Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HQH1_LEIBR

TriTrypDb:

LbrM.35.6840 , LBRM2903_350081400

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HQH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	560	564	PF00656	0.317
CLV_NRD_NRD_1	103	105	PF00675	0.367
CLV_NRD_NRD_1	151	153	PF00675	0.536
CLV_NRD_NRD_1	191	193	PF00675	0.433
CLV_NRD_NRD_1	435	437	PF00675	0.374
CLV_NRD_NRD_1	506	508	PF00675	0.452
CLV_NRD_NRD_1	97	99	PF00675	0.378
CLV_PCSK_KEX2_1	103	105	PF00082	0.368
CLV_PCSK_KEX2_1	151	153	PF00082	0.535
CLV_PCSK_KEX2_1	191	193	PF00082	0.432
CLV_PCSK_KEX2_1	335	337	PF00082	0.374
CLV_PCSK_KEX2_1	434	436	PF00082	0.392
CLV_PCSK_KEX2_1	708	710	PF00082	0.555
CLV_PCSK_KEX2_1	97	99	PF00082	0.373
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.374
CLV_PCSK_PC1ET2_1	708	710	PF00082	0.491
CLV_PCSK_SKI1_1	131	135	PF00082	0.406
CLV_PCSK_SKI1_1	184	188	PF00082	0.432
CLV_PCSK_SKI1_1	204	208	PF00082	0.512
CLV_PCSK_SKI1_1	557	561	PF00082	0.606
CLV_PCSK_SKI1_1	617	621	PF00082	0.592
CLV_PCSK_SKI1_1	628	632	PF00082	0.485
CLV_PCSK_SKI1_1	708	712	PF00082	0.507
CLV_Separin_Metazoa	300	304	PF03568	0.533
DEG_APCC_DBOX_1	308	316	PF00400	0.467
DEG_APCC_DBOX_1	472	480	PF00400	0.505
DEG_Nend_UBRbox_3	1	3	PF02207	0.578
DEG_SCF_FBW7_2	146	153	PF00400	0.679
DEG_SPOP_SBC_1	538	542	PF00917	0.575
DOC_CDC14_PxL_1	631	639	PF14671	0.299
DOC_CKS1_1	159	164	PF01111	0.674
DOC_CKS1_1	455	460	PF01111	0.541
DOC_CKS1_1	466	471	PF01111	0.581
DOC_CYCLIN_yCln2_LP_2	547	553	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	576	582	PF00134	0.294
DOC_MAPK_DCC_7	44	54	PF00069	0.367
DOC_MAPK_gen_1	46	54	PF00069	0.367
DOC_MAPK_gen_1	507	518	PF00069	0.624
DOC_MAPK_gen_1	617	627	PF00069	0.285
DOC_MAPK_gen_1	65	74	PF00069	0.336
DOC_MAPK_MEF2A_6	48	57	PF00069	0.414
DOC_MAPK_MEF2A_6	67	76	PF00069	0.340
DOC_PP1_RVXF_1	27	33	PF00149	0.215
DOC_PP2B_LxvP_1	547	550	PF13499	0.442
DOC_PP2B_LxvP_1	576	579	PF13499	0.330
DOC_PP2B_LxvP_1	580	583	PF13499	0.337
DOC_SPAK_OSR1_1	44	48	PF12202	0.372
DOC_USP7_MATH_1	133	137	PF00917	0.616
DOC_USP7_MATH_1	206	210	PF00917	0.644
DOC_USP7_MATH_1	217	221	PF00917	0.690
DOC_USP7_MATH_1	230	234	PF00917	0.696
DOC_USP7_MATH_1	260	264	PF00917	0.662
DOC_USP7_MATH_1	289	293	PF00917	0.526
DOC_USP7_MATH_1	471	475	PF00917	0.598
DOC_USP7_MATH_1	480	484	PF00917	0.642
DOC_USP7_MATH_1	522	526	PF00917	0.469
DOC_USP7_MATH_1	644	648	PF00917	0.402
DOC_USP7_UBL2_3	349	353	PF12436	0.542
DOC_WW_Pin1_4	107	112	PF00397	0.601
DOC_WW_Pin1_4	142	147	PF00397	0.728
DOC_WW_Pin1_4	155	160	PF00397	0.821
DOC_WW_Pin1_4	18	23	PF00397	0.589
DOC_WW_Pin1_4	226	231	PF00397	0.658
DOC_WW_Pin1_4	244	249	PF00397	0.688
DOC_WW_Pin1_4	256	261	PF00397	0.675
DOC_WW_Pin1_4	265	270	PF00397	0.641
DOC_WW_Pin1_4	376	381	PF00397	0.546
DOC_WW_Pin1_4	425	430	PF00397	0.582
DOC_WW_Pin1_4	454	459	PF00397	0.528
DOC_WW_Pin1_4	465	470	PF00397	0.576
DOC_WW_Pin1_4	47	52	PF00397	0.365
DOC_WW_Pin1_4	540	545	PF00397	0.513
DOC_WW_Pin1_4	661	666	PF00397	0.405
LIG_14-3-3_CanoR_1	191	197	PF00244	0.730
LIG_14-3-3_CanoR_1	240	248	PF00244	0.660
LIG_14-3-3_CanoR_1	262	269	PF00244	0.696
LIG_14-3-3_CanoR_1	29	33	PF00244	0.215
LIG_14-3-3_CanoR_1	361	371	PF00244	0.536
LIG_14-3-3_CanoR_1	65	74	PF00244	0.339
LIG_Actin_WH2_2	173	190	PF00022	0.600
LIG_Actin_WH2_2	692	710	PF00022	0.285
LIG_Actin_WH2_2	74	91	PF00022	0.261
LIG_deltaCOP1_diTrp_1	680	687	PF00928	0.307
LIG_DLG_GKlike_1	192	200	PF00625	0.735
LIG_eIF4E_1	351	357	PF01652	0.482
LIG_eIF4E_1	37	43	PF01652	0.215
LIG_eIF4E_1	633	639	PF01652	0.316
LIG_EVH1_2	582	586	PF00568	0.392
LIG_FHA_1	177	183	PF00498	0.630
LIG_FHA_1	19	25	PF00498	0.559
LIG_FHA_1	213	219	PF00498	0.743
LIG_FHA_1	240	246	PF00498	0.685
LIG_FHA_1	327	333	PF00498	0.587
LIG_FHA_1	394	400	PF00498	0.497
LIG_FHA_1	450	456	PF00498	0.487
LIG_FHA_1	575	581	PF00498	0.338
LIG_FHA_1	598	604	PF00498	0.377
LIG_FHA_1	634	640	PF00498	0.357
LIG_FHA_1	667	673	PF00498	0.366
LIG_FHA_1	679	685	PF00498	0.278
LIG_FHA_1	85	91	PF00498	0.419
LIG_FHA_2	111	117	PF00498	0.511
LIG_FHA_2	364	370	PF00498	0.527
LIG_FHA_2	403	409	PF00498	0.575
LIG_FHA_2	455	461	PF00498	0.541
LIG_FHA_2	558	564	PF00498	0.415
LIG_FHA_2	605	611	PF00498	0.397
LIG_FHA_2	690	696	PF00498	0.302
LIG_HCF-1_HBM_1	592	595	PF13415	0.424
LIG_LIR_Apic_2	292	298	PF02991	0.612
LIG_LIR_Gen_1	116	127	PF02991	0.501
LIG_LIR_Gen_1	253	261	PF02991	0.621
LIG_LIR_Gen_1	369	378	PF02991	0.525
LIG_LIR_Gen_1	584	594	PF02991	0.403
LIG_LIR_Gen_1	680	690	PF02991	0.310
LIG_LIR_Nem_3	116	122	PF02991	0.506
LIG_LIR_Nem_3	253	258	PF02991	0.621
LIG_LIR_Nem_3	31	37	PF02991	0.358
LIG_LIR_Nem_3	369	374	PF02991	0.459
LIG_LIR_Nem_3	584	589	PF02991	0.398
LIG_LIR_Nem_3	68	73	PF02991	0.434
LIG_MYND_1	545	549	PF01753	0.463
LIG_NRBOX	626	632	PF00104	0.290
LIG_PDZ_Class_2	707	712	PF00595	0.298
LIG_SH2_CRK	255	259	PF00017	0.622
LIG_SH2_CRK	295	299	PF00017	0.549
LIG_SH2_CRK	375	379	PF00017	0.578
LIG_SH2_GRB2like	371	374	PF00017	0.505
LIG_SH2_PTP2	37	40	PF00017	0.215
LIG_SH2_PTP2	371	374	PF00017	0.505
LIG_SH2_SRC	371	374	PF00017	0.505
LIG_SH2_STAP1	395	399	PF00017	0.492
LIG_SH2_STAP1	406	410	PF00017	0.547
LIG_SH2_STAP1	595	599	PF00017	0.400
LIG_SH2_STAT3	395	398	PF00017	0.492
LIG_SH2_STAT3	415	418	PF00017	0.428
LIG_SH2_STAT3	442	445	PF00017	0.543
LIG_SH2_STAT3	673	676	PF00017	0.361
LIG_SH2_STAT5	333	336	PF00017	0.529
LIG_SH2_STAT5	351	354	PF00017	0.533
LIG_SH2_STAT5	37	40	PF00017	0.215
LIG_SH2_STAT5	371	374	PF00017	0.419
LIG_SH2_STAT5	375	378	PF00017	0.543
LIG_SH2_STAT5	387	390	PF00017	0.502
LIG_SH2_STAT5	395	398	PF00017	0.470
LIG_SH2_STAT5	415	418	PF00017	0.428
LIG_SH2_STAT5	453	456	PF00017	0.518
LIG_SH2_STAT5	585	588	PF00017	0.334
LIG_SH2_STAT5	633	636	PF00017	0.359
LIG_SH2_STAT5	84	87	PF00017	0.350
LIG_SH3_3	156	162	PF00018	0.754
LIG_SH3_3	165	171	PF00018	0.620
LIG_SH3_3	242	248	PF00018	0.719
LIG_SH3_3	452	458	PF00018	0.574
LIG_SH3_3	460	466	PF00018	0.547
LIG_SH3_3	50	56	PF00018	0.376
LIG_SH3_3	527	533	PF00018	0.262
LIG_SH3_3	542	548	PF00018	0.457
LIG_SH3_3	576	582	PF00018	0.294
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.566
LIG_SUMO_SIM_anti_2	120	126	PF11976	0.506
LIG_SUMO_SIM_anti_2	310	317	PF11976	0.515
LIG_SUMO_SIM_anti_2	474	480	PF11976	0.498
LIG_SUMO_SIM_par_1	110	117	PF11976	0.502
LIG_SxIP_EBH_1	44	58	PF03271	0.370
LIG_TRAF2_1	405	408	PF00917	0.542
LIG_UBA3_1	382	390	PF00899	0.440
LIG_UBA3_1	85	89	PF00899	0.298
LIG_WW_1	582	585	PF00397	0.296
LIG_WW_2	545	548	PF00397	0.459
MOD_CDC14_SPxK_1	259	262	PF00782	0.620
MOD_CDK_SPK_2	146	151	PF00069	0.723
MOD_CDK_SPxK_1	146	152	PF00069	0.724
MOD_CDK_SPxK_1	256	262	PF00069	0.620
MOD_CDK_SPxxK_3	244	251	PF00069	0.618
MOD_CK1_1	110	116	PF00069	0.499
MOD_CK1_1	138	144	PF00069	0.657
MOD_CK1_1	158	164	PF00069	0.691
MOD_CK1_1	195	201	PF00069	0.806
MOD_CK1_1	209	215	PF00069	0.661
MOD_CK1_1	219	225	PF00069	0.697
MOD_CK1_1	231	237	PF00069	0.713
MOD_CK1_1	263	269	PF00069	0.711
MOD_CK1_1	310	316	PF00069	0.513
MOD_CK1_1	355	361	PF00069	0.504
MOD_CK1_1	605	611	PF00069	0.357
MOD_CK1_1	8	14	PF00069	0.585
MOD_CK2_1	110	116	PF00069	0.562
MOD_CK2_1	117	123	PF00069	0.555
MOD_CK2_1	317	323	PF00069	0.534
MOD_CK2_1	363	369	PF00069	0.524
MOD_CK2_1	402	408	PF00069	0.497
MOD_CK2_1	604	610	PF00069	0.396
MOD_CK2_1	661	667	PF00069	0.303
MOD_CK2_1	689	695	PF00069	0.400
MOD_Cter_Amidation	189	192	PF01082	0.436
MOD_GlcNHglycan	135	138	PF01048	0.403
MOD_GlcNHglycan	263	266	PF01048	0.581
MOD_GlcNHglycan	280	283	PF01048	0.258
MOD_GlcNHglycan	291	294	PF01048	0.394
MOD_GlcNHglycan	319	322	PF01048	0.383
MOD_GlcNHglycan	418	421	PF01048	0.326
MOD_GlcNHglycan	482	485	PF01048	0.430
MOD_GlcNHglycan	499	502	PF01048	0.358
MOD_GlcNHglycan	534	537	PF01048	0.303
MOD_GlcNHglycan	572	575	PF01048	0.690
MOD_GlcNHglycan	607	610	PF01048	0.656
MOD_GSK3_1	138	145	PF00069	0.730
MOD_GSK3_1	151	158	PF00069	0.846
MOD_GSK3_1	192	199	PF00069	0.725
MOD_GSK3_1	204	211	PF00069	0.761
MOD_GSK3_1	212	219	PF00069	0.748
MOD_GSK3_1	226	233	PF00069	0.682
MOD_GSK3_1	235	242	PF00069	0.742
MOD_GSK3_1	256	263	PF00069	0.730
MOD_GSK3_1	278	285	PF00069	0.487
MOD_GSK3_1	287	294	PF00069	0.553
MOD_GSK3_1	363	370	PF00069	0.535
MOD_GSK3_1	398	405	PF00069	0.482
MOD_GSK3_1	480	487	PF00069	0.671
MOD_GSK3_1	522	529	PF00069	0.463
MOD_GSK3_1	566	573	PF00069	0.365
MOD_GSK3_1	597	604	PF00069	0.380
MOD_GSK3_1	629	636	PF00069	0.379
MOD_GSK3_1	661	668	PF00069	0.396
MOD_LATS_1	226	232	PF00433	0.634
MOD_N-GLC_1	231	236	PF02516	0.579
MOD_N-GLC_1	317	322	PF02516	0.309
MOD_NEK2_1	196	201	PF00069	0.735
MOD_NEK2_1	235	240	PF00069	0.670
MOD_NEK2_1	261	266	PF00069	0.726
MOD_NEK2_1	352	357	PF00069	0.479
MOD_NEK2_1	413	418	PF00069	0.520
MOD_NEK2_1	566	571	PF00069	0.383
MOD_NEK2_1	601	606	PF00069	0.379
MOD_NEK2_1	688	693	PF00069	0.297
MOD_NEK2_2	84	89	PF00069	0.328
MOD_PIKK_1	144	150	PF00454	0.697
MOD_PIKK_1	220	226	PF00454	0.679
MOD_PKA_1	151	157	PF00069	0.652
MOD_PKA_2	151	157	PF00069	0.704
MOD_PKA_2	220	226	PF00069	0.760
MOD_PKA_2	235	241	PF00069	0.672
MOD_PKA_2	261	267	PF00069	0.766
MOD_PKA_2	28	34	PF00069	0.230
MOD_PKA_2	310	316	PF00069	0.513
MOD_PKA_2	644	650	PF00069	0.401
MOD_PKB_1	192	200	PF00069	0.688
MOD_PKB_1	643	651	PF00069	0.305
MOD_Plk_1	231	237	PF00069	0.636
MOD_Plk_1	307	313	PF00069	0.637
MOD_Plk_1	317	323	PF00069	0.604
MOD_Plk_1	449	455	PF00069	0.489
MOD_Plk_1	526	532	PF00069	0.248
MOD_Plk_1	574	580	PF00069	0.397
MOD_Plk_1	595	601	PF00069	0.390
MOD_Plk_1	623	629	PF00069	0.398
MOD_Plk_1	666	672	PF00069	0.283
MOD_Plk_4	110	116	PF00069	0.499
MOD_Plk_4	310	316	PF00069	0.513
MOD_Plk_4	352	358	PF00069	0.537
MOD_Plk_4	363	369	PF00069	0.554
MOD_Plk_4	566	572	PF00069	0.349
MOD_Plk_4	585	591	PF00069	0.315
MOD_Plk_4	597	603	PF00069	0.341
MOD_Plk_4	629	635	PF00069	0.353
MOD_Plk_4	678	684	PF00069	0.303
MOD_ProDKin_1	107	113	PF00069	0.600
MOD_ProDKin_1	142	148	PF00069	0.730
MOD_ProDKin_1	155	161	PF00069	0.819
MOD_ProDKin_1	18	24	PF00069	0.585
MOD_ProDKin_1	226	232	PF00069	0.659
MOD_ProDKin_1	244	250	PF00069	0.686
MOD_ProDKin_1	256	262	PF00069	0.674
MOD_ProDKin_1	265	271	PF00069	0.637
MOD_ProDKin_1	376	382	PF00069	0.538
MOD_ProDKin_1	425	431	PF00069	0.583
MOD_ProDKin_1	454	460	PF00069	0.537
MOD_ProDKin_1	465	471	PF00069	0.572
MOD_ProDKin_1	47	53	PF00069	0.365
MOD_ProDKin_1	540	546	PF00069	0.509
MOD_ProDKin_1	661	667	PF00069	0.405
TRG_DiLeu_BaEn_1	69	74	PF01217	0.420
TRG_DiLeu_BaEn_2	299	305	PF01217	0.539
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.477
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.558
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.338
TRG_ENDOCYTIC_2	255	258	PF00928	0.623
TRG_ENDOCYTIC_2	351	354	PF00928	0.527
TRG_ENDOCYTIC_2	37	40	PF00928	0.215
TRG_ENDOCYTIC_2	371	374	PF00928	0.419
TRG_ENDOCYTIC_2	83	86	PF00928	0.227
TRG_ER_diArg_1	102	104	PF00400	0.583
TRG_ER_diArg_1	150	152	PF00400	0.725
TRG_ER_diArg_1	191	194	PF00400	0.694
TRG_ER_diArg_1	273	276	PF00400	0.598
TRG_ER_diArg_1	309	312	PF00400	0.470
TRG_ER_diArg_1	433	436	PF00400	0.592
TRG_ER_diArg_1	45	48	PF00400	0.373
TRG_ER_diArg_1	97	99	PF00400	0.557
TRG_NES_CRM1_1	170	185	PF08389	0.586
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	421	426	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHH7	Leptomonas seymouri	43%	100%
A0A3S7XCG4	Leishmania donovani	69%	100%
A4ICA7	Leishmania infantum	69%	100%
E9AU84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4Q0A7	Leishmania major	68%	100%