Putative ubiquitin fusion degradation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin fusion degradation protein, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HQI1_LEIBR

TriTrypDb:

LbrM.35.6940 , LBRM2903_350081300

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQI1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	60	62	PF00082	0.449
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.449
CLV_PCSK_SKI1_1	123	127	PF00082	0.449
CLV_PCSK_SKI1_1	30	34	PF00082	0.449
DOC_CDC14_PxL_1	130	138	PF14671	0.650
DOC_CKS1_1	54	59	PF01111	0.650
DOC_MAPK_DCC_7	43	52	PF00069	0.650
DOC_MAPK_MEF2A_6	123	130	PF00069	0.650
DOC_MAPK_MEF2A_6	89	96	PF00069	0.650
DOC_MAPK_NFAT4_5	123	131	PF00069	0.650
DOC_PP4_FxxP_1	119	122	PF00568	0.650
DOC_WD40_RPTOR_TOS_1	151	157	PF00400	0.650
DOC_WW_Pin1_4	53	58	PF00397	0.650
LIG_14-3-3_CanoR_1	43	47	PF00244	0.650
LIG_Actin_WH2_2	75	91	PF00022	0.650
LIG_BIR_II_1	1	5	PF00653	0.780
LIG_Clathr_ClatBox_1	116	120	PF01394	0.650
LIG_deltaCOP1_diTrp_1	80	83	PF00928	0.650
LIG_eIF4E_1	27	33	PF01652	0.650
LIG_FHA_1	138	144	PF00498	0.650
LIG_FHA_1	8	14	PF00498	0.549
LIG_FHA_1	89	95	PF00498	0.650
LIG_LIR_Gen_1	80	88	PF02991	0.650
LIG_LIR_Nem_3	80	86	PF02991	0.650
LIG_LYPXL_yS_3	133	136	PF13949	0.650
LIG_SH2_CRK	63	67	PF00017	0.650
LIG_SH2_STAP1	63	67	PF00017	0.650
LIG_SH2_STAP1	8	12	PF00017	0.549
LIG_SH2_STAT3	48	51	PF00017	0.650
LIG_SH2_STAT5	146	149	PF00017	0.650
LIG_SH3_3	28	34	PF00018	0.650
LIG_SH3_3	73	79	PF00018	0.650
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.650
LIG_SUMO_SIM_par_1	140	145	PF11976	0.650
LIG_SUMO_SIM_par_1	154	160	PF11976	0.475
LIG_SUMO_SIM_par_1	9	16	PF11976	0.650
LIG_UBA3_1	158	162	PF00899	0.650
MOD_CDK_SPxK_1	53	59	PF00069	0.650
MOD_CDK_SPxxK_3	53	60	PF00069	0.650
MOD_CK1_1	16	22	PF00069	0.537
MOD_CK1_1	7	13	PF00069	0.549
MOD_GlcNHglycan	15	18	PF01048	0.449
MOD_GSK3_1	134	141	PF00069	0.650
MOD_NEK2_1	88	93	PF00069	0.650
MOD_PKA_2	42	48	PF00069	0.650
MOD_PKA_2	88	94	PF00069	0.650
MOD_Plk_4	102	108	PF00069	0.475
MOD_Plk_4	138	144	PF00069	0.650
MOD_Plk_4	33	39	PF00069	0.650
MOD_Plk_4	42	48	PF00069	0.537
MOD_Plk_4	72	78	PF00069	0.650
MOD_Plk_4	88	94	PF00069	0.449
MOD_ProDKin_1	53	59	PF00069	0.650
TRG_ENDOCYTIC_2	133	136	PF00928	0.650
TRG_ENDOCYTIC_2	63	66	PF00928	0.650
TRG_NLS_MonoExtN_4	57	63	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
O42915	SCHPO	34%	48%
P53044	YEAST	30%	46%
P70362	MOUSE	31%	54%
Q19584	CAEEL	35%	48%
Q55BK0	DICDI	34%	50%
Q92890	HUMAN	31%	54%
Q9ES53	RAT	31%	54%
Q9VTF9	DROME	34%	52%