Similarity to endo-1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similarity to endo-1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HQH7_LEIBR

TriTrypDb:

LbrM.35.6900 , LBRM2903_350082000

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	195	201	PF00089	0.301
CLV_NRD_NRD_1	220	222	PF00675	0.281
CLV_PCSK_KEX2_1	54	56	PF00082	0.409
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.393
CLV_PCSK_SKI1_1	162	166	PF00082	0.382
CLV_PCSK_SKI1_1	228	232	PF00082	0.281
DOC_CYCLIN_RxL_1	222	233	PF00134	0.593
DOC_MAPK_DCC_7	162	171	PF00069	0.481
DOC_MAPK_gen_1	162	170	PF00069	0.582
DOC_MAPK_MEF2A_6	162	171	PF00069	0.586
DOC_PP2B_LxvP_1	169	172	PF13499	0.680
DOC_USP7_MATH_1	33	37	PF00917	0.582
DOC_USP7_UBL2_3	14	18	PF12436	0.523
DOC_WW_Pin1_4	19	24	PF00397	0.664
DOC_WW_Pin1_4	214	219	PF00397	0.510
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	43	47	PF00533	0.555
LIG_CtBP_PxDLS_1	153	157	PF00389	0.481
LIG_deltaCOP1_diTrp_1	82	87	PF00928	0.550
LIG_FHA_2	215	221	PF00498	0.582
LIG_GBD_Chelix_1	42	50	PF00786	0.382
LIG_LIR_Gen_1	100	109	PF02991	0.623
LIG_LIR_Gen_1	62	73	PF02991	0.543
LIG_LIR_Nem_3	100	105	PF02991	0.588
LIG_LIR_Nem_3	20	24	PF02991	0.491
LIG_LIR_Nem_3	27	31	PF02991	0.335
LIG_LIR_Nem_3	44	50	PF02991	0.683
LIG_LIR_Nem_3	62	68	PF02991	0.601
LIG_Pex14_1	83	87	PF04695	0.539
LIG_REV1ctd_RIR_1	204	212	PF16727	0.582
LIG_REV1ctd_RIR_1	232	240	PF16727	0.622
LIG_SH2_CRK	21	25	PF00017	0.489
LIG_SH2_NCK_1	21	25	PF00017	0.646
LIG_SH2_STAT5	196	199	PF00017	0.481
LIG_SH2_STAT5	21	24	PF00017	0.543
LIG_SH2_STAT5	216	219	PF00017	0.582
LIG_SH2_STAT5	65	68	PF00017	0.501
LIG_SH3_3	64	70	PF00018	0.582
LIG_Sin3_3	112	119	PF02671	0.576
LIG_SUMO_SIM_par_1	39	45	PF11976	0.539
LIG_TRAF2_1	217	220	PF00917	0.574
LIG_UBA3_1	115	123	PF00899	0.533
LIG_UBA3_1	46	54	PF00899	0.593
LIG_WRC_WIRS_1	102	107	PF05994	0.593
MOD_CDK_SPxxK_3	214	221	PF00069	0.481
MOD_CK2_1	170	176	PF00069	0.539
MOD_CK2_1	214	220	PF00069	0.582
MOD_GlcNHglycan	88	91	PF01048	0.377
MOD_GSK3_1	97	104	PF00069	0.660
MOD_N-GLC_1	133	138	PF02516	0.281
MOD_N-GLC_1	154	159	PF02516	0.281
MOD_N-GLC_2	7	9	PF02516	0.633
MOD_NEK2_1	235	240	PF00069	0.494
MOD_NEK2_1	50	55	PF00069	0.481
MOD_Plk_1	133	139	PF00069	0.481
MOD_Plk_4	133	139	PF00069	0.509
MOD_ProDKin_1	19	25	PF00069	0.668
MOD_ProDKin_1	214	220	PF00069	0.510
MOD_SUMO_rev_2	214	224	PF00179	0.593
TRG_DiLeu_BaEn_1	62	67	PF01217	0.559
TRG_ENDOCYTIC_2	196	199	PF00928	0.501
TRG_ENDOCYTIC_2	21	24	PF00928	0.483
TRG_ENDOCYTIC_2	65	68	PF00928	0.501
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P241	Leptomonas seymouri	61%	99%
A0A0S4KTD2	Bodo saltans	40%	100%
A0A2V5GSC6	Aspergillus violaceofuscus (strain CBS 115571)	31%	98%
A0A3S7XCB3	Leishmania donovani	74%	100%
A4ICB3	Leishmania infantum	74%	100%
B8M9K0	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	28%	94%
E9AU90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
O14359	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	96%
O67802	Aquifex aeolicus (strain VF5)	25%	100%
P46209	Aquifex pyrophilus	24%	100%
Q43914	Azospirillum brasilense	29%	100%
Q4Q0A1	Leishmania major	72%	100%
Q5RBU3	Pongo abelii	25%	98%
Q5XH09	Xenopus laevis	26%	98%
Q6P7K0	Xenopus tropicalis	27%	98%
Q7TP52	Rattus norvegicus	25%	98%
Q8R1G2	Mus musculus	26%	98%
Q96DG6	Homo sapiens	25%	98%
Q9P7U1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	97%
Q9ZT66	Zea mays	28%	79%