Putative histidine secretory acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histidine secretory acid phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HQG9_LEIBR

TriTrypDb:

LbrM.35.6820 , LBRM2903_350080800

Length:

520

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 40, no: 4
NetGPI	no	yes: 0, no: 44

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	32
GO:0110165	cellular anatomical entity	1	32

Expansion

Sequence features

A4HQG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQG9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0003993	acid phosphatase activity	6	3
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.305
CLV_C14_Caspase3-7	264	268	PF00656	0.270
CLV_C14_Caspase3-7	406	410	PF00656	0.486
CLV_NRD_NRD_1	376	378	PF00675	0.495
CLV_NRD_NRD_1	421	423	PF00675	0.397
CLV_NRD_NRD_1	493	495	PF00675	0.710
CLV_PCSK_KEX2_1	376	378	PF00082	0.469
CLV_PCSK_KEX2_1	421	423	PF00082	0.426
CLV_PCSK_KEX2_1	491	493	PF00082	0.721
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.479
CLV_PCSK_SKI1_1	239	243	PF00082	0.457
CLV_PCSK_SKI1_1	39	43	PF00082	0.489
CLV_Separin_Metazoa	66	70	PF03568	0.215
DEG_COP1_1	138	150	PF00400	0.285
DEG_SCF_FBW7_1	467	473	PF00400	0.499
DEG_SPOP_SBC_1	392	396	PF00917	0.320
DEG_SPOP_SBC_1	451	455	PF00917	0.732
DOC_CKS1_1	254	259	PF01111	0.281
DOC_CKS1_1	467	472	PF01111	0.501
DOC_MAPK_MEF2A_6	306	315	PF00069	0.265
DOC_PP4_FxxP_1	476	479	PF00568	0.529
DOC_PP4_MxPP_1	305	308	PF00568	0.499
DOC_USP7_MATH_1	17	21	PF00917	0.564
DOC_USP7_MATH_1	451	455	PF00917	0.707
DOC_USP7_MATH_1	471	475	PF00917	0.501
DOC_WW_Pin1_4	155	160	PF00397	0.440
DOC_WW_Pin1_4	253	258	PF00397	0.371
DOC_WW_Pin1_4	272	277	PF00397	0.451
DOC_WW_Pin1_4	466	471	PF00397	0.504
DOC_WW_Pin1_4	485	490	PF00397	0.511
DOC_WW_Pin1_4	84	89	PF00397	0.410
LIG_14-3-3_CanoR_1	103	111	PF00244	0.370
LIG_14-3-3_CanoR_1	7	15	PF00244	0.385
LIG_14-3-3_CanoR_1	94	100	PF00244	0.369
LIG_APCC_ABBA_1	311	316	PF00400	0.255
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BIR_III_4	323	327	PF00653	0.313
LIG_BRCT_BRCA1_1	86	90	PF00533	0.414
LIG_CtBP_PxDLS_1	479	483	PF00389	0.509
LIG_eIF4E_1	79	85	PF01652	0.370
LIG_FHA_1	113	119	PF00498	0.345
LIG_FHA_1	136	142	PF00498	0.399
LIG_FHA_1	218	224	PF00498	0.535
LIG_FHA_1	245	251	PF00498	0.573
LIG_FHA_1	310	316	PF00498	0.440
LIG_FHA_1	502	508	PF00498	0.463
LIG_FHA_1	9	15	PF00498	0.452
LIG_FHA_2	262	268	PF00498	0.569
LIG_FHA_2	294	300	PF00498	0.450
LIG_FHA_2	383	389	PF00498	0.465
LIG_FHA_2	404	410	PF00498	0.539
LIG_FHA_2	467	473	PF00498	0.499
LIG_LIR_Apic_2	123	129	PF02991	0.379
LIG_LIR_Apic_2	380	384	PF02991	0.425
LIG_LIR_Apic_2	473	479	PF02991	0.523
LIG_LIR_Apic_2	77	82	PF02991	0.408
LIG_LIR_Gen_1	174	182	PF02991	0.491
LIG_LIR_Gen_1	312	318	PF02991	0.257
LIG_LIR_Gen_1	395	404	PF02991	0.443
LIG_LIR_LC3C_4	22	27	PF02991	0.495
LIG_LIR_Nem_3	124	130	PF02991	0.434
LIG_LIR_Nem_3	174	178	PF02991	0.494
LIG_LIR_Nem_3	275	281	PF02991	0.455
LIG_LIR_Nem_3	312	317	PF02991	0.426
LIG_LIR_Nem_3	418	423	PF02991	0.397
LIG_LYPXL_yS_3	227	230	PF13949	0.528
LIG_Rb_pABgroove_1	199	207	PF01858	0.500
LIG_SH2_CRK	238	242	PF00017	0.340
LIG_SH2_CRK	381	385	PF00017	0.506
LIG_SH2_CRK	420	424	PF00017	0.354
LIG_SH2_GRB2like	398	401	PF00017	0.440
LIG_SH2_NCK_1	205	209	PF00017	0.500
LIG_SH2_NCK_1	381	385	PF00017	0.506
LIG_SH2_NCK_1	79	83	PF00017	0.354
LIG_SH2_PTP2	328	331	PF00017	0.524
LIG_SH2_STAP1	132	136	PF00017	0.494
LIG_SH2_STAP1	205	209	PF00017	0.383
LIG_SH2_STAP1	309	313	PF00017	0.377
LIG_SH2_STAT3	344	347	PF00017	0.323
LIG_SH2_STAT3	516	519	PF00017	0.477
LIG_SH2_STAT5	101	104	PF00017	0.272
LIG_SH2_STAT5	126	129	PF00017	0.461
LIG_SH2_STAT5	240	243	PF00017	0.403
LIG_SH2_STAT5	328	331	PF00017	0.419
LIG_SH2_STAT5	344	347	PF00017	0.306
LIG_SH3_3	483	489	PF00018	0.524
LIG_SH3_3	82	88	PF00018	0.415
LIG_Sin3_3	10	17	PF02671	0.499
LIG_SUMO_SIM_par_1	291	296	PF11976	0.471
LIG_TRAF2_1	512	515	PF00917	0.486
MOD_CDC14_SPxK_1	488	491	PF00782	0.514
MOD_CDK_SPxK_1	485	491	PF00069	0.519
MOD_CDK_SPxxK_3	272	279	PF00069	0.449
MOD_CDK_SPxxK_3	485	492	PF00069	0.496
MOD_CK1_1	104	110	PF00069	0.420
MOD_CK1_1	143	149	PF00069	0.437
MOD_CK1_1	382	388	PF00069	0.380
MOD_CK1_1	452	458	PF00069	0.750
MOD_CK1_1	459	465	PF00069	0.761
MOD_CK2_1	346	352	PF00069	0.492
MOD_CK2_1	80	86	PF00069	0.433
MOD_DYRK1A_RPxSP_1	485	489	PF00069	0.508
MOD_GlcNHglycan	112	115	PF01048	0.343
MOD_GlcNHglycan	161	164	PF01048	0.567
MOD_GlcNHglycan	212	216	PF01048	0.362
MOD_GlcNHglycan	282	286	PF01048	0.432
MOD_GlcNHglycan	348	351	PF01048	0.380
MOD_GlcNHglycan	357	360	PF01048	0.347
MOD_GlcNHglycan	39	42	PF01048	0.468
MOD_GlcNHglycan	435	438	PF01048	0.439
MOD_GlcNHglycan	458	461	PF01048	0.704
MOD_GlcNHglycan	464	467	PF01048	0.532
MOD_GlcNHglycan	472	476	PF01048	0.520
MOD_GSK3_1	130	137	PF00069	0.422
MOD_GSK3_1	151	158	PF00069	0.432
MOD_GSK3_1	281	288	PF00069	0.377
MOD_GSK3_1	392	399	PF00069	0.495
MOD_GSK3_1	445	452	PF00069	0.619
MOD_GSK3_1	454	461	PF00069	0.712
MOD_GSK3_1	462	469	PF00069	0.697
MOD_GSK3_1	80	87	PF00069	0.382
MOD_GSK3_1	90	97	PF00069	0.269
MOD_N-GLC_1	134	139	PF02516	0.471
MOD_N-GLC_1	244	249	PF02516	0.468
MOD_N-GLC_1	301	306	PF02516	0.394
MOD_N-GLC_1	45	50	PF02516	0.468
MOD_N-GLC_1	455	460	PF02516	0.780
MOD_N-GLC_1	95	100	PF02516	0.374
MOD_NEK2_1	151	156	PF00069	0.517
MOD_NEK2_1	161	166	PF00069	0.594
MOD_NEK2_1	211	216	PF00069	0.486
MOD_NEK2_1	250	255	PF00069	0.452
MOD_NEK2_1	261	266	PF00069	0.444
MOD_NEK2_1	281	286	PF00069	0.436
MOD_NEK2_1	293	298	PF00069	0.372
MOD_NEK2_1	346	351	PF00069	0.523
MOD_NEK2_1	393	398	PF00069	0.469
MOD_NEK2_1	74	79	PF00069	0.390
MOD_NEK2_2	301	306	PF00069	0.307
MOD_NEK2_2	309	314	PF00069	0.236
MOD_PIKK_1	104	110	PF00454	0.374
MOD_PIKK_1	250	256	PF00454	0.412
MOD_PIKK_1	393	399	PF00454	0.451
MOD_PIKK_1	445	451	PF00454	0.663
MOD_PIKK_1	45	51	PF00454	0.438
MOD_PKA_2	102	108	PF00069	0.372
MOD_PKA_2	382	388	PF00069	0.402
MOD_Plk_1	286	292	PF00069	0.392
MOD_Plk_1	301	307	PF00069	0.419
MOD_Plk_1	45	51	PF00069	0.452
MOD_Plk_1	471	477	PF00069	0.521
MOD_Plk_1	95	101	PF00069	0.322
MOD_Plk_4	137	143	PF00069	0.430
MOD_Plk_4	146	152	PF00069	0.391
MOD_Plk_4	261	267	PF00069	0.506
MOD_Plk_4	309	315	PF00069	0.381
MOD_Plk_4	50	56	PF00069	0.506
MOD_Plk_4	80	86	PF00069	0.401
MOD_Plk_4	95	101	PF00069	0.394
MOD_ProDKin_1	155	161	PF00069	0.434
MOD_ProDKin_1	253	259	PF00069	0.371
MOD_ProDKin_1	272	278	PF00069	0.448
MOD_ProDKin_1	466	472	PF00069	0.504
MOD_ProDKin_1	485	491	PF00069	0.509
MOD_ProDKin_1	84	90	PF00069	0.410
MOD_SUMO_rev_2	218	226	PF00179	0.285
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.534
TRG_ENDOCYTIC_2	227	230	PF00928	0.487
TRG_ENDOCYTIC_2	238	241	PF00928	0.378
TRG_ENDOCYTIC_2	278	281	PF00928	0.496
TRG_ENDOCYTIC_2	328	331	PF00928	0.488
TRG_ENDOCYTIC_2	398	401	PF00928	0.447
TRG_ENDOCYTIC_2	420	423	PF00928	0.292
TRG_ER_diArg_1	375	377	PF00400	0.454
TRG_ER_diArg_1	420	422	PF00400	0.410
TRG_ER_diArg_1	482	485	PF00400	0.511
TRG_ER_diArg_1	492	494	PF00400	0.456
TRG_ER_diArg_1	76	79	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	34%	91%
A0A0N1I756	Leptomonas seymouri	38%	100%
A0A0N1PEH4	Leptomonas seymouri	63%	100%
A0A0S4IRF5	Bodo saltans	23%	78%
A0A0S4IV77	Bodo saltans	33%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	27%	100%
A0A0S4JW09	Bodo saltans	25%	100%
A0A1X0NNY4	Trypanosomatidae	35%	94%
A0A1X0NQL4	Trypanosomatidae	29%	95%
A0A1X0NY34	Trypanosomatidae	24%	100%
A0A1X0P7V5	Trypanosomatidae	38%	100%
A0A3Q8IR23	Leishmania donovani	36%	91%
A0A3R7KSH4	Trypanosoma rangeli	26%	100%
A0A3R7MEN7	Trypanosoma rangeli	39%	100%
A0A3R7MHJ7	Trypanosoma rangeli	27%	100%
A0A3S5H827	Leishmania donovani	38%	100%
A0A3S7WXU0	Leishmania donovani	35%	98%
A0A3S7X1W4	Leishmania donovani	33%	95%
A4HCZ0	Leishmania braziliensis	35%	100%
A4HGW8	Leishmania braziliensis	35%	100%
A4HPC1	Leishmania braziliensis	37%	100%
A4HPC5	Leishmania braziliensis	37%	100%
A4HQG6	Leishmania braziliensis	99%	100%
A4I0H5	Leishmania infantum	35%	98%
A4I3Z8	Leishmania infantum	33%	95%
A4ICA5	Leishmania infantum	79%	78%
A4ICG3	Leishmania infantum	38%	100%
A4ICG5	Leishmania infantum	36%	91%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	99%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	91%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	98%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	95%
P24638	Mus musculus	24%	100%
Q4Q0A9	Leishmania major	57%	86%
Q4Q1G2	Leishmania major	37%	100%
Q4Q1G4	Leishmania major	39%	100%
Q4Q7Z7	Leishmania major	34%	100%
Q4QB35	Leishmania major	34%	100%
Q5R8C0	Pongo abelii	24%	100%
Q9NPH0	Homo sapiens	24%	100%
V5BCI2	Trypanosoma cruzi	28%	100%
V5BIM1	Trypanosoma cruzi	24%	100%
V5BK91	Trypanosoma cruzi	37%	100%
V5BL75	Trypanosoma cruzi	28%	100%