AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQJ3_LEIBR

TriTrypDb:

LbrM.35.7060 , LBRM2903_350083700

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	6	10	PF00656	0.548
CLV_NRD_NRD_1	182	184	PF00675	0.423
CLV_NRD_NRD_1	271	273	PF00675	0.764
CLV_NRD_NRD_1	361	363	PF00675	0.361
CLV_NRD_NRD_1	403	405	PF00675	0.412
CLV_NRD_NRD_1	85	87	PF00675	0.421
CLV_PCSK_FUR_1	83	87	PF00082	0.450
CLV_PCSK_KEX2_1	182	184	PF00082	0.438
CLV_PCSK_KEX2_1	340	342	PF00082	0.487
CLV_PCSK_KEX2_1	361	363	PF00082	0.433
CLV_PCSK_KEX2_1	403	405	PF00082	0.409
CLV_PCSK_KEX2_1	83	85	PF00082	0.412
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.517
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.459
CLV_PCSK_SKI1_1	221	225	PF00082	0.408
CLV_PCSK_SKI1_1	42	46	PF00082	0.363
CLV_PCSK_SKI1_1	72	76	PF00082	0.432
DEG_Nend_UBRbox_2	1	3	PF02207	0.643
DEG_SCF_FBW7_1	443	449	PF00400	0.635
DEG_SCF_TRCP1_1	306	312	PF00400	0.379
DEG_SPOP_SBC_1	63	67	PF00917	0.483
DOC_CDC14_PxL_1	253	261	PF14671	0.537
DOC_CKS1_1	415	420	PF01111	0.660
DOC_CKS1_1	443	448	PF01111	0.629
DOC_CYCLIN_RxL_1	398	410	PF00134	0.624
DOC_CYCLIN_RxL_1	466	477	PF00134	0.599
DOC_MAPK_DCC_7	251	261	PF00069	0.517
DOC_MAPK_gen_1	143	150	PF00069	0.478
DOC_PP1_RVXF_1	401	408	PF00149	0.615
DOC_PP2B_LxvP_1	138	141	PF13499	0.598
DOC_USP7_MATH_1	108	112	PF00917	0.575
DOC_USP7_MATH_1	206	210	PF00917	0.585
DOC_USP7_MATH_1	235	239	PF00917	0.654
DOC_USP7_MATH_1	265	269	PF00917	0.457
DOC_USP7_MATH_1	277	281	PF00917	0.544
DOC_USP7_MATH_1	316	320	PF00917	0.538
DOC_USP7_MATH_1	327	331	PF00917	0.555
DOC_USP7_MATH_1	446	450	PF00917	0.662
DOC_USP7_MATH_1	54	58	PF00917	0.628
DOC_WW_Pin1_4	414	419	PF00397	0.662
DOC_WW_Pin1_4	442	447	PF00397	0.622
DOC_WW_Pin1_4	89	94	PF00397	0.651
LIG_14-3-3_CanoR_1	145	149	PF00244	0.588
LIG_14-3-3_CanoR_1	190	195	PF00244	0.549
LIG_14-3-3_CanoR_1	341	351	PF00244	0.344
LIG_14-3-3_CanoR_1	451	456	PF00244	0.646
LIG_14-3-3_CanoR_1	64	73	PF00244	0.621
LIG_14-3-3_CanoR_1	84	90	PF00244	0.613
LIG_Actin_WH2_2	146	161	PF00022	0.562
LIG_Actin_WH2_2	30	48	PF00022	0.475
LIG_BRCT_BRCA1_1	160	164	PF00533	0.565
LIG_eIF4E_1	73	79	PF01652	0.490
LIG_FHA_1	145	151	PF00498	0.567
LIG_FHA_1	209	215	PF00498	0.618
LIG_FHA_1	28	34	PF00498	0.543
LIG_FHA_1	415	421	PF00498	0.668
LIG_FHA_1	425	431	PF00498	0.580
LIG_FHA_1	443	449	PF00498	0.521
LIG_FHA_1	73	79	PF00498	0.570
LIG_FHA_2	150	156	PF00498	0.603
LIG_FHA_2	90	96	PF00498	0.615
LIG_GBD_Chelix_1	467	475	PF00786	0.396
LIG_LIR_Gen_1	135	142	PF02991	0.649
LIG_LIR_Gen_1	16	25	PF02991	0.530
LIG_LIR_Gen_1	474	481	PF02991	0.665
LIG_LIR_LC3C_4	112	117	PF02991	0.621
LIG_LIR_Nem_3	16	21	PF02991	0.522
LIG_LIR_Nem_3	225	230	PF02991	0.587
LIG_LIR_Nem_3	474	479	PF02991	0.656
LIG_PDZ_Class_2	476	481	PF00595	0.577
LIG_Pex14_1	133	137	PF04695	0.632
LIG_Pex14_2	164	168	PF04695	0.549
LIG_Pex14_2	296	300	PF04695	0.448
LIG_Rb_pABgroove_1	403	411	PF01858	0.600
LIG_SH2_CRK	166	170	PF00017	0.641
LIG_SH2_CRK	253	257	PF00017	0.537
LIG_SH2_CRK	344	348	PF00017	0.413
LIG_SH2_PTP2	18	21	PF00017	0.520
LIG_SH2_STAP1	344	348	PF00017	0.363
LIG_SH2_STAP1	409	413	PF00017	0.598
LIG_SH2_STAT5	137	140	PF00017	0.657
LIG_SH2_STAT5	18	21	PF00017	0.518
LIG_SH2_STAT5	36	39	PF00017	0.469
LIG_SH2_STAT5	60	63	PF00017	0.525
LIG_SH2_STAT5	73	76	PF00017	0.538
LIG_SH3_3	18	24	PF00018	0.579
LIG_SH3_3	261	267	PF00018	0.223
LIG_SH3_3	328	334	PF00018	0.338
LIG_SH3_CIN85_PxpxPR_1	267	272	PF14604	0.466
LIG_SUMO_SIM_par_1	146	152	PF11976	0.423
LIG_SUMO_SIM_par_1	257	262	PF11976	0.417
LIG_SUMO_SIM_par_1	30	35	PF11976	0.642
LIG_TRAF2_1	126	129	PF00917	0.669
LIG_TRAF2_1	197	200	PF00917	0.687
LIG_TRFH_1	476	480	PF08558	0.568
LIG_TYR_ITIM	342	347	PF00017	0.413
MOD_CK1_1	239	245	PF00069	0.595
MOD_CK1_1	27	33	PF00069	0.535
MOD_CK1_1	280	286	PF00069	0.563
MOD_CK1_1	62	68	PF00069	0.676
MOD_CK2_1	123	129	PF00069	0.673
MOD_CK2_1	149	155	PF00069	0.594
MOD_CK2_1	190	196	PF00069	0.559
MOD_CK2_1	89	95	PF00069	0.638
MOD_CK2_1	96	102	PF00069	0.573
MOD_GlcNHglycan	15	18	PF01048	0.315
MOD_GlcNHglycan	26	29	PF01048	0.316
MOD_GlcNHglycan	267	270	PF01048	0.423
MOD_GlcNHglycan	306	309	PF01048	0.679
MOD_GlcNHglycan	312	315	PF01048	0.726
MOD_GlcNHglycan	318	321	PF01048	0.708
MOD_GlcNHglycan	344	347	PF01048	0.280
MOD_GlcNHglycan	393	396	PF01048	0.428
MOD_GlcNHglycan	61	64	PF01048	0.357
MOD_GlcNHglycan	80	83	PF01048	0.457
MOD_GSK3_1	132	139	PF00069	0.482
MOD_GSK3_1	190	197	PF00069	0.608
MOD_GSK3_1	206	213	PF00069	0.741
MOD_GSK3_1	23	30	PF00069	0.552
MOD_GSK3_1	235	242	PF00069	0.614
MOD_GSK3_1	304	311	PF00069	0.450
MOD_GSK3_1	442	449	PF00069	0.567
MOD_GSK3_1	59	66	PF00069	0.463
MOD_GSK3_1	85	92	PF00069	0.673
MOD_NEK2_1	132	137	PF00069	0.591
MOD_NEK2_1	158	163	PF00069	0.577
MOD_NEK2_1	210	215	PF00069	0.654
MOD_NEK2_1	236	241	PF00069	0.567
MOD_NEK2_1	315	320	PF00069	0.582
MOD_NEK2_1	342	347	PF00069	0.388
MOD_NEK2_1	393	398	PF00069	0.578
MOD_NEK2_1	423	428	PF00069	0.656
MOD_NEK2_1	471	476	PF00069	0.637
MOD_NEK2_1	8	13	PF00069	0.608
MOD_NEK2_1	96	101	PF00069	0.607
MOD_PIKK_1	446	452	PF00454	0.646
MOD_PKA_1	85	91	PF00069	0.606
MOD_PKA_2	144	150	PF00069	0.548
MOD_PKA_2	158	164	PF00069	0.613
MOD_PKA_2	63	69	PF00069	0.562
MOD_PKA_2	85	91	PF00069	0.606
MOD_PKB_1	83	91	PF00069	0.682
MOD_Plk_1	123	129	PF00069	0.539
MOD_Plk_1	206	212	PF00069	0.709
MOD_Plk_1	469	475	PF00069	0.624
MOD_Plk_1	8	14	PF00069	0.559
MOD_Plk_2-3	194	200	PF00069	0.583
MOD_Plk_4	144	150	PF00069	0.634
MOD_Plk_4	173	179	PF00069	0.561
MOD_Plk_4	236	242	PF00069	0.561
MOD_Plk_4	28	34	PF00069	0.477
MOD_Plk_4	471	477	PF00069	0.653
MOD_Plk_4	8	14	PF00069	0.588
MOD_Plk_4	96	102	PF00069	0.579
MOD_ProDKin_1	414	420	PF00069	0.661
MOD_ProDKin_1	442	448	PF00069	0.632
MOD_ProDKin_1	89	95	PF00069	0.649
TRG_DiLeu_BaEn_1	200	205	PF01217	0.642
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.611
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.576
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.292
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.621
TRG_ENDOCYTIC_2	137	140	PF00928	0.573
TRG_ENDOCYTIC_2	166	169	PF00928	0.635
TRG_ENDOCYTIC_2	18	21	PF00928	0.520
TRG_ENDOCYTIC_2	253	256	PF00928	0.537
TRG_ENDOCYTIC_2	344	347	PF00928	0.363
TRG_ENDOCYTIC_2	409	412	PF00928	0.511
TRG_ER_diArg_1	181	183	PF00400	0.635
TRG_ER_diArg_1	402	404	PF00400	0.620
TRG_ER_diArg_1	83	86	PF00400	0.632
TRG_NES_CRM1_1	128	144	PF08389	0.535
TRG_NLS_MonoExtN_4	360	365	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR4	Leptomonas seymouri	64%	100%
A0A0S4ISX7	Bodo saltans	27%	100%
A0A1X0NN06	Trypanosomatidae	43%	100%
A0A3Q8IM62	Leishmania donovani	81%	100%
A0A3R7MQC3	Trypanosoma rangeli	43%	100%
D0A3P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AI02	Leishmania infantum	81%	100%
E9AUA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q085	Leishmania major	80%	98%
V5BHM6	Trypanosoma cruzi	41%	100%