Transcriptional regulator

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQI6_LEIBR

TriTrypDb:

LbrM.35.6990 , LBRM2903_350082900

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HQI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQI6

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0080156	mitochondrial mRNA modification	7	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1900864	mitochondrial RNA modification	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.513
CLV_C14_Caspase3-7	65	69	PF00656	0.453
CLV_NRD_NRD_1	2	4	PF00675	0.591
CLV_PCSK_KEX2_1	166	168	PF00082	0.378
CLV_PCSK_KEX2_1	2	4	PF00082	0.624
CLV_PCSK_KEX2_1	57	59	PF00082	0.470
CLV_PCSK_KEX2_1	84	86	PF00082	0.534
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.464
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.470
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.568
CLV_PCSK_SKI1_1	13	17	PF00082	0.427
CLV_PCSK_SKI1_1	176	180	PF00082	0.467
DEG_Nend_UBRbox_1	1	4	PF02207	0.602
DOC_CKS1_1	14	19	PF01111	0.526
DOC_MAPK_gen_1	2	9	PF00069	0.649
DOC_MAPK_gen_1	57	64	PF00069	0.515
DOC_MAPK_gen_1	84	90	PF00069	0.425
DOC_MAPK_MEF2A_6	2	9	PF00069	0.649
DOC_PP4_FxxP_1	80	83	PF00568	0.488
DOC_USP7_MATH_1	120	124	PF00917	0.649
DOC_USP7_UBL2_3	57	61	PF12436	0.517
DOC_WW_Pin1_4	13	18	PF00397	0.491
DOC_WW_Pin1_4	176	181	PF00397	0.331
LIG_14-3-3_CanoR_1	118	123	PF00244	0.460
LIG_BIR_III_2	71	75	PF00653	0.488
LIG_FHA_2	108	114	PF00498	0.718
LIG_LIR_Nem_3	163	168	PF02991	0.391
LIG_LIR_Nem_3	177	181	PF02991	0.543
LIG_NRBOX	47	53	PF00104	0.433
LIG_PCNA_yPIPBox_3	49	61	PF02747	0.460
LIG_Pex14_1	76	80	PF04695	0.413
LIG_PTB_Apo_2	34	41	PF02174	0.391
LIG_SH2_GRB2like	35	38	PF00017	0.398
LIG_SH2_STAP1	35	39	PF00017	0.416
LIG_SH2_STAT5	149	152	PF00017	0.374
LIG_SH2_STAT5	184	187	PF00017	0.506
LIG_SH2_STAT5	39	42	PF00017	0.399
LIG_SH3_2	109	114	PF14604	0.488
LIG_SH3_3	106	112	PF00018	0.649
LIG_SH3_3	11	17	PF00018	0.524
LIG_TRAF2_1	93	96	PF00917	0.495
LIG_UBA3_1	150	156	PF00899	0.307
MOD_CK1_1	160	166	PF00069	0.295
MOD_CK2_1	107	113	PF00069	0.714
MOD_DYRK1A_RPxSP_1	13	17	PF00069	0.484
MOD_GlcNHglycan	159	162	PF01048	0.555
MOD_GSK3_1	103	110	PF00069	0.579
MOD_GSK3_1	120	127	PF00069	0.600
MOD_GSK3_1	16	23	PF00069	0.453
MOD_GSK3_1	176	183	PF00069	0.430
MOD_NEK2_1	130	135	PF00069	0.343
MOD_NEK2_1	137	142	PF00069	0.298
MOD_NEK2_1	20	25	PF00069	0.412
MOD_NEK2_1	30	35	PF00069	0.394
MOD_PK_1	118	124	PF00069	0.456
MOD_Plk_1	130	136	PF00069	0.331
MOD_Plk_1	96	102	PF00069	0.498
MOD_Plk_4	130	136	PF00069	0.381
MOD_Plk_4	16	22	PF00069	0.501
MOD_Plk_4	180	186	PF00069	0.406
MOD_Plk_4	30	36	PF00069	0.479
MOD_Plk_4	96	102	PF00069	0.498
MOD_ProDKin_1	13	19	PF00069	0.487
MOD_ProDKin_1	176	182	PF00069	0.331
MOD_SUMO_rev_2	63	72	PF00179	0.506
TRG_DiLeu_BaEn_1	170	175	PF01217	0.478
TRG_DiLeu_BaEn_3	95	101	PF01217	0.566
TRG_ENDOCYTIC_2	148	151	PF00928	0.560
TRG_ENDOCYTIC_2	77	80	PF00928	0.425
TRG_ER_diArg_1	1	3	PF00400	0.628
TRG_NES_CRM1_1	145	158	PF08389	0.390
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY3	Leptomonas seymouri	57%	91%
A0A0S4J9F6	Bodo saltans	33%	72%
A0A1X0NLX2	Trypanosomatidae	49%	97%
A0A3Q8IK45	Leishmania donovani	82%	100%
A0A422NK09	Trypanosoma rangeli	55%	100%
D0A3N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
E9AHZ5	Leishmania infantum	82%	100%
E9AU99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q092	Leishmania major	82%	100%