LeishMANIAdb
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Putative histidine secretory acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative histidine secretory acid phosphatase
Gene product:
histidine secretory acid phosphatase, putative
Species:
Leishmania braziliensis
UniProt:
A4HQG6_LEIBR
TriTrypDb:
LbrM.35.6790 , LBRM2903_350080800 *
Length:
441

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. yes yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 70
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 43, no: 4
NetGPI no yes: 0, no: 47
Cellular components
Term Name Level Count
GO:0016020 membrane 2 33
GO:0110165 cellular anatomical entity 1 33

Expansion

Sequence features

A4HQG6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HQG6

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016311 dephosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0003993 acid phosphatase activity 6 3
GO:0016787 hydrolase activity 2 8
GO:0016788 hydrolase activity, acting on ester bonds 3 8
GO:0016791 phosphatase activity 5 8
GO:0042578 phosphoric ester hydrolase activity 4 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.379
CLV_C14_Caspase3-7 378 382 PF00656 0.569
CLV_NRD_NRD_1 348 350 PF00675 0.548
CLV_NRD_NRD_1 393 395 PF00675 0.452
CLV_PCSK_KEX2_1 348 350 PF00082 0.530
CLV_PCSK_KEX2_1 393 395 PF00082 0.508
CLV_PCSK_SKI1_1 11 15 PF00082 0.574
CLV_PCSK_SKI1_1 211 215 PF00082 0.523
CLV_Separin_Metazoa 38 42 PF03568 0.292
DEG_COP1_1 110 122 PF00400 0.359
DEG_SPOP_SBC_1 364 368 PF00917 0.661
DEG_SPOP_SBC_1 423 427 PF00917 0.801
DOC_CKS1_1 226 231 PF01111 0.333
DOC_MAPK_MEF2A_6 278 287 PF00069 0.600
DOC_PP4_MxPP_1 277 280 PF00568 0.570
DOC_USP7_MATH_1 423 427 PF00917 0.780
DOC_WW_Pin1_4 127 132 PF00397 0.496
DOC_WW_Pin1_4 225 230 PF00397 0.440
DOC_WW_Pin1_4 244 249 PF00397 0.515
DOC_WW_Pin1_4 56 61 PF00397 0.481
LIG_14-3-3_CanoR_1 66 72 PF00244 0.449
LIG_14-3-3_CanoR_1 75 83 PF00244 0.447
LIG_APCC_ABBA_1 283 288 PF00400 0.312
LIG_BIR_III_4 295 299 PF00653 0.373
LIG_BRCT_BRCA1_1 58 62 PF00533 0.498
LIG_eIF4E_1 51 57 PF01652 0.471
LIG_FHA_1 108 114 PF00498 0.504
LIG_FHA_1 190 196 PF00498 0.570
LIG_FHA_1 217 223 PF00498 0.613
LIG_FHA_1 282 288 PF00498 0.510
LIG_FHA_1 85 91 PF00498 0.435
LIG_FHA_2 266 272 PF00498 0.524
LIG_FHA_2 355 361 PF00498 0.506
LIG_FHA_2 376 382 PF00498 0.593
LIG_LIR_Apic_2 352 356 PF02991 0.496
LIG_LIR_Apic_2 95 101 PF02991 0.477
LIG_LIR_Gen_1 146 154 PF02991 0.567
LIG_LIR_Gen_1 284 290 PF02991 0.611
LIG_LIR_Gen_1 367 376 PF02991 0.503
LIG_LIR_Nem_3 146 150 PF02991 0.575
LIG_LIR_Nem_3 247 253 PF02991 0.535
LIG_LIR_Nem_3 284 289 PF02991 0.482
LIG_LIR_Nem_3 390 395 PF02991 0.467
LIG_LIR_Nem_3 96 102 PF02991 0.495
LIG_LYPXL_yS_3 199 202 PF13949 0.594
LIG_Rb_pABgroove_1 171 179 PF01858 0.573
LIG_SH2_CRK 210 214 PF00017 0.414
LIG_SH2_CRK 353 357 PF00017 0.572
LIG_SH2_CRK 392 396 PF00017 0.424
LIG_SH2_GRB2like 370 373 PF00017 0.511
LIG_SH2_NCK_1 177 181 PF00017 0.569
LIG_SH2_NCK_1 353 357 PF00017 0.579
LIG_SH2_NCK_1 51 55 PF00017 0.433
LIG_SH2_PTP2 300 303 PF00017 0.593
LIG_SH2_STAP1 104 108 PF00017 0.547
LIG_SH2_STAP1 177 181 PF00017 0.485
LIG_SH2_STAP1 281 285 PF00017 0.454
LIG_SH2_STAT3 316 319 PF00017 0.395
LIG_SH2_STAT5 212 215 PF00017 0.501
LIG_SH2_STAT5 300 303 PF00017 0.500
LIG_SH2_STAT5 316 319 PF00017 0.380
LIG_SH2_STAT5 335 338 PF00017 0.473
LIG_SH2_STAT5 73 76 PF00017 0.367
LIG_SH2_STAT5 98 101 PF00017 0.498
LIG_SH3_3 54 60 PF00018 0.493
LIG_SUMO_SIM_par_1 263 268 PF11976 0.541
MOD_CDK_SPxxK_3 244 251 PF00069 0.529
MOD_CK1_1 115 121 PF00069 0.522
MOD_CK1_1 354 360 PF00069 0.390
MOD_CK1_1 424 430 PF00069 0.822
MOD_CK1_1 76 82 PF00069 0.485
MOD_CK2_1 318 324 PF00069 0.567
MOD_CK2_1 52 58 PF00069 0.508
MOD_GlcNHglycan 11 14 PF01048 0.555
MOD_GlcNHglycan 133 136 PF01048 0.613
MOD_GlcNHglycan 184 188 PF01048 0.403
MOD_GlcNHglycan 254 258 PF01048 0.499
MOD_GlcNHglycan 320 323 PF01048 0.442
MOD_GlcNHglycan 329 332 PF01048 0.385
MOD_GlcNHglycan 407 410 PF01048 0.506
MOD_GlcNHglycan 428 431 PF01048 0.762
MOD_GlcNHglycan 84 87 PF01048 0.424
MOD_GSK3_1 102 109 PF00069 0.520
MOD_GSK3_1 123 130 PF00069 0.403
MOD_GSK3_1 253 260 PF00069 0.446
MOD_GSK3_1 364 371 PF00069 0.485
MOD_GSK3_1 417 424 PF00069 0.681
MOD_GSK3_1 52 59 PF00069 0.453
MOD_GSK3_1 62 69 PF00069 0.349
MOD_N-GLC_1 106 111 PF02516 0.562
MOD_N-GLC_1 17 22 PF02516 0.554
MOD_N-GLC_1 216 221 PF02516 0.550
MOD_N-GLC_1 273 278 PF02516 0.469
MOD_N-GLC_1 67 72 PF02516 0.461
MOD_NEK2_1 123 128 PF00069 0.582
MOD_NEK2_1 133 138 PF00069 0.562
MOD_NEK2_1 183 188 PF00069 0.571
MOD_NEK2_1 222 227 PF00069 0.549
MOD_NEK2_1 233 238 PF00069 0.523
MOD_NEK2_1 253 258 PF00069 0.508
MOD_NEK2_1 265 270 PF00069 0.442
MOD_NEK2_1 318 323 PF00069 0.589
MOD_NEK2_1 365 370 PF00069 0.443
MOD_NEK2_2 273 278 PF00069 0.370
MOD_NEK2_2 281 286 PF00069 0.289
MOD_PIKK_1 17 23 PF00454 0.521
MOD_PIKK_1 222 228 PF00454 0.514
MOD_PIKK_1 365 371 PF00454 0.517
MOD_PIKK_1 417 423 PF00454 0.713
MOD_PIKK_1 76 82 PF00454 0.452
MOD_PKA_2 354 360 PF00069 0.475
MOD_PKA_2 74 80 PF00069 0.455
MOD_Plk_1 17 23 PF00069 0.533
MOD_Plk_1 258 264 PF00069 0.462
MOD_Plk_1 273 279 PF00069 0.493
MOD_Plk_1 67 73 PF00069 0.409
MOD_Plk_4 109 115 PF00069 0.502
MOD_Plk_4 118 124 PF00069 0.481
MOD_Plk_4 22 28 PF00069 0.606
MOD_Plk_4 233 239 PF00069 0.589
MOD_Plk_4 281 287 PF00069 0.457
MOD_Plk_4 52 58 PF00069 0.460
MOD_Plk_4 67 73 PF00069 0.489
MOD_ProDKin_1 127 133 PF00069 0.489
MOD_ProDKin_1 225 231 PF00069 0.439
MOD_ProDKin_1 244 250 PF00069 0.511
MOD_ProDKin_1 56 62 PF00069 0.481
MOD_SUMO_rev_2 190 198 PF00179 0.340
TRG_DiLeu_BaLyEn_6 299 304 PF01217 0.599
TRG_ENDOCYTIC_2 199 202 PF00928 0.563
TRG_ENDOCYTIC_2 210 213 PF00928 0.449
TRG_ENDOCYTIC_2 250 253 PF00928 0.573
TRG_ENDOCYTIC_2 300 303 PF00928 0.563
TRG_ENDOCYTIC_2 370 373 PF00928 0.512
TRG_ENDOCYTIC_2 392 395 PF00928 0.351
TRG_ER_diArg_1 347 349 PF00400 0.526
TRG_ER_diArg_1 392 394 PF00400 0.481
TRG_ER_diArg_1 48 51 PF00400 0.498
TRG_Pf-PMV_PEXEL_1 377 381 PF00026 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 34% 77%
A0A0N1I756 Leptomonas seymouri 38% 85%
A0A0N1PEH4 Leptomonas seymouri 64% 96%
A0A0S4IUV8 Bodo saltans 22% 100%
A0A0S4IV77 Bodo saltans 33% 85%
A0A0S4JEA9 Bodo saltans 27% 88%
A0A0S4JJK3 Bodo saltans 27% 91%
A0A0S4JW09 Bodo saltans 25% 92%
A0A1X0NNY4 Trypanosomatidae 35% 80%
A0A1X0NQL4 Trypanosomatidae 29% 80%
A0A1X0NY34 Trypanosomatidae 25% 94%
A0A1X0P7V5 Trypanosomatidae 38% 84%
A0A3Q8ILZ1 Leishmania donovani 79% 100%
A0A3Q8IR23 Leishmania donovani 37% 77%
A0A3R7KSH4 Trypanosoma rangeli 26% 93%
A0A3R7MEN7 Trypanosoma rangeli 40% 85%
A0A3R7MHJ7 Trypanosoma rangeli 28% 87%
A0A3S5H827 Leishmania donovani 39% 86%
A0A3S7WXU0 Leishmania donovani 35% 83%
A0A3S7X1W4 Leishmania donovani 34% 80%
A4HCZ0 Leishmania braziliensis 34% 100%
A4HGW8 Leishmania braziliensis 35% 100%
A4HPC1 Leishmania braziliensis 37% 100%
A4HPC5 Leishmania braziliensis 37% 100%
A4HQG9 Leishmania braziliensis 99% 85%
A4I0H5 Leishmania infantum 35% 83%
A4I3Z8 Leishmania infantum 34% 80%
A4ICA2 Leishmania infantum 80% 100%
A4ICA5 Leishmania infantum 78% 66%
A4ICG3 Leishmania infantum 39% 86%
A4ICG5 Leishmania infantum 37% 77%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 84%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 88%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 89%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 84%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 85%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 77%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 83%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 80%
Q4Q0A9 Leishmania major 58% 97%
Q4Q1G2 Leishmania major 38% 100%
Q4Q1G4 Leishmania major 39% 100%
Q4Q7Z7 Leishmania major 34% 100%
Q4QB35 Leishmania major 34% 100%
Q5R8C0 Pongo abelii 24% 100%
Q9NPH0 Homo sapiens 24% 100%
V5BCI2 Trypanosoma cruzi 28% 94%
V5BIM1 Trypanosoma cruzi 24% 91%
V5BK91 Trypanosoma cruzi 40% 87%
V5BL75 Trypanosoma cruzi 28% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS