Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQH6_LEIBR

TriTrypDb:

LbrM.35.6890 , LBRM2903_350081900

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000126	transcription factor TFIIIB complex	4	1
GO:0005667	transcription regulator complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0090576	RNA polymerase III transcription regulator complex	3	1

Expansion

Sequence features

A4HQH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0070897	transcription preinitiation complex assembly	7	1
GO:0070898	RNA polymerase III preinitiation complex assembly	8	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0001025	RNA polymerase III general transcription initiation factor binding	5	1
GO:0001156	TFIIIC-class transcription factor complex binding	6	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008134	transcription factor binding	3	1
GO:0140296	general transcription initiation factor binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.551
CLV_C14_Caspase3-7	157	161	PF00656	0.501
CLV_C14_Caspase3-7	326	330	PF00656	0.561
CLV_NRD_NRD_1	169	171	PF00675	0.634
CLV_NRD_NRD_1	211	213	PF00675	0.326
CLV_NRD_NRD_1	319	321	PF00675	0.662
CLV_PCSK_FUR_1	167	171	PF00082	0.639
CLV_PCSK_FUR_1	209	213	PF00082	0.388
CLV_PCSK_KEX2_1	169	171	PF00082	0.634
CLV_PCSK_KEX2_1	19	21	PF00082	0.483
CLV_PCSK_KEX2_1	211	213	PF00082	0.326
CLV_PCSK_KEX2_1	215	217	PF00082	0.329
CLV_PCSK_KEX2_1	317	319	PF00082	0.660
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.483
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.312
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.660
CLV_PCSK_PC7_1	211	217	PF00082	0.312
CLV_PCSK_PC7_1	314	320	PF00082	0.664
CLV_PCSK_SKI1_1	212	216	PF00082	0.388
CLV_PCSK_SKI1_1	334	338	PF00082	0.761
CLV_PCSK_SKI1_1	74	78	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DEG_SIAH_1	93	101	PF03145	0.609
DEG_SPOP_SBC_1	76	80	PF00917	0.625
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.681
DOC_MAPK_FxFP_2	36	39	PF00069	0.550
DOC_MAPK_FxFP_2	6	9	PF00069	0.562
DOC_MAPK_MEF2A_6	367	374	PF00069	0.424
DOC_PP1_RVXF_1	175	181	PF00149	0.352
DOC_PP2B_LxvP_1	292	295	PF13499	0.679
DOC_PP4_FxxP_1	36	39	PF00568	0.550
DOC_PP4_FxxP_1	6	9	PF00568	0.562
DOC_USP7_MATH_1	124	128	PF00917	0.664
DOC_USP7_MATH_1	280	284	PF00917	0.608
DOC_USP7_MATH_1	286	290	PF00917	0.631
DOC_USP7_MATH_1	351	355	PF00917	0.557
DOC_USP7_MATH_1	86	90	PF00917	0.636
DOC_USP7_MATH_1	94	98	PF00917	0.670
DOC_WW_Pin1_4	108	113	PF00397	0.672
DOC_WW_Pin1_4	19	24	PF00397	0.593
LIG_14-3-3_CanoR_1	74	82	PF00244	0.741
LIG_14-3-3_CanoR_1	93	99	PF00244	0.611
LIG_APCC_ABBA_1	358	363	PF00400	0.399
LIG_CtBP_PxDLS_1	238	242	PF00389	0.388
LIG_FHA_1	259	265	PF00498	0.446
LIG_FHA_2	127	133	PF00498	0.553
LIG_FHA_2	208	214	PF00498	0.255
LIG_FHA_2	298	304	PF00498	0.641
LIG_LIR_Apic_2	3	9	PF02991	0.578
LIG_LIR_Apic_2	34	39	PF02991	0.639
LIG_LIR_Gen_1	187	195	PF02991	0.334
LIG_LIR_Gen_1	197	207	PF02991	0.379
LIG_LIR_Gen_1	353	360	PF02991	0.609
LIG_LIR_Nem_3	187	192	PF02991	0.334
LIG_LIR_Nem_3	197	202	PF02991	0.379
LIG_LIR_Nem_3	353	359	PF02991	0.542
LIG_PCNA_yPIPBox_3	352	362	PF02747	0.484
LIG_PCNA_yPIPBox_3	62	73	PF02747	0.588
LIG_PDZ_Class_2	389	394	PF00595	0.495
LIG_SH2_CRK	189	193	PF00017	0.388
LIG_SH2_SRC	117	120	PF00017	0.548
LIG_SH2_STAT5	117	120	PF00017	0.596
LIG_SH3_2	312	317	PF14604	0.660
LIG_SH3_3	165	171	PF00018	0.559
LIG_SH3_3	201	207	PF00018	0.312
LIG_SH3_3	309	315	PF00018	0.566
LIG_SH3_3	55	61	PF00018	0.543
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.312
LIG_SUMO_SIM_anti_2	369	374	PF11976	0.428
LIG_TRAF2_1	130	133	PF00917	0.628
LIG_TRAF2_2	10	15	PF00917	0.553
LIG_WRC_WIRS_1	185	190	PF05994	0.312
MOD_CK1_1	127	133	PF00069	0.674
MOD_CK1_1	89	95	PF00069	0.710
MOD_CK2_1	126	132	PF00069	0.638
MOD_CK2_1	178	184	PF00069	0.342
MOD_GlcNHglycan	126	129	PF01048	0.669
MOD_GlcNHglycan	198	202	PF01048	0.345
MOD_GlcNHglycan	282	285	PF01048	0.731
MOD_GlcNHglycan	88	91	PF01048	0.591
MOD_GSK3_1	108	115	PF00069	0.630
MOD_GSK3_1	154	161	PF00069	0.606
MOD_GSK3_1	19	26	PF00069	0.645
MOD_GSK3_1	190	197	PF00069	0.312
MOD_N-GLC_1	337	342	PF02516	0.574
MOD_N-GLC_1	65	70	PF02516	0.582
MOD_NEK2_1	258	263	PF00069	0.467
MOD_NEK2_1	32	37	PF00069	0.478
MOD_NEK2_1	77	82	PF00069	0.684
MOD_NEK2_2	351	356	PF00069	0.434
MOD_PIKK_1	101	107	PF00454	0.695
MOD_PIKK_1	190	196	PF00454	0.312
MOD_PIKK_1	231	237	PF00454	0.231
MOD_PKA_1	169	175	PF00069	0.466
MOD_PKA_1	319	325	PF00069	0.667
MOD_PKA_2	169	175	PF00069	0.470
MOD_PKA_2	319	325	PF00069	0.797
MOD_PKB_1	167	175	PF00069	0.471
MOD_Plk_1	197	203	PF00069	0.312
MOD_Plk_1	65	71	PF00069	0.579
MOD_Plk_2-3	366	372	PF00069	0.421
MOD_Plk_4	351	357	PF00069	0.551
MOD_Plk_4	43	49	PF00069	0.473
MOD_ProDKin_1	108	114	PF00069	0.675
MOD_ProDKin_1	19	25	PF00069	0.595
MOD_SUMO_for_1	287	290	PF00179	0.632
MOD_SUMO_rev_2	326	336	PF00179	0.716
MOD_SUMO_rev_2	363	369	PF00179	0.408
TRG_DiLeu_BaEn_1	254	259	PF01217	0.455
TRG_DiLeu_BaEn_2	266	272	PF01217	0.582
TRG_DiLeu_BaEn_4	267	273	PF01217	0.583
TRG_ENDOCYTIC_2	189	192	PF00928	0.317
TRG_ER_diArg_1	166	169	PF00400	0.646
TRG_ER_diArg_1	209	212	PF00400	0.343
TRG_ER_diArg_1	318	320	PF00400	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV5	Leptomonas seymouri	49%	100%
A0A3Q8IM42	Leishmania donovani	79%	99%
A4ICB2	Leishmania infantum	79%	99%
E9AU89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4Q0A2	Leishmania major	80%	100%