Putative ubiquitin fusion degradation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin fusion degradation protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HQH0_LEIBR

TriTrypDb:

LbrM.35.6830 , LBRM2903_350081300

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

A4HQH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQH0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	6	1
GO:0006950	response to stress	2	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071712	ER-associated misfolded protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.685
CLV_NRD_NRD_1	323	325	PF00675	0.593
CLV_PCSK_KEX2_1	323	325	PF00082	0.571
CLV_PCSK_KEX2_1	60	62	PF00082	0.338
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.338
CLV_PCSK_SKI1_1	123	127	PF00082	0.327
CLV_PCSK_SKI1_1	281	285	PF00082	0.797
CLV_PCSK_SKI1_1	30	34	PF00082	0.273
DOC_CDC14_PxL_1	130	138	PF14671	0.482
DOC_CKS1_1	196	201	PF01111	0.683
DOC_CKS1_1	54	59	PF01111	0.562
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.589
DOC_MAPK_DCC_7	43	52	PF00069	0.562
DOC_MAPK_MEF2A_6	123	130	PF00069	0.562
DOC_MAPK_MEF2A_6	89	96	PF00069	0.405
DOC_MAPK_NFAT4_5	123	131	PF00069	0.562
DOC_PP1_RVXF_1	180	186	PF00149	0.482
DOC_PP2B_LxvP_1	189	192	PF13499	0.495
DOC_PP4_FxxP_1	119	122	PF00568	0.562
DOC_PP4_FxxP_1	185	188	PF00568	0.482
DOC_PP4_FxxP_1	227	230	PF00568	0.659
DOC_USP7_MATH_1	249	253	PF00917	0.762
DOC_USP7_MATH_1	259	263	PF00917	0.779
DOC_WD40_RPTOR_TOS_1	151	157	PF00400	0.586
DOC_WW_Pin1_4	191	196	PF00397	0.533
DOC_WW_Pin1_4	202	207	PF00397	0.591
DOC_WW_Pin1_4	213	218	PF00397	0.594
DOC_WW_Pin1_4	304	309	PF00397	0.505
DOC_WW_Pin1_4	53	58	PF00397	0.551
LIG_14-3-3_CanoR_1	43	47	PF00244	0.527
LIG_14-3-3_CterR_2	323	325	PF00244	0.522
LIG_Actin_WH2_2	75	91	PF00022	0.492
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_Clathr_ClatBox_1	116	120	PF01394	0.562
LIG_CtBP_PxDLS_1	229	233	PF00389	0.736
LIG_CtBP_PxDLS_1	308	312	PF00389	0.573
LIG_deltaCOP1_diTrp_1	80	83	PF00928	0.562
LIG_eIF4E_1	27	33	PF01652	0.562
LIG_FHA_1	138	144	PF00498	0.486
LIG_FHA_1	8	14	PF00498	0.468
LIG_FHA_1	89	95	PF00498	0.487
LIG_LIR_Apic_2	184	188	PF02991	0.482
LIG_LIR_Gen_1	252	259	PF02991	0.752
LIG_LIR_Gen_1	80	88	PF02991	0.583
LIG_LIR_Nem_3	252	256	PF02991	0.757
LIG_LIR_Nem_3	80	86	PF02991	0.579
LIG_LYPXL_yS_3	133	136	PF13949	0.482
LIG_SH2_CRK	63	67	PF00017	0.496
LIG_SH2_STAP1	63	67	PF00017	0.586
LIG_SH2_STAP1	8	12	PF00017	0.447
LIG_SH2_STAT3	48	51	PF00017	0.482
LIG_SH2_STAT5	146	149	PF00017	0.481
LIG_SH3_3	189	195	PF00018	0.514
LIG_SH3_3	233	239	PF00018	0.638
LIG_SH3_3	28	34	PF00018	0.482
LIG_SH3_3	295	301	PF00018	0.782
LIG_SH3_3	73	79	PF00018	0.496
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.562
LIG_SUMO_SIM_par_1	140	145	PF11976	0.513
LIG_SUMO_SIM_par_1	154	160	PF11976	0.431
LIG_SUMO_SIM_par_1	9	16	PF11976	0.586
LIG_TRAF2_1	266	269	PF00917	0.695
LIG_TRAF2_1	307	310	PF00917	0.626
LIG_UBA3_1	158	162	PF00899	0.562
LIG_WRC_WIRS_1	253	258	PF05994	0.547
MOD_CDK_SPxK_1	53	59	PF00069	0.551
MOD_CDK_SPxxK_3	53	60	PF00069	0.562
MOD_CK1_1	16	22	PF00069	0.538
MOD_CK1_1	215	221	PF00069	0.694
MOD_CK1_1	252	258	PF00069	0.773
MOD_CK1_1	262	268	PF00069	0.755
MOD_CK1_1	276	282	PF00069	0.535
MOD_CK1_1	7	13	PF00069	0.415
MOD_CK2_1	191	197	PF00069	0.547
MOD_CK2_1	261	267	PF00069	0.763
MOD_CK2_1	304	310	PF00069	0.619
MOD_GlcNHglycan	15	18	PF01048	0.365
MOD_GlcNHglycan	200	203	PF01048	0.745
MOD_GlcNHglycan	275	278	PF01048	0.736
MOD_GlcNHglycan	292	296	PF01048	0.684
MOD_GSK3_1	134	141	PF00069	0.482
MOD_GSK3_1	191	198	PF00069	0.622
MOD_GSK3_1	283	290	PF00069	0.722
MOD_N-GLC_1	287	292	PF02516	0.756
MOD_NEK2_1	273	278	PF00069	0.636
MOD_NEK2_1	88	93	PF00069	0.562
MOD_NEK2_2	168	173	PF00069	0.482
MOD_PKA_2	42	48	PF00069	0.541
MOD_PKA_2	88	94	PF00069	0.405
MOD_Plk_4	102	108	PF00069	0.469
MOD_Plk_4	138	144	PF00069	0.478
MOD_Plk_4	33	39	PF00069	0.562
MOD_Plk_4	42	48	PF00069	0.562
MOD_Plk_4	72	78	PF00069	0.535
MOD_Plk_4	88	94	PF00069	0.564
MOD_ProDKin_1	191	197	PF00069	0.543
MOD_ProDKin_1	202	208	PF00069	0.587
MOD_ProDKin_1	213	219	PF00069	0.596
MOD_ProDKin_1	304	310	PF00069	0.501
MOD_ProDKin_1	53	59	PF00069	0.551
TRG_ENDOCYTIC_2	133	136	PF00928	0.482
TRG_ENDOCYTIC_2	253	256	PF00928	0.543
TRG_ENDOCYTIC_2	63	66	PF00928	0.493
TRG_NLS_MonoExtN_4	57	63	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J4	Leptomonas seymouri	67%	100%
A0A1X0NLA2	Trypanosomatidae	43%	100%
A0A3Q8IWM4	Leishmania donovani	86%	100%
A0A3R7LYH5	Trypanosoma rangeli	40%	100%
A4ICA6	Leishmania infantum	86%	100%
D0A3M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AU83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0A8	Leishmania major	87%	100%
V5BHL3	Trypanosoma cruzi	41%	100%