Amino acid transporter

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQI5_LEIBR

TriTrypDb:

LbrM.35.6980 , LBRM2903_350082800

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HQI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	388	390	PF00675	0.499
CLV_NRD_NRD_1	74	76	PF00675	0.460
CLV_PCSK_KEX2_1	388	390	PF00082	0.499
CLV_PCSK_KEX2_1	74	76	PF00082	0.460
CLV_PCSK_SKI1_1	272	276	PF00082	0.379
DOC_CDC14_PxL_1	14	22	PF14671	0.569
DOC_CKS1_1	9	14	PF01111	0.580
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.551
DOC_MAPK_gen_1	191	198	PF00069	0.686
DOC_MAPK_gen_1	74	82	PF00069	0.689
DOC_MAPK_HePTP_8	72	84	PF00069	0.584
DOC_MAPK_MEF2A_6	341	348	PF00069	0.346
DOC_MAPK_MEF2A_6	75	84	PF00069	0.731
DOC_MAPK_RevD_3	374	389	PF00069	0.501
DOC_PP2B_LxvP_1	173	176	PF13499	0.533
DOC_PP4_FxxP_1	142	145	PF00568	0.497
DOC_WW_Pin1_4	228	233	PF00397	0.572
DOC_WW_Pin1_4	8	13	PF00397	0.642
LIG_14-3-3_CanoR_1	23	29	PF00244	0.677
LIG_14-3-3_CanoR_1	327	336	PF00244	0.736
LIG_14-3-3_CanoR_1	341	345	PF00244	0.332
LIG_14-3-3_CanoR_1	91	97	PF00244	0.673
LIG_Actin_WH2_2	283	298	PF00022	0.556
LIG_Actin_WH2_2	58	76	PF00022	0.440
LIG_BRCT_BRCA1_1	198	202	PF00533	0.501
LIG_BRCT_BRCA1_1	357	361	PF00533	0.249
LIG_EH_1	180	184	PF12763	0.712
LIG_FHA_1	110	116	PF00498	0.385
LIG_FHA_1	300	306	PF00498	0.459
LIG_FHA_1	341	347	PF00498	0.469
LIG_FHA_1	400	406	PF00498	0.697
LIG_FHA_1	9	15	PF00498	0.728
LIG_FHA_1	95	101	PF00498	0.726
LIG_LIR_Gen_1	106	115	PF02991	0.381
LIG_LIR_Gen_1	284	295	PF02991	0.607
LIG_LIR_Gen_1	3	12	PF02991	0.716
LIG_LIR_Nem_3	199	204	PF02991	0.407
LIG_LIR_Nem_3	255	259	PF02991	0.462
LIG_LIR_Nem_3	284	290	PF02991	0.508
LIG_LIR_Nem_3	3	7	PF02991	0.690
LIG_LIR_Nem_3	317	321	PF02991	0.297
LIG_NRBOX	372	378	PF00104	0.447
LIG_PDZ_Class_2	403	408	PF00595	0.675
LIG_Pex14_2	243	247	PF04695	0.404
LIG_Pex14_2	318	322	PF04695	0.397
LIG_SH2_NCK_1	89	93	PF00017	0.717
LIG_SH2_PTP2	162	165	PF00017	0.249
LIG_SH2_PTP2	41	44	PF00017	0.501
LIG_SH2_STAP1	137	141	PF00017	0.526
LIG_SH2_STAT5	123	126	PF00017	0.424
LIG_SH2_STAT5	162	165	PF00017	0.249
LIG_SH2_STAT5	227	230	PF00017	0.522
LIG_SH2_STAT5	234	237	PF00017	0.546
LIG_SH2_STAT5	311	314	PF00017	0.482
LIG_SH2_STAT5	41	44	PF00017	0.489
LIG_SH3_3	115	121	PF00018	0.430
LIG_SH3_3	182	188	PF00018	0.704
LIG_SH3_3	6	12	PF00018	0.704
LIG_Sin3_3	36	43	PF02671	0.229
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.399
LIG_SUMO_SIM_par_1	250	255	PF11976	0.385
LIG_SUMO_SIM_par_1	345	350	PF11976	0.480
LIG_SUMO_SIM_par_1	42	47	PF11976	0.249
LIG_TRFH_1	277	281	PF08558	0.695
LIG_TYR_ITIM	160	165	PF00017	0.412
LIG_TYR_ITIM	274	279	PF00017	0.700
LIG_TYR_ITIM	39	44	PF00017	0.482
LIG_WRC_WIRS_1	1	6	PF05994	0.732
MOD_CK1_1	307	313	PF00069	0.249
MOD_CK1_1	94	100	PF00069	0.616
MOD_GlcNHglycan	237	240	PF01048	0.743
MOD_GlcNHglycan	396	399	PF01048	0.545
MOD_GlcNHglycan	46	49	PF01048	0.423
MOD_GSK3_1	228	235	PF00069	0.481
MOD_GSK3_1	295	302	PF00069	0.444
MOD_GSK3_1	303	310	PF00069	0.454
MOD_GSK3_1	347	354	PF00069	0.380
MOD_GSK3_1	90	97	PF00069	0.677
MOD_N-GLC_1	225	230	PF02516	0.624
MOD_NEK2_1	295	300	PF00069	0.397
MOD_NEK2_1	304	309	PF00069	0.372
MOD_NEK2_1	340	345	PF00069	0.514
MOD_NEK2_1	68	73	PF00069	0.387
MOD_PKA_2	340	346	PF00069	0.526
MOD_PKA_2	90	96	PF00069	0.699
MOD_Plk_4	103	109	PF00069	0.590
MOD_Plk_4	197	203	PF00069	0.378
MOD_Plk_4	24	30	PF00069	0.551
MOD_Plk_4	252	258	PF00069	0.430
MOD_Plk_4	307	313	PF00069	0.434
MOD_Plk_4	314	320	PF00069	0.438
MOD_Plk_4	68	74	PF00069	0.397
MOD_ProDKin_1	228	234	PF00069	0.571
MOD_ProDKin_1	8	14	PF00069	0.641
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.784
TRG_ENDOCYTIC_2	123	126	PF00928	0.307
TRG_ENDOCYTIC_2	162	165	PF00928	0.412
TRG_ENDOCYTIC_2	180	183	PF00928	0.711
TRG_ENDOCYTIC_2	276	279	PF00928	0.739
TRG_ENDOCYTIC_2	41	44	PF00928	0.482
TRG_ENDOCYTIC_2	79	82	PF00928	0.703
TRG_ENDOCYTIC_2	89	92	PF00928	0.712
TRG_ER_diArg_1	388	390	PF00400	0.701
TRG_ER_diArg_1	73	75	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I240	Leptomonas seymouri	48%	100%
A0A1X0NN35	Trypanosomatidae	22%	100%
A0A3S7XCE6	Leishmania donovani	74%	100%
E9AHZ4	Leishmania infantum	74%	100%
E9AU98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q093	Leishmania major	73%	100%