082	0.387
CLV_PCSK_SKI1_1	216	220	PF00082	0.410
DEG_APCC_DBOX_1	57	65	PF00400	0.422
DOC_CKS1_1	201	206	PF01111	0.583
DOC_MAPK_gen_1	233	242	PF00069	0.560
DOC_MAPK_gen_1	58	66	PF00069	0.422
DOC_MAPK_HePTP_8	230	242	PF00069	0.564
DOC_MAPK_MEF2A_6	233	242	PF00069	0.642
DOC_PP1_RVXF_1	227	233	PF00149	0.570
DOC_USP7_MATH_1	83	87	PF00917	0.199
DOC_USP7_MATH_1	9	13	PF00917	0.530
DOC_USP7_UBL2_3	260	264	PF12436	0.608
DOC_WW_Pin1_4	200	205	PF00397	0.569
DOC_WW_Pin1_4	5	10	PF00397	0.572
LIG_14-3-3_CanoR_1	112	121	PF00244	0.528
LIG_14-3-3_CanoR_1	217	221	PF00244	0.581
LIG_14-3-3_CanoR_1	28	36	PF00244	0.504
LIG_14-3-3_CanoR_1	99	105	PF00244	0.594
LIG_Actin_RPEL_3	51	70	PF02755	0.442
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.563
LIG_deltaCOP1_diTrp_1	221	225	PF00928	0.461
LIG_eIF4E_1	201	207	PF01652	0.645
LIG_FHA_1	201	207	PF00498	0.583
LIG_FHA_1	33	39	PF00498	0.504
LIG_FHA_2	243	249	PF00498	0.653
LIG_LIR_Apic_2	198	204	PF02991	0.567
LIG_LIR_Apic_2	44	50	PF02991	0.393
LIG_LIR_Nem_3	103	109	PF02991	0.679
LIG_LIR_Nem_3	169	174	PF02991	0.582
LIG_LIR_Nem_3	245	249	PF02991	0.561
LIG_LIR_Nem_3	65	69	PF02991	0.391
LIG_Pex14_1	190	194	PF04695	0.566
LIG_Pex14_2	207	211	PF04695	0.638
LIG_REV1ctd_RIR_1	240	248	PF16727	0.579
LIG_SH2_CRK	78	82	PF00017	0.379
LIG_SH2_PTP2	201	204	PF00017	0.645
LIG_SH2_STAP1	115	119	PF00017	0.556
LIG_SH2_STAP1	78	82	PF00017	0.362
LIG_SH2_STAT3	110	113	PF00017	0.590
LIG_SH2_STAT3	121	124	PF00017	0.473
LIG_SH2_STAT5	171	174	PF00017	0.504
LIG_SH2_STAT5	201	204	PF00017	0.578
LIG_SH2_STAT5	209	212	PF00017	0.542
LIG_SH2_STAT5	63	66	PF00017	0.441
LIG_SH3_3	158	164	PF00018	0.527
LIG_SH3_3	232	238	PF00018	0.565
LIG_SH3_3	66	72	PF00018	0.372
LIG_SH3_4	260	267	PF00018	0.618
LIG_TYR_ITSM	167	174	PF00017	0.490
MOD_CK1_1	31	37	PF00069	0.646
MOD_CK2_1	242	248	PF00069	0.527
MOD_CMANNOS	222	225	PF00535	0.313
MOD_GlcNHglycan	30	33	PF01048	0.669
MOD_GSK3_1	24	31	PF00069	0.657
MOD_GSK3_1	5	12	PF00069	0.681
MOD_GSK3_1	50	57	PF00069	0.642
MOD_N-GLC_1	256	261	PF02516	0.560
MOD_N-GLC_1	32	37	PF02516	0.429
MOD_NEK2_1	242	247	PF00069	0.448
MOD_NEK2_1	76	81	PF00069	0.424
MOD_PIKK_1	135	141	PF00454	0.512
MOD_PIKK_1	7	13	PF00454	0.496
MOD_PKA_1	216	222	PF00069	0.481
MOD_PKA_2	113	119	PF00069	0.464
MOD_PKA_2	216	222	PF00069	0.481
MOD_PKA_2	98	104	PF00069	0.651
MOD_Plk_1	32	38	PF00069	0.622
MOD_Plk_4	76	82	PF00069	0.416
MOD_ProDKin_1	200	206	PF00069	0.456
MOD_ProDKin_1	5	11	PF00069	0.745
MOD_SUMO_for_1	179	182	PF00179	0.492
TRG_ENDOCYTIC_2	171	174	PF00928	0.349
TRG_ENDOCYTIC_2	63	66	PF00928	0.558
TRG_ENDOCYTIC_2	78	81	PF00928	0.281
TRG_ER_diArg_1	112	115	PF00400	0.529
TRG_ER_diArg_1	131	134	PF00400	0.276
TRG_ER_diArg_1	253	255	PF00400	0.560
TRG_NLS_MonoExtN_4	108	115	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFV7	Leptomonas seymouri	76%	100%
A0A0S4JY76	Bodo saltans	49%	100%
A0A1X0NLD5	Trypanosomatidae	67%	100%
A0A3Q8II78	Leishmania donovani	90%	100%
D0A3P5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AI06	Leishmania infantum	90%	100%
E9AUA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q081	Leishmania major	88%	100%
V5BHN0	Trypanosoma cruzi	65%	100%