Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Species:

Leishmania braziliensis

UniProt:

A4HQI8_LEIBR

TriTrypDb:

LbrM.35.7010 , LBRM2903_350083200

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	12
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HQI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQI8

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006006	glucose metabolic process	5	12
GO:0006007	glucose catabolic process	6	12
GO:0006082	organic acid metabolic process	3	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006094	gluconeogenesis	6	1
GO:0006096	glycolytic process	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004619	phosphoglycerate mutase activity	5	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0030145	manganese ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046537	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity	6	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.612
CLV_C14_Caspase3-7	271	275	PF00656	0.558
CLV_C14_Caspase3-7	441	445	PF00656	0.551
CLV_C14_Caspase3-7	452	456	PF00656	0.597
CLV_NRD_NRD_1	14	16	PF00675	0.482
CLV_NRD_NRD_1	47	49	PF00675	0.412
CLV_PCSK_KEX2_1	14	16	PF00082	0.482
CLV_PCSK_SKI1_1	15	19	PF00082	0.404
CLV_PCSK_SKI1_1	481	485	PF00082	0.412
CLV_PCSK_SKI1_1	86	90	PF00082	0.351

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I9	Leptomonas seymouri	85%	100%
A0A0S4IMK1	Bodo saltans	71%	100%
A0A1X0NLC7	Trypanosomatidae	80%	100%
A0A3Q8IWN1	Leishmania donovani	90%	100%
A0A3R7MH76	Trypanosoma rangeli	79%	100%
A0ALE0	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	34%	100%
A0KR77	Shewanella sp. (strain ANA-3)	32%	100%
A0LDF3	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	37%	100%
A0PYP3	Clostridium novyi (strain NT)	34%	100%
A0Q5M6	Francisella tularensis subsp. novicida (strain U112)	32%	100%

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