ACB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acyl CoA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQH9_LEIBR

TriTrypDb:

LbrM.35.6920 , LBRM2903_350082200

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH9

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	11
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0033218	amide binding	2	11
GO:0036094	small molecule binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0120227	acyl-CoA binding	3	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901567	fatty acid derivative binding	3	11
GO:1901681	sulfur compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.617
CLV_PCSK_KEX2_1	224	226	PF00082	0.617
CLV_PCSK_SKI1_1	211	215	PF00082	0.593
CLV_PCSK_SKI1_1	286	290	PF00082	0.707
CLV_PCSK_SKI1_1	34	38	PF00082	0.335
CLV_Separin_Metazoa	11	15	PF03568	0.267
CLV_Separin_Metazoa	206	210	PF03568	0.524
DEG_APCC_DBOX_1	193	201	PF00400	0.376
DEG_SCF_FBW7_1	23	30	PF00400	0.437
DOC_PP1_RVXF_1	32	38	PF00149	0.355
DOC_USP7_MATH_1	146	150	PF00917	0.740
DOC_USP7_MATH_1	161	165	PF00917	0.791
DOC_USP7_MATH_1	176	180	PF00917	0.480
DOC_USP7_MATH_1	231	235	PF00917	0.709
DOC_USP7_MATH_1	250	254	PF00917	0.419
DOC_USP7_MATH_1	52	56	PF00917	0.378
DOC_WW_Pin1_4	157	162	PF00397	0.766
DOC_WW_Pin1_4	23	28	PF00397	0.512
DOC_WW_Pin1_4	315	320	PF00397	0.616
DOC_WW_Pin1_4	72	77	PF00397	0.227
LIG_14-3-3_CanoR_1	147	155	PF00244	0.501
LIG_14-3-3_CanoR_1	232	236	PF00244	0.601
LIG_14-3-3_CanoR_1	286	293	PF00244	0.711
LIG_14-3-3_CanoR_1	311	321	PF00244	0.540
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BIR_III_1	1	5	PF00653	0.348
LIG_BIR_III_3	1	5	PF00653	0.348
LIG_Clathr_ClatBox_1	91	95	PF01394	0.366
LIG_deltaCOP1_diTrp_1	323	327	PF00928	0.539
LIG_eIF4E_1	202	208	PF01652	0.570
LIG_FHA_1	115	121	PF00498	0.609
LIG_FHA_1	24	30	PF00498	0.226
LIG_LIR_Gen_1	75	84	PF02991	0.347
LIG_MYND_1	259	263	PF01753	0.687
LIG_PDZ_Class_1	326	331	PF00595	0.442
LIG_Pex14_2	83	87	PF04695	0.447
LIG_PTB_Apo_2	196	203	PF02174	0.544
LIG_PTB_Phospho_1	196	202	PF10480	0.544
LIG_SH2_STAT5	15	18	PF00017	0.407
LIG_SH2_STAT5	19	22	PF00017	0.439
LIG_SH2_STAT5	202	205	PF00017	0.447
LIG_SH3_3	125	131	PF00018	0.649
LIG_SH3_3	235	241	PF00018	0.607
LIG_SH3_3	257	263	PF00018	0.597
LIG_SH3_3	272	278	PF00018	0.614
LIG_SUMO_SIM_par_1	172	179	PF11976	0.458
LIG_TRAF2_1	164	167	PF00917	0.777
MOD_CK1_1	100	106	PF00069	0.648
MOD_CK1_1	193	199	PF00069	0.591
MOD_CK1_1	284	290	PF00069	0.586
MOD_CK1_1	306	312	PF00069	0.727
MOD_CK2_1	161	167	PF00069	0.792
MOD_CK2_1	175	181	PF00069	0.554
MOD_CK2_1	284	290	PF00069	0.707
MOD_CK2_1	72	78	PF00069	0.335
MOD_CK2_1	93	99	PF00069	0.552
MOD_CMANNOS	321	324	PF00535	0.508
MOD_GlcNHglycan	149	152	PF01048	0.706
MOD_GlcNHglycan	178	181	PF01048	0.619
MOD_GlcNHglycan	269	272	PF01048	0.588
MOD_GlcNHglycan	283	286	PF01048	0.582
MOD_GlcNHglycan	311	314	PF01048	0.774
MOD_GlcNHglycan	315	318	PF01048	0.712
MOD_GSK3_1	101	108	PF00069	0.714
MOD_GSK3_1	153	160	PF00069	0.733
MOD_GSK3_1	23	30	PF00069	0.535
MOD_GSK3_1	309	316	PF00069	0.717
MOD_GSK3_1	48	55	PF00069	0.372
MOD_GSK3_1	93	100	PF00069	0.582
MOD_N-GLC_1	267	272	PF02516	0.684
MOD_NEK2_1	175	180	PF00069	0.510
MOD_NEK2_1	326	331	PF00069	0.442
MOD_PIKK_1	153	159	PF00454	0.540
MOD_PIKK_1	93	99	PF00454	0.552
MOD_PK_1	303	309	PF00069	0.515
MOD_PKA_1	303	309	PF00069	0.515
MOD_PKA_2	146	152	PF00069	0.634
MOD_PKA_2	193	199	PF00069	0.575
MOD_PKA_2	231	237	PF00069	0.613
MOD_PKA_2	281	287	PF00069	0.686
MOD_Plk_1	98	104	PF00069	0.466
MOD_Plk_4	52	58	PF00069	0.335
MOD_ProDKin_1	157	163	PF00069	0.763
MOD_ProDKin_1	23	29	PF00069	0.504
MOD_ProDKin_1	315	321	PF00069	0.608
MOD_ProDKin_1	72	78	PF00069	0.227
MOD_SUMO_rev_2	118	125	PF00179	0.594
TRG_DiLeu_BaEn_4	24	30	PF01217	0.480
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.349
TRG_DiLeu_LyEn_5	24	29	PF01217	0.541
TRG_ENDOCYTIC_2	9	12	PF00928	0.372
TRG_ER_diArg_1	208	211	PF00400	0.456
TRG_ER_diArg_1	223	225	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	201	206	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMA6	Leptomonas seymouri	42%	100%
A0A1X0NL99	Trypanosomatidae	35%	100%
A0A3S7XC89	Leishmania donovani	67%	100%
A0A422P468	Trypanosoma rangeli	27%	100%
E9AHY9	Leishmania infantum	67%	100%
E9AU92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q099	Leishmania major	65%	100%
V5A2D1	Trypanosoma cruzi	37%	100%
V5B4W0	Trypanosoma cruzi	37%	100%