LeishMANIAdb
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Coiled-coil domain-containing protein 164

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Coiled-coil domain-containing protein 164
Gene product:
Sperm tail/Sperm tail C-terminal domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HQI2_LEIBR
TriTrypDb:
LbrM.35.6950 , LBRM2903_350082500
Length:
648

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005858 axonemal dynein complex 4 12
GO:0005875 microtubule associated complex 2 12
GO:0030286 dynein complex 3 12
GO:0032991 protein-containing complex 1 12
GO:1902494 catalytic complex 2 12
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HQI2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQI2

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0043933 protein-containing complex organization 4 12
GO:0065003 protein-containing complex assembly 5 12
GO:0070286 axonemal dynein complex assembly 6 12
GO:0071840 cellular component organization or biogenesis 2 12
GO:0001539 cilium or flagellum-dependent cell motility 3 1
GO:0003352 regulation of cilium movement 6 1
GO:0032886 regulation of microtubule-based process 4 1
GO:0048870 cell motility 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0060285 cilium-dependent cell motility 4 1
GO:0060632 regulation of microtubule-based movement 5 1
GO:0065007 biological regulation 1 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.467
CLV_NRD_NRD_1 132 134 PF00675 0.267
CLV_NRD_NRD_1 204 206 PF00675 0.391
CLV_NRD_NRD_1 223 225 PF00675 0.282
CLV_NRD_NRD_1 230 232 PF00675 0.404
CLV_NRD_NRD_1 557 559 PF00675 0.457
CLV_NRD_NRD_1 596 598 PF00675 0.224
CLV_NRD_NRD_1 82 84 PF00675 0.231
CLV_PCSK_FUR_1 221 225 PF00082 0.324
CLV_PCSK_KEX2_1 223 225 PF00082 0.321
CLV_PCSK_KEX2_1 260 262 PF00082 0.395
CLV_PCSK_KEX2_1 332 334 PF00082 0.458
CLV_PCSK_KEX2_1 556 558 PF00082 0.526
CLV_PCSK_KEX2_1 82 84 PF00082 0.231
CLV_PCSK_PC1ET2_1 260 262 PF00082 0.395
CLV_PCSK_PC1ET2_1 332 334 PF00082 0.458
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.640
CLV_PCSK_PC7_1 552 558 PF00082 0.518
CLV_PCSK_SKI1_1 358 362 PF00082 0.554
CLV_PCSK_SKI1_1 393 397 PF00082 0.255
CLV_PCSK_SKI1_1 612 616 PF00082 0.248
CLV_PCSK_SKI1_1 635 639 PF00082 0.553
CLV_Separin_Metazoa 218 222 PF03568 0.276
DEG_APCC_DBOX_1 260 268 PF00400 0.310
DEG_APCC_KENBOX_2 299 303 PF00400 0.456
DEG_SPOP_SBC_1 34 38 PF00917 0.483
DOC_CKS1_1 630 635 PF01111 0.344
DOC_CYCLIN_yCln2_LP_2 400 406 PF00134 0.375
DOC_MAPK_DCC_7 429 438 PF00069 0.436
DOC_MAPK_gen_1 308 316 PF00069 0.333
DOC_MAPK_HePTP_8 426 438 PF00069 0.448
DOC_MAPK_MEF2A_6 429 438 PF00069 0.436
DOC_PP1_RVXF_1 391 397 PF00149 0.249
DOC_PP1_SILK_1 446 451 PF00149 0.495
DOC_PP2B_LxvP_1 119 122 PF13499 0.480
DOC_PP2B_LxvP_1 400 403 PF13499 0.374
DOC_SPAK_OSR1_1 454 458 PF12202 0.316
DOC_USP7_MATH_1 464 468 PF00917 0.540
DOC_USP7_MATH_1 546 550 PF00917 0.477
DOC_USP7_MATH_1 77 81 PF00917 0.424
DOC_USP7_UBL2_3 308 312 PF12436 0.350
DOC_USP7_UBL2_3 361 365 PF12436 0.435
DOC_WW_Pin1_4 629 634 PF00397 0.502
LIG_14-3-3_CanoR_1 180 187 PF00244 0.402
LIG_14-3-3_CanoR_1 287 291 PF00244 0.441
LIG_14-3-3_CanoR_1 486 496 PF00244 0.533
LIG_14-3-3_CanoR_1 635 644 PF00244 0.489
LIG_APCC_ABBA_1 109 114 PF00400 0.515
LIG_BIR_II_1 1 5 PF00653 0.540
LIG_BIR_III_3 1 5 PF00653 0.540
LIG_eIF4E_1 631 637 PF01652 0.486
LIG_FHA_1 198 204 PF00498 0.433
LIG_FHA_1 287 293 PF00498 0.609
LIG_FHA_1 340 346 PF00498 0.407
LIG_FHA_1 482 488 PF00498 0.416
LIG_FHA_1 506 512 PF00498 0.483
LIG_FHA_1 602 608 PF00498 0.389
LIG_FHA_2 179 185 PF00498 0.406
LIG_FHA_2 335 341 PF00498 0.492
LIG_FHA_2 469 475 PF00498 0.563
LIG_FHA_2 51 57 PF00498 0.569
LIG_FHA_2 580 586 PF00498 0.364
LIG_LIR_Apic_2 629 634 PF02991 0.502
LIG_LIR_Gen_1 250 259 PF02991 0.411
LIG_LIR_Nem_3 137 142 PF02991 0.355
LIG_LIR_Nem_3 158 164 PF02991 0.515
LIG_LIR_Nem_3 250 256 PF02991 0.417
LIG_LIR_Nem_3 498 502 PF02991 0.436
LIG_LIR_Nem_3 625 631 PF02991 0.488
LIG_NRBOX 319 325 PF00104 0.521
LIG_PCNA_yPIPBox_3 310 324 PF02747 0.427
LIG_PCNA_yPIPBox_3 608 618 PF02747 0.424
LIG_SH2_CRK 631 635 PF00017 0.504
LIG_SH2_PTP2 161 164 PF00017 0.515
LIG_SH2_STAT3 186 189 PF00017 0.443
LIG_SH2_STAT3 208 211 PF00017 0.518
LIG_SH2_STAT3 230 233 PF00017 0.462
LIG_SH2_STAT3 290 293 PF00017 0.422
LIG_SH2_STAT3 590 593 PF00017 0.424
LIG_SH2_STAT5 161 164 PF00017 0.480
LIG_SH2_STAT5 186 189 PF00017 0.379
LIG_SH2_STAT5 208 211 PF00017 0.450
LIG_SH2_STAT5 281 284 PF00017 0.537
LIG_SH2_STAT5 352 355 PF00017 0.511
LIG_SH2_STAT5 499 502 PF00017 0.430
LIG_SH2_STAT5 524 527 PF00017 0.468
LIG_SH2_STAT5 590 593 PF00017 0.424
LIG_SH2_STAT5 631 634 PF00017 0.373
LIG_SH3_3 400 406 PF00018 0.375
LIG_SH3_3 427 433 PF00018 0.567
LIG_SUMO_SIM_anti_2 505 513 PF11976 0.593
LIG_TRAF2_1 128 131 PF00917 0.491
LIG_TRAF2_1 241 244 PF00917 0.486
LIG_TRAF2_1 471 474 PF00917 0.537
LIG_TRAF2_1 529 532 PF00917 0.492
LIG_TYR_ITIM 497 502 PF00017 0.431
LIG_UBA3_1 444 450 PF00899 0.416
LIG_WW_3 632 636 PF00397 0.562
MOD_CDK_SPxK_1 629 635 PF00069 0.345
MOD_CK1_1 38 44 PF00069 0.596
MOD_CK1_1 642 648 PF00069 0.579
MOD_CK2_1 248 254 PF00069 0.462
MOD_CK2_1 334 340 PF00069 0.429
MOD_CK2_1 468 474 PF00069 0.582
MOD_CK2_1 488 494 PF00069 0.429
MOD_CK2_1 50 56 PF00069 0.444
MOD_GlcNHglycan 250 253 PF01048 0.529
MOD_GlcNHglycan 303 306 PF01048 0.372
MOD_GlcNHglycan 37 40 PF01048 0.530
MOD_GlcNHglycan 544 547 PF01048 0.480
MOD_GlcNHglycan 56 60 PF01048 0.431
MOD_GlcNHglycan 644 647 PF01048 0.420
MOD_GlcNHglycan 71 74 PF01048 0.351
MOD_GSK3_1 175 182 PF00069 0.591
MOD_GSK3_1 29 36 PF00069 0.495
MOD_GSK3_1 444 451 PF00069 0.431
MOD_GSK3_1 464 471 PF00069 0.349
MOD_GSK3_1 542 549 PF00069 0.563
MOD_GSK3_1 599 606 PF00069 0.516
MOD_GSK3_1 635 642 PF00069 0.500
MOD_N-GLC_1 29 34 PF02516 0.598
MOD_N-GLC_1 301 306 PF02516 0.372
MOD_N-GLC_1 487 492 PF02516 0.533
MOD_N-GLC_1 69 74 PF02516 0.520
MOD_NEK2_1 175 180 PF00069 0.507
MOD_NEK2_1 219 224 PF00069 0.508
MOD_NEK2_1 274 279 PF00069 0.589
MOD_NEK2_1 316 321 PF00069 0.399
MOD_NEK2_1 334 339 PF00069 0.353
MOD_NEK2_1 444 449 PF00069 0.425
MOD_NEK2_1 456 461 PF00069 0.421
MOD_NEK2_1 468 473 PF00069 0.652
MOD_NEK2_1 568 573 PF00069 0.435
MOD_NEK2_1 622 627 PF00069 0.572
MOD_PIKK_1 352 358 PF00454 0.556
MOD_PIKK_1 448 454 PF00454 0.497
MOD_PIKK_1 469 475 PF00454 0.416
MOD_PIKK_1 585 591 PF00454 0.486
MOD_PIKK_1 635 641 PF00454 0.660
MOD_PIKK_1 77 83 PF00454 0.467
MOD_PKA_2 179 185 PF00069 0.459
MOD_PKA_2 286 292 PF00069 0.445
MOD_PKA_2 488 494 PF00069 0.539
MOD_PKB_1 16 24 PF00069 0.504
MOD_Plk_1 197 203 PF00069 0.413
MOD_Plk_1 2 8 PF00069 0.385
MOD_Plk_1 29 35 PF00069 0.467
MOD_Plk_1 505 511 PF00069 0.503
MOD_Plk_1 622 628 PF00069 0.345
MOD_Plk_4 2 8 PF00069 0.504
MOD_Plk_4 319 325 PF00069 0.380
MOD_ProDKin_1 629 635 PF00069 0.503
MOD_SUMO_for_1 259 262 PF00179 0.309
MOD_SUMO_for_1 360 363 PF00179 0.295
MOD_SUMO_rev_2 198 207 PF00179 0.402
MOD_SUMO_rev_2 210 219 PF00179 0.442
MOD_SUMO_rev_2 229 239 PF00179 0.282
MOD_SUMO_rev_2 41 51 PF00179 0.588
MOD_SUMO_rev_2 431 439 PF00179 0.415
MOD_SUMO_rev_2 531 536 PF00179 0.560
TRG_DiLeu_BaEn_1 160 165 PF01217 0.515
TRG_DiLeu_BaEn_1 171 176 PF01217 0.603
TRG_DiLeu_BaEn_1 215 220 PF01217 0.374
TRG_DiLeu_BaEn_1 507 512 PF01217 0.555
TRG_DiLeu_BaEn_1 613 618 PF01217 0.424
TRG_DiLeu_BaEn_2 134 140 PF01217 0.355
TRG_ENDOCYTIC_2 161 164 PF00928 0.515
TRG_ENDOCYTIC_2 253 256 PF00928 0.417
TRG_ENDOCYTIC_2 370 373 PF00928 0.495
TRG_ENDOCYTIC_2 499 502 PF00928 0.430
TRG_ER_diArg_1 16 19 PF00400 0.471
TRG_ER_diArg_1 220 223 PF00400 0.289
TRG_ER_diArg_1 82 85 PF00400 0.361
TRG_NLS_MonoExtN_4 308 314 PF00514 0.339
TRG_Pf-PMV_PEXEL_1 454 458 PF00026 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAH6 Leptomonas seymouri 66% 100%
A0A0S4J8E8 Bodo saltans 40% 100%
A0A1X0NL92 Trypanosomatidae 48% 100%
A0A3R7KG47 Trypanosoma rangeli 44% 99%
A0A3S7XCE4 Leishmania donovani 82% 100%
D0A3N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AHZ1 Leishmania infantum 82% 100%
E9AU95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
F1QRC1 Danio rerio 26% 97%
P0DL09 Chlamydomonas reinhardtii 27% 93%
Q32KY1 Bos taurus 25% 91%
Q3USS3 Mus musculus 24% 86%
Q4Q096 Leishmania major 81% 100%
Q7T0Y4 Xenopus laevis 26% 94%
V5BD07 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS