PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cop9 signalosome complex subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HQH2_LEIBR

TriTrypDb:

LbrM.35.6850 , LBRM2903_350081500

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HQH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	374	378	PF00656	0.568
CLV_NRD_NRD_1	40	42	PF00675	0.403
CLV_PCSK_KEX2_1	40	42	PF00082	0.502
CLV_PCSK_SKI1_1	142	146	PF00082	0.267
CLV_PCSK_SKI1_1	230	234	PF00082	0.330
CLV_PCSK_SKI1_1	257	261	PF00082	0.340
CLV_PCSK_SKI1_1	300	304	PF00082	0.351
DEG_APCC_DBOX_1	229	237	PF00400	0.330
DOC_CKS1_1	260	265	PF01111	0.297
DOC_MAPK_gen_1	391	399	PF00069	0.537
DOC_MAPK_JIP1_4	393	399	PF00069	0.518
DOC_MAPK_MEF2A_6	391	398	PF00069	0.528
DOC_PP1_RVXF_1	109	116	PF00149	0.366
DOC_PP1_SILK_1	296	301	PF00149	0.299
DOC_PP4_FxxP_1	260	263	PF00568	0.305
DOC_USP7_MATH_1	211	215	PF00917	0.345
DOC_WW_Pin1_4	129	134	PF00397	0.455
DOC_WW_Pin1_4	259	264	PF00397	0.401
DOC_WW_Pin1_4	33	38	PF00397	0.440
LIG_14-3-3_CanoR_1	154	160	PF00244	0.371
LIG_14-3-3_CanoR_1	210	216	PF00244	0.353
LIG_14-3-3_CanoR_1	349	355	PF00244	0.294
LIG_14-3-3_CanoR_1	381	389	PF00244	0.409
LIG_14-3-3_CanoR_1	79	88	PF00244	0.539
LIG_Actin_WH2_2	130	147	PF00022	0.268
LIG_APCC_ABBA_1	323	328	PF00400	0.389
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BIR_III_4	21	25	PF00653	0.360
LIG_BRCT_BRCA1_1	121	125	PF00533	0.381
LIG_BRCT_BRCA1_1	4	8	PF00533	0.569
LIG_deltaCOP1_diTrp_1	70	78	PF00928	0.406
LIG_FHA_1	191	197	PF00498	0.286
LIG_FHA_1	260	266	PF00498	0.396
LIG_FHA_1	356	362	PF00498	0.411
LIG_FHA_2	102	108	PF00498	0.474
LIG_FHA_2	130	136	PF00498	0.363
LIG_FHA_2	26	32	PF00498	0.407
LIG_FHA_2	331	337	PF00498	0.404
LIG_FHA_2	372	378	PF00498	0.703
LIG_LIR_Apic_2	258	263	PF02991	0.312
LIG_LIR_Apic_2	70	76	PF02991	0.404
LIG_LIR_Gen_1	101	109	PF02991	0.356
LIG_LIR_Gen_1	264	273	PF02991	0.285
LIG_LIR_Gen_1	314	323	PF02991	0.388
LIG_LIR_Gen_1	336	345	PF02991	0.375
LIG_LIR_Gen_1	357	367	PF02991	0.428
LIG_LIR_Gen_1	376	386	PF02991	0.375
LIG_LIR_Gen_1	42	53	PF02991	0.381
LIG_LIR_Gen_1	7	18	PF02991	0.511
LIG_LIR_Nem_3	101	106	PF02991	0.455
LIG_LIR_Nem_3	122	128	PF02991	0.383
LIG_LIR_Nem_3	165	170	PF02991	0.403
LIG_LIR_Nem_3	214	218	PF02991	0.415
LIG_LIR_Nem_3	264	269	PF02991	0.287
LIG_LIR_Nem_3	314	318	PF02991	0.391
LIG_LIR_Nem_3	336	341	PF02991	0.380
LIG_LIR_Nem_3	357	363	PF02991	0.398
LIG_LIR_Nem_3	376	382	PF02991	0.474
LIG_LIR_Nem_3	42	48	PF02991	0.384
LIG_LIR_Nem_3	7	13	PF02991	0.530
LIG_MLH1_MIPbox_1	122	126	PF16413	0.455
LIG_NRBOX	336	342	PF00104	0.379
LIG_PDZ_Class_2	394	399	PF00595	0.545
LIG_Pex14_2	212	216	PF04695	0.401
LIG_RPA_C_Fungi	217	229	PF08784	0.287
LIG_SH2_CRK	167	171	PF00017	0.478
LIG_SH2_CRK	266	270	PF00017	0.370
LIG_SH2_CRK	338	342	PF00017	0.373
LIG_SH2_NCK_1	103	107	PF00017	0.439
LIG_SH2_PTP2	268	271	PF00017	0.382
LIG_SH2_STAP1	250	254	PF00017	0.295
LIG_SH2_STAP1	338	342	PF00017	0.368
LIG_SH2_STAT3	273	276	PF00017	0.457
LIG_SH2_STAT3	293	296	PF00017	0.460
LIG_SH2_STAT5	103	106	PF00017	0.426
LIG_SH2_STAT5	194	197	PF00017	0.337
LIG_SH2_STAT5	208	211	PF00017	0.350
LIG_SH2_STAT5	268	271	PF00017	0.347
LIG_SH2_STAT5	293	296	PF00017	0.369
LIG_SH3_3	289	295	PF00018	0.380
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.337
LIG_TYR_ITSM	99	106	PF00017	0.416
LIG_UBA3_1	308	313	PF00899	0.345
LIG_WRC_WIRS_1	212	217	PF05994	0.426
MOD_CDK_SPxxK_3	129	136	PF00069	0.450
MOD_CDK_SPxxK_3	33	40	PF00069	0.347
MOD_CK1_1	147	153	PF00069	0.432
MOD_CK1_1	2	8	PF00069	0.604
MOD_CK1_1	46	52	PF00069	0.380
MOD_CK1_1	80	86	PF00069	0.602
MOD_CK2_1	129	135	PF00069	0.292
MOD_CK2_1	238	244	PF00069	0.325
MOD_CK2_1	25	31	PF00069	0.454
MOD_CK2_1	330	336	PF00069	0.430
MOD_GlcNHglycan	122	125	PF01048	0.476
MOD_GlcNHglycan	157	160	PF01048	0.452
MOD_GlcNHglycan	177	180	PF01048	0.448
MOD_GlcNHglycan	21	25	PF01048	0.397
MOD_GlcNHglycan	230	233	PF01048	0.309
MOD_GlcNHglycan	278	281	PF01048	0.433
MOD_GlcNHglycan	300	303	PF01048	0.276
MOD_GlcNHglycan	350	353	PF01048	0.329
MOD_GlcNHglycan	382	385	PF01048	0.364
MOD_GlcNHglycan	83	86	PF01048	0.570
MOD_GSK3_1	120	127	PF00069	0.514
MOD_GSK3_1	294	301	PF00069	0.299
MOD_GSK3_1	380	387	PF00069	0.469
MOD_GSK3_1	77	84	PF00069	0.534
MOD_GSK3_1	98	105	PF00069	0.530
MOD_N-GLC_1	80	85	PF02516	0.611
MOD_NEK2_1	120	125	PF00069	0.487
MOD_NEK2_1	144	149	PF00069	0.379
MOD_NEK2_1	228	233	PF00069	0.251
MOD_NEK2_1	340	345	PF00069	0.438
MOD_NEK2_1	363	368	PF00069	0.420
MOD_NEK2_2	211	216	PF00069	0.397
MOD_NEK2_2	250	255	PF00069	0.297
MOD_PIKK_1	43	49	PF00454	0.370
MOD_PKA_2	147	153	PF00069	0.420
MOD_PKA_2	238	244	PF00069	0.315
MOD_PKA_2	348	354	PF00069	0.299
MOD_PKA_2	380	386	PF00069	0.398
MOD_PKA_2	81	87	PF00069	0.496
MOD_PKB_1	173	181	PF00069	0.578
MOD_Plk_2-3	330	336	PF00069	0.339
MOD_Plk_4	162	168	PF00069	0.471
MOD_Plk_4	190	196	PF00069	0.258
MOD_Plk_4	211	217	PF00069	0.365
MOD_Plk_4	261	267	PF00069	0.310
MOD_Plk_4	294	300	PF00069	0.325
MOD_Plk_4	340	346	PF00069	0.447
MOD_ProDKin_1	129	135	PF00069	0.450
MOD_ProDKin_1	259	265	PF00069	0.393
MOD_ProDKin_1	33	39	PF00069	0.444
TRG_DiLeu_BaEn_1	336	341	PF01217	0.380
TRG_ENDOCYTIC_2	103	106	PF00928	0.366
TRG_ENDOCYTIC_2	128	131	PF00928	0.382
TRG_ENDOCYTIC_2	167	170	PF00928	0.398
TRG_ENDOCYTIC_2	266	269	PF00928	0.362
TRG_ENDOCYTIC_2	338	341	PF00928	0.375
TRG_ER_diArg_1	173	176	PF00400	0.588
TRG_ER_diArg_1	54	57	PF00400	0.340
TRG_NES_CRM1_1	207	220	PF08389	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K5	Leptomonas seymouri	56%	100%
A0A3S7XCD5	Leishmania donovani	81%	100%
A4ICA8	Leishmania infantum	81%	100%
E9AU85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q0A6	Leishmania major	79%	100%