Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQJ0_LEIBR

TriTrypDb:

LbrM.35.7030 , LBRM2903_350083400

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	1
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HQJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQJ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.518
CLV_NRD_NRD_1	142	144	PF00675	0.276
CLV_PCSK_SKI1_1	143	147	PF00082	0.469
CLV_PCSK_SKI1_1	36	40	PF00082	0.394
DOC_PP4_FxxP_1	71	74	PF00568	0.282
DOC_USP7_MATH_1	74	78	PF00917	0.304
DOC_USP7_MATH_2	32	38	PF00917	0.453
DOC_USP7_UBL2_3	121	125	PF12436	0.343
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_deltaCOP1_diTrp_1	116	122	PF00928	0.285
LIG_FHA_2	37	43	PF00498	0.363
LIG_LIR_Gen_1	77	86	PF02991	0.377
LIG_LIR_Nem_3	123	129	PF02991	0.386
LIG_LIR_Nem_3	2	6	PF02991	0.471
LIG_LIR_Nem_3	77	81	PF02991	0.377
LIG_LYPXL_yS_3	126	129	PF13949	0.314
LIG_Pex14_1	118	122	PF04695	0.239
LIG_Pex14_2	6	10	PF04695	0.308
LIG_PTB_Apo_2	5	12	PF02174	0.320
LIG_REV1ctd_RIR_1	8	18	PF16727	0.481
LIG_SH2_CRK	55	59	PF00017	0.443
LIG_SH2_STAP1	78	82	PF00017	0.372
LIG_SH2_STAT3	139	142	PF00017	0.457
LIG_SH2_STAT5	139	142	PF00017	0.337
LIG_SH3_3	26	32	PF00018	0.438
LIG_TRAF2_1	134	137	PF00917	0.385
LIG_TRAF2_1	39	42	PF00917	0.369
LIG_TRAF2_1	96	99	PF00917	0.318
LIG_WRC_WIRS_1	35	40	PF05994	0.413
MOD_CK1_1	22	28	PF00069	0.678
MOD_CK2_1	111	117	PF00069	0.182
MOD_CK2_1	36	42	PF00069	0.363
MOD_CK2_1	93	99	PF00069	0.282
MOD_GlcNHglycan	21	24	PF01048	0.578
MOD_GlcNHglycan	66	69	PF01048	0.241
MOD_N-GLC_1	19	24	PF02516	0.667
MOD_SUMO_rev_2	117	127	PF00179	0.464
MOD_SUMO_rev_2	31	38	PF00179	0.595
TRG_ENDOCYTIC_2	126	129	PF00928	0.323
TRG_ENDOCYTIC_2	55	58	PF00928	0.284
TRG_ENDOCYTIC_2	78	81	PF00928	0.258
TRG_ER_diArg_1	140	143	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C7	Leptomonas seymouri	70%	99%
A0A0N1I2M9	Leptomonas seymouri	37%	90%
A0A0N1I427	Leptomonas seymouri	38%	79%
A0A0S4IM89	Bodo saltans	54%	100%
A0A0S4IWT4	Bodo saltans	40%	85%
A0A0S4KHZ8	Bodo saltans	42%	95%
A0A1X0NM31	Trypanosomatidae	54%	100%
A0A1X0NTL9	Trypanosomatidae	34%	92%
A0A1X0P9U9	Trypanosomatidae	38%	88%
A0A3Q8IGX1	Leishmania donovani	82%	100%
A0A3R7L838	Trypanosoma rangeli	61%	100%
A0A3R7RC54	Trypanosoma rangeli	42%	82%
A0A3S7WTB2	Leishmania donovani	38%	90%
A0A3S7X865	Leishmania donovani	37%	83%
A0A422NSD0	Trypanosoma rangeli	32%	100%
A4H7Y9	Leishmania braziliensis	37%	100%
A4HB24	Leishmania braziliensis	36%	100%
A4HWB7	Leishmania infantum	38%	90%
A4IA81	Leishmania infantum	37%	83%
C9ZM28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	96%
C9ZNV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	92%
E9AHZ9	Leishmania infantum	82%	100%
E9AQ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	90%
E9AUA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B594	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	83%
O00264	Homo sapiens	33%	75%
O13995	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	89%
O55022	Mus musculus	33%	75%
P70580	Rattus norvegicus	37%	75%
Q12091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	97%
Q17QC0	Bos taurus	35%	76%
Q1JQA5	Bos taurus	40%	87%
Q4Q088	Leishmania major	79%	100%
Q4Q2N9	Leishmania major	34%	100%
Q4QFG4	Leishmania major	40%	100%
Q5RED0	Pongo abelii	33%	75%
Q5XIU9	Rattus norvegicus	34%	68%
Q5ZKN2	Gallus gallus	31%	77%
Q6IUR5	Rattus norvegicus	40%	86%
Q7YZW5	Caenorhabditis elegans	34%	80%
Q80UU9	Mus musculus	34%	68%
Q95250	Sus scrofa	34%	76%
Q9CQ45	Mus musculus	39%	86%
Q9UMX5	Homo sapiens	38%	85%
Q9XFM6	Arabidopsis thaliana	43%	67%
V5DM24	Trypanosoma cruzi	43%	82%