Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQH5_LEIBR

TriTrypDb:

LbrM.35.6880 , LBRM2903_350081800

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.602
CLV_NRD_NRD_1	102	104	PF00675	0.548
CLV_NRD_NRD_1	119	121	PF00675	0.464
CLV_NRD_NRD_1	325	327	PF00675	0.526
CLV_NRD_NRD_1	422	424	PF00675	0.633
CLV_NRD_NRD_1	470	472	PF00675	0.611
CLV_NRD_NRD_1	577	579	PF00675	0.682
CLV_PCSK_FUR_1	117	121	PF00082	0.529
CLV_PCSK_KEX2_1	102	104	PF00082	0.548
CLV_PCSK_KEX2_1	119	121	PF00082	0.464
CLV_PCSK_KEX2_1	168	170	PF00082	0.550
CLV_PCSK_KEX2_1	325	327	PF00082	0.400
CLV_PCSK_KEX2_1	422	424	PF00082	0.603
CLV_PCSK_KEX2_1	470	472	PF00082	0.611
CLV_PCSK_KEX2_1	518	520	PF00082	0.774
CLV_PCSK_KEX2_1	577	579	PF00082	0.571
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.589
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.774
CLV_PCSK_SKI1_1	155	159	PF00082	0.724
CLV_PCSK_SKI1_1	169	173	PF00082	0.354
CLV_PCSK_SKI1_1	293	297	PF00082	0.476
CLV_PCSK_SKI1_1	410	414	PF00082	0.633
CLV_PCSK_SKI1_1	434	438	PF00082	0.584
DEG_APCC_DBOX_1	409	417	PF00400	0.648
DEG_COP1_1	143	152	PF00400	0.502
DEG_SPOP_SBC_1	260	264	PF00917	0.477
DEG_SPOP_SBC_1	84	88	PF00917	0.533
DOC_CKS1_1	302	307	PF01111	0.548
DOC_CKS1_1	385	390	PF01111	0.446
DOC_CKS1_1	530	535	PF01111	0.762
DOC_CYCLIN_RxL_1	229	237	PF00134	0.406
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.745
DOC_MAPK_DCC_7	102	111	PF00069	0.537
DOC_MAPK_DCC_7	501	511	PF00069	0.769
DOC_MAPK_gen_1	117	126	PF00069	0.568
DOC_MAPK_gen_1	168	176	PF00069	0.361
DOC_MAPK_gen_1	500	506	PF00069	0.518
DOC_MAPK_gen_1	577	584	PF00069	0.573
DOC_MAPK_MEF2A_6	102	111	PF00069	0.777
DOC_PP1_RVXF_1	153	159	PF00149	0.729
DOC_PP1_RVXF_1	230	237	PF00149	0.406
DOC_PP2B_LxvP_1	212	215	PF13499	0.477
DOC_PP2B_LxvP_1	282	285	PF13499	0.456
DOC_PP2B_LxvP_1	531	534	PF13499	0.742
DOC_PP4_FxxP_1	236	239	PF00568	0.665
DOC_PP4_FxxP_1	357	360	PF00568	0.586
DOC_PP4_FxxP_1	385	388	PF00568	0.448
DOC_SPAK_OSR1_1	356	360	PF12202	0.617
DOC_USP7_MATH_1	107	111	PF00917	0.721
DOC_USP7_MATH_1	142	146	PF00917	0.570
DOC_USP7_MATH_1	150	154	PF00917	0.501
DOC_USP7_MATH_1	260	264	PF00917	0.697
DOC_USP7_MATH_1	494	498	PF00917	0.671
DOC_USP7_MATH_1	505	509	PF00917	0.593
DOC_USP7_MATH_1	552	556	PF00917	0.677
DOC_USP7_MATH_1	84	88	PF00917	0.533
DOC_USP7_MATH_1	92	96	PF00917	0.519
DOC_USP7_UBL2_3	40	44	PF12436	0.440
DOC_WW_Pin1_4	118	123	PF00397	0.779
DOC_WW_Pin1_4	301	306	PF00397	0.584
DOC_WW_Pin1_4	384	389	PF00397	0.564
DOC_WW_Pin1_4	529	534	PF00397	0.683
DOC_WW_Pin1_4	546	551	PF00397	0.727
LIG_14-3-3_CanoR_1	169	177	PF00244	0.512
LIG_14-3-3_CanoR_1	193	197	PF00244	0.480
LIG_14-3-3_CanoR_1	204	213	PF00244	0.593
LIG_14-3-3_CanoR_1	293	302	PF00244	0.692
LIG_14-3-3_CanoR_1	33	38	PF00244	0.610
LIG_14-3-3_CanoR_1	42	52	PF00244	0.666
LIG_14-3-3_CanoR_1	422	428	PF00244	0.696
LIG_14-3-3_CanoR_1	486	495	PF00244	0.631
LIG_14-3-3_CanoR_1	519	529	PF00244	0.769
LIG_Actin_WH2_2	409	424	PF00022	0.441
LIG_BRCT_BRCA1_1	142	146	PF00533	0.754
LIG_BRCT_BRCA1_1	353	357	PF00533	0.601
LIG_deltaCOP1_diTrp_1	352	357	PF00928	0.566
LIG_FHA_1	302	308	PF00498	0.630
LIG_FHA_1	32	38	PF00498	0.588
LIG_FHA_1	332	338	PF00498	0.455
LIG_FHA_1	385	391	PF00498	0.655
LIG_FHA_1	443	449	PF00498	0.404
LIG_FHA_1	452	458	PF00498	0.365
LIG_FHA_1	530	536	PF00498	0.747
LIG_FHA_1	558	564	PF00498	0.690
LIG_FHA_2	127	133	PF00498	0.754
LIG_FHA_2	170	176	PF00498	0.584
LIG_FHA_2	267	273	PF00498	0.409
LIG_FHA_2	43	49	PF00498	0.560
LIG_FHA_2	430	436	PF00498	0.624
LIG_FHA_2	439	445	PF00498	0.487
LIG_FHA_2	453	459	PF00498	0.464
LIG_LIR_Apic_2	233	239	PF02991	0.648
LIG_LIR_Apic_2	354	360	PF02991	0.613
LIG_LIR_Apic_2	383	388	PF02991	0.441
LIG_LIR_Gen_1	143	152	PF02991	0.502
LIG_LIR_Gen_1	180	190	PF02991	0.393
LIG_LIR_Gen_1	343	351	PF02991	0.436
LIG_LIR_Nem_3	143	149	PF02991	0.645
LIG_LIR_Nem_3	180	185	PF02991	0.398
LIG_LIR_Nem_3	228	234	PF02991	0.649
LIG_MAD2	380	388	PF02301	0.550
LIG_NRBOX	54	60	PF00104	0.595
LIG_PCNA_PIPBox_1	430	439	PF02747	0.678
LIG_Pex14_1	353	357	PF04695	0.568
LIG_SH2_STAP1	346	350	PF00017	0.529
LIG_SH2_STAT5	290	293	PF00017	0.466
LIG_SH2_STAT5	30	33	PF00017	0.599
LIG_SH2_STAT5	358	361	PF00017	0.638
LIG_SH2_STAT5	537	540	PF00017	0.496
LIG_SH3_3	299	305	PF00018	0.692
LIG_SH3_3	501	507	PF00018	0.723
LIG_SH3_3	508	514	PF00018	0.701
LIG_SH3_3	527	533	PF00018	0.766
LIG_SH3_3	551	557	PF00018	0.691
LIG_SH3_3	78	84	PF00018	0.500
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.323
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.298
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.518
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.638
LIG_WRC_WIRS_1	337	342	PF05994	0.566
MOD_CK1_1	110	116	PF00069	0.763
MOD_CK1_1	161	167	PF00069	0.613
MOD_CK1_1	22	28	PF00069	0.644
MOD_CK1_1	32	38	PF00069	0.603
MOD_CK1_1	401	407	PF00069	0.690
MOD_CK1_1	485	491	PF00069	0.726
MOD_CK1_1	520	526	PF00069	0.617
MOD_CK1_1	86	92	PF00069	0.752
MOD_CK2_1	126	132	PF00069	0.522
MOD_CK2_1	205	211	PF00069	0.668
MOD_CK2_1	266	272	PF00069	0.544
MOD_CK2_1	341	347	PF00069	0.407
MOD_CK2_1	402	408	PF00069	0.554
MOD_CK2_1	438	444	PF00069	0.539
MOD_CK2_1	452	458	PF00069	0.464
MOD_CK2_1	493	499	PF00069	0.737
MOD_CK2_1	584	590	PF00069	0.612
MOD_CK2_1	9	15	PF00069	0.579
MOD_GlcNHglycan	177	180	PF01048	0.425
MOD_GlcNHglycan	227	230	PF01048	0.567
MOD_GlcNHglycan	315	318	PF01048	0.411
MOD_GlcNHglycan	394	397	PF01048	0.690
MOD_GlcNHglycan	404	407	PF01048	0.634
MOD_GlcNHglycan	423	426	PF01048	0.700
MOD_GlcNHglycan	448	451	PF01048	0.618
MOD_GlcNHglycan	472	476	PF01048	0.647
MOD_GlcNHglycan	488	491	PF01048	0.753
MOD_GlcNHglycan	496	499	PF01048	0.722
MOD_GlcNHglycan	523	526	PF01048	0.624
MOD_GlcNHglycan	550	553	PF01048	0.684
MOD_GSK3_1	107	114	PF00069	0.619
MOD_GSK3_1	221	228	PF00069	0.643
MOD_GSK3_1	230	237	PF00069	0.611
MOD_GSK3_1	29	36	PF00069	0.537
MOD_GSK3_1	293	300	PF00069	0.691
MOD_GSK3_1	336	343	PF00069	0.402
MOD_GSK3_1	359	366	PF00069	0.420
MOD_GSK3_1	38	45	PF00069	0.559
MOD_GSK3_1	398	405	PF00069	0.699
MOD_GSK3_1	438	445	PF00069	0.588
MOD_GSK3_1	482	489	PF00069	0.655
MOD_GSK3_1	5	12	PF00069	0.599
MOD_GSK3_1	517	524	PF00069	0.567
MOD_GSK3_1	548	555	PF00069	0.735
MOD_GSK3_1	83	90	PF00069	0.773
MOD_GSK3_1	92	99	PF00069	0.729
MOD_N-GLC_1	205	210	PF02516	0.638
MOD_N-GLC_1	398	403	PF02516	0.679
MOD_NEK2_1	158	163	PF00069	0.502
MOD_NEK2_1	225	230	PF00069	0.517
MOD_NEK2_1	234	239	PF00069	0.533
MOD_NEK2_1	274	279	PF00069	0.485
MOD_NEK2_1	31	36	PF00069	0.581
MOD_NEK2_1	313	318	PF00069	0.339
MOD_NEK2_1	338	343	PF00069	0.522
MOD_NEK2_1	363	368	PF00069	0.510
MOD_NEK2_1	38	43	PF00069	0.602
MOD_NEK2_1	392	397	PF00069	0.710
MOD_NEK2_1	421	426	PF00069	0.621
MOD_NEK2_1	457	462	PF00069	0.608
MOD_NEK2_1	5	10	PF00069	0.555
MOD_NEK2_1	85	90	PF00069	0.767
MOD_NEK2_2	429	434	PF00069	0.620
MOD_PIKK_1	50	56	PF00454	0.646
MOD_PKA_1	517	523	PF00069	0.760
MOD_PKA_2	192	198	PF00069	0.427
MOD_PKA_2	288	294	PF00069	0.619
MOD_PKA_2	297	303	PF00069	0.716
MOD_PKA_2	32	38	PF00069	0.617
MOD_PKA_2	421	427	PF00069	0.664
MOD_PKA_2	452	458	PF00069	0.400
MOD_PKA_2	485	491	PF00069	0.762
MOD_PKA_2	50	56	PF00069	0.521
MOD_PKA_2	518	524	PF00069	0.771
MOD_Plk_1	220	226	PF00069	0.574
MOD_Plk_1	234	240	PF00069	0.440
MOD_Plk_1	266	272	PF00069	0.544
MOD_Plk_1	457	463	PF00069	0.649
MOD_Plk_1	471	477	PF00069	0.443
MOD_Plk_1	584	590	PF00069	0.658
MOD_Plk_4	177	183	PF00069	0.383
MOD_Plk_4	33	39	PF00069	0.642
MOD_Plk_4	333	339	PF00069	0.445
MOD_Plk_4	341	347	PF00069	0.388
MOD_Plk_4	507	513	PF00069	0.497
MOD_Plk_4	584	590	PF00069	0.627
MOD_ProDKin_1	118	124	PF00069	0.779
MOD_ProDKin_1	301	307	PF00069	0.571
MOD_ProDKin_1	384	390	PF00069	0.567
MOD_ProDKin_1	529	535	PF00069	0.684
MOD_ProDKin_1	546	552	PF00069	0.727
MOD_SUMO_rev_2	374	382	PF00179	0.642
MOD_SUMO_rev_2	496	503	PF00179	0.753
TRG_DiLeu_BaEn_4	68	74	PF01217	0.631
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.670
TRG_ENDOCYTIC_2	182	185	PF00928	0.384
TRG_ENDOCYTIC_2	231	234	PF00928	0.645
TRG_ENDOCYTIC_2	346	349	PF00928	0.440
TRG_ER_diArg_1	118	120	PF00400	0.536
TRG_ER_diArg_1	201	204	PF00400	0.502
TRG_ER_diArg_1	421	423	PF00400	0.598
TRG_ER_diArg_1	469	471	PF00400	0.607
TRG_ER_diArg_1	576	578	PF00400	0.586
TRG_NES_CRM1_1	60	75	PF08389	0.393
TRG_NLS_Bipartite_1	500	521	PF00514	0.518
TRG_NLS_MonoExtN_4	514	521	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K6	Leptomonas seymouri	53%	97%
A0A1X0NLK5	Trypanosomatidae	35%	100%
A0A3R7NFJ5	Trypanosoma rangeli	35%	100%
A0A3S7XCD6	Leishmania donovani	77%	100%
A4ICB1	Leishmania infantum	77%	87%
D0A3M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AU88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q0A3	Leishmania major	76%	100%
V5DDT5	Trypanosoma cruzi	34%	100%