Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQI4_LEIBR

TriTrypDb:

LbrM.35.6970 , LBRM2903_350082700

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0110165	cellular anatomical entity	1	26
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HQI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQI4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0006862	nucleotide transport	6	1
GO:0015748	organophosphate ester transport	5	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0035352	NAD transmembrane transport	4	1
GO:0043132	NAD transport	7	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1901679	nucleotide transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015215	nucleotide transmembrane transporter activity	4	1
GO:0015605	organophosphate ester transmembrane transporter activity	3	1
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0051724	NAD transmembrane transporter activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.344
CLV_PCSK_KEX2_1	296	298	PF00082	0.318
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.318
CLV_PCSK_SKI1_1	18	22	PF00082	0.686
DEG_APCC_DBOX_1	17	25	PF00400	0.356
DEG_APCC_DBOX_1	203	211	PF00400	0.331
DEG_APCC_DBOX_1	301	309	PF00400	0.553
DEG_Nend_UBRbox_1	1	4	PF02207	0.368
DOC_AGCK_PIF_1	338	343	PF00069	0.142
DOC_CDC14_PxL_1	24	32	PF14671	0.498
DOC_CYCLIN_RxL_1	248	259	PF00134	0.245
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.317
DOC_MAPK_DCC_7	47	57	PF00069	0.390
DOC_MAPK_gen_1	296	303	PF00069	0.504
DOC_MAPK_MEF2A_6	204	212	PF00069	0.396
DOC_MAPK_MEF2A_6	29	36	PF00069	0.327
DOC_MAPK_NFAT4_5	29	37	PF00069	0.327
DOC_PP2B_LxvP_1	34	37	PF13499	0.382
DOC_USP7_MATH_1	164	168	PF00917	0.470
DOC_USP7_MATH_1	173	177	PF00917	0.460
DOC_USP7_MATH_1	272	276	PF00917	0.327
DOC_USP7_MATH_1	40	44	PF00917	0.438
DOC_WW_Pin1_4	154	159	PF00397	0.485
DOC_WW_Pin1_4	9	14	PF00397	0.562
LIG_14-3-3_CanoR_1	188	194	PF00244	0.437
LIG_14-3-3_CanoR_1	240	244	PF00244	0.456
LIG_14-3-3_CanoR_1	29	35	PF00244	0.528
LIG_14-3-3_CanoR_1	47	55	PF00244	0.285
LIG_14-3-3_CanoR_1	88	95	PF00244	0.537
LIG_14-3-3_CanoR_1	99	107	PF00244	0.499
LIG_BRCT_BRCA1_1	199	203	PF00533	0.387
LIG_deltaCOP1_diTrp_1	140	146	PF00928	0.518
LIG_EH_1	160	164	PF12763	0.441
LIG_EH_1	282	286	PF12763	0.348
LIG_EVH1_1	36	40	PF00568	0.363
LIG_FHA_1	188	194	PF00498	0.460
LIG_FHA_1	207	213	PF00498	0.276
LIG_FHA_1	259	265	PF00498	0.328
LIG_FHA_1	31	37	PF00498	0.438
LIG_FHA_1	40	46	PF00498	0.365
LIG_FHA_1	65	71	PF00498	0.320
LIG_FHA_1	84	90	PF00498	0.404
LIG_HCF-1_HBM_1	180	183	PF13415	0.483
LIG_LIR_Gen_1	46	57	PF02991	0.323
LIG_LIR_Gen_1	65	76	PF02991	0.236
LIG_LIR_LC3C_4	209	212	PF02991	0.430
LIG_LIR_Nem_3	122	128	PF02991	0.432
LIG_LIR_Nem_3	140	146	PF02991	0.403
LIG_LIR_Nem_3	157	163	PF02991	0.500
LIG_LIR_Nem_3	216	222	PF02991	0.278
LIG_LIR_Nem_3	224	229	PF02991	0.279
LIG_LIR_Nem_3	46	52	PF02991	0.331
LIG_LIR_Nem_3	65	71	PF02991	0.219
LIG_PCNA_yPIPBox_3	314	322	PF02747	0.377
LIG_Pex14_1	219	223	PF04695	0.275
LIG_PTB_Apo_2	280	287	PF02174	0.270
LIG_PTB_Phospho_1	280	286	PF10480	0.289
LIG_SH2_CRK	68	72	PF00017	0.348
LIG_SH2_STAT5	126	129	PF00017	0.427
LIG_SH2_STAT5	286	289	PF00017	0.434
LIG_SH3_3	156	162	PF00018	0.486
LIG_SH3_3	208	214	PF00018	0.337
LIG_SH3_3	240	246	PF00018	0.416
LIG_SH3_3	278	284	PF00018	0.255
LIG_SH3_3	298	304	PF00018	0.527
LIG_SH3_3	34	40	PF00018	0.478
LIG_SH3_CIN85_PxpxPR_1	13	18	PF14604	0.345
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.483
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.396
LIG_TRAF2_1	137	140	PF00917	0.602
LIG_TYR_ITIM	123	128	PF00017	0.486
LIG_WRC_WIRS_1	223	228	PF05994	0.313
LIG_WRC_WIRS_1	58	63	PF05994	0.291
MOD_CDK_SPK_2	13	18	PF00069	0.388
MOD_CK1_1	175	181	PF00069	0.533
MOD_CK1_1	350	356	PF00069	0.343
MOD_CK1_1	43	49	PF00069	0.375
MOD_CK1_1	9	15	PF00069	0.539
MOD_Cter_Amidation	294	297	PF01082	0.318
MOD_GlcNHglycan	115	118	PF01048	0.263
MOD_GlcNHglycan	184	187	PF01048	0.196
MOD_GlcNHglycan	258	261	PF01048	0.578
MOD_GlcNHglycan	42	45	PF01048	0.587
MOD_GlcNHglycan	8	11	PF01048	0.745
MOD_GlcNHglycan	89	92	PF01048	0.290
MOD_GSK3_1	172	179	PF00069	0.459
MOD_GSK3_1	182	189	PF00069	0.460
MOD_GSK3_1	39	46	PF00069	0.366
MOD_GSK3_1	57	64	PF00069	0.256
MOD_GSK3_1	83	90	PF00069	0.468
MOD_GSK3_1	9	16	PF00069	0.497
MOD_N-GLC_1	6	11	PF02516	0.564
MOD_NEK2_1	203	208	PF00069	0.322
MOD_NEK2_1	22	27	PF00069	0.509
MOD_NEK2_1	255	260	PF00069	0.413
MOD_NEK2_1	57	62	PF00069	0.247
MOD_NEK2_1	66	71	PF00069	0.223
MOD_PIKK_1	164	170	PF00454	0.421
MOD_PIKK_1	350	356	PF00454	0.449
MOD_PKA_2	1	7	PF00069	0.372
MOD_PKA_2	187	193	PF00069	0.445
MOD_PKA_2	203	209	PF00069	0.289
MOD_PKA_2	239	245	PF00069	0.464
MOD_PKA_2	87	93	PF00069	0.471
MOD_PKA_2	98	104	PF00069	0.550
MOD_Plk_1	22	28	PF00069	0.470
MOD_Plk_4	115	121	PF00069	0.452
MOD_Plk_4	189	195	PF00069	0.465
MOD_Plk_4	203	209	PF00069	0.264
MOD_Plk_4	239	245	PF00069	0.339
MOD_Plk_4	273	279	PF00069	0.253
MOD_Plk_4	66	72	PF00069	0.310
MOD_ProDKin_1	154	160	PF00069	0.485
MOD_ProDKin_1	9	15	PF00069	0.555
MOD_SUMO_for_1	313	316	PF00179	0.518
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.387
TRG_ENDOCYTIC_2	125	128	PF00928	0.447
TRG_ENDOCYTIC_2	223	226	PF00928	0.237
TRG_ENDOCYTIC_2	68	71	PF00928	0.277
TRG_ER_diArg_1	288	291	PF00400	0.441
TRG_ER_FFAT_2	178	189	PF00635	0.520
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.187

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8S5	Leptomonas seymouri	80%	98%
A0A0N1IHK9	Leptomonas seymouri	29%	91%
A0A0S4J045	Bodo saltans	25%	100%
A0A0S4JF45	Bodo saltans	25%	87%
A0A0S4JH99	Bodo saltans	28%	70%
A0A0U2IR85	Ustilago maydis	26%	100%
A0A1X0NN16	Trypanosomatidae	54%	100%
A0A1X0NQB5	Trypanosomatidae	28%	92%
A0A1X0NUM8	Trypanosomatidae	26%	100%
A0A1X0P6Z0	Trypanosomatidae	29%	89%
A0A3Q8IC78	Leishmania donovani	30%	90%
A0A3Q8IS12	Leishmania donovani	92%	96%
A0A3R7L1P3	Trypanosoma rangeli	57%	100%
A0A3S7WUZ5	Leishmania donovani	26%	80%
A0A422NGL1	Trypanosoma rangeli	29%	96%
A0A422P0Q3	Trypanosoma rangeli	30%	91%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	26%	100%
A4H690	Leishmania braziliensis	29%	100%
A4H9K7	Leishmania braziliensis	26%	100%
A4HUL3	Leishmania infantum	30%	90%
A4HXX3	Leishmania infantum	26%	80%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	26%	100%
C9ZVP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
C9ZZS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	89%
D0A9Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AHZ3	Leishmania infantum	92%	96%
E9ANB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	90%
E9ARN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	79%
E9AU97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	96%
F4HT41	Arabidopsis thaliana	27%	100%
O43772	Homo sapiens	24%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q4Q094	Leishmania major	92%	100%
Q4QDU2	Leishmania major	27%	100%
Q4QHB2	Leishmania major	29%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	100%
Q54VX4	Dictyostelium discoideum	24%	100%
Q55E45	Dictyostelium discoideum	23%	100%
Q7XA87	Arabidopsis thaliana	24%	100%
Q8HXY2	Macaca fascicularis	25%	100%
Q9Z2Z6	Mus musculus	24%	100%
V5BTA6	Trypanosoma cruzi	27%	100%
V5BTU3	Trypanosoma cruzi	30%	98%
V5DDT9	Trypanosoma cruzi	56%	92%
V5DN72	Trypanosoma cruzi	27%	90%