DNA-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA-binding protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQH4_LEIBR

TriTrypDb:

LbrM.35.6870 , LBRM2903_350081700

Length:

136

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HQH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.378
CLV_PCSK_KEX2_1	11	13	PF00082	0.419
CLV_PCSK_KEX2_1	129	131	PF00082	0.351
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.449
DEG_Nend_UBRbox_3	1	3	PF02207	0.727
DOC_CDC14_PxL_1	41	49	PF14671	0.438
DOC_MAPK_FxFP_2	42	45	PF00069	0.438
DOC_MAPK_RevD_3	114	130	PF00069	0.240
DOC_PP4_FxxP_1	42	45	PF00568	0.438
LIG_14-3-3_CanoR_1	102	111	PF00244	0.398
LIG_FHA_1	15	21	PF00498	0.349
LIG_FHA_1	36	42	PF00498	0.371
LIG_FHA_1	75	81	PF00498	0.573
LIG_LIR_Apic_2	60	66	PF02991	0.357
LIG_LIR_Gen_1	36	47	PF02991	0.360
LIG_LIR_Gen_1	76	86	PF02991	0.560
LIG_LIR_Nem_3	36	42	PF02991	0.286
LIG_LIR_Nem_3	4	10	PF02991	0.669
LIG_LIR_Nem_3	76	81	PF02991	0.560
LIG_LYPXL_S_1	43	47	PF13949	0.438
LIG_LYPXL_yS_3	44	47	PF13949	0.438
LIG_Pex14_2	53	57	PF04695	0.357
LIG_SH2_CRK	63	67	PF00017	0.564
LIG_SH2_CRK	7	11	PF00017	0.701
LIG_SH2_CRK	78	82	PF00017	0.317
LIG_SH2_STAP1	59	63	PF00017	0.433
LIG_SH2_STAT3	59	62	PF00017	0.395
LIG_SH2_STAT5	125	128	PF00017	0.529
LIG_SH2_STAT5	59	62	PF00017	0.444
LIG_SH3_1	63	69	PF00018	0.529
LIG_SH3_3	63	69	PF00018	0.484
LIG_TYR_ITSM	3	10	PF00017	0.529
LIG_Vh1_VBS_1	79	97	PF01044	0.240
LIG_WRC_WIRS_1	15	20	PF05994	0.467
MOD_CK1_1	14	20	PF00069	0.331
MOD_GlcNHglycan	25	28	PF01048	0.240
MOD_GSK3_1	31	38	PF00069	0.279
MOD_NEK2_1	80	85	PF00069	0.395
MOD_NEK2_1	88	93	PF00069	0.341
MOD_PK_1	11	17	PF00069	0.418
MOD_PKA_1	11	17	PF00069	0.418
MOD_PKA_2	11	17	PF00069	0.418
MOD_PKA_2	128	134	PF00069	0.535
MOD_Plk_1	35	41	PF00069	0.366
MOD_Plk_4	121	127	PF00069	0.438
MOD_Plk_4	43	49	PF00069	0.454
MOD_Plk_4	74	80	PF00069	0.573
MOD_Plk_4	88	94	PF00069	0.240
TRG_DiLeu_BaEn_1	76	81	PF01217	0.560
TRG_ENDOCYTIC_2	39	42	PF00928	0.306
TRG_ENDOCYTIC_2	44	47	PF00928	0.376
TRG_ENDOCYTIC_2	7	10	PF00928	0.700
TRG_ENDOCYTIC_2	78	81	PF00928	0.438
TRG_ER_diLys_1	132	136	PF00400	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A5	Leptomonas seymouri	64%	95%
A0A1X0NLY5	Trypanosomatidae	29%	97%
A0A3Q8IGW1	Leishmania donovani	79%	100%
A0A3R7MNP5	Trypanosoma rangeli	28%	95%
A4ICB0	Leishmania infantum	80%	100%
E9AU87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q0A4	Leishmania major	79%	100%