Pre-rRNA-processing protein esf1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQH3_LEIBR

TriTrypDb:

LbrM.35.6860 , LBRM2903_350081600

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HQH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.436
CLV_C14_Caspase3-7	393	397	PF00656	0.683
CLV_C14_Caspase3-7	461	465	PF00656	0.781
CLV_NRD_NRD_1	148	150	PF00675	0.393
CLV_NRD_NRD_1	272	274	PF00675	0.393
CLV_NRD_NRD_1	413	415	PF00675	0.466
CLV_NRD_NRD_1	49	51	PF00675	0.639
CLV_NRD_NRD_1	523	525	PF00675	0.465
CLV_NRD_NRD_1	54	56	PF00675	0.530
CLV_NRD_NRD_1	575	577	PF00675	0.489
CLV_NRD_NRD_1	696	698	PF00675	0.453
CLV_PCSK_FUR_1	407	411	PF00082	0.614
CLV_PCSK_KEX2_1	147	149	PF00082	0.385
CLV_PCSK_KEX2_1	191	193	PF00082	0.477
CLV_PCSK_KEX2_1	272	274	PF00082	0.469
CLV_PCSK_KEX2_1	409	411	PF00082	0.531
CLV_PCSK_KEX2_1	413	415	PF00082	0.520
CLV_PCSK_KEX2_1	49	51	PF00082	0.634
CLV_PCSK_KEX2_1	523	525	PF00082	0.465
CLV_PCSK_KEX2_1	54	56	PF00082	0.530
CLV_PCSK_KEX2_1	575	577	PF00082	0.489
CLV_PCSK_KEX2_1	648	650	PF00082	0.520
CLV_PCSK_KEX2_1	668	670	PF00082	0.571
CLV_PCSK_KEX2_1	677	679	PF00082	0.597
CLV_PCSK_KEX2_1	695	697	PF00082	0.395
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.477
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.568
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.545
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.624
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.645
CLV_PCSK_PC7_1	50	56	PF00082	0.622
CLV_PCSK_SKI1_1	2	6	PF00082	0.743
CLV_PCSK_SKI1_1	525	529	PF00082	0.486
CLV_PCSK_SKI1_1	532	536	PF00082	0.469
CLV_PCSK_SKI1_1	581	585	PF00082	0.483
CLV_PCSK_SKI1_1	591	595	PF00082	0.475
CLV_PCSK_SKI1_1	620	624	PF00082	0.479
CLV_PCSK_SKI1_1	648	652	PF00082	0.585
CLV_PCSK_SKI1_1	69	73	PF00082	0.451
DEG_APCC_DBOX_1	553	561	PF00400	0.603
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DEG_SPOP_SBC_1	103	107	PF00917	0.508
DOC_ANK_TNKS_1	681	688	PF00023	0.484
DOC_MAPK_gen_1	198	206	PF00069	0.482
DOC_MAPK_gen_1	646	656	PF00069	0.452
DOC_MAPK_MEF2A_6	198	206	PF00069	0.431
DOC_PP1_RVXF_1	353	359	PF00149	0.423
DOC_PP4_FxxP_1	324	327	PF00568	0.430
DOC_PP4_FxxP_1	36	39	PF00568	0.495
DOC_SPAK_OSR1_1	40	44	PF12202	0.498
DOC_USP7_MATH_1	103	107	PF00917	0.596
DOC_USP7_MATH_1	340	344	PF00917	0.462
DOC_USP7_MATH_1	388	392	PF00917	0.559
DOC_USP7_MATH_1	434	438	PF00917	0.764
DOC_USP7_MATH_1	681	685	PF00917	0.620
DOC_USP7_UBL2_3	405	409	PF12436	0.612
DOC_USP7_UBL2_3	521	525	PF12436	0.485
DOC_USP7_UBL2_3	528	532	PF12436	0.474
DOC_USP7_UBL2_3	573	577	PF12436	0.505
DOC_WW_Pin1_4	323	328	PF00397	0.506
LIG_14-3-3_CanoR_1	35	39	PF00244	0.477
LIG_14-3-3_CanoR_1	355	359	PF00244	0.428
LIG_14-3-3_CanoR_1	365	370	PF00244	0.467
LIG_14-3-3_CanoR_1	454	460	PF00244	0.575
LIG_14-3-3_CanoR_1	54	60	PF00244	0.594
LIG_14-3-3_CanoR_1	598	605	PF00244	0.517
LIG_14-3-3_CanoR_1	649	657	PF00244	0.428
LIG_14-3-3_CanoR_1	682	686	PF00244	0.647
LIG_14-3-3_CanoR_1	695	700	PF00244	0.398
LIG_CaM_IQ_9	494	510	PF13499	0.612
LIG_CSL_BTD_1	135	138	PF09270	0.627
LIG_FHA_1	291	297	PF00498	0.272
LIG_FHA_1	344	350	PF00498	0.319
LIG_FHA_1	507	513	PF00498	0.649
LIG_FHA_1	604	610	PF00498	0.680
LIG_FHA_1	649	655	PF00498	0.386
LIG_FHA_2	374	380	PF00498	0.506
LIG_FHA_2	610	616	PF00498	0.553
LIG_LIR_Apic_2	321	327	PF02991	0.433
LIG_LIR_Gen_1	156	165	PF02991	0.373
LIG_LIR_Nem_3	156	160	PF02991	0.343
LIG_LIR_Nem_3	164	169	PF02991	0.360
LIG_LIR_Nem_3	336	341	PF02991	0.357
LIG_Pex14_2	32	36	PF04695	0.505
LIG_Pex14_2	354	358	PF04695	0.406
LIG_Pex14_2	70	74	PF04695	0.563
LIG_REV1ctd_RIR_1	689	700	PF16727	0.625
LIG_SH2_CRK	166	170	PF00017	0.391
LIG_SH2_CRK	416	420	PF00017	0.488
LIG_SH2_NCK_1	283	287	PF00017	0.321
LIG_SH2_STAP1	166	170	PF00017	0.356
LIG_SH2_STAP1	416	420	PF00017	0.445
LIG_SH2_STAT5	317	320	PF00017	0.415
LIG_SH2_STAT5	385	388	PF00017	0.527
LIG_SH3_3	237	243	PF00018	0.745
LIG_SUMO_SIM_anti_2	651	660	PF11976	0.372
LIG_SUMO_SIM_par_1	178	183	PF11976	0.414
LIG_TRAF2_1	122	125	PF00917	0.696
LIG_TRAF2_1	376	379	PF00917	0.673
LIG_TYR_ITIM	296	301	PF00017	0.302
LIG_WRC_WIRS_1	285	290	PF05994	0.367
LIG_WRC_WIRS_1	341	346	PF05994	0.422
MOD_CDK_SPxxK_3	323	330	PF00069	0.502
MOD_CK1_1	101	107	PF00069	0.718
MOD_CK1_1	290	296	PF00069	0.351
MOD_CK1_1	343	349	PF00069	0.410
MOD_CK1_1	94	100	PF00069	0.717
MOD_CK2_1	373	379	PF00069	0.619
MOD_CK2_1	388	394	PF00069	0.501
MOD_CK2_1	443	449	PF00069	0.629
MOD_CK2_1	453	459	PF00069	0.618
MOD_CK2_1	568	574	PF00069	0.519
MOD_CK2_1	609	615	PF00069	0.552
MOD_Cter_Amidation	189	192	PF01082	0.379
MOD_Cter_Amidation	47	50	PF01082	0.500
MOD_Cter_Amidation	666	669	PF01082	0.601
MOD_GlcNHglycan	101	104	PF01048	0.769
MOD_GlcNHglycan	218	223	PF01048	0.722
MOD_GlcNHglycan	266	269	PF01048	0.434
MOD_GlcNHglycan	289	292	PF01048	0.375
MOD_GlcNHglycan	307	311	PF01048	0.426
MOD_GlcNHglycan	346	349	PF01048	0.464
MOD_GlcNHglycan	435	439	PF01048	0.666
MOD_GlcNHglycan	570	573	PF01048	0.518
MOD_GlcNHglycan	75	78	PF01048	0.502
MOD_GSK3_1	102	109	PF00069	0.708
MOD_GSK3_1	180	187	PF00069	0.415
MOD_GSK3_1	238	245	PF00069	0.699
MOD_GSK3_1	340	347	PF00069	0.461
MOD_GSK3_1	365	372	PF00069	0.456
MOD_GSK3_1	439	446	PF00069	0.803
MOD_GSK3_1	49	56	PF00069	0.769
MOD_GSK3_1	628	635	PF00069	0.530
MOD_GSK3_1	691	698	PF00069	0.596
MOD_GSK3_1	83	90	PF00069	0.646
MOD_GSK3_1	94	101	PF00069	0.678
MOD_NEK2_1	180	185	PF00069	0.535
MOD_NEK2_1	344	349	PF00069	0.405
MOD_NEK2_1	369	374	PF00069	0.592
MOD_NEK2_1	4	9	PF00069	0.537
MOD_NEK2_1	41	46	PF00069	0.536
MOD_NEK2_1	527	532	PF00069	0.592
MOD_NEK2_1	603	608	PF00069	0.550
MOD_NEK2_1	641	646	PF00069	0.624
MOD_NEK2_1	656	661	PF00069	0.367
MOD_NEK2_1	691	696	PF00069	0.535
MOD_NEK2_2	340	345	PF00069	0.435
MOD_PIKK_1	347	353	PF00454	0.420
MOD_PIKK_1	42	48	PF00454	0.492
MOD_PIKK_1	53	59	PF00454	0.517
MOD_PIKK_1	598	604	PF00454	0.678
MOD_PIKK_1	609	615	PF00454	0.591
MOD_PIKK_1	641	647	PF00454	0.583
MOD_PKA_1	49	55	PF00069	0.762
MOD_PKA_1	648	654	PF00069	0.496
MOD_PKA_2	34	40	PF00069	0.448
MOD_PKA_2	354	360	PF00069	0.418
MOD_PKA_2	453	459	PF00069	0.558
MOD_PKA_2	49	55	PF00069	0.552
MOD_PKA_2	568	574	PF00069	0.665
MOD_PKA_2	648	654	PF00069	0.400
MOD_PKA_2	681	687	PF00069	0.612
MOD_PKA_2	99	105	PF00069	0.524
MOD_Plk_1	180	186	PF00069	0.413
MOD_Plk_1	448	454	PF00069	0.596
MOD_Plk_1	482	488	PF00069	0.564
MOD_Plk_1	80	86	PF00069	0.674
MOD_Plk_2-3	233	239	PF00069	0.674
MOD_Plk_2-3	444	450	PF00069	0.546
MOD_Plk_4	180	186	PF00069	0.413
MOD_Plk_4	369	375	PF00069	0.428
MOD_Plk_4	474	480	PF00069	0.669
MOD_ProDKin_1	323	329	PF00069	0.502
MOD_SUMO_rev_2	398	406	PF00179	0.623
MOD_SUMO_rev_2	487	495	PF00179	0.536
MOD_SUMO_rev_2	672	679	PF00179	0.648
TRG_DiLeu_BaEn_4	124	130	PF01217	0.623
TRG_ENDOCYTIC_2	166	169	PF00928	0.382
TRG_ENDOCYTIC_2	282	285	PF00928	0.346
TRG_ENDOCYTIC_2	298	301	PF00928	0.391
TRG_ENDOCYTIC_2	416	419	PF00928	0.440
TRG_ER_diArg_1	147	149	PF00400	0.410
TRG_ER_diArg_1	17	20	PF00400	0.579
TRG_ER_diArg_1	271	273	PF00400	0.454
TRG_ER_diArg_1	278	281	PF00400	0.417
TRG_ER_diArg_1	364	367	PF00400	0.423
TRG_ER_diArg_1	412	414	PF00400	0.484
TRG_ER_diArg_1	522	524	PF00400	0.479
TRG_ER_diArg_1	695	697	PF00400	0.428
TRG_NES_CRM1_1	164	178	PF08389	0.352
TRG_NES_CRM1_1	450	464	PF08389	0.658
TRG_NLS_Bipartite_1	576	598	PF00514	0.493
TRG_NLS_MonoExtC_3	527	532	PF00514	0.479
TRG_NLS_MonoExtC_3	593	598	PF00514	0.517
TRG_NLS_MonoExtC_3	667	673	PF00514	0.622
TRG_NLS_MonoExtN_4	525	532	PF00514	0.503
TRG_NLS_MonoExtN_4	591	598	PF00514	0.474
TRG_NLS_MonoExtN_4	665	672	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.317
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z4	Leptomonas seymouri	67%	96%
A0A0S4IQI8	Bodo saltans	45%	95%
A0A3S5IRC1	Trypanosoma rangeli	52%	100%
A0A3S7XCB2	Leishmania donovani	82%	100%
A4ICA9	Leishmania infantum	81%	100%
D0A3M2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9AU86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0A5	Leishmania major	80%	100%
V5AXL9	Trypanosoma cruzi	51%	100%